F8 | MedChemExpress (MCE) Life Science Reagents

By Targets:	Apoptosis (1) Biochemical Assay Reagents (1) CD2 (1) CD3 (1) Endogenous Metabolite (2) Fluorescent Dye (1) GSK-3 (1) Interleukin Related (2) Liposome (1) PI3K (1) SARS-CoV (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (1) Metabolic Disease (2)
Oligonucleotides:	Cationic Lipids (1) Human Pre-designed siRNA Sets (3) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D2377

F8	Fluorescent Dye	Others
F8 is a small molecule GPR84 fluorescent probe that can visualize and detect GPR84 protein levels at the cellular and tissue levels .

HY-157252

CL4F8-6	Liposome	Cancer
CL4F8-6 is an ionizable cationic lipid with a pK_a of 6.14. CL4F8-6 can be used in lipid nanoparticles (LNPs)-based mRNA therapeutics .

HY-RS04646

F8 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
F8 Human Pre-designed siRNA Set A contains three designed siRNAs for F8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

F8 Human Pre-designed siRNA Set A F8 Human Pre-designed siRNA Set A

HY-147845

F8-S40	SARS-CoV	Infection
F8-S40 is an inhibitor of SARS-CoV-2 main protease, with an IC₅₀ of 10.88 μM .

HY-147844

F8-S43-S3	SARS-CoV	Infection
F8-S43-S3 is an inhibitor of SARS-CoV-2 main protease, with an IC₅₀ of 9.69 μM .

HY-W391641

F8BT	Biochemical Assay Reagents Endogenous Metabolite
F8BT is a polymer material with excellent photoelectric properties. F8BT is widely used in organic light-emitting diodes (OLEDs) and organic solar cells (PLEDs), and can effectively improve the luminous efficiency and energy conversion efficiency of the devices. The structure of F8BT makes it perform well in photoelectric conversion and electron transport, making it an important object of modern electronic material research.

HY-RS04647

F8A1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
F8A1 Human Pre-designed siRNA Set A contains three designed siRNAs for F8A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

F8A1 Human Pre-designed siRNA Set A F8A1 Human Pre-designed siRNA Set A

HY-171036

GAPDH-IN-1	Endogenous Metabolite	Metabolic Disease
GAPDH-IN-1 (Compound F8) is a GAPDH inhibitor (IC₅₀ of 39.31 μM for GAPDH enzymatic activity). GAPDH-IN-1 forms a covalent adduct with an aspartic acid in the active site to displace NAD ⁺, a cofactor of the enzyme, with concomitant enhancement of the cysteine-reactive probe reaction with the catalytic cysteine .

HY-157125

PI3Kα-IN-14	PI3K Apoptosis	Cancer
PI3Kα-IN-14 (compound F8) is a selective PI3Kα inhibitor with an IC₅₀ of 0.14 nM. PI3Kα-IN-14 induces a great decrease in mitochondrial membrane which caused cell cycle arrest at G1 phase and apoptosis in U87-MG cells. PI3Kα-IN-14 shows significant anti-proliferative activities against three tumor-derived cell lines (PC-3: IC₅₀ of 0.28 μM; HCT-116: IC₅₀ of 0.57 μM; and U87-MG: IC₅₀ of 1.37 μM) .

HY-107530

3F8	GSK-3	Cardiovascular Disease Metabolic Disease Cancer
3F8 is a potent and selective GSK-3β inhibitor that could be useful as new reagent and potential therapeutic candidate for GSK3 related diseases .

HY-P99757

Nivatrotamab Hu3F8-BsAb	CD2 CD3	Cancer
Nivatrotamab (Hu3F8-BsAb) is a humanized anti-GD2/CD3 bispecific antibody. Nivatrotamab is a CD3- and GD2-specific bsAb-based T-cell engager. Nivatrotamab can be used in research of neuroblastoma .

HY-P990214

Anti-Mouse IL-3 Antibody (MP2-8F8)	Interleukin Related	Others
Anti-Mouse IL-3 Antibody (MP2-8F8) is a rat-derived IgG1 type antibody inhibitor, targeting to mouse IL-3.

HY-RS04117

E2F8 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
E2F8 Human Pre-designed siRNA Set A contains three designed siRNAs for E2F8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

E2F8 Human Pre-designed siRNA Set A E2F8 Human Pre-designed siRNA Set A

HY-P990221

Anti-Mouse IL-17F Antibody (MM17F8F5.1A9)	Interleukin Related	Others
Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) is a mouse-derived IgG1, κ type antibody inhibitor, targeting to mouse IL-17F.

Cat. No.	Product Name	Type

HY-D2377

F8	Fluorescent Dyes/Probes
F8 is a small molecule GPR84 fluorescent probe that can visualize and detect GPR84 protein levels at the cellular and tissue levels .

Cat. No.	Product Name	Type

HY-157252

CL4F8-6	Drug Delivery
CL4F8-6 is an ionizable cationic lipid with a pK_a of 6.14. CL4F8-6 can be used in lipid nanoparticles (LNPs)-based mRNA therapeutics .

Cat. No.	Product Name	Target	Research Area

HY-P99757

Nivatrotamab Hu3F8-BsAb	CD2 CD3	Cancer
Nivatrotamab (Hu3F8-BsAb) is a humanized anti-GD2/CD3 bispecific antibody. Nivatrotamab is a CD3- and GD2-specific bsAb-based T-cell engager. Nivatrotamab can be used in research of neuroblastoma .

HY-P99206

Naxitamab Naxitamab-gqgk; Humanized 3F8; Hu3F8	Inhibitory Antibodies	Cancer
Naxitamab (Hu3F8) is a humanized monoclonal antibody targeting the disialoganglioside GD2. Naxitamab can be used in research of neuroblastoma, osteosarcoma and other GD2-positive cancers .

HY-P990214

Anti-Mouse IL-3 Antibody (MP2-8F8)	Interleukin Related	Others
Anti-Mouse IL-3 Antibody (MP2-8F8) is a rat-derived IgG1 type antibody inhibitor, targeting to mouse IL-3.

HY-P990412

Anti-F8/Factor VIII Antibody	Inhibitory Antibodies	Inflammation/Immunology
Anti-F8/Factor VIII Antibody is a CHO-expressed human antibody that targets F8/Factor VIII. Anti-F8/Factor VIII Antibody has a huIgG4 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-F8/Factor VIII Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990221

Anti-Mouse IL-17F Antibody (MM17F8F5.1A9)	Interleukin Related	Others
Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) is a mouse-derived IgG1, κ type antibody inhibitor, targeting to mouse IL-17F.

Species:	Human (5) Mouse (1)
Tag:	His (4) Tag Free (2)
Source:	CHO (1) P. pastoris (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P74803AF

	Animal-Free IL-36 beta/IL-1F8 Protein, Human (His) Il36b; Fil1e; Il1F8; Interleukin-36 beta; Interleukin-1 family member 8; IL-1F8	Human	E. coli
	IL-36 beta/IL-1F8 protein signals through IL-36R, activates NF-kappa-B and MAPK pathways, and induces pro-inflammatory responses.It is present in the epithelial barrier and shares the IL-1 system coreceptor IL1RAP.Animal-Free IL-36 beta/IL-1F8 Protein, Human (His) is the recombinant human-derived animal-FreeIL-36 beta/IL-1F8 protein, expressed by E.coli , with C-His labeled tag.This product is for cell culture use only.

HY-P72546

	IL-36 beta/IL-1F8 Protein, Mouse Interleukin-36 beta; FIL1 eta; IL-1 eta; IL-1F8; IL-1H2; IL36B	Mouse	E. coli
	IL-36 beta (IL-1F8), a subform of IL-36 family, belongs to IL-1 superfamily. IL-36 beta mediates inflammatory response. L-36 beta binds to IL-36R and recruits the co-receptor IL-1RacP, and thereby activating NF-κB and MAPK signaling pathways, but the activation requires N-terminal cleavage by neutrophil granule-derived proteases. IL-36 beta/IL-1F8 Protein, Mouse is a recombinant mouse IL-36 beta without any tag, which is produced in E. coli.

HY-P73541

	Von Willebrand Factor/vWF Protein, Human (CHO, His) von Willebrand factor; vWF; von Willebrand antigen II; F8VWF	Human	CHO
	Von Willebrand Factor/vWF Protein, Human (CHO, His) is the recombinant human-derived Von Willebrand Factor/vWF protein, expressed by CHO , with C-His labeled tag. The total length of Von Willebrand Factor/vWF Protein, Human (CHO, His) is 2791 a.a., with molecular weight of ~260 & 350 kDa, respectively.

HY-P71777

	PTPRZ1 Protein, Human (P.pastoris, His) 3F8 chondroitin sulfate proteoglycan; 3H1 keratan sulfate proteoglycan; HPTPZ; HPTPzeta; Phosphacan; PTPRZ	Human	P. pastoris
	The PTPRZ1 protein is an important tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. It plays a crucial role in guiding the normal differentiation of precursor cells into mature oligodendrocytes and may act as an anti-apoptotic factor. PTPRZ1 Protein, Human (P.pastoris, His) is the recombinant human-derived PTPRZ1 protein, expressed by P. pastoris , with N-His labeled tag.

HY-P74803

	IL-36 beta/IL-1F8 Protein, Human (His) Il36b; Fil1e; Il1F8; Interleukin-36 beta; Interleukin-1 family member 8; IL-1F8	Human	E. coli
	IL-36 beta (IL-1F8), a subform of IL-36 family, belongs to IL-1 superfamily. IL-36 beta mediates inflammatory response. L-36 beta binds to IL-36R and recruits the co-receptor IL-1RacP, and thereby activating NF-κB and MAPK signaling pathways, but the activation requires N-terminal cleavage by neutrophil granule-derived proteases. IL-36 beta/IL-1F8 Protein, Human (His) is a recombinant human IL-36 beta with N terminal His tag, which is produced in E. coli.

HY-P72545

	IL-36 beta/IL-1F8 Protein, Human Interleukin-36 beta; FIL1 eta; IL-1 eta; IL-1F8; IL-1H2; IL36B	Human	E. coli
	IL-36 beta (IL-1F8), a subform of IL-36 family, belongs to IL-1 superfamily. IL-36 beta mediates inflammatory response. L-36 beta binds to IL-36R and recruits the co-receptor IL-1RacP, and thereby activating NF-κB and MAPK signaling pathways, but the activation requires N-terminal cleavage by neutrophil granule-derived proteases. IL-36 beta/IL-1F8 Protein, Human is a recombinant human IL-36 beta without any tag, which is produced in E. coli.

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Gene ID
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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82661

	von Willebrand Factor Antibody (YA2406) VWF; von Willebrand factor; von Willebrand antigen II; F8VWF	WB, IHC-P	Rat
	von Willebrand Factor Antibody (YA2406) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2406), targeting von Willebrand Factor, with a predicted molecular weight of 309 kDa (observed band size: 309 kDa). von Willebrand Factor Antibody (YA2406) can be used for WB, IHC-P experiment in rat background.

HY-P81682

	LMAN1 Antibody (YA1427) ERGIC5; F5F8D; FMFD1; Gp58; Lman1; MCFD1; MR60	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	LMAN1 Antibody (YA1427) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1427), targeting LMAN1, with a predicted molecular weight of 58 kDa (observed band size: 58 kDa). LMAN1 Antibody (YA1427) can be used for WB, IHC-P, ICC/IF experiment in human, mouse, rat background.

HY-P82631

	CD239 Antibody (YA2376) BCAM; LU; MSK19; Basal cell adhesion molecule; Auberger B antigen; B-CAM cell surface glycoprotein; F8/G253 antigen; Lutheran antigen; Lutheran blood group glycoprotein; CD239	WB, IHC-P, IP, FC	Human, Mouse, Rat
	CD239 Antibody (YA2376) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2376), targeting CD239, with a predicted molecular weight of 67 kDa (observed band size: 85 kDa). CD239 Antibody (YA2376) can be used for WB, IHC-P, IP, FC experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-157252

CL4F8-6		Cationic Lipids
CL4F8-6 is an ionizable cationic lipid with a pK_a of 6.14. CL4F8-6 can be used in lipid nanoparticles (LNPs)-based mRNA therapeutics .

HY-RS04646

F8 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
F8 Human Pre-designed siRNA Set A contains three designed siRNAs for F8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS04647

F8A1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
F8A1 Human Pre-designed siRNA Set A contains three designed siRNAs for F8A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS04117

E2F8 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
E2F8 Human Pre-designed siRNA Set A contains three designed siRNAs for E2F8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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F8

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Oligonucleotides