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Pathways Recommended: Stem Cell/Wnt Cell Cycle/DNA Damage
Results for "

L1210 cell

" in MedChemExpress (MCE) Product Catalog:

35

Inhibitors & Agonists

1

Peptides

8

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-117708
    Antitumor agent-144

    		Others Cancer
    Antitumor agent-144 (16) is an antitumor agent, with IC50 values of 2.6 μM and 8.4 μM in L1210 and KB cells, respectively .
    Antitumor agent-144
  • HY-W194107
    Antitumor agent-152

    		Others Cancer
    Antitumor agent-152 (Compound 5) is an anticancer agent that can inhibit the uptake of 3H-dC in L1210 leukemia cells with an IC50 value of 1.12 μM .
    Antitumor agent-152
  • HY-N10206
    11-epi-Chaetomugilin I

    		Endogenous Metabolite Cancer
    11-epi-Chaetomugilin I is a metabolite found in Chaetomium globosum. 11-epi-Chaetomugilin I exhibits significant cytotoxic activity against the murine P388 leukemia cell line, the human HL-60 leukemia cell line, the murine L1210 leukemia cell line, and the human KB epidermoid carcinoma cell line .
    11-epi-Chaetomugilin I
  • HY-124116
    PD 121373

    		DNA/RNA Synthesis Cancer
    PD 121373 is a DNA complexing agent with antitumor activity. PD 121373 can bind tightly to DNA and RNA and inhibit the synthesis of DNA and RNA. The IC50 values ??of PD 121373 for inhibiting DNA and RNA synthesis in L1210 cells are 0.5 μM and 0.3 μM, respectively .
    PD 121373
  • HY-10819
    AG2034

    		Others Cancer
    AG2034 is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a Ki of 28 nM against human GARFT, and it binds with high affinity to the folate receptor (Kd of 0.0042 nM). Additionally, AG2034 is a substrate for rat liver folylpolyglutamate synthetase, with a Km of 6.4 µM. AG2034 inhibits the growth of L1210 and CCRF-CEM cells, with IC50 values of 4 nM and 2.9 nM, respectively, and it has demonstrated antitumor activity in xenograft models such as 6C3HED .
    AG2034
  • HY-106423A
    Mivobulin isethionate

    CI-980; NSC 613862 isethionate; (S)-(-)-NSC 613862 isethionate

    		 Antifolate Microtubule/Tubulin Cancer
    Mivobulin (isethionate) (CI-980) is an orally active, brain-penetrant and potent folate antagonist and a tubulin-binding mitotic inhibitor. Mivobulin (isethionate) accumulates rapidly in L1210 and CHO/K1 cells to levels many-fold higher than those in the extracellular medium and efflux is also quite rapid. Mivobulin (isethionate) is promising for research of cancers .
    Mivobulin isethionate
  • HY-113700
    PD 116779

    		Antibiotic Cancer
    PD 116779 is an Antibiotic with anticancer activity. PD 116779 demonstrates moderate cytotoxicity against L1210 lymphocytic leukemia and HCT-8 human colon adenocarcinoma cell lines with IC50 values of 3.55x10 -7 and 4.08x10 -7 M, respectively .
    PD 116779
  • HY-115836
    DDPO

    		Dihydrofolate reductase (DHFR) Cancer
    DDPO is an inhibitor for dihydrofolate reductase (DHFR) with an IC50 of 0.035 µM. DDPO inhibits the cell growth of cancer cell L1210 and WI-L2with IC50 of 5 and 0.28 µM .
    DDPO
  • HY-16189
    Elliptinium acetate

    NSC 264137; Celiptium

    		 DNA Stain Cancer
    Elliptinium acetate (NSC 264137) is a DNA intercalating agent that is highly cytotoxic to L1 210 cells and covalently binds to nucleic acids from L1210 cells. Elliptinium acetate can be used in cancer research, particularly in metastatic breast cancer .
    Elliptinium acetate
  • HY-23120
    1-Hydroxyguanidine sulfate

    		Antibiotic Virus Protease Infection Cancer
    1-Hydroxyguanidine sulfate is an antitumor agent that inhibits mast cell P815, leukaemia P388, leukaemia L1210 and carcinosarcoma Walker 256 cells growth. 1-Hydroxyguanidine sulfate also has antiviral activity .
    1-Hydroxyguanidine sulfate
  • HY-129564
    Acetomycin

