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Leukotriene C-4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Leukotriene Receptor (9) Apoptosis (2) Calcium Channel (2) Drug Metabolite (1) Endogenous Metabolite (7) FLAP (1) Glutathione S-transferase (3) Histamine Receptor (5) Isotope-Labeled Compounds (3) Lipoxygenase (2) P-glycoprotein (2) Prostaglandin Receptor (4)
By Research Areas:	Cancer (3) Cardiovascular Disease (4) Endocrinology (4) Inflammation/Immunology (17)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Leukotriene Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113446

Leukotriene C4	Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Leukotriene C4 is a eicosanoid lipid mediator and produced by immune cells during type 2 inflammation. Leukotriene C4 can mediate inflammation,allergy, bronchoconstriction, and vascular leakage .

HY-113446S

Leukotriene C4-d5	Endogenous Metabolite Isotope-Labeled Compounds	Cardiovascular Disease Inflammation/Immunology
Leukotriene C4-d₅ is the deuterium labeled Leukotriene C4. Leukotriene C4 is the parent cysteinyl leukotriene produced by the LTC4 synthase catalyzed conjugation of glutathione to LTA4.

HY-117143

TK05	Glutathione S-transferase	Inflammation/Immunology
TK05 is a potent and selective inhibitor of leukotriene C₄ synthase (LTC4S) with an IC₅₀ of 95 nM .

HY-13448

Nedocromil FPL 59002	Histamine Receptor Leukotriene Receptor Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Nedocromil suppresses the action or formation of multiple mediators, including histamine, leukotriene C₄ (LTC₄), and prostaglandin D₂ (PGD₂).

HY-126716

Leukotriene C4 methyl ester	Endogenous Metabolite	Inflammation/Immunology
Leukotriene C4 methyl ester is a methyl ester of leukotriene C4. Leukotriene C4 methyl ester can be used for the research of psoriasis .

HY-113446R

Leukotriene C4 (Standard)	Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Leukotriene C4 (Standard) is the analytical standard of Leukotriene C4. This product is intended for research and analytical applications. Leukotriene C4 is a eicosanoid lipid mediator and produced by immune cells during type 2 inflammation. Leukotriene C4 can mediate inflammation,allergy, bronchoconstriction, and vascular leakage .

HY-126716S

Leukotriene C4-d5 methyl ester	Isotope-Labeled Compounds	Others
Leukotriene C4-d₅ methyl ester is the deuterium labeled Leukotriene C4 methyl ester[1].

HY-130429

*14,15-Leukotriene* C4** Eoxin C4	Endogenous Metabolite	Inflammation/Immunology
14,15-Leukotriene C4 (Eoxin C4) is a Leukotriene compound produced by the enzymatic reaction of arachidonic acid. 14,15-Leukotriene C4 has the activity of promoting inflammatory response. 14,15-Leukotriene C4 can increase the permeability of blood vessels, causing fluid and white blood cells to leak out of the blood vessels, which increases the number of inflammatory cells in the tissue. 14,15-Leukotriene C4 can be used in studies of asthma and other inflammatory diseases .

HY-113460

*11-trans-Leukotriene* C4**	Endogenous Metabolite	Inflammation/Immunology
11-trans-Leukotriene C4 is trans-Leukotriene C4 (LTC4). LTC4 is an important inflammatory mediator and regulator of allergic responses .

HY-134092

*N-Methyl Leukotriene* C4** N-Methyl-LTC4	Leukotriene Receptor	Inflammation/Immunology
N-Methyl Leukotriene C4 stimulates contraction of airway smooth muscle in animals, with efficacy varying by tissue and species. For example, it can stimulate the lungs of bullfrogs to contract .

HY-16344

Nedocromil sodium FPL 59002KP; Nedocromil disodium salt	Histamine Receptor Leukotriene Receptor Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Nedocromil sodium suppresses the action or formation of multiple mediators, including histamine, leukotriene C₄ (LTC₄), and prostaglandin D₂ (PGD₂).

