DNA primer

Pathways Recommended:	Cell Cycle/DNA Damage

By Targets:	DNA/RNA Synthesis (7) Antibiotic (1) Apoptosis (3) Drug Metabolite (2) Fluorescent Dye (1) Histone Methyltransferase (1) HIV (1) Nucleoside Antimetabolite/Analog (2)
By Research Areas:	Cancer (4) Infection (1)

Targets Recommended: DNA-PK DNA Methyltransferase DNA Stain DNA Alkylator/Crosslinker DNA/RNA Synthesis

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D1720

Cy5-dATP	DNA/RNA Synthesis	Others
Cy5-dATP is a Cy5 (HY-D0821)-labeled dATP (HY-136648). Cy5-dATP can be incorporated into a DNA primer .

HY-15349

Trovirdine 1 Publications Verification LY300046	HIV	Infection
Trovirdine inhibits HIV-1 RT with an IC50 of 7 nM when employing heteropolymeric primer/template (oligo-DNA/ribosomal RNA)and dGTP as substrate.

HY-E70094

T4 UvsX Recombinase	DNA/RNA Synthesis	Others
T4 UvsX Recombinase helps initiate DNA replication on a double-stranded DNA template by catalyzing synapsis between the template and a homologous DNA single strand that serves as primer. T4 UvsX Recombinase greatly amplifies the snap-back (hairpin-primed) DNA synthesis that is catalyzed by the T4 DNA polymerase holoenzyme on linear, single-stranded DNA templates .

HY-136650A

Fludarabine triphosphate trisodium 1 Publications Verification F-ara-ATP trisodium	Nucleoside Antimetabolite/Analog Drug Metabolite DNA/RNA Synthesis Apoptosis	Cancer
Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC₅₀ of 2.3 μM and a K_i of 6.1 μM. Fludarabine triphosphate trisodium inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate trisodium inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis .

HY-43520

BODIPY-FL	Fluorescent Dye	Others
BODIPY-FL is a green fluorescent dye that can be used to label probes or primers. BODIPY-FL fluorescence can be quenched after interacting with uniquely positioned guanine, making it useful for quantifying specific DNA or RNA molecules. BODIPY-FL-labeled sphingolipid analogs can be used to investigate sphingolipid internalization, transport, and endocytosis in mouse embryonic stem cells. BODIPY-FL-labeled monoterpenes can quickly penetrate bacteria, mammalian, and fungal cells, allowing for the detection of characteristics of a broad spectrum of Gram-positive and Gram-negative bacteria, as well as pathogenic fungi. The maximum absorption wavelength of BODIPY-FL is 505 nm, and the maximum emission wavelength is 513 nm .

HY-155869

5-fluoro-dCTP 5-Fluoro-2′-deoxycytidine 5′-triphosphate	DNA/RNA Synthesis	Others
5-fluoro-dCTP is a fluorinated pyrimidine dNTP that can be used as a substrate for the incorporation of fluorine modification into specific DNA sequences by primer extension (PEX) catalyzed by Pwo polymerase .

HY-155869A

5-fluoro-dCTP sodium 5-Fluoro-2′-deoxycytidine 5′-triphosphate sodium	DNA/RNA Synthesis	Others
5-fluoro-dCTP sodium is a fluorinated pyrimidine dNTP that can be used as a substrate for the incorporation of fluorine modification into specific DNA sequences by primer extension (PEX) catalyzed by Pwo polymerase .

HY-136650

Fludarabine triphosphate F-ara-ATP	Nucleoside Antimetabolite/Analog Drug Metabolite DNA/RNA Synthesis Apoptosis	Cancer
Fludarabine triphosphate (F-ara-ATP), the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC₅₀ of 2.3 μM and a K_i of 6.1 μM. Fludarabine triphosphate inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis .

HY-122532

Fagaronine chloride	Histone Methyltransferase	Cancer
Fagaronine chloride is an alkaloid with inhibitory activity against reverse transcriptase and topoisomerase I. Fagaronine chloride can effectively inhibit the reverse transcriptase of RSii tumor virus at a concentration of 6-60 μg/mL. Fagaronine chloride rapidly blocks the synthesis of DNA polymerase by interacting with the template primer. Fagaronine chloride has shown anti-tumor potential, especially in the study of retroviral infection .

HY-100513A

Dehydroaltenusin	Apoptosis DNA/RNA Synthesis Antibiotic	Cancer
Dehydroaltenusin is a small molecule selective inhibitor of eukaryotic DNA polymerase α, a type of antibiotic produced by a fungus with an IC₅₀ value of 0.68 μM. The inhibitory mode of action of dehydroaltenusin against mammalian pol α activity is competitive with respect to the DNA template primer (K_i=0.23 µM) and non-competitive with respect to the 2'-deoxyribonucleoside 5'-triphosphate substrate (K_i=0.18 µM) . Dehydroaltenusin arrests the cancer cell cycle at the S-phase and triggers apoptosis . Dehydroaltenusin possesses anti-tumor activity against human adenocarcinoma tumor in vivo .

Cat. No.	Product Name	Type

HY-D1720

Cy5-dATP	Fluorescent Dyes/Probes
Cy5-dATP is a Cy5 (HY-D0821)-labeled dATP (HY-136648). Cy5-dATP can be incorporated into a DNA primer .

HY-43520

BODIPY-FL	Fluorescent Dyes/Probes
BODIPY-FL is a green fluorescent dye that can be used to label probes or primers. BODIPY-FL fluorescence can be quenched after interacting with uniquely positioned guanine, making it useful for quantifying specific DNA or RNA molecules. BODIPY-FL-labeled sphingolipid analogs can be used to investigate sphingolipid internalization, transport, and endocytosis in mouse embryonic stem cells. BODIPY-FL-labeled monoterpenes can quickly penetrate bacteria, mammalian, and fungal cells, allowing for the detection of characteristics of a broad spectrum of Gram-positive and Gram-negative bacteria, as well as pathogenic fungi. The maximum absorption wavelength of BODIPY-FL is 505 nm, and the maximum emission wavelength is 513 nm .

BODIPY-FL

Fluorescent Dyes/Probes

BODIPY-FL is a green fluorescent dye that can be used to label probes or primers. BODIPY-FL fluorescence can be quenched after interacting with uniquely positioned guanine, making it useful for quantifying specific DNA or RNA molecules. BODIPY-FL-labeled sphingolipid analogs can be used to investigate sphingolipid internalization, transport, and endocytosis in mouse embryonic stem cells. BODIPY-FL-labeled monoterpenes can quickly penetrate bacteria, mammalian, and fungal cells, allowing for the detection of characteristics of a broad spectrum of Gram-positive and Gram-negative bacteria, as well as pathogenic fungi. The maximum absorption wavelength of BODIPY-FL is 505 nm, and the maximum emission wavelength is 513 nm .

Cat. No.	Product Name

HY-KE8008

T4 DNA Polymerase
T4 DNA polymerase has 5´→3´ DNA polymerase activity and can catalyze the synthesis of DNA along the 5´→3´ direction with the presence of templates and primers.

HY-K0501

SYBR Green qPCR Master Mix Maximum Cited Publications 220 Publications Verification
MCE qPCR Master Mix is provided as a simple-to-use, stabilized 2× formulation that includes all components for qPCR except sample DNA, primers and water.

HY-K0533

2× High-Fidelity PCR Master Mix 1 Publications Verification
2× High-Fidelity PCR Master Mix is provided as a simple-to-use, stabilized 2× formulation that includes all components for PCR except sample DNA, primers and water.

HY-K0531

2× PCR Master Mix (with Dye)
2× PCR Master Mix (with Dye) is provided as a simple-to-use, stabilized 2× formulation that includes all components for PCR except sample DNA, primers and water, in which bromophenol blue dye is included.

HY-K0523

SYBR Green qPCR Master Mix (No ROX) 20+ Cited Publications
SYBR Green qPCR Master Mix (No ROX) is provided as a simple-to-use, stabilized 2× formulation that includes all components for qPCR except sample DNA, primers and water, in which no ROX Reference Dye is included.

HY-K0532

2× Fast PCR Master Mix (with Dye) 2 Publications Verification
2× Fast PCR Master Mix (with Dye) is provided as a simple-to-use, stabilized 2× formulation that includes all components for fast PCR except sample DNA, primers and water, in which bromophenol blue dye is included.

HY-K0521

SYBR Green qPCR Master Mix (High ROX) 2 Publications Verification
SYBR Green qPCR Master Mix (High ROX) is provided as a simple-to-use, stabilized 2× formulation that includes all components for qPCR except sample DNA, primers and water, in which High ROX Reference Dye is included.

HY-K0522

SYBR Green qPCR Master Mix (Low ROX) 15+ Cited Publications
SYBR Green qPCR Master Mix (Low ROX) is provided as a simple-to-use, stabilized 2× formulation that includes all components for qPCR except sample DNA, primers and water, in which Low ROX Reference Dye is included.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-100513A

Dehydroaltenusin	Structural Classification Monophenols Microorganisms Classification of Application Fields Antibiotics Source classification Phenols Disease Research Anticancer Disease Research Fields Other Antibiotics Cancer	Apoptosis DNA/RNA Synthesis Antibiotic
Dehydroaltenusin is a small molecule selective inhibitor of eukaryotic DNA polymerase α, a type of antibiotic produced by a fungus with an IC₅₀ value of 0.68 μM. The inhibitory mode of action of dehydroaltenusin against mammalian pol α activity is competitive with respect to the DNA template primer (K_i=0.23 µM) and non-competitive with respect to the 2'-deoxyribonucleoside 5'-triphosphate substrate (K_i=0.18 µM) . Dehydroaltenusin arrests the cancer cell cycle at the S-phase and triggers apoptosis . Dehydroaltenusin possesses anti-tumor activity against human adenocarcinoma tumor in vivo .

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