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IMPDH

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (6) Apoptosis (8) Arenavirus (1) Bacterial (8) Bcl-2 Family (1) Caspase (1) CDK (1) Dengue virus (5) DNA/RNA Synthesis (1) Drug Metabolite (5) Endogenous Metabolite (7) Flavivirus (6) Fungal (4) HBV (1) HCV (3) Isotope-Labeled Compounds (2) MDM-2/p53 (1) Nucleoside Antimetabolite/Analog (1) Orthopoxvirus (1) Parasite (2) SARS-CoV (2) Sirtuin (1) Small Interfering RNA (siRNA) (2) VEGFR (1)
By Research Areas:	Cancer (14) Infection (12) Inflammation/Immunology (6)
Oligonucleotides:	Pre-designed siRNA Sets (2) siRNAs (2)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145286

IMPDH2-IN-2	Bacterial	Infection Cancer
IMPDH2-IN-2 is a potent inhibitor of inosine 5’-monophosphate dehydrogenase (IMPDH) with a K_i,app value of 14 μM, respectively. IMPDH2-IN-2 displays moderate antibacterial activity (MIC = 6.3 and 11 μM in minimal GAST/Fe and rich 7H9/ADC/Tween media, respectively). IMPDH2-IN-2 is a potential anti-tuberculosis agent .

HY-110217

BMS-566419	Others	Others
BMS-566419 is an acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase (IMPDH). Inosine monophosphate dehydrogenase (IMPDH) is a key enzyme in the de novo synthesis of guanosine nucleotides. BMS-566419 has clinical utility for the research of transplant rejection .

HY-136498A

T-705RMP ammonium	Drug Metabolite	Infection
T-705RMP (ammonium) is the ammonium form of T-705RMP. T-705RMP (ammonium)’s the inhibition of IMP dehydrogenase (IMPDH) activity is weak .

HY-168509

IMPDH-IN-1	Bacterial	Infection
IMPDH-IN-1 (compound 44) is a bacterial inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitor. IMPDH-IN-1 specifically binds to the catalytic domain of IMPDH. IMPDH-IN-1 potently inhibits the IMPDH of Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli .

HY-169296

IMPDH2-IN-4	VEGFR CDK	Cancer
IMPDH2-IN-4 (compound 2d), a Mycophenolic acid (HY-B0421) analogue, is a selective *IMPDH2* inhibitor with a K_i of 1.8 μM. IMPDH2-IN-4 exhibits good cytotoxic activity against osteosarcoma cancer cell lines. IMPDH2-IN-4 possesses a high affinity for VEGFR-2, CDK2, and IMPDH .

HY-RS06798

IMPDH1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IMPDH1 Human Pre-designed siRNA Set A contains three designed siRNAs for IMPDH1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IMPDH1 Human Pre-designed siRNA Set A IMPDH1 Human Pre-designed siRNA Set A

HY-RS06799

IMPDH2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IMPDH2 Human Pre-designed siRNA Set A contains three designed siRNAs for IMPDH2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IMPDH2 Human Pre-designed siRNA Set A IMPDH2 Human Pre-designed siRNA Set A

HY-117124

BMS-337197	Others	Others
BMS-337197 is a *IMPDH* inhibitor .

HY-136498

T-705RMP	Drug Metabolite	Infection
T-705RMP, a phosphorylated metabolite of T-705, exhibits a very weak inhibitory effect on the IMP dehydrogenase (IMPDH) activities of the host cells, with an IC₅₀ of 601 μM .

HY-147342

β-Benzamide adenine dinucleotide	Others	Others
β-Benzamide adenine dinucleotide is a bioactive metabolite of benzamide nucleoside and a potent inhibitor of inosine 5 '-monophosphate dehydrogenase (IMPDH). β-Benzamide adenine dinucleotide is a potent, competitive inhibitor of human NAD kinase (K_i = 90 µM) .

HY-17470

Mizoribine 4 Publications Verification NSC 289637; HE 69	HCV SARS-CoV Antibiotic Parasite	Inflammation/Immunology
Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC₅₀ of approximately 100 μM for anti-HCV activity. Immunosuppressant . Mizoribine, an *IMPDH* inhibitor, inhibits replication of SARS-CoV with IC₅₀s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively .

HY-17470R

Mizoribine (Standard)	HCV SARS-CoV Antibiotic Parasite	Inflammation/Immunology
Mizoribine (Standard) is the analytical standard of Mizoribine. This product is intended for research and analytical applications. Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC₅₀ of approximately 100 μM for anti-HCV activity. Immunosuppressant . Mizoribine, an *IMPDH* inhibitor, inhibits replication of SARS-CoV with IC₅₀s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively .

HY-B0421

Mycophenolic acid 5+ Cited Publications Mycophenolate	Dengue virus Apoptosis Bacterial Fungal Endogenous Metabolite Antibiotic Flavivirus	Infection Inflammation/Immunology Cancer
Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC₅₀ of 0.24 µM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects .

HY-B0421A

Mycophenolic acid sodium 5+ Cited Publications Mycophenolate sodium	Dengue virus Apoptosis Bacterial Fungal Antibiotic Endogenous Metabolite Flavivirus	Infection Inflammation/Immunology Cancer
Mycophenolic acid sodium is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC₅₀ of 0.24 µM. Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid sodium is an immunosuppressive agent. Antiangiogenic and antitumor effects .

HY-B0421R

Mycophenolic acid (Standard)	Dengue virus Apoptosis Bacterial Fungal Endogenous Metabolite Antibiotic Flavivirus	Infection Inflammation/Immunology Cancer
Mycophenolic acid (Standard) is the analytical standard of Mycophenolic acid. This product is intended for research and analytical applications. Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM.?Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects .

HY-B0421AR

Mycophenolic acid sodium (Standard)	Dengue virus Apoptosis Bacterial Fungal Antibiotic Endogenous Metabolite Flavivirus	Infection Inflammation/Immunology Cancer
Mycophenolic acid (sodium) (Standard) is the analytical standard of Mycophenolic acid (sodium). This product is intended for research and analytical applications. Mycophenolic acid sodium is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid sodium is an immunosuppressive agent. Antiangiogenic and antitumor effects .

HY-15869

Inauhzin 2 Publications Verification INZ	Sirtuin MDM-2/p53	Cancer
Inauhzin is a dual *SirT1/IMPDH2* inhibitor, and acts as an activator p53, used in the research of cancer.

HY-B0421S2

Mycophenolic acid-13C17 Mycophenolate-¹³C₁₇	Isotope-Labeled Compounds Flavivirus	Cancer
Mycophenolic acid-13C17 (Mycophenolate-13C17) is the 13C labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.

HY-13986

Merimepodib 2 Publications Verification VX-497; MMPD	Flavivirus Dengue virus HBV HCV	Infection
Merimepodib (VX-497) is a noncompetitive and oral inhibitor of inosine monophosphate dehydrogenase (IMPDH) with broad spectrum antiviral activities.

HY-13560

AVN-944 4 Publications Verification VX-944	Arenavirus DNA/RNA Synthesis Apoptosis Caspase Bcl-2 Family	Infection Cancer
AVN-944 (VX-944) is an orally active, potent, selective, noncompetitive and specific inhibitor of *IMPDH* (inosine monophosphate dehydrogenase). AVN-944 is an essential rate-limiting enzyme in de novo guanine nucleotide synthesis. AVN-944 is also an inhibitor of arenavirus RNA synthesis, and blocks arenavirus infection. AVN-944 has broad anti-cancer activities, and can be used for multiple myeloma (MM) and acute myeloid leukemia (AML) research .

HY-13986A

(R)-Merimepodib (R)-VX-497; (R)-MMPD	Others	Infection
(R)-Merimepodib is the isomer of Merimepodib (HY-13986), and can be used as an experimental control. Merimepodib (VX-497) is a noncompetitive and oral inhibitor of inosine monophosphate dehydrogenase (IMPDH) with broad spectrum antiviral activities.

HY-114570

Tiazofurin NSC 286193; Riboxamide	Nucleoside Antimetabolite/Analog Orthopoxvirus	Infection Cancer
Tiazofurin (NSC 286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH) . Tiazofurin also has anti-orthopoxvirus and anti-variola activities .

