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Results for "

ITCH

" in MedChemExpress (MCE) Product Catalog:

34

Inhibitors & Agonists

2

Peptides

2

Inhibitory Antibodies

2

Natural
Products

2

Recombinant Proteins

1

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1183
    Hydrocortisone acetate

    Hydrocortisone 21-acetate; Cortisol 21-acetate

    		 Glucocorticoid Receptor Endogenous Metabolite Inflammation/Immunology Endocrinology
    Hydrocortisone acetate (Hydrocortisone 21-acetate) is a corticosteroid used to reduce swelling, itching and pain caused by minor skin irritations or hemorrhoids .
    Hydrocortisone acetate
  • HY-148949
    Kallikrein 5-IN-2

    		Kallikrein Others
    Kallikrein 5-IN-2 (compound 21) is a selective Kallikrein KLK5 inhibitor (pIC50=7.1). KLK5 inhibition may normalise epidermal shedding and reduce the associated inflammation and itching .
    Kallikrein 5-IN-2
  • HY-148244
    MS47134
    1 Publications Verification

    		 Mas-related G-protein-coupled Receptor (MRGPR) Others
    MS47134 is a potent and selective MRGPRX4 agonist with an EC50 value of 149 nM. MS47134 can be used for research of pain, itch and mast cell-mediated hypersensitivity .
    MS47134
  • HY-118069
    (R)-ZINC-3573

    		Mas-related G-protein-coupled Receptor (MRGPR) Infection
    (R)-ZINC-3573 is a selective Mas-related G protein-coupled receptor X2 (MRGPRX2) agonist with an EC50 value of 740 nM. (R)-ZINC-3573 can be used as a MRGPRX2 probe for the research of pain and itch .
    (R)-ZINC-3573
  • HY-145997
    MRGPRX4 modulator-1

    		Mas-related G-protein-coupled Receptor (MRGPR) Inflammation/Immunology
    MRGPRX4 modulator-1 (compound 31-2) is a potent mas-related g-protein receptor X4 (MRGPR X4) modulator, with antagonist activity of IC50 < 100 nM for MRGPR4. MRGPRX4 modulator-1 can be used for researching MRGPR X4 dependent diseases such as itch, pain, and autoimmune disorders .
    MRGPRX4 modulator-1
  • HY-145153
    S-777469

    		Cannabinoid Receptor Neurological Disease
    S-777469 is a selective and orally available cannabinoid type 2 receptor (CB2) agonist with a Ki of 36 nM. S-777469 significantly suppresses compound 48/80-induced scratching behavior in mice in a dose-dependent manner. S-777469 produces its antipruritic effects by inhibiting itch signal transmission through CB2 agonism .
    S-777469
  • HY-RS06943
    ITCH Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ITCH Human Pre-designed siRNA Set A contains three designed siRNAs for ITCH gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ITCH Human Pre-designed siRNA Set A
    ITCH Human Pre-designed siRNA Set A
  • HY-163840
    GFRα2/3-IN-1

    		Others Neurological Disease
    GFRα2/3-IN-1 (Compound 16) is a selective GFRα2/3 inhibitor with IC50 values of 0.1 and 0.2 μM for GFRα2 and GFRα3, respectively. GFRα2/3-IN-1 can be used to study pain and itch .
    GFRα2/3-IN-1
  • HY-143481
    Nav1.8-IN-2

    		Sodium Channel Neurological Disease
    Nav1.8-IN-2 (compound 35A) is a potent Nav1.8 inhibitor with an IC50 value of 0.4 nM. Nav1.8-IN-2 can be used for researching pain disorders, cough disorders, and acute and chronic itch disorders .
    Nav1.8-IN-2
  • HY-14939
    Vapitadine

    		Others Inflammation/Immunology
    Vapitadine is a non-sedative antihistamine compound that alleviates itching associated with atopic dermatitis.
    Vapitadine
  • HY-136642
    Fluocinolone

    		Others Inflammation/Immunology
    Fluocinolone is a corticosteroid that is used to relieve redness, itching, swelling, or other discomfort caused by skin conditions .
    Fluocinolone
  • HY-106566
    Alclometasone dipropionate

    Sch 22219

    		 Others Inflammation/Immunology
    Alclometasone dipropionate (Sch 22219) is a steroid compound. Alclometasone dipropionate can be used for the research of dermatitis and skin itch .
    Alclometasone dipropionate
  • HY-P5357
    SFNGGP-NH2

    		Protease Activated Receptor (PAR) Others
    SFNGGP-NH2 is a biological active peptide. (PAR-3 is a high-affinity thrombin receptor. PAR-3 mRNA is expressed in the cutaneous mast cells of humans. Protease-Activated Receptors (PARs) have been studied for their roles in itch and their itch-associated response through histamine-dependent/independent pathways have been reported. PAR-3 has been shown not to induce itching alone but possibly in conjunction with PAR-4. Co-expression of PAR-3 and PAR-4 enhances thrombin action suggesting that PAR-3 alone does not mediate transmembrane signaling but instead functions as a cofactor to activate PAR-4.)
    SFNGGP-NH2
  • HY-103368
    Eact

