Search Result
Results for "
Lipid M
" in MedChemExpress (MCE) Product Catalog:
11
Biochemical Assay Reagents
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-154974
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Liposome
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Cancer
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LNP Lipid-8 (11-A-M) is an ionizable lipid, which can be used for lipid nanoparticles (LNP) to deliver siRNA to T cells without targeting to ligands. LNP LIPs-8 loaded with GFP siRNA (siGFP), and significantly causes GFP gene silencing in mice model .
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- HY-154804
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Liposome
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Others
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DLin-M-C4-DMA (Compound MC4) is a cationic lipid. DLin-M-C4-DMA can be used for delivery of nucleic acids .
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- HY-W440821
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- HY-166983
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Biochemical Assay Reagents
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Others
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m-PEG-DMG (MW 5000) is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. m-PEG-DMG (MW 5000) can be used in drug delivery research .
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- HY-W440924
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Biochemical Assay Reagents
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Others
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m-PEG-DSPE (sodium) (MW 3000) is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. m-PEG-DSPE (sodium) (MW 3000) can be used in drug delivery research .
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- HY-132289
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- HY-W440925
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Biochemical Assay Reagents
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Others
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m-PEG-DSPE (sodium) (MW 5000) is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. m-PEG-DSPE (sodium) (MW 5000) can be used in drug delivery research .
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- HY-W440922
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Biochemical Assay Reagents
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Others
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m-PEG-DSPE (sodium) (MW 1000) is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. m-PEG-DSPE (sodium) (MW 1000) can be used in drug delivery research .
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- HY-166980
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Biochemical Assay Reagents
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Others
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m-PEG-DPPE (MW 2000) is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. m-PEG-DPPE (MW 2000) can be used in drug delivery research .
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- HY-W441015A
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Liposome
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Others
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DSPE-m-PEG-NHS (MW 3400) is a pegylated phospholipid derivatives which can be used to prepare liposome or lipid nanoparticles for targeted drug delivery system, such as DNA or mRNA vaccine.
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- HY-164190
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DNA/RNA Synthesis
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Others
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m7(3'Ma-Biotin)Gppp(2'OMe)ApG ammonium is a Biotin-labled cap analogue that can be used for mRNA synthesis. The efficiency of mRNA delivery can be determined by the detection of Biotin by flow cytometry, which can be used to track mRNA in cells and in living animals and to screen delivery lipid ratios.
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- HY-164191
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DNA/RNA Synthesis
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Others
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m7(3'Ma-Peg5-FAM)Gppp(2'OMe)ApG ammonium is a FAM-labled cap analogue that can be used for mRNA synthesis. The efficiency of mRNA delivery can be determined by the detection of FAM by flow cytometry, which can be used to track mRNA in cells and in living animals and to screen delivery lipid ratios.
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- HY-164189
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DNA/RNA Synthesis
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Others
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m7(3'Ma-Cy3)Gppp(2'OMe)ApG ammonium is a Cy3-labled cap analogue that can be used for mRNA synthesis. The efficiency of mRNA delivery can be determined by the detection of Cy3 by flow cytometry, which can be used to track mRNA in cells and in living animals and to screen delivery lipid ratios.
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- HY-164188
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DNA/RNA Synthesis
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Others
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m7(3'Ma-Cy5)Gppp(2'OMe)ApG ammonium is a Cy5-labled cap analogue that can be used for mRNA synthesis. The efficiency of mRNA delivery can be determined by the detection of Cy5 by flow cytometry, which can be used to track mRNA in cells and in living animals and to screen delivery lipid ratios.
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- HY-164187
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DNA/RNA Synthesis
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Others
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m7(3'Ma-Cy7)Gppp(2'OMe)ApG ammonium is a Cy7-labled cap analogue that can be used for mRNA synthesis. The efficiency of mRNA delivery can be determined by the detection of Cy7 by flow cytometry, which can be used to track mRNA in cells and in living animals and to screen delivery lipid ratios.
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- HY-146683
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Aldehyde Dehydrogenase (ALDH)
Apoptosis
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Cancer
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KS106 is a potent ALDH inhibitor with IC50s of 334, 2137, 360 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS106 shows antiproliferative and anticancer effects with low low toxic.KS106 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS106 induces apoptosis and cell cycle arrest at the G2/M phase .