    		Antibiotic Cancer
    Acetomycin is an antibiotic. Acetomycin inhibits the growth of CT-8 human colon adenocarcinoma cells (IC50: 1.5 μg/mL) and L1210 murine leukemia cells (IC50: 2.2 μg/mL). Acetomycin can be isolated from actinomycete WP-2661 .
    Acetomycin
  • HY-N8512
    Asperfuran

    		Fungal Infection
    Asperfuran is an antifungal dihydrobenzofuran derivative produced by a strain of Aspergillus oryzae. Asperfuran weakly inhibits chitin synthase from Coprinus cinereus. Asperfuran shows weak cytotoxicity In HeLa S3 and L1210 cells with an IC50 of 25 μg/ml .
    Asperfuran
  • HY-121412
    Lankacidin C

    		Antibiotic Bacterial Infection Cancer
    Lankacidin C is an inhibitor of protein synthesis in vitro. Lankacidin C inhibits the activity of L1210 leukemia, B16 melanoma and 6C3 HED/OG lymphosarcoma cell lines. Lankacidin C has antibacterial activity and antitumor activity .
    Lankacidin C
  • HY-N11519
    Polyporusterone C

    		Others Cancer
    Polyporusterone C (Compound 3) is a natural product that can be isolated from Polyporus umbellatus. Polyporusterone C shows cytotoxic activities with IC50s of 37, 26 and 42 μg/mL against L-1210 cells at 3, 5 and 7 days, respectively .
    Polyporusterone C
  • HY-19839
    Ansamitocin P 3'

    Antibiotic C 15003P3'; Maytansinol butyrate

    		 Antibiotic Infection Cancer
    Ansamitocin P 3' (Antibiotic C 15003P3') is an anti-tumor antibiotic. Ansamitocin P 3' prolongs the survival of mice with leukemia P388, melanoma B16, leukemia L1210, sarcoma 180, Ehrlich carcinoma and mast cell tumor P815 .
    Ansamitocin P 3'
  • HY-N8519
    Urdamycin B

    		Bacterial Fungal Antibiotic Infection Cancer
    Urdamycin B is an antibiotic that effectively inhibits fungi and bacteria. Urdamycin B also exhibits anti-proliferative activity against mouse leukemia cells L1210. Urdamycin B can be obtained from the metabolic products of Streptomyces fradiae. Urdamycin B can be used for research on cancer as well as bacterial and fungal infections .
    Urdamycin B
  • HY-113578
    PD 116152

    		Antibiotic Bacterial Infection Cancer
    PD 116152 is a phenazine Antibiotic with antimicrobial and antitumor activity. PD 116152 possesses cytotoxic activity against L1210 lymphocytic leukemia and human colon adenocarcinoma (HCT-8) cells with IC50 values of 5.2 x 10 -7 M and 7.1 x 10 -7 M, respectively. PD 116152 is promising for research of P388 lymphocytic leukemia .
    PD 116152
  • HY-101775
    9-Hydroxyellipticin

    		Topoisomerase Cardiovascular Disease Cancer
    9-hydroxyellipticine is an inhibitor of Topo II and RyR, exhibiting high affinity for DNA with a Pka value of 9.8 at pH 7.4. It has antitumor, antioxidant, and catecholamine-releasing activities, with IC50 values of 1.6 μM and 1.2 μM for Hela S-3 and 293T cells, respectively. It also demonstrates anticancer effects in L1210 leukemia mice .
    9-Hydroxyellipticin
  • HY-124093
    8-Deazahomofolic acid

    		Thymidylate Synthase Bacterial Infection Cancer
    8-Deazahomofolic acid is an inhibitor of thymidylate synthase (TS) and other folate-related enzymes. 8-Deazahomofolic acid shows inhibitory activity against folate-dependent S. faecium, L. casei, and MTX (HY-14519) resistant strains. 8-Deazahomofolic acid also inhibits the growth of L1210 leukemia cells, with an IC50 value of 87.5 μM. 8-Deazahomofolic acid can be used in research on bacterial infections and tumors .
    8-Deazahomofolic acid
  • HY-129983
    5-Hydroxymethyl-2'-deoxyuridine

