Search Result

Pathways Recommended:	Antibody-drug Conjugate/ADC Related

Results for "

IgG2 monoclonal antibody

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (1) Antibody-Drug Conjugates (ADCs) (1) Amyloid-β (2) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (3) Biochemical Assay Reagents (1) CD20 (1) CD28 (1) CD3 (1) CGRP Receptor (1) Complement System (1) Dipeptidyl Peptidase (1) EGFR (4) IGF-1R (1) Insulin Receptor (1) Integrin (3) Interleukin Related (8) Microtubule/Tubulin (1) Notch (1) Radionuclide-Drug Conjugates (RDCs) (1) SARS-CoV (1) Thrombin (1) Tim3 (1) TNF Receptor (3) Transmembrane Glycoprotein (2) Trk Receptor (1) Wnt (1)
By Research Areas:	Cancer (18) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (25) Neurological Disease (7)

By Targets:

ADC Antibody (1)

Antibody-Drug Conjugates (ADCs) (1)

Amyloid-β (2)

Anaplastic lymphoma kinase (ALK) (1)

Apoptosis (3)

Biochemical Assay Reagents (1)

CD20 (1)

CD28 (1)

CD3 (1)

CGRP Receptor (1)

Complement System (1)

Dipeptidyl Peptidase (1)

EGFR (4)

IGF-1R (1)

Insulin Receptor (1)

Integrin (3)

Interleukin Related (8)

Microtubule/Tubulin (1)

Notch (1)

Radionuclide-Drug Conjugates (RDCs) (1)

SARS-CoV (1)

Thrombin (1)

Tim3 (1)

TNF Receptor (3)

Transmembrane Glycoprotein (2)

Trk Receptor (1)

Wnt (1)

By Research Areas:

Cancer (18)

Cardiovascular Disease (1)

Infection (2)

Inflammation/Immunology (25)

Neurological Disease (7)

Inhibitors & Agonists

MCE Kits

Inhibitory Antibodies

Targets Recommended: ADC Antibody Antibody-Drug Conjugates (ADCs) ADC Linker PROTAC-Linker Conjugates for PAC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99589

Sotevtamab 16B5; AB-16B5	Apoptosis	Cancer
Sotevtamab (16B5) is a humanized IgG2 anti-clusterin monoclonal antibody (mAb). Sotevtamab is an inhibitor of the epithelial to mesenchymal transition. Sotevtamab can be used for cancer research .

HY-P99332

Visilizumab Anti-Human CD3E Recombinant antibody; HuM291	Apoptosis	Inflammation/Immunology Cancer
Visilizumab (Anti-Human CD3E Recombinant Antibody) is a humanized low-Fc receptor binding anti-CD3 monoclonal IgG2 antibody. Visilizumab can be used for ulcerative colitis and Crohn's disease research .

HY-P99205

Glembatumumab	ADC Antibody	Cancer
Glembatumumab is a fully human IgG2 monoclonal antibody directed against the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma. Glembatumumab can be coupled to the microtubule inhibitor monomethyl auristatin E to form glembatumumab vedotin. Glembatumumab vedotin is an antibody-agent coupling (ADC) with antitumor activity .

HY-P99444

Astegolimab 2 Publications Verification MSTT 1041A; RG 6149	Interleukin Related	Inflammation/Immunology
Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody that blocks IL-33 signaling by targeting ST2, the IL-33 receptor. Astegolimab has the potential for chronic obstructive pulmonary disease (COPD) research .

HY-P99041

Panitumumab 1 Publications Verification ABX-EGF	EGFR	Cancer
Panitumumab (ABX-EGF) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab can be used in the research of cancers, such as colon cancer .

HY-P99041A

Panitumumab (anti-EGFR)	EGFR	Cancer
Panitumumab (anti-EGFR) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab (anti-EGFR) inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab (anti-EGFR) can be used in the research of cancers, such as colon cancer .

