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Antiplasmodial activity

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53

Inhibitors & Agonists

36

Natural
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1

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N4307
    Laetanine
    1 Publications Verification

    		 Parasite Infection
    Laetanine, a noraporphine alkaloid from Litsea laeta, exhibits antiplasmodial activity .
    Laetanine
  • HY-N1198
    Strictosamide

    		Parasite Fungal Infection Inflammation/Immunology
    Strictosamide has important effects on inflammation and inflammatory pain. Strictosamide possesses antiplasmodial and antifungal activities .
    Strictosamide
  • HY-112728
    MMV024101

    		Parasite Infection
    MMV024101 shows potency against P. falciparum NF54 with an IC50 value of 543 nM, which has antiplasmodial activity .
    MMV024101
  • HY-N8349
    19,20-Epoxycytochalasin D

    		Parasite Endogenous Metabolite Infection Cancer
    19,20-Epoxycytochalasin D, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin D shows potent in vitro antiplasmodial activity and phytotoxicity .
    19,20-Epoxycytochalasin D
  • HY-N8385
    19,20-Epoxycytochalasin C

    		Parasite Endogenous Metabolite Infection Cancer
    19,20-Epoxycytochalasin C, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin C shows potent in vitro antiplasmodial activity and phytotoxicity .
    19,20-Epoxycytochalasin C
  • HY-N3497
    Isochamaejasmin

    		NF-κB DNA/RNA Synthesis Parasite Apoptosis Infection Cancer
    Isochamaejasmin is a biflavonoid with anti-cancer, antiplasmodial and insecticidal activities. Isochamaejasmin displays a potent NF-κB (NF-κB) activation activity. Isochamaejasmin could cause DNA damage and induce apoptosis via the mitochondrial pathway in AW1 cells . Isochamaejasmin also has a moderate antiplasmodial activity (IC50 of 7.3 μM for P. falciparum) and relatively low cytotoxicity (CC50 of 29.0 μM) .
    Isochamaejasmin
  • HY-151574
    PfGSK3/PfPK6-IN-1

    		Parasite Infection
    PfGSK3/PfPK6-IN-1 (compound 23e) is a potent inhibitor of plasmodial kinases PfGSK3 and PfPK6, with IC50s of 97 nM and 8 nM, respectively. PfGSK3/PfPK6-IN-1 exerts antiplasmodial activity against blood stage Pf3D7 parasites with an EC50 value of 1.4 mM .
    PfGSK3/PfPK6-IN-1
  • HY-N6251
    Cratoxylone

    		Parasite Infection
    Cratoxylone, isolated from the bark of Cratoxylum Cochinchinense, possesses antiplasmodial activity .
    Cratoxylone
  • HY-N12538
    trans-Cinnamic anhydride

    		Parasite Infection
    trans-Cinnamic anhydride is a Parasite inhibitor tnat can be isolated from Cinnamomum zeylanicum and exhibits moderate activity against Plasmodium falciparum .
    trans-Cinnamic anhydride
  • HY-N10624
    Koshidacin B

    		Parasite Infection
    Koshidacin B is an antiplasmodial cyclic tetrapeptide with antiplasmodial activity against P. falciparum FCR3 and K1 strain with IC50 values of 0.89 and 0.83 μM, respectively. Koshidacin B suppresses malaria parasites in vivo, it can be used for the research of parasites infection .
    Koshidacin B
  • HY-N8476
    Sahandol

    		Parasite Infection
    Sahandol is a diterpene, that can be isolated from Salvia sahendica. Sahandol shows antiplasmodial, antitrypanosomal, and cytotoxic activities .
    Sahandol
  • HY-126417
    Methylenetanshinquinone

    		Parasite Infection
    Methylenetanshinquinone is a natural compound with antiplasmodial, antitrypanosomal and antioxidative activities. Methylenetanshinquinone can be used for the research of parasite infection .
    Methylenetanshinquinone
  • HY-N3301
    Melilotigenin C

    		Parasite Bacterial Infection
    Melilotigenin C can be isolated from genus Erythrina. Melilotigenin C can be used for research on antiplasmodial activity, antimycobacterial activity and cytotoxicity .
    Melilotigenin C
  • HY-N7985
    Pendulone

    		Parasite Bacterial Infection Cancer
    Pendulone is a isoflavanquinone with good antiplasmodial activity with an IC50 of 7.0 µM. Pendulone also has antileishmanial, antibacterial and anticancer activity .
    Pendulone
  • HY-E70250
    Neocryptolepine

    Cryptotackieine

    		 Parasite Bacterial Fungal Infection
    Neocryptolepine (Cryptotackieine) has antiplasmodial activity. Neocryptolepine also shows antibacterial activity against Gram-positive bacteria (MIC < 100 μg/mL), and antifungal activity .
    Neocryptolepine
  • HY-163063
    Antimalarial agent 34

    		Parasite Infection
    Antimalarial agent 34 is a modest PfARK1/3 inhibitor and shows potent antiplasmodial activity (EC50 = 0.16 μM) .
    Antimalarial agent 34
  • HY-132906
    Antimalarial agent 3

    		Parasite Infection
    Antimalarial agent 3 shows nanomolar antiplasmodial activity (IC50 = 0.035 μM) and has a very high selectivity index with respect to mammalian cells.
    Antimalarial agent 3
  • HY-N8383
    Butyrolactone V

    		Parasite Infection
    Butyrolactone V is a butanolide compound. Butyrolactone V shows antiplasmodial activity against Plasmodium falciparum K1 with an IC50 of 7.9 µg/ml .
    Butyrolactone V
  • HY-N5107
    Epimagnolin A

    (+)-epi-Magnolin

    		 Parasite Infection
    Epimagnolin A, a furfuran lignan, shows mild antiplasmodial activities (IC50=5.7 μg/mL) without noticeable toxicity on mammalian normal cells .
    Epimagnolin A
  • HY-148180
    Antimycobacterial agent-4

    		Bacterial Parasite Infection
    Antimycobacterial agent-4 is a 2-amino-4-(2-pyridyl) thiazole derivative, with antimycobacterial activity, antiplasmodial activity, and cytotoxicity on a mammalian cell line .
    Antimycobacterial agent-4
  • HY-N3378
    Lipiferolide

    		Farnesyl Transferase Parasite Infection
    Lipiferolide is an antiplasmodial agent (IC50: 1.8 μg/mL) that can be isolated from Liriodendron tulipifera. Lipiferolide also inhibits FPTase, and has antitumor activity .
    Lipiferolide
  • HY-N9343
    Kulactone

    		Bacterial Fungal Parasite Infection Inflammation/Immunology
    Kulactone, a natural bioflavonoid and an inhibitor against jRdRp, possesses antifungal, antibacterial and antiplasmodial activities. Kulactone exhibit no crossing through Blood Brain Barrier (BBB) .
    Kulactone
  • HY-156843
    Antiproliferative agent-38

    		Others Cancer
    Antiproliferative agent-38 (com 18) is a tetracyclic ring, but its most reactive ring nitrogen (probably the quinoline moiety) cannot undergo N-alkylation. Antiproliferative agent-38 lacks anti-malarial activity and lacks anti-cancer cell proliferation activity .
    Antiproliferative agent-38
  • HY-136943
    K-41

    		Antibiotic Parasite Bacterial Infection
    K-41 is an orally active antibiotic. K-41 can be obtained from Streptomyces hygroscopicus. K-41 has antibacterial and antiplasmodial activity .
    K-41
  • HY-168208
    Antimalarial agent 45

    		Parasite Infection
    Antimalarial agent 45 (compound 8I) is a antimalarial agent and shows antiplasmodial activity the IC50 of 0.21 μM. Antimalarial agent 45 can be used for study of malaria .
    Antimalarial agent 45
  • HY-169339
    Villalstonine

    		Parasite Infection Cancer
    Villalstonine is a bisindole alkaloid with various biological activities including anticancer, antimalarial, and antiamoebic activities. Villalstonine exhibits potent antiplasmodial activity against the multidrug-resistant K1 strain of P. falciparum with an IC50 value of 0.27 μM .
    Villalstonine
  • HY-N11031
    Z-Antiepilepsirine

    		Parasite Infection
    Z-Antiepilepsirine is an amide alkaloid that can be found in Piper capense L.f. Z-Antiepilepsirine shows antiplasmodial activity with an IC50 value of 27 µM for W2 strain of Plasmodium falciparum .
    Z-Antiepilepsirine
  • HY-N2903
    Artoheterophyllin B

    		Parasite Infection
    Artoheterophyllin B can be isolated from A. heterophyllus. Artoheterophyllin B shows antiplasmodial activity (IC50: 13.7 μM against FcB1 strain). Artoheterophyllin B can be used for anti-malarial research .
    Artoheterophyllin B
  • HY-161171
    Antimalarial agent 37

    		Parasite Ephrin Receptor Cancer
    Antimalarial agent 37 (compound 33) is a selective inhibitor against Type Ⅱ kinase with antiplasmodial activity. Antimalarial agent 37 exhibited cytotoxicity and selectivity towards cancer cells HepG2 and MCF 7 .
    Antimalarial agent 37
  • HY-N1219
    Stephanine

    (-)-Stephanine; l-Stephanine

    		 Apoptosis Parasite Infection Inflammation/Immunology Cancer
    Stephanine ((-)-Stephanine) is an isoquinoline aporphine-type alkaloid. Stephanine induce apoptosis through the reverse of mitotic exit. Stephanine exhibits Antiplasmodial activity. Stephanine can be used for the research of stomach pain, abdominal pain, arthritis and cancer .
    Stephanine
  • HY-N1581
    Quassin

    Nigakilactone D

    		 Parasite Infection Endocrinology
    Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits P. falciparum with an IC50 of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity .
    Quassin
  • HY-148178
    MMV688533

    		Parasite Infection
    MMV688533 is an antimalarial agent with rapid anti-plasmodial activity and effective single-dose activity against Plasmodium falciparum infection in humanized mouse models. MMV688533 can inhibit the activity of asexual blood stage parasites with an IC50 value of 1.3 nM. MMV688533 exhibits excellent pharmacokinetic properties and safety .
    MMV688533
  • HY-N5109
    Cheilanthifoline

    		Parasite Infection
    Cheilanthifoline, an alkaloid, is isolated from Corydalis calliantha. Cheilanthifoline exhibits antiplasmodial activities against Plasmodium falciparum, with IC50s of 0.90 μg/mL and 1.22 μg/mL for wild type (TM4) and multidrug resistant (K1) strains, respectively .
    Cheilanthifoline
  • HY-N7648
    Atherosperminine

    Atherospermine

    		 Parasite Infection
    Atherosperminine（Atherospermine）is a nature occurring alkaloid, has antiplasmodial activities in vitro, with an IC50 of 5.80 μM. Atherosperminine is a good reductant with the ability to chelate metals. Atherosperminine has scavenging activity towards the free radical DPPH, with an IC50 of 29.56 µg/mL. Atherosperminine exerts a non-specific relaxant effect on the trachealis .
    Atherosperminine
  • HY-W026467
    MMV665916

    		Parasite Infection
    MMV665916, a quinazolinedione derivative, is an antimalarial agent. MMV665916 displays antiplasmodial activity against P. falciparum FcB1 strain with EC50 value of 0.4 µM and presents the high selectivity index (SI>250) .
    MMV665916
  • HY-N10754
    Aschantin

    		mTOR Cytochrome P450 Infection Cardiovascular Disease Cancer
    Aschantin, a bisepoxylignan, can be isolated from Magnolia biondii. Aschantin has antiplasmodial, Ca 2+-antagonistic, platelet activating factor-antagonistic, and chemopreventive activities. Aschantin is a mTOR kinase inhibitor. Aschantin is also an inhibitor of Cytochrome P450 and UGT enzyme .
    Aschantin
  • HY-N2932
    β-Yohimbine

    Amsonin; Amsonine; NSC 93133

    		 Parasite Infection
    β-Yohimbine (Amsonin) is an indole alkaloid that can be isolated from Aspidosperma ulei Markgr. β-Yohimbine shows antiplasmodial activity against the Chloroquine (HY-17589A)-resistant Fc M29-Cameroon strain (IC50: > 1 μg/mL) .
    β-Yohimbine
  • HY-N8691
    2',6'-Dihydroxy-4'-methoxydihydrochalcone

    		Parasite Infection Inflammation/Immunology
    2',6'-Dihydroxy-4'-methoxydihydrochalcone is an orally active dihydrochalcone compound with antiplasmodial and anti-inflammatory activities. 2',6'-Dihydroxy-4'-methoxydihydrochalcone reduces the IL-1β, TNF, and nitrite levels in vitro .
    2',6'-Dihydroxy-4'-methoxydihydrochalcone
  • HY-121200
    Azadirone

    		TNF Receptor Bcl-2 Family Parasite Infection Cancer
    Azadirone sensitized cancer cells to TNF-related apoptosis-inducing ligand (TRAIL) through ROS-ERK-CHOP-mediated up-regulation of DR5 and DR4 expression, down-regulation of cell survival proteins, and up-regulation of proapoptotic proteins (Bid). Azadirone has antiplasmodial activity .
    Azadirone
  • HY-N5005
    Guanfu base H

    Atisinium chloride

    		 Parasite Infection
    Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid isolated from Aconitum coreanum and has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 with IC50 values of 4 μM and 3.6 μM, respectively .
    Guanfu base H
  • HY-147971
    Anticancer agent 75

    		Parasite Topoisomerase Infection Cancer
    Anticancer agent 75 is a potent anticancer agent. Anticancer agent 75 shows cytotoxicity and selectivity in cancer cell lines. Anticancer agent 75 shows cytotoxicity to normal human kidney cell lines is at least 35 times lower than that of the Doxorubicin standard. Anticancer agent 75 shows good activity of antiplasmodial .
    Anticancer agent 75
  • HY-N1581R
    Quassin (Standard)

    		Parasite Infection Endocrinology
    Quassin (Standard) is the analytical standard of Quassin. This product is intended for research and analytical applications. Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits P. falciparum with an IC50 of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity .
    Quassin (Standard)
  • HY-N9746
    (R)-4-Methoxydalbergione

    		Parasite Infection
    (R)-4-Methoxydalbergione is a urease inhibitor with IC50s of 59.72 and 67.33 μM for Bacillus pasteurii urease and Jack bean urease. (R)-4-Methoxydalbergione also has antiplasmodial activity. (R)-4-Methoxydalbergione can be isolated from Ranunculus repens .
    (R)-4-Methoxydalbergione
  • HY-N6009
    8-Deoxygartanin

    		Parasite NF-κB Infection
    8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE) . 8-Deoxygartanin exhibits antiplasmodial activity with an IC50 of 11.8 μM for the W2 strain of Plasmodium falciparum . 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC50 of 11.3 μM .
    8-Deoxygartanin
  • HY-N0749
    Jatrorrhizine

    		Cholinesterase (ChE) 5-HT Receptor Bacterial Neurological Disease
    Jatrorrhizine is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .
    Jatrorrhizine
  • HY-N0740
    Jatrorrhizine chloride
    1 Publications Verification

    		 Cholinesterase (ChE) 5-HT Receptor Bacterial Neurological Disease Inflammation/Immunology
    Jatrorrhizine chloride is an alkaloid isolated from?Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine chloride is a potent and orally active inhibitor of?AChE?(IC50=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine chloride reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .
    Jatrorrhizine chloride
  • HY-155354
    Antimalarial agent 33

    		Parasite Infection
    Antimalarial agent 33 (compound 5g) has antiplasmodial activity against erythrocytic and hepatic stages of Plasmodium with an EC50 of 1.1 μM for K1 P. falciparum strain. Antimalarial agent 33 demonstrats enhanced microsomal stability (T1/2=29 min). Antimalarial agent 33 has no significant cytotoxicity against primary hepatocytes .
    Antimalarial agent 33
  • HY-149961
    Anti-inflammatory agent 40

    		Parasite Infection Inflammation/Immunology
    Anti-inflammatory agent 40 is a potential and orally active anti-malarial and anti-inflammatory agent. Anti-inflammatory agent 40 inhibits carrageenan induced paw swelling in vivo.
    Anti-inflammatory agent 40
  • HY-N0749A
    Jatrorrhizine hydroxide
    1 Publications Verification

    		 Cholinesterase (ChE) 5-HT Receptor Bacterial Neurological Disease Inflammation/Immunology
    Jatrorrhizine hydroxide is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine hydroxide is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine hydroxide reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .
    Jatrorrhizine hydroxide
  • HY-133192
    Bis-propargyl-PEG3

    		PROTAC Linkers Infection Cancer
    Bis-propargyl-PEG3 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG3 is used in the synthesis of zinc-dipicolylamine (ZnDPA) complexes with antiplasmodial activity . Bis-propargyl-PEG3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Bis-propargyl-PEG3

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