    		HSV Infection Cancer
    5-Hydroxymethyl-2'-deoxyuridine is a nucleoside analog. 5-Hydroxymethyl-2'-deoxyuridine inhibits the replication of multiple human leukemia cell lines with IC50 values of 1.7-5.8 μM. 5-Hydroxymethyl-2'-deoxyuridine prolongs the survival of mice carrying L1210 leukemia. 5-Hydroxymethyl-2'-deoxyuridine can be used for the research of cell replication and leukemia .
    5-Hydroxymethyl-2'-deoxyuridine
  • HY-N10653
    Altemicidin

    (-)-Altemicidin

    		 Others Cancer
    Altemicidin is a monoterpene alkaloid originally isolated from S. sioyaensis with acaricidal and anticancer activities. It is acaricidal to two-spotted spider mites (T. urticae) in a greenhouse pot test at concentrations of 10 and 100 ppm. Altemicidin inhibits the growth of murine L1210 lymphocytic leukemia and IMC carcinoma cells (IC50s=0.84 and 0.82 μg/mL, respectively). It is toxic to mice with an LD50 value of 0.3 mg/kg.
    Altemicidin
  • HY-117247
    5,6,7,8-Tetrahydro-8-deazahomofolic acid

    		Others Infection
    5,6,7,8-Tetrahydro-8-deazahomofolic acid is a potential thymidylate synthase (TS) inhibitor with inhibitory activity against other folate-related enzymes. 5,6,7,8-Tetrahydro-8-deazahomofolic acid showed mild growth inhibition against enterococci, lactic acid bacteria, and L1210 cells in culture. 5,6,7,8-Tetrahydro-8-deazahomofolic acid also showed weak inhibition against thymidylate synthase, dihydrofolate reductase, glycyl-ribonucleoside aminotransferase, and aminoimidazole-carboxyacyl-ribonucleoside aminotransferase. 5,6,7,8-Tetrahydro-8-deazahomofolic acid showed low substrate activity for thymidylate synthase .
    5,6,7,8-Tetrahydro-8-deazahomofolic acid
  • HY-123597
    NSC 109555

    DDUG; NCI C04808

    		 Others Cancer
    NSC 109555 is an ATP-competitive inhibitor of checkpoint kinase 2 (Chk2; IC50=200 nM in a cell-free kinase assay). It is selective for Chk2 over Chk1 and 16 kinases in a panel but does inhibit Brk, c-Met, IGFR, and LCK with IC50 values of 210, 6,000, 7,400, and 7,100 nM, respectively. NSC 109555 inhibits Chk2 autophosphorylation and phosphorylation of the Chk2 substrate histone H1 in vitro (IC50=240 nM). It inhibits the growth of, and induces autophagy in, L1210 leukemia cells in vitro.2 NSC 109555 (1,250 nM) potentiates gemcitabine-induced cytotoxicity in MIA PaCa-2, CFPAC-1, PANC-1, and BxPC-3 pancreatic cancer cells, as well as reduces gemcitabine-induced increases in Chk2 phosphorylation and enhances gemcitabine-induced production of reactive oxygen species (ROS) in MIA PaCa-2 cells.
    NSC 109555
  • HY-116028
    15-deoxy-Δ12,14-Prostaglandin D2

    15-Deoxy-Δ12,14-PGD2

    		 Endogenous Metabolite Cardiovascular Disease
    15-deoxy-Δ12,14-PGD2 is a metabolite of PGD2. It is an agonist of PGD2 receptor 2 (DP2) that binds DP2 (Ki=50 nM for the mouse receptor expressed in HEK293 cell membranes) and induces activation of eosinophils (EC50=8 nM). It also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ) and induces PPARγ-mediated transcription in a reporter assay when used at a concentration of 5 μM.1 15-deoxy-Δ12,14-PGD2 is cytotoxic to L1210 murine leukemia cells (IC50=0.3 μg/mL). It inhibits ADP-induced platelet aggregation (IC50=320 ng/ml) less potently than PGD2.
    15-deoxy-Δ12,14-Prostaglandin D2
  • HY-159803
    IST-622