HY-123103

Linetastine	Lipoxygenase Histamine Receptor	Inflammation/Immunology
Linetastine is an orally active and potent 5-Lipoxygenase inhibitor. Linetastine shows antihistamine activity. Linetastine inhibits leukotriene production and antagonizes the effect of histamine. Linetastine inhibits the release of leukotrienes B4 and C4 from calcium ionophore-stimulated human leukocytes .

HY-135336A

(S)-Verapamil hydrochloride (S)-(-)-Verapamil hydrochloride	P-glycoprotein Leukotriene Receptor Calcium Channel Apoptosis	Cancer
(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells .

HY-N11424

Bilirubin diglucuronide	Drug Metabolite P-glycoprotein	Cancer
Bilirubin diglucuronide is the metabolite of Bilirubin (HY-N0323). Bilirubin diglucuronide inhibits MRP1/2 mediated ATP-dependent transport of leukotriene C4 (LTC4) in membrane vesicles .

HY-14165

Veliflapon BAY X 1005; DG-031	FLAP Leukotriene Receptor	Cardiovascular Disease Inflammation/Immunology
Veliflapon (BAY X 1005; DG-031) is an orally active and selective 5-lipoxygenase activating protein (FLAP) inhibitor . Veliflapon inhibits the synthesis of the leukotrienes B4 and C4 .

HY-13448R

Nedocromil (Standard)	Histamine Receptor Leukotriene Receptor Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Nedocromil (Standard) is the analytical standard of Nedocromil. This product is intended for research and analytical applications. Nedocromil suppresses the action or formation of multiple mediators, including histamine, leukotriene C₄ (LTC₄), and prostaglandin D₂ (PGD₂).

HY-168498

GJG057	Glutathione S-transferase	Inflammation/Immunology
GJG057 is a selective, orally active inhibitor for leukotriene C4 synthase (LTC4S) with an IC₅₀ of 44 nM. GJG057 exhibits anti-inflammatory activity in mouse skin inflammation model and mouse asthma model .

HY-135336AS

(S)-Verapamil-d7 hydrochloride (S)-(-)-Verapamil-d₇ hydrochloride	Isotope-Labeled Compounds Leukotriene Receptor Calcium Channel Apoptosis	Cancer
(S)-Verapamil-d₇ (hydrochloride) is a deuterium labeled (S)-Verapamil hydrochloride. (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells[1][2].

HY-U00364

CI-949	Histamine Receptor Prostaglandin Receptor Leukotriene Receptor	Inflammation/Immunology Endocrinology
CI-949 is an allergic mediator release inhibitor, which inhibits histamine, leukotriene C₄/D₄ (LTC₄/LTD₄), and thromboxane B₂ (TXB₂) release with IC₅₀s of 11.4 μM, 0.5 μM and 0.1 μM, respectively.

HY-126329

AZD9898	Glutathione S-transferase	Inflammation/Immunology
AZD9898 is an orally active leukotriene-C4 synthetase (LTC4S, glutathione S-transferase II) inhibitor, with an IC₅₀ of 0.28 nM. AZD9898 mitigates the GABA binding and hepatic toxicity signal. AZD9898 has the potential to treat asthma .

HY-113693

ONO-RS-347	Leukotriene Receptor	Others
ONO-RS-347 is an orally active and potent antagonist of leukotriene C4 and D4. ONO-RS-347 inhibits LTD4-induced bronchoconstriction in guinea pigs. ONO-RS-347 is promising for research of allergic asthma and other immediate hypersensitivty diseases .

HY-155169

hLTA4H/hLTA4S-IN-1	Endogenous Metabolite	Inflammation/Immunology
hLTA4H/hLTA4S-IN-1 is a possible dual inhibitor that has the activity of inhibiting both human leukotriene hydrolase (hLTA4H) and human leukotriene C4 synthase (hLTC4S). hLTA4H/hLTA4S-IN-1 was identified by computer-assisted methods and is able to effectively interfere with the leukotriene biosynthesis pathway in cells. hLTA4H/hLTA4S-IN-1 can be used to study inflammatory responses .

