2. Search Result
Search Result
Results for "

MALT1

" in MedChemExpress (MCE) Product Catalog:

32

Inhibitors & Agonists

2

Peptides

1

Antibodies

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-12276
    MALT1 inhibitor MI-2
    5 Publications Verification

    		 MALT1 Cancer
    MALT1 inhibitor MI-2 is a MALT1 inhibitor (IC50=5.84 μM). MALT1 inhibitor MI-2 binds directly to MALT1, irreversibly suppresses protease function and is accompanied by NF-κB reporter activity suppression, c-REL nuclear localization inhibition, and NF-κB target gene downregulation. MALT1 inhibitor MI-2 shows nontoxic to animals [1].
    MALT1 inhibitor MI-2
  • HY-RS07995
    MALT1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    MALT1 Human Pre-designed siRNA Set A contains three designed siRNAs for MALT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MALT1 Human Pre-designed siRNA Set A
    MALT1 Human Pre-designed siRNA Set A
  • HY-RS07996
    Malt1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Malt1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Malt1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Malt1 Mouse Pre-designed siRNA Set A
    Malt1 Mouse Pre-designed siRNA Set A
  • HY-RS07997
    Malt1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Malt1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Malt1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Malt1 Rat Pre-designed siRNA Set A
    Malt1 Rat Pre-designed siRNA Set A
  • HY-143427
    MALT1-IN-9

    		MALT1 Cancer
    MALT1-IN-9 is a potent MALT1 protease inhibitor with a IC50 of <500 nM in Raji MALT1-GloSensor cells. MALT1-IN-9 has anticancer effects (WO2021000855A1; Compound 5) [1].
    MALT1-IN-9
  • HY-143423
    MALT1-IN-5

    		MALT1 Cancer
    MALT1-IN-5 (compound 1) is a potent MALT1 protease inhibitor. MALT1-IN-5 can be used for cancer research [1].
    MALT1-IN-5
  • HY-143425
    MALT1-IN-7

    		MALT1 Cancer
    MALT1-IN-7 (compound 142b) is a potent MALT1 protease inhibitor. MALT1-IN-7 has the potential for cancer research [1].
    MALT1-IN-7
  • HY-143424
    MALT1-IN-6

    		MALT1 Cancer
    MALT1-IN-6 is a potent MALT1 protease inhibitor with a Ki of 9 nM. MALT1-IN-6 has anticancer effects (WO2018226150A1; Compound 4) [1].
    MALT1-IN-6
  • HY-150232
    MALT1-IN-11

    		MALT1 Inflammation/Immunology Cancer
    MALT1-IN-11 (Example 151 in reference Patent) is a MALT1 protease inhibitor (IC50 < 10 nM). MALT1-IN-11 inhibits IL10 secretion with an IC50 of 10-100 nM. MALT1-IN-11 can be used for the research of cancer, autoimmune and inflammatory disorders [1].
    MALT1-IN-11
  • HY-162268
    MALT1-IN-13

    		MALT1 Apoptosis Inflammation/Immunology Cancer
    MALT1-IN-13 (compound 10m) is inhibitor for mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), which to binds MALT1 protease covalently and irreversibly, inhibits MALT1 with the IC50 of 1.7 μM. MALT1-IN-13 inhibits proliferation against ABC-DLBCL and induces apoptosis in ABC-DLBCL HBL1. MALT1-IN-13 regulates mTOR and PI3K-Akt pathways [1].
    MALT1-IN-13
  • HY-143426
    MALT1-IN-8

    		MALT1 Cancer
    MALT1-IN-8 is a potent MALT1 protease inhibitor with a IC50 of 2 nM. MALT1-IN-8 inhibits the growth of OCI-LY3 lymphoma cells with an IC50 of 1.16 μM. MALT1-IN-8 has anticancer effects (WO2018165385A1; Compound 8) [1].
    MALT1-IN-8
  • HY-164560
    MALT1-IN-14

    		MALT1 Others
    MALT1-IN-14 (comp 2) is a MALT1 inhibitor, with an IC50 of 0.081 μM [1].
    MALT1-IN-14
  • HY-143422
    MALT1-IN-3

    		MALT1 Cancer
    MALT1-IN-3 (compound 122) is a potent MALT1 protease inhibitor, with an IC50 of 0.06 μM. MALT1-IN-3 has IC50 of 0.14 and 0.13 μM for human IL6/IL10 in OCI-LY3 cells, respectively [1].
    MALT1-IN-3
  • HY-143423A
    (S)-MALT1-IN-5

    		MALT1 Inflammation/Immunology Cancer
    (S)-MALT1-IN-5 is a potent inhibitor of MALT1 protease. (S)-MALT1-IN-5 inhibits the activity of MALT1 is expected to be able to correct the enhancement of MALT1 activity due to abnormality of T cell receptor signal or B cell receptor signal, and cancer or inflammatory disease caused by MALT1 activity is expected. (S)-MALT1-IN-5 has the potential for the research of MALT1-related diseases (extracted from patent WO2020111087A1, compound 1) [1].
    (S)-MALT1-IN-5
  • HY-143422A
    (R)-MALT1-IN-3

    		MALT1 Cancer
    (R)-MALT1-IN-3 (compound 121) is a potent MALT1 protease inhibitor with an IC50 of 20 nM. (R)-MALT1-IN-3 has IC50 of 60 nM, 40 nM for human IL6/IL10 in OCI-LY3 cells, respectively [1].
    (R)-MALT1-IN-3
  • HY-148249
    NVS-MALT1