    		Chloride Channel Neurological Disease
    Eact is a selective and potent activator of TMEM16A, directly activates the TRPV1 channels in sensory nociceptors and produces itch, acute nociception and thermal hypersensitivity .
    Eact
  • HY-157496
    EP3 antagonist 7

    		Prostaglandin Receptor Others
    EP3 antagonist 7 (Compound II) is an EP3 receptor antagonist. EP3 antagonist 7 can be used in the study of itching, pain, dysuria or stress disorders .
    EP3 antagonist 7
  • HY-N12040
    γ-Isofagarine

    Iso-γ-fagarine

    		 Others Inflammation/Immunology
    γ-Isofagarine (Iso-γ-fagarine) is an alkaloid that can be isolated from the root bark of Dictamnus angustifolius. Dictamnus angustifolius has been used in the research of rheumatism, bleeding, itching, jaundice, chronic hepatitis, skin diseases, etc .
    γ-Isofagarine
  • HY-P1192
    GR-73632

    		Neurokinin Receptor Neurological Disease Endocrinology
    GR-73632 is a novel tachykinin neurokinin 1 (NK-1) receptor agonist . GR-73632 acts directly on the peripheral terminals of primary sensory neurons through NK1 receptor which convey itch signals .
    GR-73632
  • HY-P99162
    Nemolizumab

    CIM331

    		 Interleukin Related Inflammation/Immunology
    Nemolizumab (CIM331) is a humanized monoclonal antibody that targets the human interleukin-31 receptor a, preventing interleukin-31 (IL-31) from binding to its receptor and the subsequent signaling. Nemolizumab can help reduce itching and sleep disturbances, and it is being studied for atopic dermatitis (AD) .
    Nemolizumab
  • HY-147051
    MRGPRX4 modulator-2

    		Mas-related G-protein-coupled Receptor (MRGPR) Inflammation/Immunology
    MRGPRX4 modulator-2 (compound 1-55) is a potent MRGPR X4 modulator, possessing antagonist activity against MRGPR X4 with an IC50 < 100 nM. MRGPRX4 modulator-2 can be used for researching autoimmune diseases such as psoriasis, multiple sclerosis, Steven Johnson’s Syndrome, and other chronic itch conditions .
    MRGPRX4 modulator-2
  • HY-B0548
    Hydroxyzine

    		Histamine Receptor Inflammation/Immunology Endocrinology
    Hydroxyzine, a benzodiazepine antihistamine agent, acts as an orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine has anxiolytic effect and can be used for the research of generalised anxiety disorder .
    Hydroxyzine
  • HY-B0548A
    Hydroxyzine dihydrochloride

    		Histamine Receptor Inflammation/Immunology Endocrinology
    Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine?H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder .
    Hydroxyzine dihydrochloride
  • HY-B0548R
    Hydroxyzine (Standard)

    		Histamine Receptor Inflammation/Immunology Endocrinology
    Hydroxyzine (Standard) is the analytical standard of Hydroxyzine. This product is intended for research and analytical applications. Hydroxyzine, a benzodiazepine antihistamine agent, acts as an orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine has anxiolytic effect and can be used for the research of generalised anxiety disorder .
    Hydroxyzine (Standard)
  • HY-124356
    Alcaftadine carboxylic acid

    		Others Inflammation/Immunology
    Alcaftadine carboxylic acid is a broad-spectrum antihistamine compound with high affinity for histamine H1 and H2 receptors and low affinity for H4 receptors. Alcaftadine carboxylic acid has also demonstrated effects on modulating immune cell recruitment and stabilizing mast cells. Alcaftadine carboxylic acid is more effective than placebo in preventing ocular itching associated with allergic conjunctivitis and is at least as effective as olopatadine 0.01% .
    Alcaftadine carboxylic acid
  • HY-135495
    AM-0466

    		Others Inflammation/Immunology
    AM-0466 is a sodium channel inhibitor with nanomolar levels of NaV1.7 inhibitory activity. AM-0466 exhibits potent pharmacodynamic activity in a NaV1.7-dependent histamine-induced itch model. AM-0466 also showed significant analgesic effects in capsaicin-induced pain models. After optimizing its pharmacokinetic properties, AM-0466 was advanced into in vivo targeting and efficacy models for testing .
    AM-0466
  • HY-108425A
    AMG8380