HY-103158

BW B70C	Lipoxygenase	Others
BW B70C is a potent, selective and orally activearachidonic acid 5-lipoxygenase inhibitor. BW B70C inhibits both acute and allergic bronchoconstriction and late-phase eosinophil accumulation subsequent to allergen inhalation in guinea-pigs. BW B70C prevents leukotriene C4 synthesis and reduces leucocyte migration to the airways lumen as well as albumin microvascular leakage. BW B70C has the potential for the research of anti-asthma agent .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113446

Leukotriene C4	Infection Structural Classification Natural Products Immune System Disorder Classification of Application Fields Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Inflammation/Immunology Disease Research Fields Cardiovascular System Disorder	Endogenous Metabolite
Leukotriene C4 is a eicosanoid lipid mediator and produced by immune cells during type 2 inflammation. Leukotriene C4 can mediate inflammation,allergy, bronchoconstriction, and vascular leakage .

HY-113446R

Leukotriene C4 (Standard)	Infection Structural Classification Natural Products Immune System Disorder Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder	Endogenous Metabolite
Leukotriene C4 (Standard) is the analytical standard of Leukotriene C4. This product is intended for research and analytical applications. Leukotriene C4 is a eicosanoid lipid mediator and produced by immune cells during type 2 inflammation. Leukotriene C4 can mediate inflammation,allergy, bronchoconstriction, and vascular leakage .

HY-130429

*14,15-Leukotriene* C4** Eoxin C4	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
14,15-Leukotriene C4 (Eoxin C4) is a Leukotriene compound produced by the enzymatic reaction of arachidonic acid. 14,15-Leukotriene C4 has the activity of promoting inflammatory response. 14,15-Leukotriene C4 can increase the permeability of blood vessels, causing fluid and white blood cells to leak out of the blood vessels, which increases the number of inflammatory cells in the tissue. 14,15-Leukotriene C4 can be used in studies of asthma and other inflammatory diseases .

HY-113460

*11-trans-Leukotriene* C4**	Structural Classification Natural Products Animals Source classification	Endogenous Metabolite
11-trans-Leukotriene C4 is trans-Leukotriene C4 (LTC4). LTC4 is an important inflammatory mediator and regulator of allergic responses .

HY-N11424

Bilirubin diglucuronide	Structural Classification Polysaccharides Microorganisms Source classification Endogenous metabolite Saccharides	Drug Metabolite P-glycoprotein
Bilirubin diglucuronide is the metabolite of Bilirubin (HY-N0323). Bilirubin diglucuronide inhibits MRP1/2 mediated ATP-dependent transport of leukotriene C4 (LTC4) in membrane vesicles .

Species:	Human (3) Bovine (1)
Tag:	GFP (1) His (4) Strep (1)
Source:	HEK293 (1) E. coli Cell-free (1) Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P75919

	LTC4S Protein, Human (sf9, His) Leukotriene C4 synthase; LTC4 synthase; LTC4S	Human	Sf9 insect cells
	LTC4S protein catalyzes the specific binding of leukotriene A4 and reduced glutathione (GSH) to generate leukotriene C4. LTC4S Protein, Human (sf9, His) is the recombinant human-derived LTC4S protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P702379

	MGST2 Protein, Human (Cell-Free, His) Microsomal glutathione S-transferase 2; Glutathione peroxidase MGST2; 1.11.1.-; Leukotriene C4 synthase MGST2; 4.4.1.20; Microsomal glutathione S-transferase II; Microsomal GST-II	Human	E. coli Cell-free
	As a multifunctional enzyme, MGST2 protein catalyzes the synthesis of cyclic ADP-β-D-ribose (cADPR) from NAD(+) and subsequently hydrolyzes cADPR into ADP-D-ribose (ADPR). This dual function makes MGST2 a key player in regulating intracellular calcium mobilization, as cADPR acts as an endogenous second messenger that triggers the release of intracellular stored calcium. MGST2 Protein, Human (Cell-Free, His) is the recombinant human-derived MGST2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag.