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- HY-146682
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Aldehyde Dehydrogenase (ALDH)
Apoptosis
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Cancer
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KS100 is a potent ALDH inhibitor with IC50s of 230, 1542, 193 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS100 shows antiproliferative and anticancer effects with low low toxic. KS100 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS10600 induces apoptosis and cell cycle arrest at the G2/M phase .
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- HY-139282
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C16:0 1-Deoxyceramide; C16:0 Ceramide (m18:1/16:0); Cer(m18:1/16:0)
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Endogenous Metabolite
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Metabolic Disease
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C16 1-Deoxyceramide (m18:1/16:0) (C16:0 1-Deoxyceramide) is a lipid molecule, which is composed of a long-chain fatty acid (16:0) and a 1-deoxysphingoid backbone. Deoxyceramide accumulates under the conditions of obesity and type 2 diabetes (T2D). Deoxyceramide is unable to be further metabolized to more complex sphingolipid, and is toxic when accumulates in the body. Deoxyceramide increases in differentiated adipocytes in vitro .
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- HY-139284
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C24:1 Deoxy dihydroceramide; C24:1 DeoxyDHceramide; Cer(m18:0/24:1)
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Endogenous Metabolite
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Metabolic Disease
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C24:1 Dihydro 1-deoxyceramide (m18:0/24:1) (C24:1 Deoxy dihydroceramide) is a lipid molecule, which is composed of a long-chain fatty acid (24:1) and a 1-deoxysphingoid backbone. Deoxyceramide accumulates under the conditions of obesity and type 2 diabetes (T2D). Deoxyceramide is unable to be further metabolized to more complex sphingolipid, and is toxic when accumulates in the body. Deoxyceramide increases in differentiated adipocytes in vitro .
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- HY-168639
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Mitochondrial Metabolism
AMPK
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Metabolic Disease
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AP39 prodrug 1 (Compound M1) is a mitochondria-targeted H2S prodrug. AP39 prodrug 1 induces ROS-dependent mild mitochondrial uncoupling, activating mitochondria-associated AMPK to suppress Palmitic acid (PA) (HY-N0830)-induced lipid deposition in hepatocytes .
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- HY-139283
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C24:1(15Z) 1-Deoxyceramide; C24:1 Ceramide (m18:1/24:1(15Z)); Cer(m18:1/24:1(15Z))
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Endogenous Metabolite
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Metabolic Disease
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C24:1 1-Deoxyceramide (m18:1/24:1(15Z)) (C24:1(15Z) 1-Deoxyceramide) is a lipid molecule, which is composed of a long-chain fatty acid (24:1) and a 1-deoxysphingoid backbone. Deoxyceramide accumulates under the conditions of obesity and type 2 diabetes (T2D). Deoxyceramide is unable to be further metabolized to more complex sphingolipid, and is toxic when accumulates in the body. Deoxyceramide increases in differentiated adipocytes in vitro .
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- HY-W440807
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Biochemical Assay Reagents
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Others
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Oleoyl-Gly-Lys-(m-PEG11)-NH2 is a PEG-lipid molecule featuring an oleoyl amide linked to a Gly-Lys dipeptide and a methoxy PEG11 chain on the C-terminus of the lysine. The lysine primary amine may be used in a wide variety of reactions with carboxylic acids, NHS esters, and carbonyl groups. The PEG linker provides aqueous solubility.
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- HY-W127391
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(Rac)-1,2-Didodecanoylglycerol
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Biochemical Assay Reagents
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Others
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1,2-Dilaurin is a diacylglycerol containing lauric acid at the sn-1 and sn-2 positions. It has been used as an internal standard for the quantification of diglycerides in rat desheathed sciatic nerves. [1] Monomolecular films containing 1,2-dilauroyl-rac-glycerol have been used as substrates to measure surface pressure and the effect of pancreatic procolipase and colipase on porcine pancreatic lipase activity. [2] References: [1]. Zhu, X. and Eichberg, J. 1,2-Diacylglycerol content and its arachidonyl-containing molecular species are reduced in the sciatic nerve of streptozotocin-induced diabetic rats. J. Neurochemistry. 55(3), 1087-1090 (1990).[2]. Wieloch, T., Borgstr m, B., Piéroni, G. et al. Porcine trypsinogen and its trypsin-activated form: lipid binding and lipase activation on monomolecular membranes. FEBS Express. 128(2), 217-220 (1981).