HY-P99901

Sibeprenlimab VIS649	SARS-CoV	Inflammation/Immunology Cancer
Sibeprenlimab (VIS649) is a humanized *IgG2* monoclonal antibody which inhibits a proliferation-inducing ligand (APRIL). Sibeprenlimab suppresses pathogenic immunoglobulins (IgA and IgM), while preserving antibody responses to mRNA-based vaccines against SARS-COV-2. Sibeprenlimab reduces urinary protein-to-creatinine ratio (UPCR) and glomerular filtration rate (GFR). Sibeprenlimab is promising for the research of IgA nephropathy (IgAN) .

HY-P9974

Vantictumab OMP-18R5	Wnt	Cancer
Vantictumab (OMP-18R5) is a fully human IgG2 monoclonal antibody. Vantictumab inhibits Wnt pathway signaling by binding to FZD1/2/5/7/8 receptors. Vantictumab can be studied against cancers through direct actions on tumor cells, including CSCs, and effects on the stroma, such as metastatic HER2-negative breast cancer and metastatic pancreatic adenocarcinoma .

HY-P990712

Ersodetug	Insulin Receptor	Inflammation/Immunology
Ersodetug is an anti-INSR (insulin receptor) human IgG2 κ monoclonal antibody . Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P99465

Befovacimab BAY 1093884	Thrombin	Cardiovascular Disease
Befovacimab (BAY 1093884) is a fully human monoclonal IgG2 antibody able to bind to tissue factor pathway inhibitor (TFPI). Befovacimab can be used for haemophilia A/B research .

HY-P990713

Nolavetbart	Interleukin Related	Inflammation/Immunology
Nolavetbart is an anti-Canlupfam IL31RA human IgG2 κ monoclonal antibody . Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P990699

Riltovetbart ZTS-00008183	Interleukin Related	Inflammation/Immunology
Riltovetbart is a canine-derived IgG2 κ monoclonal antibody raised against Canlupfam IL13 .

HY-P991045

Donanemab (Mouse IgG2a)	Amyloid-β	Neurological Disease
Donanemab (Mouse IgG2a) (mE8-IgG2a) is a mouse-derived IgG2 monoclonal antibody used in the research of Alzheimer's disease.

HY-P99200

Fulranumab	Trk Receptor	Neurological Disease
Fulranumab is a human IgG2 monoclonal antibody against nerve growth factor (NGF) and can be used for the research of pain .

HY-P990753

Omoprubart	Complement System	Inflammation/Immunology
Omoprubart is an anti-C5 human?IgG2-G4 κ monoclonal antibody .

HY-P991111

Anti-Mouse TIGIT Antibody (10A7)	Transmembrane Glycoprotein	Inflammation/Immunology
Anti-Mouse TIGIT Antibody (10A7) is a mouse IgG2 monoclonal antibody that targets TIGIT. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978).

HY-P991110

Anti-Mouse CD25 Antibody (7D4)	Interleukin Related	Inflammation/Immunology
Anti-Mouse CD25 Antibody (7D4) is a mouse IgG2 monoclonal antibody that targets CD25. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978).

HY-P991112

Anti-Mouse CD8α Antibody (YTS169.4)	Transmembrane Glycoprotein	Inflammation/Immunology
Anti-Mouse CD8α Antibody (YTS169.4) is an IgG2 monoclonal antibody that targets CD8α. Recommend Isotype Controls: Rat IgG2b kappa, Isotype Control (HY-P990682).

HY-P99320

Tarextumab OMP 59R5; Anti-Human NOTCH2 Recombinant antibody	Notch	Cancer
Tarextumab (OMP-59R5) is an anti-Notch2/3 fully human IgG2 monoclonal antibody. Tarextumab shows anti-tumor activity .

HY-P9925

Brodalumab 3 Publications Verification AMG 827; KHK4827	Interleukin Related	Inflammation/Immunology
Brodalumab (AMG 827) is a human anti-interleukin-17-receptor IgG2 monoclonal antibody that can be used for the research of moderate-to-severe plaque psoriasis and rheumatoid arthritis .

HY-P99411

Ontamalimab SHP647	Integrin	Inflammation/Immunology
Ontamalimab (SHP647) is a fully-human IgG2 monoclonal antibody targeting mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Ontamalimab can be used for the research of Crohn's disease .