HY-P701355

	ABCC1 Protein, Bovine (HEK293, GFP, StrepⅡ, His) ABCC1; Multidrug resistance-associated protein 1; ATP-binding cassette sub-family C member 1; Glutathione-S-conjugate-translocating ATPase ABCC1; Leukotriene C(4) transporter; LTC4 transporter	Bovine	HEK293
	The ABCC1 protein plays a key role in cellular physiology, mediating the ATP-dependent export of a variety of substrates, including drugs and organic anions. Notably, it confers resistance to anticancer drugs, actively reducing their intracellular accumulation. ABCC1 Protein, Bovine (HEK293, GFP, Strep, His) is the recombinant bovine-derived ABCC1 protein, expressed by HEK293 , with C-10*His, C-GFP, C-StrepII labeled tag.

HY-P72069

	ABCC1 Protein, Human (His) ABC 29; ABC29; ABCC 1; ABCC; Abcc1; ATP binding cassette sub family C CFTR/MRP; member 1; ATP binding cassette sub-family C member 1; ATP binding cassette subfamily C member 1; ATP binding cassette transporter variant ABCC1delta ex13; ATP binding cassette transporter variant ABCC1delta ex13&14; ATP binding cassette transporter variant ABCC1delta ex25; ATP binding cassette transporter variant ABCC1delta ex25&26; ATP binding cassette, sub-family C CFTR/MRP; , member 1; ATP-binding cassette sub-family C member 1; DKFZp686N04233; DKFZp781G125; GS X; GSX; Leukotriene C4; transporter; LTC4 transporter; MRP 1; MRP; MRP1; MRP1_HUMAN; Multidrug resistance associated protein 1; Multidrug resistance protein; Multidrug resistance-associated protein 1; Multiple drug resistance associated protein; Multiple drug resistance protein 1	Human	E. coli
	ABCC1, Human (His) is a multitasking ATP-binding cassette (ABC) transporter. ABCC1, Human plays a part in inflammatory and other immunological diseases, age-related macular degeneration, cardiovascular disease, and certain neurological disorders as well as tumor progression.

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Cat. No.	Product Name	Chemical Structure

HY-113446S

Leukotriene C4-d5
Leukotriene C4-d₅ is the deuterium labeled Leukotriene C4. Leukotriene C4 is the parent cysteinyl leukotriene produced by the LTC4 synthase catalyzed conjugation of glutathione to LTA4.

HY-126716S

Leukotriene C4-d5 methyl ester
Leukotriene C4-d₅ methyl ester is the deuterium labeled Leukotriene C4 methyl ester[1].

HY-135336AS

(S)-Verapamil-d7 hydrochloride
(S)-Verapamil-d₇ (hydrochloride) is a deuterium labeled (S)-Verapamil hydrochloride. (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells[1][2].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81838

	MRP1 Antibody (YA1583) ABC29; Abcc1; GSX; Leukotriene C(4) transporter; LTC4 transporter; MRP1	WB, FC	Human
	MRP1 Antibody (YA1583) is a non-conjugated IgG antibody, targeting MRP1, with a predicted molecular weight of 172 kDa. MRP1 Antibody (YA1583) can be used for WB, FC experiment in human background.

HY-P82889

	GGT1 Antibody (YA2634) GGT1; GGT; Gamma-glutamyltranspeptidase 1; GGT 1; Gamma-glutamyltransferase 1; Glutathione hydrolase 1; Leukotriene-C4 hydrolase; CD224	WB, IHC-P	Human
	GGT1 Antibody (YA2634) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2634), targeting GGT1, with a predicted molecular weight of 61 kDa (observed band size: 50-60 kDa). GGT1 Antibody (YA2634) can be used for WB, IHC-P experiment in human background.

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Leukotriene C-4

Inhibitors & Agonists

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

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Natural
Products