    		MALT1 Cancer
    NVS-MALT1 is a MALT1 allosteric inhibitor [1].
    NVS-MALT1
  • HY-143425A
    (R)-MALT1-IN-7

    		MALT1 Cancer
    (R)-MALT1-IN-7 (compound 142a) is a potent MALT1 protease inhibitor. (R)-MALT1-IN-7 has the potential for cancer research [1].
    (R)-MALT1-IN-7
  • HY-142648A
    (R)-MLT-985

    		MALT1 Cancer
    (R)-MLT-985 (compound 11) is a potent MALT1 protease inhibitor with an IC50 of 3 nM. (R)-MLT-985 has an IC50 of 20 nM for MALT1-dependent IL-2 production in Jurkat cells. (R)-MLT-985 suppresses growth and aberrant CARD11/BCL10/MALT1 complex signaling in ABC-DLBCL cells [1].
    (R)-MLT-985
  • HY-120231
    Z-VRPR-FMK

    		MALT1 Cancer
    Z-VRPR-FMK is an irreversible MALT1 protein inhibitor. Z-VRPR-FMK inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression [1].
    Z-VRPR-FMK
  • HY-124587
    MLT-747

    		MALT1 Inflammation/Immunology
    MLT-747 is a potent, selective, allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 14 nM [1].
    MLT-747
  • HY-115466
    MLT-748
    2 Publications Verification

    		 MALT1 Inflammation/Immunology
    MLT-748 is a potent, selective and allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 5 nM [1].
    MLT-748
  • HY-121282B
    Mepazine acetate

    Pecazine acetate

    		 Apoptosis MALT1 Others
    Mepazine acetate (Pecazine acetate) is a drug that has the activity to inhibit the protease activity of MALT1. Mepazine acetate is often used to study the role of MALT1 in biology. Treatment of mouse bone marrow precursor cells with mepazine acetate strongly inhibited RANK ligand (RANKL)-induced osteoclast formation. Mepazine acetate also inhibited the expression of multiple osteoclast markers such as TRAP, feline hepsin K, and calcitonin. The protective effect of mepazine acetate was not affected by MALT1 deficiency. The mechanism of action of mepazine acetate may involve MALT1-independent mechanisms, and this aspect needs to be considered in future studies [1].
    Mepazine acetate
  • HY-142648
    MLT-985

    		MALT1 Cancer
    MLT-985 is a highly selective allosteric MALT1 inhibitor with an IC50 value of 3 nM.
    MLT-985
  • HY-151805
    RGT-068A

    		MALT1 Cancer
    RGT-068A is a potent, selective and oral bioavailable MALT1 inhibitor [1].
    RGT-068A
  • HY-160698
    SGR-1505

    		MALT1 Cancer
    SGR-1505 is an orally active MALT1 allosteric inhibitor. SGR-1505 inhibits MALT1 enzymatic activity and shows anti-proliferative activity in BTK inhibitor (BTKi)-sensitive and BTKi-resistant activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) cell lines. SGR-1505 can be used for research of B-cell lymphomas [1].
    SGR-1505
  • HY-134820
    MLT-943

    		MALT1 Inflammation/Immunology
    MLT-943 is a potent, selective and orally active MALT1 protease inhibitor. MLT-943 inhibits stimulated-IL-2 secretion in PBMC or in whole blood with a similar IC50 across species (0.07-0.09 μM in PBMC, 0.6-0.8 μM in whole blood). MLT-943 has anti-inflammatory activities and can be used for FcgR-mediated inflammation research [1].
    MLT-943
  • HY-139399
    Safimaltib
    1 Publications Verification

    JNJ-67856633

    		 MALT1 Cancer
    Safimaltib (JNJ-67856633) is an orally active, first-in-class, potent, selective and allosteric MALT1 protease inhibitor. Safimaltib in some cases lead to tumor stasis [1] .
    Safimaltib
  • HY-P1407
    Z-VRPR-FMK TFA

    VRPR

    		 MALT1 Influenza Virus Infection Cancer
    Z-VRPR-FMK (TFA) (VRPR), a tetrapeptide, is a selective and irreversible MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor. Z-VRPR-FMK (TFA) can protect against influenza A virus (IAV) infection [1].
    Z-VRPR-FMK TFA
  • HY-P4544
    Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone

    		MALT1 Cancer
    Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone is a potent MALT1 inhibitor. Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone inhibits cell proliferation and migration. Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone shows anticancer activity [1].
    Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone
  • HY-121282
    Mepazine
    2 Publications Verification

    Pecazine

    		 MALT1 Apoptosis Cancer
    Mepazine (Pecazine) is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine affects viability of ABC-DLBCL cells by enhancing apoptosis [1].
    Mepazine
  • HY-121282A
    Mepazine hydrochloride
    2 Publications Verification

    Pecazine hydrochloride

    		 MALT1 Apoptosis Cancer
    Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine hydrochloride affects viability of ABC-DLBCL cells by enhancing apoptosis [1].
    Mepazine hydrochloride
  • HY-131902
    MLT-231

    		MALT1 Cancer
    MLT-231 is a potent, highly selective allosteric MALT1 Inhibitor with an IC50 of 9 nM. MLT-231 specifically prevents endogenous BCL10 cleavage with IC50 of 160 nM. MLT-231 shows antitumor activity in an ABC-DLBCL type xenograft model in mouse [1].
    MLT-231

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: