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BCA

" in MedChemExpress (MCE) Product Catalog:

17

Inhibitors & Agonists

5

Biochemical Assay Reagents

1

Inhibitory Antibodies

3

Natural
Products

7

Recombinant Proteins

2

Isotope-Labeled Compounds

7

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15908
    BCA
    5 Publications Verification

    Disodium bicinchoninate

    Beta-secretase Neurological Disease Cancer
    BCA (Disodium bicinchoninate) is an orally active and non-competitive Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 value of 28 µM, a Ki value of 43 µM. BCA shows anticancer activity. BCA has the potential for the research of Alzheimer's disease (AD) .
    BCA
  • HY-W440823A

    DSPE-PEG-NH2, MW 1000 ammonium

    Liposome Others
    DSPE-PEG-Amine, MW 1000 (ammonium) is a phosphoethanolamine involved in the synthesis of liposomes for delivery systems. The amino group of DSPE-PEG-Amine, MW 1000 (ammonium) can be converted to an aromatic aldehyde, which reacts with an acetone-protected aromatic hydrazine on the surface of the bovine carbonic anhydrase (BCA) molecule. Liposomes form a liposome-BAH-BCA conjugate by forming a bisarylhydrazone (BAH) with the target enzyme molecule. The conjugate catalyzes the hydration of carbon dioxide to bicarbonate.
    DSPE-PEG-Amine, MW 1000 ammonium
  • HY-RS01399

    Small Interfering RNA (siRNA) Others

    BCAS1 Human Pre-designed siRNA Set A contains three designed siRNAs for BCAS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    BCAS1 Human Pre-designed siRNA Set A
    BCAS1 Human Pre-designed siRNA Set A
  • HY-RS01400

    Small Interfering RNA (siRNA) Others

    BCAS2 Human Pre-designed siRNA Set A contains three designed siRNAs for BCAS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    BCAS2 Human Pre-designed siRNA Set A
    BCAS2 Human Pre-designed siRNA Set A
  • HY-RS01401

    Small Interfering RNA (siRNA) Others

    BCAS3 Human Pre-designed siRNA Set A contains three designed siRNAs for BCAS3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    BCAS3 Human Pre-designed siRNA Set A
    BCAS3 Human Pre-designed siRNA Set A
  • HY-P990957

    BCA-101; FMAB2

    EGFR Inflammation/Immunology
    HY-P990957 is an EGFR-targeting IgG1κ type chimeric antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .
    Ficerafusp alfa
  • HY-155887

    DSPE-PEG-NH2, MW 3400 ammonium

    Liposome Others
    DSPE-PEG-Amine, MW 3400 (ammonium) is a phosphoethanolamine involved in the synthesis of liposomes for delivery systems. The amino group of DSPE-PEG-Amine, MW 3400 (ammonium) can be converted to aromatic aldehydes by reacting with acetone-protected aromatic hydrazines on the surface of bovine carbonic anhydrase (BCA) molecules. Liposomes form a liposome-BAH-BCA conjugate by forming a bisarylhydrazone (BAH) with the target enzyme molecule. The conjugate catalyzes the hydration of carbon dioxide to bicarbonate.
    DSPE-PEG-Amine, MW 3400 ammonium
  • HY-155908

    DSPE-PEG-NH2, MW 10000 ammonium

    Liposome Others
    DSPE-PEG-Amine, MW 10000 (ammonium) is a phosphoethanolamine involved in the synthesis of liposomes for delivery systems. The amino group of DSPE-PEG-Amine, MW 10000 (ammonium) can be converted into aromatic aldehydes by reacting with acetone-protected aromatic hydrazines on the surface of bovine carbonic anhydrase (BCA) molecules. Liposomes form a liposome-BAH-BCA conjugate by forming a bisarylhydrazone (BAH) with the target enzyme molecule. The conjugate catalyzes the hydration of carbon dioxide to bicarbonate.
    DSPE-PEG-Amine, MW 10000 ammonium
  • HY-155907

    DSPE-PEG-NH2, MW 5000 ammonium

    Liposome Others
    DSPE-PEG-Amine, MW 5000 (ammonium) is a phosphoethanolamine involved in the synthesis of liposomes for delivery systems. DSPE-PEG-Amine, MW 5000 (ammonium) amino group can be converted to aromatic aldehydes that react with acetone-protected aromatic hydrazides on the surface of the bovine carbonic anhydrase (BCA) molecule. Liposomes produce liposome-Bah-BCA conjugates by forming diaryl hydrazone (BAH) with target enzyme molecules. The conjugate catalyzes the hydration of carbon dioxide to bicarbonate.
    DSPE-PEG-Amine, MW 5000 ammonium
  • HY-W031519

    Carbonic Anhydrase Cardiovascular Disease
    Chloraminophenamide (Compound 14) is a carbonic anhydrase inhibitor, with Kis of 75, 160 and 8400 nM for hCA II, bCA IV and hCA I, respectively. Chloraminophenamide has the potential for antiglaucoma research .
    Chloraminophenamide
  • HY-32933

    Carbonic Anhydrase Metabolic Disease
    4-Acetylphenylboronic acid is a potent inhibitor of carbonic anhydrases II(CA II), with IC50s of 246 μM and 281.40 μM for bovine CA II (bCA II) and human CA II (hCA II), respectively .
    4-Acetylphenylboronic acid
  • HY-16993
    OICR-9429
    Maximum Cited Publications
    8 Publications Verification

    Apoptosis WDR5 Cancer
    OICR-9429 is high affinity WD repeat domain 5 (WDR5) inhibitor, competitively blocks WDR5 interaction with MLL protein via binding the central peptide-binding pocket of WDR5. OICR-9429 can suppress histone H3K4 trimethylation and can be used for the research of various cancers including non-MLL-rearranged leukaemia, colon, pancreatic, prostate cancer and bladder cancer (BCa) .
    OICR-9429
  • HY-101392
    Harmane
    1 Publications Verification

    Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor nAChR GABA Receptor Opioid Receptor Neurological Disease Inflammation/Immunology
    Harmane is a benzodiazepine receptor inhibitor (IC50=7 μM), with IC50 values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC50 = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .
    Harmane
  • HY-101392A

    Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor nAChR GABA Receptor Opioid Receptor Neurological Disease Inflammation/Immunology
    Harmane hydrochloride is a benzodiazepine receptor inhibitor (IC50=7 μM), with IC50 values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane hydrochloride inhibits the I1 imidazoline receptor (IC50 = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane hydrochloride inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane hydrochloride can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .
    Harmane hydrochloride
  • HY-101392S1

    Isotope-Labeled Compounds Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor Neurological Disease Cancer
    Harmane-d2 is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].
    Harmane-d2
  • HY-101392S

    Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor Neurological Disease Cancer
    Harmane-d is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].
    Harmane-d1
  • HY-101392R

    Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor Neurological Disease Cancer
    Harmane (Standard) is the analytical standard of Harmane. This product is intended for research and analytical applications. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively). Harmane exhibits comutagenic effect .
    Harmane (Standard)

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