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- HY-D1056F
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Biotin-LPS, from Escherichia coli (O111:B4)
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Biochemical Assay Reagents
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Others
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Biotin-Lipopolysaccharide, from E.coli O111:B4 (Biotin-LPS, from Escherichia coli (O111:B4)) is a biotin-conjugated Lipopolysaccharide (LPS) (HY-D1056A1) that can be coupled with streptavidin protein. Biotin-Lipopolysaccharide, from E.coli O111:B4 can be used to identify Lipopolysaccharide ligands. Lipopolysaccharides, from E. coli O111:B4 (LPS, from Escherichia coli (O111:B4)) are endotoxins and TLR4 activators extracted from Escherichia coli (E. coli O111:B4) and are classified as S (smooth) type LPS. Lipopolysaccharides, from E. coli O111:B4 possess the typical three-part structure: O-antigen, R3-type core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O111:B4 activate TLR-4 in immune cells and can cause significant gastric diseases. Lipopolysaccharides, from E. coli O111:B4 can also induce M1-type polarization in mouse macrophages .
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HY-L168
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504 compounds
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Extracellular vesicles (EVs) are small membrane binding structures that are released from cells into the surrounding environment and play a crucial role in mediating and regulating intercellular communication related to physiological and pathological processes. EVs are lipid membrane vesicles composed of proteins, lipids, and nucleic acids. EVs can be divided into several types based on their source, such as extracellular vesicles, microcapsules, and apoptotic vesicles. The size range of exosomes is 30-150nm, which are endocrine in multi vesicular endosomes (MVEs); microvesicles (50-1000nm) are secreted directly through extracellular interactions, thereby releasing plasma membrane vesicles. In contrast, apoptotic bodies are usually larger, ranging in size from 1 to 5 μ m. This is generated during programmed cell death. EV plays a crucial role in transmitting information between cells and influencing the behavior and function of receptor cells.
MCE designs a unique collection of 504 small molecules related to extracellular vesicles (EVs). It is a good tool to be used for research on metabolize, cancer and other diseases.
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| Cat. No. |
Product Name |
Type |
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- HY-154804
-
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Drug Delivery
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DLin-M-C4-DMA (Compound MC4) is a cationic lipid. DLin-M-C4-DMA can be used for delivery of nucleic acids .
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- HY-W440821
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Drug Delivery
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m-PEG-DMG (MW 2000) is a PEG lipid for the preparation of liposomes and can be used in drug delivery studies .
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- HY-166983
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Drug Delivery
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m-PEG-DMG (MW 5000) is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. m-PEG-DMG (MW 5000) can be used in drug delivery research .
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- HY-W440924
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Drug Delivery
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m-PEG-DSPE (sodium) (MW 3000) is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. m-PEG-DSPE (sodium) (MW 3000) can be used in drug delivery research .
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- HY-W127391
-
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(Rac)-1,2-Didodecanoylglycerol
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Drug Delivery
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1,2-Dilaurin is a diacylglycerol containing lauric acid at the sn-1 and sn-2 positions. It has been used as an internal standard for the quantification of diglycerides in rat desheathed sciatic nerves. [1] Monomolecular films containing 1,2-dilauroyl-rac-glycerol have been used as substrates to measure surface pressure and the effect of pancreatic procolipase and colipase on porcine pancreatic lipase activity. [2] References: [1]. Zhu, X. and Eichberg, J. 1,2-Diacylglycerol content and its arachidonyl-containing molecular species are reduced in the sciatic nerve of streptozotocin-induced diabetic rats. J. Neurochemistry. 55(3), 1087-1090 (1990).[2]. Wieloch, T., Borgstr m, B., Piéroni, G. et al. Porcine trypsinogen and its trypsin-activated form: lipid binding and lipase activation on monomolecular membranes. FEBS Express. 128(2), 217-220 (1981).
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- HY-132289
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Drug Delivery
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Lipid M (pKa: 6.75) can be used to deliver mRNA vaccine and yield a robust immune response with improved tolerability .
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- HY-W440925
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Drug Delivery
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m-PEG-DSPE (sodium) (MW 5000) is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. m-PEG-DSPE (sodium) (MW 5000) can be used in drug delivery research .
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- HY-W440922
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Drug Delivery
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m-PEG-DSPE (sodium) (MW 1000) is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. m-PEG-DSPE (sodium) (MW 1000) can be used in drug delivery research .
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- HY-166980
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Drug Delivery
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m-PEG-DPPE (MW 2000) is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. m-PEG-DPPE (MW 2000) can be used in drug delivery research .
