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Results for "

CHIKV Inhibitor

" in MedChemExpress (MCE) Product Catalog:

13

Inhibitors & Agonists

1

Peptides

3

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-161762
    RA-0002034

    		Virus Protease Infection
    RA-0002034 is a Chikungunya virus (CHIKV) nsP2 protease inhibitor with an IC50 of 58 nM. RA-0002034 covalently modifies the catalytic cysteine in a site-specific manner .
    RA-0002034
  • HY-132174
    CHIKV-IN-2

    		Flavivirus Dengue Virus Dihydroorotate Dehydrogenase Infection
    CHIKV-IN-2 is a potent inhibitor against Chikungunya virus (CHIKV), with excellent cellular antiviral activity (EC90=270 nM) and improved liver microsomal stability. CHIKV-IN-2 shows inhibitory activity against a cellular target Dihydroorotate Dehydrogenase (DHODH), which interacts with various viruses and regulate their replication via depleting intracellular pyrimidine pools .
    CHIKV-IN-2
  • HY-N0862
    Harringtonine
    10+ Cited Publications

    		 Influenza Virus Infection Cancer
    Harringtonine is a natural Cephalotaxus alkaloid that inhibits protein synthesis. Harringtonine has anti-chikungunya virus (CHIKV) activities with an EC50 of 0.24 μM.
    Harringtonine
  • HY-N2086
    Ethyl palmitate
    2 Publications Verification

    Ethyl hexadecanoate

    		 TNF Receptor Interleukin Related NF-κB Infection Inflammation/Immunology
    Ethyl palmitate (Ethyl hexadecanoate) is a CHIKV virus inhibitor with an EC50 value of 0.0068 μM. Ethyl palmitate can reduce levels of TNF-α, IL-6, and NF-κB in endotoxemic rats, showing anti-inflammatory activity .
    Ethyl palmitate
  • HY-163088
    CHIKV-IN-4

    		Flavivirus Infection
    CHIKV-IN-4 (compound 31b) is a potent and selective CHIKV inhibitor. CHIKV-IN-4 inhibits the Chikungunya virus with the EC50 value of 0.6 μM .
    CHIKV-IN-4
  • HY-144334
    CHIKV-IN-3

    		DNA/RNA Synthesis Infection
    CHIKV-IN-3 is a potent against two low-passage CHIKV inhibitor with EC50 values of 1.55 and 0.14 µM for CHIKV-122508 and CHIKV-6708, respectively. CHIKV-IN-3 acts on the host cells to interfere with the viral replication. CHIKV-IN-3 displays minimal cytotoxic liability(CC50 > 100 µM). Prophylactic effect .
    CHIKV-IN-3
  • HY-169429
    CHIKV-IN-5

    		Flavivirus Infection
    CHIKV-IN-5 (Compound 26) is a CHIKV inhibitor (EC90 = 0.45 μM). CHIKV-IN-5 inhibits CHIKV replication at a late stage in the virus life cycle by blocking structural protein translation. CHIKV-IN-5 has great in vitro mouse microsomal stability. CHIKV-IN-5 reduces footpad swelling and decreases virus dissemination to other tissues in mice infected with CHIKV .
    CHIKV-IN-5
  • HY-169102
    CHIKV nsP2 protease-IN-1

    		Virus Protease Infection
    CHIKV nsP2 protease-IN-1(compound J13) is an oral active non-structural protein 2 protease inhibitor with the EC50 of 0.39 μM aganist of CHIKV S27. CHIKV nsP2 protease-IN-1 can be used for study of Chikungunya virus .
    CHIKV nsP2 protease-IN-1
  • HY-168050
    nsP2 Protease-IN-1

    		Virus Protease Infection
    nsP2 Protease-IN-1 is a potent irreversible covalent inhibitor of Chikungunya (CHIKV) nsP2 cysteine protease with an IC50 value of 60 nM. nsP2 Protease-IN-1 demonstrates potent antialphavirus activity, inhibiting CHIKV and VEEV replication with EC50 = 0.01 and 0.3 µM, respectively .
    nsP2 Protease-IN-1
  • HY-161762A
    (E/Z)-RA-0002034

    		Influenza Virus Cancer
    (E/Z)-RA-0002034 is a Chikungunya virus (CHIKV) nsP2 protease inhibitor with IC50 of 58 nM. RA-0002034 covalently modifies the catalytic cysteine in a site-specific manner.
    (E/Z)-RA-0002034
  • HY-B0641
    Felbinac

    4-Biphenylacetic acid

    		 COX Inflammation/Immunology
    Felbinac is a metabolite of fenbufen, an orally active nonsteroidal anti-inflammatory agent and a cyclooxygenase (COX) inhibitor with an IC50 of 865.68 nM for COX1 and 976 nM for COX2. Felbinac reduces the production of prostaglandins by inhibiting COX to relieve pain, reduce inflammation and reduce fever. Felbinac can inhibit CHIKV viral activity .
    Felbinac
  • HY-125033
    EIDD-1931
    Maximum Cited Publications
    23 Publications Verification

    β-D-N4-hydroxycytidine; NHC

    		 SARS-CoV Enterovirus HCV Topoisomerase Infection
    EIDD-1931 (Beta-d-N4-hydroxycytidine; NHC) is a novel nucleoside analog and behaves as a potent anti-virus agent. EIDD-1931 effectively inhibits the replication activity of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV) .
    EIDD-1931
  • HY-135867D
    NHC-diphosphate
    1 Publications Verification

    		 Endogenous Metabolite Enterovirus HCV Topoisomerase SARS-CoV Infection
    NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a diphosphate form . NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV)  and hepatitis C virus (HCV) .
    NHC-diphosphate

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