HY-B0199

Mycophenolate Mofetil Maximum Cited Publications 8 Publications Verification RS 61443; TM-MMF	Drug Metabolite Apoptosis Endogenous Metabolite Bacterial	Cancer
Mycophenolate mofetil (RS 61443) is the morpholinoethylester proagent of Mycophenolic acid. Mycophenolate mofetil inhibits de novo purine synthesis via the inhibition of inosine monophosphate dehydrogenase (IMPDH). Mycophenolate mofetil shows selective lymphocyte antiproliferative effects involve both T and B cells, preventing antibody formation .

HY-B0199S

Mycophenolate Mofetil-d4	Isotope-Labeled Compounds Drug Metabolite Apoptosis Endogenous Metabolite	Cancer
Mycophenolate Mofetil-d₄ is the deuterium labeled Mycophenolate Mofetil. Mycophenolate mofetil (RS 61443) is the morpholinoethylester proagent of Mycophenolic acid. Mycophenolate mofetil inhibits de novo purine synthesis via the inhibition of inosine monophosphate dehydrogenase (IMPDH). Mycophenolate mofetil shows selective lymphocyte antiproliferative effects involve both T and B cells, preventing antibody formation[1].

HY-B0199R

Mycophenolate Mofetil (Standard) RS 61443 (Standard); TM-MMF (Standard)	Drug Metabolite Apoptosis Endogenous Metabolite Bacterial	Cancer
Mycophenolate Mofetil (Standard) is the analytical standard of Mycophenolate Mofetil. This product is intended for research and analytical applications. Mycophenolate mofetil (RS 61443) is the morpholinoethylester proagent of Mycophenolic acid. Mycophenolate mofetil inhibits de novo purine synthesis via the inhibition of inosine monophosphate dehydrogenase (IMPDH). Mycophenolate mofetil shows selective lymphocyte antiproliferative effects involve both T and B cells, preventing antibody formation .

HY-161712

Nampt-IN-12	Others	Cancer
Nampt-IN-12 (compound 9) is a derivative of N-Pyridinylthiophene carboxamide, exhibiting activity against peripheral nerve sheath tumor cells. Nampt-IN-12 is metabolized via the enzymes NAMPT and NMNAT1, both integral to the NAD salvage pathway, into an adenosine diphosphate (AD) derivative, which is an analog of NAD and capable of inhibiting inosine monophosphate dehydrogenase (IMPDH), leading to the accumulation of inosine monophosphate (IMP) within cells. With its favorable ability to cross the blood-brain barrier, Nampt-IN-12 holds potential for research in cancers affecting both the central and peripheral nervous systems .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-17470

Mizoribine 4 Publications Verification NSC 289637; HE 69	Alkaloids Structural Classification Microorganisms Classification of Application Fields Other Alkaloids Source classification Inflammation/Immunology Disease Research Fields	HCV SARS-CoV Antibiotic Parasite
Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC₅₀ of approximately 100 μM for anti-HCV activity. Immunosuppressant . Mizoribine, an *IMPDH* inhibitor, inhibits replication of SARS-CoV with IC₅₀s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively .

HY-B0421

Mycophenolic acid 5+ Cited Publications Mycophenolate	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Dengue virus Apoptosis Bacterial Fungal Endogenous Metabolite Antibiotic Flavivirus
Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC₅₀ of 0.24 µM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects .

HY-B0421A

Mycophenolic acid sodium 5+ Cited Publications Mycophenolate sodium	Infection Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	Dengue virus Apoptosis Bacterial Fungal Antibiotic Endogenous Metabolite Flavivirus
Mycophenolic acid sodium is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC₅₀ of 0.24 µM. Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid sodium is an immunosuppressive agent. Antiangiogenic and antitumor effects .

HY-B0199

Mycophenolate Mofetil Maximum Cited Publications 8 Publications Verification RS 61443; TM-MMF	Structural Classification Monophenols Classification of Application Fields Source classification Phenols Endogenous metabolite Disease Research Fields Cancer	Drug Metabolite Apoptosis Endogenous Metabolite Bacterial
Mycophenolate mofetil (RS 61443) is the morpholinoethylester proagent of Mycophenolic acid. Mycophenolate mofetil inhibits de novo purine synthesis via the inhibition of inosine monophosphate dehydrogenase (IMPDH). Mycophenolate mofetil shows selective lymphocyte antiproliferative effects involve both T and B cells, preventing antibody formation .