    		Sodium Channel Neurological Disease
    AMG8380, an orally active and less active enantiomer of AMG8379, can serves as a negative control. AMG8380 inhibits human and mouse voltage-gated sodium channel NaV1.7 with IC50s of 0.907 and 0.387 μM, respectively. AMG8380 blocks Tetrodotoxin (TTX)-sensitive native channels with an IC50 of 2560 nM .
    AMG8380
  • HY-P99025
    Lebrikizumab

    TNX-650

    		 Interleukin Related Neurological Disease Inflammation/Immunology
    Lebrikizumab (TNX-650) is an IgG4 humanized anti-interleukin-13 (IL-13) mAb with anti-itch effects that specifically binds to IL-13 in a non-receptor binding domain and inhibits its function. Lebrikizumab inhibits the IL-13 driven Th2 inflammatory response and blocks the signaling of IL-4Rα/IL-13Rα1. Lebrikizumab can be used for the research of asthma, atopic dermatitis and neuroinflammatory diseases .
    Lebrikizumab
  • HY-B1144A
    Chlormidazole hydrochloride

    Clomidazole hydrochloride

    		 Fungal Infection
    Chlormidazole hydrochloride is an antifungal agent and has inhibitory activity against many fungi and some gram-positive cocci. Chlormidazole hydrochloride can be applied in fungal and bacterial infections of nails and skin, including interdigital and periungual mycoses .
    Chlormidazole hydrochloride
  • HY-108425B
    (Rac)-AMG8379

    (Rac)-AMG8380

    		 Sodium Channel Neurological Disease
    (Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379. AMG8379 is a potent, orally active and selective sulfonamide antagonist of NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively .
    (Rac)-AMG8379
  • HY-108425
    AMG8379

    		Sodium Channel Neurological Disease
    AMG8379 is a potent, orally active and selective sulfonamide antagonist of the voltage-gated sodium channel NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively. AMG8379 potently and reversibly blocks endogenous Tetrodotoxin (TTX)-sensitive sodium channels in dorsal root ganglia (DRG) neurons with an IC50 of 3.1 nM .
    AMG8379
  • HY-129047
    Trypsin
    5 Publications Verification

    		 Ser/Thr Protease Protease Activated Receptor (PAR) Infection Inflammation/Immunology
    Trypsin is a serine protease enzyme, and hydrolyzes proteins at the carboxyl side of the Lysine or Arginine. Trypsin activates PAR2 and PAR4. Trypsin induces cell-to-cell membrane fusion in PDCoV infection by the interaction of S glycoprotein of PDCoV and pAPN. Trypsin also promotes cell proliferation and differentiation. Trypsin can be used in the research of wound healing and neurogenic inflammation .
    Trypsin
  • HY-129047A
    Trypsin (MS grade)

    		Ser/Thr Protease Protease Activated Receptor (PAR) Infection Inflammation/Immunology
    Trypsin MS grade is a serine protease enzyme, and hydrolyzes proteins at the carboxyl side of the Lysine or Arginine. Trypsin MS grade activates PAR2 and PAR4. Trypsin MS grade induces cell-to-cell membrane fusion in PDCoV infection by the interaction of S glycoprotein of PDCoV and pAPN. Trypsin MS grade also promotes cell proliferation and differentiation. Trypsin MS grade can be used in the research of wound healing and neurogenic inflammation .
    Trypsin (MS grade)
  • HY-103320A
    Calhex 231 hydrochloride
    5 Publications Verification

    		 CaSR Metabolic Disease
    Calhex 231 hydrochloride is a potent negative allosteric modulator that blocks (IC50 = 0.39 μM) increases in [ 3H]inositol phosphates elicited by activating the human wild-type CaSR transiently Ca 2+-sensing receptor. Calhex 231 hydrochloride can be used in the study of traumatic hemorrhagic shock (THS) and diabetic cardiomyopathy (DCM) .
    Calhex 231 hydrochloride
  • HY-103320B
    (1R,2R)-Calhex 231 hydrochloride

    		Others Metabolic Disease
    (1R,2R)-Calhex 231 hydrochloride is the isomer of Calhex 231 hydrochloride (HY-103320A), and can be used as an experimental control. Calhex 231 hydrochloride is a CaSR inhibitor via negative allosteric modulation. Calhex 231 hydrochloride blocks Ca 2+-induced accumulation of [ 3H]inositol phosphate with an IC50 of 0.39 μM in HEK293 cells. Calhex 231 hydrochloride has the potential for diabetic cardiomyopathy (DCM) treatment .
    (1R,2R)-Calhex 231 hydrochloride
  • HY-103320
    Calhex 231

    		CaSR Metabolic Disease
    Calhex 231 is a potent negative allosteric modulator that blocks (IC50 = 0.39 μM) increases in [ 3H]inositol phosphates elicited by activating the human wild-type CaSR transiently Ca 2+-sensing receptor. Calhex 231 can be used in the study of traumatic hemorrhagic shock (THS) and diabetic cardiomyopathy (DCM) .
    Calhex 231

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