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Ginseng

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Amino Acid Derivatives (1) Amyloid-β (6) Apoptosis (11) Autophagy (2) Bacterial (2) Biochemical Assay Reagents (1) Calcium Channel (2) COX (6) DNA/RNA Synthesis (1) Drug Intermediate (1) Endogenous Metabolite (11) Free Fatty Acid Receptor (2) GABA Receptor (2) GlyT (1) HSV (2) IFNAR (1) IGF-1R (2) Influenza Virus (2) Interleukin Related (3) IRAK (2) JAK (2) Mitophagy (2) MMP (1) Na+/K+ ATPase (2) NF-κB (16) NO Synthase (2) P-glycoprotein (2) PI3K (2) Potassium Channel (2) Ras (1) Reactive Oxygen Species (2) Sodium Channel (2) STAT (1) TNF Receptor (2) VEGFR (1)
By Research Areas:	Cancer (32) Cardiovascular Disease (7) Endocrinology (3) Infection (4) Inflammation/Immunology (27) Metabolic Disease (6) Neurological Disease (12)

By Targets:

Akt (1)

Amino Acid Derivatives (1)

Amyloid-β (6)

Apoptosis (11)

Autophagy (2)

Bacterial (2)

Biochemical Assay Reagents (1)

Calcium Channel (2)

COX (6)

DNA/RNA Synthesis (1)

Drug Intermediate (1)

Endogenous Metabolite (11)

Free Fatty Acid Receptor (2)

GABA Receptor (2)

GlyT (1)

HSV (2)

IFNAR (1)

IGF-1R (2)

Influenza Virus (2)

Interleukin Related (3)

IRAK (2)

JAK (2)

Mitophagy (2)

MMP (1)

Na+/K+ ATPase (2)

NF-κB (16)

NO Synthase (2)

P-glycoprotein (2)

PI3K (2)

Potassium Channel (2)

Ras (1)

Reactive Oxygen Species (2)

Sodium Channel (2)

STAT (1)

TNF Receptor (2)

VEGFR (1)

By Research Areas:

Cancer (32)

Cardiovascular Disease (7)

Endocrinology (3)

Infection (4)

Inflammation/Immunology (27)

Metabolic Disease (6)

Neurological Disease (12)

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Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N10336

Notoginsenoside R4	VEGFR STAT Akt Ras	Others
Notoginsenoside R4 is a ginsenoside that can be isolated from ginseng roots. In the molecular docking results, Notoginsenoside R4 can target STAT3, AKT1, HRAS, VEGFA and CASP3 .

HY-N0797

(20S)-Protopanaxadiol 20-Epiprotopanaxadiol; 20(S)-APPD	P-glycoprotein Reactive Oxygen Species Apoptosis	Cancer
20S-protopanaxadiol (aPPD) is a metabolite of ginseng saponins, inhibits Akt activity and induces apoptosis in various tumor cells .

HY-N13240

Ginseng Extract	Others	Others
Ginseng Extract is a ginseng extract, and its components include: Ginsenosides. Ginseng Extract is an excellent animal nutrition feed additive that can reduce the negative effects of heat stress on animal physiology. Studies have shown that Ginseng Extract can prolong the survival time of Caenorhabditis elegans under heat stress, and its mechanism is related to the upregulation of gene expression of specific heat shock proteins and tight junction proteins. .

HY-N13224

*Siberian Ginseng* Extract**	Apoptosis	Cancer
Siberian Ginseng Extract is an Acanthopanax senticosus extract, and its components include: Eleutheroside B&E. Siberian Ginseng Extract may induce apoptosis of melanoma cells and has anticancer potential. .

HY-N4264

Vinaginsenoside R3	Others	Inflammation/Immunology
Vinaginsenoside R3 is a saponin composition of roots of Panax ginseng. Ginsengs have been not only used as therapeutic agents with tonic, anti-fatigue, and anti-gastric ulcer effect but also marketed as dietary supplements and raw materials of health food .

HY-N12533

Quinquenoside R1	Others	Others
Quinquenoside R1 (Compound 12) is a saponin compound that can be isolated from wild ginseng .

HY-N8901

20-Gluco-ginsenoside-Rf	Biochemical Assay Reagents	Others
20-Gluco-ginsenoside-Rf (compound 4) is a bisdesmosidic saponin that can be obtained from the roots of Panax ginseng .