HY-P99909

Elranatamab PF-06863135	TNF Receptor	Inflammation/Immunology
Elranatamab (PF-06863135) is an anti-CD3E/TNFRSF17 human IgG2κ monoclonal antibody . Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P99485

Brazikumab AMG 139; MEDI2070	Interleukin Related	Inflammation/Immunology
Brazikumab (AMG 139) is a human IgG2 monoclonal antibody, selectively binds the p19 subunit of IL-23, with a K_D of 0.138 nM for human IL-23. Brazikumab can be used for the research of Crohn's disease .

HY-P99353

Ascrinvacumab 2 Publications Verification Anti-ACVRL1 / ALK-1 Reference antibody (ascrinvacumab); PF-03446962	Anaplastic lymphoma kinase (ALK)	Cancer
Ascrinvacumab (PF-03446962) is a human IgG2 monoclonal antibody targets ALK-1. Ascrinvacumab shows binding efficiency with human ALK1 with a K_d value of 7 nM. Ascrinvacumab can be used for the research of hepatocellular carcinoma (HCC) .

HY-P99183

Abituzumab EMD 525797; DI17E6	Integrin	Cancer
Abituzumab (DI17E6) is a humanised anti-integrin αV monoclonal antibody (IgG2 type). Abituzumab effectively reduces the phosphorylation of FAK, Akt and ERK. Abituzumab can be used in cancer research, particularly in prostate cancer .

HY-P99216

Ponezumab 1 Publications Verification PF-04360365; RN 1219	EGFR	Neurological Disease
Ponezumab (PF-04360365) is a humanised anti-amyloid *IgG2* monoclonal antibody. Ponezumab reduces Aβ levels in the central nervous system and improves performance in mice in various models of learning and memory. Ponezumab can be used in study of Alzheimer's disease .

HY-P99729

Melrilimab GSK 3772847; CNTO-7160	Interleukin Related	Inflammation/Immunology
Melrilimab (GSK 3772847) is an IgG2-kappa *anti-IL1RL1/ST2/IL33R/DER4/FIT-1* monoclonal antibody. Melrilimab can be used for the research of asthma .

HY-P99893

Rozibafusp alfa AMG-570	CD28 TNF Receptor	Others
Rozibafusp alfa (AMG-570) is a humanized IgG2-κ monoclonal antibody targets ICOSL and BAFF. Prezalumab demonstrates beneficial activities on the arthritis of systemic lupus erythematosus. Prezalumab can be used for the research of sjogren's syndrome cutaneous lupus erythematosus, psoriasis and systemic lupus erythematosus (SLE) .

HY-P99056

Utomilumab PF 05082566	TNF Receptor	Inflammation/Immunology Cancer
Utomilumab (PF 05082566) is a fully human IgG2 agonist monoclonal antibody that selectively binds to 4-1BB/CD137. Utomilumab can be used in the research of tumors such as follicular and other CD20 ⁺ non-Hodgkin lymphomas .

HY-141604

Glembatumumab vedotin CDX-011; CR011-vcMMAE	Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin	Cancer
Glembatumumab vedotin (CDX-011) is an ADC (antibody-drug conjugates (ADCs)) comprising a fully human IgG2 monoclonal antibody (CR011) directed against glycoprotein NMB (GPNMB) and conjugated to the potent tubulinbinding cytotoxic agent MMAE via a protease-sensitive vc linker. Glembatumumab vedotin has potent anticancer effects .

HY-P99268

Seribantumab SAR 256212; MM 121; Anti-Human ERBB3/ErbB 3 Recombinant antibody	EGFR Apoptosis	Cancer
Seribantumab (MM 121) is a fully human IgG2 monoclonal antibody that targets HER3. Seribantumab blocks the activation of epidermal growth factor receptor (ErbB) family members and its downstream signal. Seribantumab inhibits neuregulin 1 (NRG1) fusion-dependent tumorigenesis in vitro and in vivo in breast, lung and ovarian patient-derived cancer models .