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- HY-W441015A
-
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Drug Delivery
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DSPE-m-PEG-NHS (MW 3400) is a pegylated phospholipid derivatives which can be used to prepare liposome or lipid nanoparticles for targeted drug delivery system, such as DNA or mRNA vaccine.
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- HY-D1056F
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Biotin-LPS, from Escherichia coli (O111:B4)
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Carbohydrates
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Biotin-Lipopolysaccharide, from E.coli O111:B4 (Biotin-LPS, from Escherichia coli (O111:B4)) is a biotin-conjugated Lipopolysaccharide (LPS) (HY-D1056A1) that can be coupled with streptavidin protein. Biotin-Lipopolysaccharide, from E.coli O111:B4 can be used to identify Lipopolysaccharide ligands. Lipopolysaccharides, from E. coli O111:B4 (LPS, from Escherichia coli (O111:B4)) are endotoxins and TLR4 activators extracted from Escherichia coli (E. coli O111:B4) and are classified as S (smooth) type LPS. Lipopolysaccharides, from E. coli O111:B4 possess the typical three-part structure: O-antigen, R3-type core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O111:B4 activate TLR-4 in immune cells and can cause significant gastric diseases. Lipopolysaccharides, from E. coli O111:B4 can also induce M1-type polarization in mouse macrophages .
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| Cat. No. |
Product Name |
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Classification |
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- HY-154803
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DLin-M-C2-DMA
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Cationic Lipids
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DLin-M-K-DMA (DLin-M-C2-DMA) is a cationic lipid that can be used in the construction of biological delivery vectors .
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- HY-154974
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Cationic Lipids
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LNP Lipid-8 (11-A-M) is an ionizable lipid, which can be used for lipid nanoparticles (LNP) to deliver siRNA to T cells without targeting to ligands. LNP LIPs-8 loaded with GFP siRNA (siGFP), and significantly causes GFP gene silencing in mice model .
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- HY-154804
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Pegylated Lipids
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DLin-M-C4-DMA (Compound MC4) is a cationic lipid. DLin-M-C4-DMA can be used for delivery of nucleic acids .
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- HY-164190
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Cap Analogs
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m7(3'Ma-Biotin)Gppp(2'OMe)ApG ammonium is a Biotin-labled cap analogue that can be used for mRNA synthesis. The efficiency of mRNA delivery can be determined by the detection of Biotin by flow cytometry, which can be used to track mRNA in cells and in living animals and to screen delivery lipid ratios.
|
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- HY-132289
-
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Cationic Lipids
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Lipid M (pKa: 6.75) can be used to deliver mRNA vaccine and yield a robust immune response with improved tolerability .
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- HY-W441015A
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Pegylated Lipids
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DSPE-m-PEG-NHS (MW 3400) is a pegylated phospholipid derivatives which can be used to prepare liposome or lipid nanoparticles for targeted drug delivery system, such as DNA or mRNA vaccine.
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- HY-164191
-
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Cap Analogs
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m7(3'Ma-Peg5-FAM)Gppp(2'OMe)ApG ammonium is a FAM-labled cap analogue that can be used for mRNA synthesis. The efficiency of mRNA delivery can be determined by the detection of FAM by flow cytometry, which can be used to track mRNA in cells and in living animals and to screen delivery lipid ratios.
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- HY-164189
-
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Cap Analogs
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m7(3'Ma-Cy3)Gppp(2'OMe)ApG ammonium is a Cy3-labled cap analogue that can be used for mRNA synthesis. The efficiency of mRNA delivery can be determined by the detection of Cy3 by flow cytometry, which can be used to track mRNA in cells and in living animals and to screen delivery lipid ratios.
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- HY-164188
-
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Cap Analogs
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m7(3'Ma-Cy5)Gppp(2'OMe)ApG ammonium is a Cy5-labled cap analogue that can be used for mRNA synthesis. The efficiency of mRNA delivery can be determined by the detection of Cy5 by flow cytometry, which can be used to track mRNA in cells and in living animals and to screen delivery lipid ratios.
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- HY-164187
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Cap Analogs
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m7(3'Ma-Cy7)Gppp(2'OMe)ApG ammonium is a Cy7-labled cap analogue that can be used for mRNA synthesis. The efficiency of mRNA delivery can be determined by the detection of Cy7 by flow cytometry, which can be used to track mRNA in cells and in living animals and to screen delivery lipid ratios.
|
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