    6-O-(3-Ethoxypropionyl)-3',4'-O-exo-benzylidenechartreusin

    		 Others Cancer
    IST-622 (6-O-(3-Ethoxypropionyl)-3',4'-O-exo-benzylidenechartreusin) is an anti-tumor agent with significant growth inhibitory activity. IST-622 exhibits significant anti-tumor effects against a variety of mouse tumors such as P388 and L1210 leukemias, B16 melanoma, Lewis lung carcinoma, Colon 26 and Colon 38 adenocarcinomas, and M5076 reticulum cell sarcoma. IST-622 was orally administered and the results showed efficacy in different tumor types. In addition, IST-622 provided significant inhibitory effects against two human tumor xenograft models: large cell lung carcinoma (Lu-116) and gastric adenocarcinoma (St-4). IST-622 also exhibited significant growth inhibitory activity against P388 leukemia in vitro, with a half inhibitory concentration (IC50) more than 20 times lower than CT .
    IST-622
  • HY-148657
    Aminopterin N-hydroxysuccinimide ester

    NHS-Methotrexate

    		 Others Inflammation/Immunology Cancer
    Aminopterin N-hydroxysuccinimide ester(NHS-methotrexate) is an irreversible Methotrexate (HY-14519) influx carrier inhibitor. Aminopterin N-hydroxysuccinimide ester can be used for the research of rheumatoid arthritis and a number of cancers (such as acute lymphoblastic leukemia) .
    Aminopterin N-hydroxysuccinimide ester
  • HY-10082A
    (E)-3-AP

    (E)-PAN-811; (E)-NSC# 663249; (E)-OCX191

    		 DNA/RNA Synthesis Cancer
    (E)-3-AP is the E configuration of 3-AP. 3-AP is a potent ribonucleotide reductase inhibitor. 3-AP shows anti-proliferative activity. 3-AP shows anticancer activity in L1210 leukemia model. 3-AP inhibits RR activity and DNA synthesis .
    (E)-3-AP
  • HY-N3065
    Pierreione B

    		Others Cancer
    Pierreione B is a pyranoisoflavone, that can be isolated from the leaves and twigs of Antheroporum pierrei. Pierreione B demonstrates solid tumor selectivity with minimal cytotoxicity .
    Pierreione B
  • HY-19825
    Rebeccamycin

    		Topoisomerase ADC Cytotoxin Antibiotic Cancer
    Rebeccamycin, an antitumor antibiotic, inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I and has negligible effect on protein kinase C and topoisomerase II .
    Rebeccamycin
  • HY-W077242
    1,4-Anthraquinone

    		DNA/RNA Synthesis Cancer
    1,4-Anthraquinone is a potent anticancer agent. 1,4-Anthraquinone blocks nucleoside transport, inhibits macromolecule synthesis, induces DNA fragmentation, and decreases the growth and viability of cancer cells. 1,4-Anthraquinone can be used to research anti-leukemia .
    1,4-Anthraquinone
  • HY-14521
    Lometrexol
    1 Publications Verification

    DDATHF

    		 Antifolate Apoptosis Caspase Bcl-2 Family Cancer
    Lometrexol (DDATHF), an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol has anticancer activity. Lometrexol also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor .
    Lometrexol
  • HY-14521B
    Lometrexol hydrate
    1 Publications Verification

    DDATHF hydrate

    		 Antifolate Apoptosis Caspase Bcl-2 Family Cancer
    Lometrexol (DDATHF) hydrate, an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol hydrate can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol hydrate has anticancer activity. Lometrexol hydrate also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor .
    Lometrexol hydrate
  • HY-14521A
    Lometrexol disodium
    1 Publications Verification

    DDATHF disodium

    		 Antifolate Apoptosis Caspase Bcl-2 Family Cancer
    Lometrexol (DDATHF) disodium, an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol disodium can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol disodium has anticancer activity. Lometrexol disodium also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor .
    Lometrexol disodium
  • HY-100875
    Bisantrene
    5 Publications Verification

    CL216942

    		 Topoisomerase Cancer
    Bisantrene is a highly effective antitumor agent, it exerts its cytotoxicity by affecting DNA intercalation. Bisantrene targets eukaryotic type II topoisomerases. Bisantrene is a substrate of MDR1 .
    Bisantrene
  • HY-100875A
    Bisantrene dihydrochloride
    5 Publications Verification

    CL-216942 dihydrochloride

    		 Topoisomerase Cancer
    Bisantrene dihydrochloride is a highly effective antitumor agent, it exerts its cytotoxicity by affecting DNA intercalation. Bisantrene dihydrochloride targets eukaryotic type II topoisomerases. Bisantrene dihydrochloride is a substrate of MDR1 .
    Bisantrene dihydrochloride

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