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Farnesyl Transferase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Farnesyl Transferase (27) Amino Acid Derivatives (1) Apoptosis (3) Autophagy (3) Microtubule/Tubulin (1) NOD-like Receptor (NLR) (1) Ras (10) VEGFR (1)
By Research Areas:	Cancer (25) Infection (6) Inflammation/Immunology (2) Metabolic Disease (1)

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Peptides

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Targets Recommended: Farnesyl Transferase Glutathione S-transferase GGTase OGT NAMPT

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128350A

FGTI-2734 mesylate 1 Publications Verification	Farnesyl Transferase	Cancer
FGTI-2734 mesylate is a RAS C-terminal mimetic dual farnesyl transferase (FT) and *geranylgeranyl transferase-1 (GGT)* inhibitor with IC₅₀s of 250 nM and 520 nM for FT and GGT, respectively. FGTI-2734 mesylate can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors .

HY-128350

FGTI-2734 1 Publications Verification	Farnesyl Transferase	Cancer
FGTI-2734 is a RAS C-terminal mimetic dual farnesyl transferase (FT) and *geranylgeranyl transferase-1 (GGT-1)* inhibitor with IC₅₀s of 250 nM and 520 nM for FT and GGT-1, respectively. FGTI-2734 can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors .

HY-15873A

FTI 276 TFA	Farnesyl Transferase	Cancer
FTI-276 is a *protein farnesyl* transferase (PFT) inhibitor with IC₅₀*s of 0.9 nM and 0.5 nM for Plasmodium falciparum* and human, respectively .

HY-16111A1

BMS-214662 mesylate	Farnesyl Transferase	Cancer
BMS-214662 mesylate is a potent and selective **farnesyl transferase inhibitor with an IC₅₀** of 1.35 nM. BMS-214662 mesylate exhibits potent antitumor activity and can be utilized in cancer research .

HY-149016

Tubulin polymerization-IN-25	Microtubule/Tubulin Farnesyl Transferase	Cancer
Tubulin polymerization-IN-25 (compound 17f) is a dual inhibitor of tubulin polymerization and **farnesyl transferase (FTase) with IC₅₀**s of 1.11 μM and 0.39 μM, respectively. Tubulin polymerization-IN-25 displays cytotoxicity and excellent antitumor activity .

HY-128041

alpha-Hydroxy farnesyl phosphonic acid HydroxyFarnesyl phosphate	Farnesyl Transferase	Others
α-hydroxy Farnesyl phosphonic acid is a nonhydrolyzable analog of farnesyl pyrophosphate which acts as a competitive inhibitor of farnesyl transferase (FTase). At concentrations greater than 1 μM, α-hydroxy farnesyl phosphonic acid inhibits the processing of Ras in Ha-ras-transformed NIH3T3 cells.

HY-118916

FTI-2148	Farnesyl Transferase	Cancer
FTI-2148 is a RAS C-terminal mimetic dual farnesyl transferase (FT-1) and *geranylgeranyl transferase-1 (GGT-1)* inhibitor with IC₅₀s of 1.4 nM and 1.7 μM, respectively .

HY-118916A

FTI-2148 diTFA	Farnesyl Transferase	Cancer
FTI-2148 diTFA is a RAS C-terminal mimetic dual farnesyl transferase (FT-1) and *geranylgeranyl transferase-1 (GGT-1)* inhibitor with IC₅₀s of 1.4 nM and 1.7 μM, respectively .

HY-15873

FTI 276	Farnesyl Transferase	Cancer
FTI-276 is a *protein farnesyl* transferase (PFT) inhibitor with IC₅₀*s of 0.9 and 0.5 nM for Plasmodium falciparum* and human.

HY-125311

Zaragozic acid D	Farnesyl Transferase	Cancer
Zaragozic acid D is a squalene synthase inhibitor. Zaragozic acid D also is a farnesyl-protein transferase (FPTase) inhibitor with an IC₅₀ value of 100 nM for bovine FPTase .

HY-W022657

H-Met-OiPr hydrochloride	Amino Acid Derivatives	Others
H-Met-OiPr hydrochloride is an Methionine derivative. H-Met-OiPr hydrochloride participates in the synthesis preparation of inhibitors of farnesyl-protein transferase (FTase), and can be used in cancer research .