HY-P991198

M6903	Tim3	Cancer
M6903 is a humanized monoclonal IgG2 antibody targeting T cell immunoglobulin and mucin domain-3 (TIM-3) (KD for human TIM-3 is 2.3 nM). M6903 binds to TIM-3, blocking the binding of TIM-3 to phosphatidylserine (PtdSer), carcinoembryonic antigen cell adhesion-related molecule 1 (CEACAM1), and galectin 9 (Gal-9), thus relieving TIM-3-mediated T cell inhibition and exerting the activities of activating antigen-specific T cells and enhancing anti-tumor immunity. M6903 is promising for research of cancers .

HY-P99867

Dusigitumab MEDI 573	IGF-1R	Others
Dusigitumab (MEDI 573) is a human IgG2λ monoclonal antibody that specifically targets IGF2 and IGF1 .

HY-P99326

Tositumomab Anti-Human CD20 Recombinant antibody	Radionuclide-Drug Conjugates (RDCs) CD20	Cancer
Tositumomab is a murine IgG2a lambda monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes .

HY-P990110

Lecanemab (Mouse IGG2a) Mab158	Amyloid-β	Neurological Disease
Lecanemab (Mouse IGG2a) is a monoclonal antibody that targets soluble β-amyloid and has the potential to reduce cognitive decline. The variable region of Lecanemab (Mouse IGG2a) is consistent with that of Lecanemab, while the constant region is of Mouse IGG2a sequence. Lecanemab (Mouse IGG2a) holds promise for research in the field of Alzheimer's disease .

HY-P99743

Mitumomab	Biochemical Assay Reagents	Cancer
Mitumomab is an anti-idiotypic mouse IgG2b monoclonal antibody that mimics the ganglioside GD3. Mitumomab can be used for the research of small-cell lung carcinoma .

HY-P99366A

Tezepelumab (anti-TSLP) AMG 157 (anti-TSLP); MEDI 19929 (anti-TSLP); Tezepelumab-ekko (anti-TSLP)	Interleukin Related	Inflammation/Immunology
Tezepelumab (anti-TSLP) is human monoclonal antibody (IgG2λ) that binds specifically to TSLP, blocking it from interacting with its heterodimeric receptor. Tezepelumab can be used for the research of severe, uncontrolled asthma .

HY-P99466

Begelomab SAND-26	Dipeptidyl Peptidase	Inflammation/Immunology
Begelomab (SAND-26) is a murine IgG2b monoclonal antibody against DPP-4/CD26. Begelomab can be used for the research of severe refractory idiopathic inflammatory myopathy .

HY-P99019

Fremanezumab 1 Publications Verification TEV-48125	CGRP Receptor	Neurological Disease
Fremanezumab (TEV-48125) is a humanized IgG2a monoclonal antibody that selectively and potently binds to calcitonin gene-related peptide (CGRP). CGRP is a 37-amino acid neuropeptide involved in central and peripheral pathophysiological events of migraine. Fremanezumab has the potential for chronic migraine research .

HY-P99336

Enlimomab BI-RR 0001; Anti-Human IL6 Recombinant antibody	Integrin	Neurological Disease Inflammation/Immunology
Enlimomab (BI-RR 0001), a murine IgG2a monoclonal antibody to the human ICAM-1, inhibits leukocyte adhesion to the vascular endothelium, thereby decreasing leukocyte extravasation and inflammatory tissue injury. Enlimomab has anti-inflammatory effects, and can be used for stroke research .

HY-P99837

Dafsolimab SPV-T3a	CD3	Infection
Dafsolimab (SPV-T3a) is an IgG2a murine monoclonal antibody (anti-CD3). Dafsolimab can induce cell death through modulation and activation of the CD3/T cell receptor complex. Dafsolimab can be used for the research of graft-versus-host disease (GVHD) .

Cat. No.	Product Name

HY-K0214

Protein G Agarose 2 Publications Verification
MCE Protein G Agarose, a 4% highly cross-linked agarose reagent coupled with recombinant Protein G, effectively purifies mammalian monoclonal and polyclonal antibodies, such as human IgG3 and rat IgG2a.

Cat. No.	Product Name	Target	Research Area