HY-N12365

Ginsenoside Rs2	Others	Others
Ginsenoside Rs2 is extracted from Panax ginseng root .

HY-N12366

Ginsenoside Rs1	Others	Others
Ginsenoside Rs1 is extracted from Panax ginseng root .

HY-N0797R

(20S)-Protopanaxadiol (Standard)	P-glycoprotein Reactive Oxygen Species Apoptosis	Cancer
(20S)-Protopanaxadiol (Standard) is the analytical standard of (20S)-Protopanaxadiol. This product is intended for research and analytical applications. 20S-protopanaxadiol (aPPD) is a metabolite of ginseng saponins, inhibits Akt activity and induces apoptosis in various tumor cells .

HY-125570

Ginsenoside Rs3	Apoptosis	Cancer
Ginsenoside Rs3 is a natural diol-type ginseng saponin with anticancer effects. Ginsenoside Rs3 selectively elevates protein levels of p53 and p21WAF1 leading to induction of apoptosis in SK-HEP-1 cells .

HY-N2504

Ginsenoside Rk2	Others	Inflammation/Immunology Cancer
Ginsenoside Rk2 is a dammarane glycoside isolated from the processed ginseng (SG; Sun Ginseng) .

HY-N4260

Ginsenoside Ra2	Others	Inflammation/Immunology
Ginsenoside Ra2 is a component from Panax ginseng .

HY-N4262

Ginsenoside Rh7 1 Publications Verification	Others	Others
Ginsenoside Rh7 is a minor saponin isolated from the leaves of Panax ginseng .

HY-N4259

Ginsenoside Ra3	Endogenous Metabolite	Cancer
Ginsenoside Ra3, isolated from Panax ginseng, possesses anti-cancer activity .

HY-N6262

20(S),24(R)-Ocotillol	Others	Others
20(S),24(R)-Ocotillol is isolated from Panax ginseng .

HY-N10477

gamma-Glutamylarginine L-γ-Glutamyl-L-arginine	Amino Acid Derivatives	Others
gamma-Glutamylarginine, an γ-glutamic acid oligopeptide, can be isolated from Panax ginseng .

HY-N6088

Isoginsenoside Rh3	Others	Others
Isoginsenoside-Rh3 is a triterpenoid saponin from the fruits of Panax ginseng C. A. Mey .

HY-N0601

Ginsenoside Rf Panaxoside Rf	Calcium Channel Endogenous Metabolite	Neurological Disease Cancer
Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca ²⁺ channel.

HY-N12015

Ginsenoside Ra6 Ginsenoside IV	Others	Others
Ginsenoside Ra6 (Ginsenoside IV) is a panaxadiol-type ginsenoside that can be isolated from the roots of ginseng .

HY-N9485

25(R)-Hydroxyprotopanaxadiol	Others	Others
25(R)-Hydroxyprotopanaxadiol is a Triterpenoids product that can be isolated from the roots of Panax ginseng C. A. Mey. .

HY-N2506

Ginsenoside Ra1	Others	Cardiovascular Disease
Ginsenoside Ra1 is a component from ginseng, inhibits protein tyrosine kinase (PTK) activation induced by hypoxia/reoxygenation .

HY-108277

Ginsenoside F5	Apoptosis	Cancer
Ginsenoside F5, from crude extracts of flower buds of Panax ginseng, remarkably inhibits the growth of HL-60 cells by the apoptosis pathway .

HY-N1400

(20R)-Ginsenoside Rh1	Others	Cancer
(20R)-Ginsenoside Rh1, the R isomer of Ginsenoside Rh1 isolated from Panax Ginseng, inhibits the thrombin-induced conversion of fibrinogen to fibrin .

HY-N1804

3-Acetoxy-24-hydroxydammara-20,25-diene	Others	Others
3-Acetoxy-24-hydroxydammara-20,25-diene is a Triterpenoids product that can be isolated from the roots of Panax ginseng C.A.Mey. .

HY-N0541

Pseudoginsenoside F11 1 Publications Verification Ginsenoside A1	Endogenous Metabolite	Others
Pseudoginsenoside F11 (Ginsenoside A1), a component of Panax quinquefolium (American ginseng), has been demonstrated to antagonize the learning and memory deficits induced by scopolamine, morphine and methamphetamine in mice.

HY-N0040

Ginsenoside Rb2 2 Publications Verification Ginsenoside C	Influenza Virus Endogenous Metabolite Free Fatty Acid Receptor	Infection Metabolic Disease Inflammation/Immunology
Ginsenoside Rb2 is one of the main bioactive components of ginseng extracts. Rb2 can upregulate GPR120 gene expression. Ginsenoside Rb2 has antiviral effects.

HY-N1376

(20R)-Ginsenoside Rg3 4 Publications Verification (20R)-Propanaxadiol; R-ginsenoside Rg3	Others	Cancer
(20R)-ginsenoside Rg3 ((20R)-Propanaxadiol), one of the active compounds present in ginseng root, inhibits angiogenesis, and has anti-carcinogenic and antimetastatic effects .

HY-N3113

Panaxyne	Others	Cancer
Panaxyne is a polyacetylene, that can be isolated from the roots of cultivated-wild ginseng. Panaxyne shows significant and selective cytotoxicity against SK-OV-3, with an ED₅₀ of 1.40 µM .

HY-N4265

Vinaginsenoside R4	Others	Inflammation/Immunology
Vinaginsenoside R4, isolated from the leaves of hydroponic Panax ginseng. It has an inhibitory effect on melanin biosynthesis without any cytotoxic effects on the melan-a cells, and enhances the depigmentation on the zebrafish .

HY-N2503

Ginsenoside F4	Apoptosis MMP	Inflammation/Immunology
Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis . Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues .

HY-N0601R

Ginsenoside Rf (Standard)	Calcium Channel Endogenous Metabolite	Neurological Disease Cancer
Ginsenoside Rf (Standard) is the analytical standard of Ginsenoside Rf. This product is intended for research and analytical applications. Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel.

HY-W067425

2-(4-Hydroxyphenyl)propionic acid	Endogenous Metabolite	Metabolic Disease
2-(4-Hydroxyphenyl)propionic acid (Compound 1) is an aromatic carboxylic acid, which can be converted into its R and S glucosyl esters and glucosides by root culture of P. ginseng (Pg-1) .

HY-N0042

Ginsenoside Rc Panaxoside Rc	GABA Receptor TNF Receptor Interleukin Related	Neurological Disease Inflammation/Immunology Cancer
Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances GABA receptor_A (GABA_A)-mediated ion channel currents (I_GABA). Ginsenoside Rc inhibits the expression of TNF-α and IL-1β.

HY-N0906

Ginsenoside Rk3	NF-κB	Cardiovascular Disease Inflammation/Immunology
Ginsenoside Rk3 is present in the roots Panax ginseng herbs. Ginsenoside Rk3 significantly inhibits TNF-α-induced NF-κB transcriptional activity, with an IC₅₀ of 14.24±1.30 μM in HepG2 cells.

HY-N0039

Ginsenoside Rb1 Maximum Cited Publications 9 Publications Verification Gypenoside III	Na+/K+ ATPase IRAK NF-κB Autophagy Mitophagy HSV	Inflammation/Immunology Cancer
Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na ⁺, K ⁺-ATPase activity with an IC₅₀ of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .

HY-N0045

Ginsenoside Rg1 Maximum Cited Publications 9 Publications Verification Panaxoside A; Panaxoside Rg1	Amyloid-β NF-κB Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Ginsenoside Rg1 is one of the major active components of Panax ginseng. Ginsenoside Rg1 ameliorates the impaired cognitive function, displays promising effects by reducing cerebral Aβ levels. Ginsenoside Rg1 also reduces NF-κB nuclear translocation.

HY-N2040

(20R)-Protopanaxadiol	Bacterial	Infection Cancer
(20R)-Protopanaxadiol is a triterpenoid saponin metabolite of 20(R)-ginsenoside Rg3 in black ginseng. (20R)-Protopanaxadiol exhibits anti-tumor activity and cytotoxicity, and potently inhibits the growth of Helicobacter pylori .

HY-N0602

Ginsenoside Rg2 3 Publications Verification Chikusetsusaponin I; Panaxoside Rg2; Prosapogenin C2	NF-κB Amyloid-β	Cardiovascular Disease Neurological Disease Cancer
Ginsenoside Rg2 is one of the major active components of ginseng. Ginsenoside Rg2 inhibits VCAM-1 and ICAM-1 expressions stimulated with lipopolysaccharide (LPS). Ginsenoside Rg2 also reduces Aβ_1-42 accumulation.

HY-N0600

Ginsenoside F3	Interleukin Related IFNAR	Inflammation/Immunology
Ginsenoside F3, a component of PPTGs (an minor saponin in the leaves of Panax ginseng), has immunoenhancing activity by regulating production and gene expression of type 1 cytokines (IL-2, IFN-gamma) and type 2 cytokines (IL-4 and IL-10) .

HY-N2515

Ginsenoside Rk1 5+ Cited Publications	NF-κB PI3K JAK Apoptosis	Inflammation/Immunology Cancer
Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures . Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB . Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis . Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway .

HY-N0040R

Ginsenoside Rb2 (Standard)	Influenza Virus Endogenous Metabolite Free Fatty Acid Receptor	Infection Metabolic Disease Inflammation/Immunology
Ginsenoside Rb2 (Standard) is the analytical standard of Ginsenoside Rb2. This product is intended for research and analytical applications. Ginsenoside Rb2 is one of the main bioactive components of ginseng extracts. Rb2 can upregulate GPR120 gene expression. Ginsenoside Rb2 has antiviral effects.

HY-N6580

Ginsenoside Rg4	Bacterial	Infection Metabolic Disease Inflammation/Immunology
Ginsenoside Rg4 is a major protopanaxatriol type ginsenoside isolated from the leaves of Panax ginseng C. A. Meyer. The protopanaxatriol type ginsenosides (such as Ginsenoside Rg4) exhibits various biological activities including anti-septic, anti-diabetic, wound healing, immune-stimulatory, and anti-antioxidant activity .

HY-N0042R

Ginsenoside Rc (Standard)	GABA Receptor TNF Receptor Interleukin Related	Neurological Disease Inflammation/Immunology Cancer
Ginsenoside Rc (Standard) is the analytical standard of Ginsenoside Rc. This product is intended for research and analytical applications. Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances GABA receptorA (GABAA)-mediated ion channel currents (IGABA). Ginsenoside Rc inhibits the expression of TNF-α and IL-1β.

HY-N15147

Panax saponin C	DNA/RNA Synthesis	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Panax saponin C is a ginsenoside found in Ginseng with biological activities including regulatory effects on immunomodulation, protection functions in the central nervous and cardiovascular systems, anti-diabetic, anti-aging, anti-carcinogenic, anti-fatigue, anti-pyretic, anti-stress, boosting physical vitality, and promotion of DNA, RNA, and protein synthesis activities .

HY-N2515R

Ginsenoside Rk1 (Standard)	NF-κB PI3K JAK Apoptosis	Inflammation/Immunology Cancer
Ginsenoside Rk1 (Standard) is the analytical standard of Ginsenoside Rk1. This product is intended for research and analytical applications. Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures . Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB . Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis . Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway .

HY-N0272

Eleutheroside E 2 Publications Verification	Apoptosis NF-κB	Neurological Disease Inflammation/Immunology
Eleutheroside E is an important component of ginseng that can be taken orally. Eleutheroside E has anti-inflammatory and antioxidant properties, and it helps reduce apoptosis in heart cells caused by hypoxia-reoxygenation (H/R) damage. Eleutheroside E can improve type 2 diabetes, enhance cognitive function, and has neuroprotective effects .

HY-128394R

L-Gulose (Standard)	Endogenous Metabolite	Metabolic Disease
(20R)-Ginsenoside Rh1 (Standard) is the analytical standard of (20R)-Ginsenoside Rh1. This product is intended for research and analytical applications. (20R)-Ginsenoside Rh1, the R isomer of Ginsenoside Rh1 isolated from Panax Ginseng, inhibits the thrombin-induced conversion of fibrinogen to fibrin .

HY-N0041

Ginsenoside Rb3 Gypenoside IV	NF-κB COX NO Synthase	Inflammation/Immunology Cancer
Ginsenoside Rb3 is extracted from steamed Panax ginseng C. A. Meyer. Ginsenoside Rb3 exhibits inhibitory effect on TNFα-induced NF-κB transcriptional activity with an IC₅₀ of 8.2 μM in 293T cell lines. Ginsenoside Rb3 also inhibits the induction of COX-2 and iNOS mRNA.

HY-N1400R

(20R)-Ginsenoside Rh1 (Standard)	Others	Cancer
(20R)-Ginsenoside Rh1 (Standard) is the analytical standard of (20R)-Ginsenoside Rh1. This product is intended for research and analytical applications. (20R)-Ginsenoside Rh1, the R isomer of Ginsenoside Rh1 isolated from Panax Ginseng, inhibits the thrombin-induced conversion of fibrinogen to fibrin .

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