HY-126871

Zaragozic acid D2	Farnesyl Transferase	Metabolic Disease Cancer
Zaragozic acid D2 is the inhibitor for squalene synthase and Ras farnesyl-protein transferase (Ras FPTase), with IC₅₀ of 2 nM and 100 nM, respectively. Zaragozic acid D2 is potentially ameliorating hypercholesterolemia and Ras-induced cancer .

HY-172423

Darlifarnib	Farnesyl Transferase	Cancer
Darlifarnib (Compound (S)-058) is the inhibitor for **farnesyl transferase and geranylgeranyltransferase with IC₅₀** ≤ 10 nM and ＞ 1000 nM. Darlifarnib exhibits good metabolic stability in human and mouse liver microsomes with the half-life time ＞ 100 min .

HY-128044

Ftase inhibitor I B581	Farnesyl Transferase	Cancer
Ftase inhibitor I (B581) is a potent, selective and peptidomimetic farnesyl transferase (FTase) inhibitor. Ftase inhibitor I shows selectivity for FTase over geranylgeranyl isoprenoid (Ras-GG) or the fatty acid myristate (Myr-Ras) .

HY-15872A

FTI-277 hydrochloride 5 Publications Verification	Farnesyl Transferase Apoptosis Ras	Infection Cancer
FTI-277 hydrochloride is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 hydrochloride can inhibit hepatitis delta virus (HDV) infection.

HY-15872

FTI-277	Farnesyl Transferase Apoptosis Ras	Infection Cancer
FTI-277 is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 can inhibit hepatitis delta virus (HDV) infection.

HY-134579

Chaetomellic acid A	Farnesyl Transferase	Inflammation/Immunology
Chaetomellic acid A can be isolated from Chaetomella acutiseta. Chaetomellic acid A is a specific inhibitor of **farnesyl-protein transferase**. Chaetomellic acid A decreases oxidative stress-induced apoptosis in cells. Chaetomellic acid A reduces renal damage after unilateral ureteral obstruction (UUO) in mice .

HY-110038

FTI-277 TFA	Farnesyl Transferase Apoptosis Ras	Infection Cancer
FTI-277 TFA is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 TFA can inhibit hepatitis delta virus (HDV) infection.

HY-118426

(Rac)-Tipifarnib (Rac)-IND 58359; (Rac)-R115777	Farnesyl Transferase Ras	Cancer
(Rac)-Tipifarnib ((Rac)-IND 58359; (Rac)-R115777) is a potent farnesyl protein transferase inhibitor that specifically targets the pro-tailation process of Ras proteins. (Rac)-Tipifarnib showed significant in vivo antitumor effects after oral administration to mice .

HY-16059

Arglabin (+)-Arglabin	NOD-like Receptor (NLR) Farnesyl Transferase Autophagy	Inflammation/Immunology Cancer
Arglabin ((+)-Arglabin), a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor. Arglabin shows anti-inflammatory and antitumor activities . The antitumor activity of Arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene .

HY-15136

Lonafarnib Maximum Cited Publications 9 Publications Verification Sch66336	Farnesyl Transferase Ras Autophagy	Infection Cancer
Lonafarnib (Sch66336) is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC₅₀ values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities.

HY-120044

L-739749	Farnesyl Transferase Ras	Cancer
L-739749 is a **farnesyl transferase inhibitor. L-739749 inhibits the selective hypersensitivity of JMML cells to granulocyte-macrophage colony-stimulating factor (GM-CSF) by blocking the prenylation of Ras**. L-739749 exhibits a strong inhibitory effect on the growth of primary human JMML cells in vitro .

HY-15136B

(Rac)-Lonafarnib Sch66336 racemate	Farnesyl Transferase	Infection Cancer
(Rac)-Lonafarnib (Sch66336 racemate) is the racemate of Lonafarnib. Lonafarnib is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC₅₀ values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities .

HY-125669

XR 3054	Farnesyl Transferase	Cancer
XR 3054 is an inhibitor for **Farnesyl Transferase, that inhibits farnesylation of CAAX recognition peptide with IC₅₀ of 50 μM. XR 3054 suppresses the farnesylation of p21 ras and activation of MAP kinase. XR 3054 inhibits the proliferation of prostate cancer cell and colon cancer cell, with IC₅₀** of 8.8-21.4 μM .

HY-15136R

Lonafarnib (Standard)	Farnesyl Transferase Ras Autophagy	Infection Cancer
Lonafarnib (Standard) is the analytical standard of Lonafarnib. This product is intended for research and analytical applications. Lonafarnib (Sch66336) is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC₅₀ values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities.

HY-117807

A-176120	Ras Farnesyl Transferase VEGFR	Cancer
A-176120 is a selective inhibitor of **farnesyl transferase (IC₅₀*=1.2 nM) based on a farnesyl* pyrophosphate (FPP) analog, with superior selectivity against GGTaseI (IC₅₀=423 nM), GGTaseII (IC₅₀=3000 nM), and SSase (IC₅₀>10 μM). A-176120 inhibits ras processing in H-ras transformed NIH3T3 cells and HCT116 K-ras mutant cells (ED₅₀=1.6 and 0.5 μM, respectively). A-176120 has antiangiogenic and antitumor activities in vivo and reduces capillary structure formation and VEGF secretion .

HY-16111

BMS-214662	Farnesyl Transferase Ras	Cancer
BMS-214662 is a **farnesyl transferase inhibitor. BMS-214662 can effectively block the localization and function of Ras protein in the cell membrane by inhibiting the pro-group modification of Ras protein, thereby exerting anti-tumor activity. BMS-214662 has an IC₅₀** value of 1.3 nM for H-Ras and 8.4 nM for K-Ras. BMS-214662 can be used to study Ras-related tumor diseases .

HY-16111A

BMS-214662 hydrochloride	Farnesyl Transferase Ras	Cancer
BMS-214662 hydrochloride is an inhibitor of farnesyltransferase (Farnesyl *Transferase). BMS-214662 hydrochloride can effectively block the localization and function of Ras* proteins on the cell membrane by inhibiting the prenylation modification of Ras proteins, thereby exerting anti-tumor activity. The IC₅₀ value of BMS-214662 hydrochloride for H-Ras is 1.3 nM, and for K-Ras it is 8.4 nM. BMS-214662 hydrochloride can be used in the research of tumor diseases related to Ras .

Cat. No.	Product Name	Target	Research Area

HY-W022657

H-Met-OiPr hydrochloride	Amino Acid Derivatives	Others
H-Met-OiPr hydrochloride is an Methionine derivative. H-Met-OiPr hydrochloride participates in the synthesis preparation of inhibitors of farnesyl-protein transferase (FTase), and can be used in cancer research .

Arglabin (+)-Arglabin	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Apios americana Medik. Plants Compositae Inflammation/Immunology Disease Research Fields	NOD-like Receptor (NLR) Farnesyl Transferase Autophagy
Arglabin ((+)-Arglabin), a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor. Arglabin shows anti-inflammatory and antitumor activities . The antitumor activity of Arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene .

Zaragozic acid D	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Farnesyl Transferase
Zaragozic acid D is a squalene synthase inhibitor. Zaragozic acid D also is a farnesyl-protein transferase (FPTase) inhibitor with an IC₅₀ value of 100 nM for bovine FPTase .

Zaragozic acid D2	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Farnesyl Transferase
Zaragozic acid D2 is the inhibitor for squalene synthase and Ras farnesyl-protein transferase (Ras FPTase), with IC₅₀ of 2 nM and 100 nM, respectively. Zaragozic acid D2 is potentially ameliorating hypercholesterolemia and Ras-induced cancer .

Chaetomellic acid A	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Farnesyl Transferase
Chaetomellic acid A can be isolated from Chaetomella acutiseta. Chaetomellic acid A is a specific inhibitor of **farnesyl-protein transferase**. Chaetomellic acid A decreases oxidative stress-induced apoptosis in cells. Chaetomellic acid A reduces renal damage after unilateral ureteral obstruction (UUO) in mice .

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