2. Apoptosis Immunology/Inflammation NF-κB
  3. TNF Receptor Interleukin Related NF-κB
  4. Ethyl palmitate

Ethyl palmitate  (Synonyms: Ethyl hexadecanoate)

Cat. No.: HY-N2086 Purity: 99.05%
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Ethyl palmitate (Ethyl hexadecanoate) is a CHIKV virus inhibitor with an EC50 value of 0.0068 μM. Ethyl palmitate can reduce levels of TNF-α, IL-6, and NF-κB in endotoxemic rats, showing anti-inflammatory activity.

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Ethyl palmitate Chemical Structure

Ethyl palmitate Chemical Structure

CAS No. : 628-97-7

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Based on 2 publication(s) in Google Scholar

Other Forms of Ethyl palmitate:

Ethyl palmitate Related Antibodies

Top Publications Citing Use of Products

2 Publications Citing Use of MCE Ethyl palmitate

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ethyl palmitate (Ethyl hexadecanoate) is a CHIKV virus inhibitor with an EC50 value of 0.0068 μM. Ethyl palmitate can reduce levels of TNF-α, IL-6, and NF-κB in endotoxemic rats, showing anti-inflammatory activity[1][2].
In Vitro

Ethyl palmitate (1 μg/mL; 24, 48 h) can inhibit the expression and viral activity of CHIKV virus E2 protein, with an EC50 value of 0.0068 μM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ethyl palmitate Related Antibodies

Western Blot Analysis[2].

Cell Line: CHIKV infected Vero cells
Concentration: 1 μg/mL
Incubation Time: 24, 48 h
Result: Resulted in no expression of CHIKV E2 protein.
In Vivo

Ethyl palmate (10 mL/kg; once; i.p.) can reduce the levels of TNF-α, IL-6, and NF-κB in endotoxemia rats, improve the histopathological changes induced by LPS, and has anti-inflammatory activity[1].
Ethyl palmate (1.5 mg/kg; once daily; 3 weeks; i.v.) can inhibit the phagocytic function of the reticuloendothelial system (RES) in dogs and reduce liver blood flow[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A rat model of lipopolysaccharide (LPS)-induced endotoxemia[1].
Dosage: 10 mL/kg
Administration: Intraperitoneal injection (i.p.); once
Result: Reduced plasma levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), decreased NF-κB expression in liver and lung tissues and ameliorated histopathological changes caused by LPS.
Animal Model: 12 dogs of both sexes, weighing between 5.0 and 11.2 kg[3].
Dosage: 1.5 mg/kg
Administration: Intravenous injection (i.v.); once daily; 3 weeks
Result: Inhibited the phagocytic activity of red blood cells and led to hepatocyte degeneration and local necrosis.
Molecular Weight

284.48

Formula

C18H36O2
CAS No.
Appearance

<24°C Solid,>26°C Liquid

Color

Colorless to light yellow

SMILES

CCCCCCCCCCCCCCCC(OCC)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (351.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5152 mL 17.5759 mL 35.1519 mL
5 mM 0.7030 mL 3.5152 mL 7.0304 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (8.79 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (8.79 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.05%

SDS (393 KB)

COA (237 KB) HNMR (133 KB) GC (329 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5152 mL 17.5759 mL 35.1519 mL 87.8796 mL
5 mM 0.7030 mL 3.5152 mL 7.0304 mL 17.5759 mL
10 mM 0.3515 mL 1.7576 mL 3.5152 mL 8.7880 mL
15 mM 0.2343 mL 1.1717 mL 2.3435 mL 5.8586 mL
20 mM 0.1758 mL 0.8788 mL 1.7576 mL 4.3940 mL
25 mM 0.1406 mL 0.7030 mL 1.4061 mL 3.5152 mL
30 mM 0.1172 mL 0.5859 mL 1.1717 mL 2.9293 mL
40 mM 0.0879 mL 0.4394 mL 0.8788 mL 2.1970 mL
50 mM 0.0703 mL 0.3515 mL 0.7030 mL 1.7576 mL
60 mM 0.0586 mL 0.2929 mL 0.5859 mL 1.4647 mL
80 mM 0.0439 mL 0.2197 mL 0.4394 mL 1.0985 mL
100 mM 0.0352 mL 0.1758 mL 0.3515 mL 0.8788 mL
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Ethyl palmitate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ethyl628-97-7Ethyl hexadecanoateTNF ReceptorInterleukin RelatedNF-κBTumor Necrosis Factor ReceptorTNFRILNuclear factor-κBNuclear factor-kappaBCHIKVantiviralanti-inflammatoryTNF-αIL-6Inhibitorinhibitorinhibit

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