HY-17470R

Mizoribine (Standard)	Alkaloids Structural Classification Microorganisms Other Alkaloids Source classification	HCV SARS-CoV Antibiotic Parasite
Mizoribine (Standard) is the analytical standard of Mizoribine. This product is intended for research and analytical applications. Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC₅₀ of approximately 100 μM for anti-HCV activity. Immunosuppressant . Mizoribine, an *IMPDH* inhibitor, inhibits replication of SARS-CoV with IC₅₀s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively .

HY-B0421R

Mycophenolic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Dengue virus Apoptosis Bacterial Fungal Endogenous Metabolite Antibiotic Flavivirus
Mycophenolic acid (Standard) is the analytical standard of Mycophenolic acid. This product is intended for research and analytical applications. Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM.?Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects .

HY-B0421AR

Mycophenolic acid sodium (Standard)	Structural Classification Monophenols Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite	Dengue virus Apoptosis Bacterial Fungal Antibiotic Endogenous Metabolite Flavivirus
Mycophenolic acid (sodium) (Standard) is the analytical standard of Mycophenolic acid (sodium). This product is intended for research and analytical applications. Mycophenolic acid sodium is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid sodium is an immunosuppressive agent. Antiangiogenic and antitumor effects .

HY-B0199R

Mycophenolate Mofetil (Standard) RS 61443 (Standard); TM-MMF (Standard)	Structural Classification Monophenols Source classification Phenols Endogenous metabolite	Drug Metabolite Apoptosis Endogenous Metabolite Bacterial
Mycophenolate Mofetil (Standard) is the analytical standard of Mycophenolate Mofetil. This product is intended for research and analytical applications. Mycophenolate mofetil (RS 61443) is the morpholinoethylester proagent of Mycophenolic acid. Mycophenolate mofetil inhibits de novo purine synthesis via the inhibition of inosine monophosphate dehydrogenase (IMPDH). Mycophenolate mofetil shows selective lymphocyte antiproliferative effects involve both T and B cells, preventing antibody formation .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P702799

	IMPDH2 Protein, Human (His) IMP dehydrogenase 2; IMPD 2; IMPDH 2	Human	E. coli
	IMPDH2 Protein, Human (His) is the recombinant human-derived IMPDH2, expressed by E. coli , with C-6*His labeled tag. ,

HY-P703151

	IMPDH1 Protein, Human IMPD1	Human	E. coli
	IMPDH1 Protein, Human is the recombinant human-derived IMPDH1, expressed by E. coli , with tag Free labeled tag. ,

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Cat. No.	Product Name	Chemical Structure

HY-B0199S

Mycophenolate Mofetil-d4
Mycophenolate Mofetil-d₄ is the deuterium labeled Mycophenolate Mofetil. Mycophenolate mofetil (RS 61443) is the morpholinoethylester proagent of Mycophenolic acid. Mycophenolate mofetil inhibits de novo purine synthesis via the inhibition of inosine monophosphate dehydrogenase (IMPDH). Mycophenolate mofetil shows selective lymphocyte antiproliferative effects involve both T and B cells, preventing antibody formation[1].

Mycophenolate Mofetil-d4

Mycophenolate Mofetil-d₄ is the deuterium labeled Mycophenolate Mofetil. Mycophenolate mofetil (RS 61443) is the morpholinoethylester proagent of Mycophenolic acid. Mycophenolate mofetil inhibits de novo purine synthesis via the inhibition of inosine monophosphate dehydrogenase (IMPDH). Mycophenolate mofetil shows selective lymphocyte antiproliferative effects involve both T and B cells, preventing antibody formation[1].

HY-B0421S2

Mycophenolic acid-13C17
Mycophenolic acid-13C17 (Mycophenolate-13C17) is the 13C labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.

Mycophenolic acid-13C17

Mycophenolic acid-13C17 (Mycophenolate-13C17) is the 13C labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82346

	IMPDH2 Antibody (YA2091) IMPD2; IMPDH 2; IMPDH II; IMPDH2	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	IMPDH2 Antibody (YA2091) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2091), targeting IMPDH2, with a predicted molecular weight of 56 kDa (observed band size: 56 kDa). IMPDH2 Antibody (YA2091) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.