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Results for "

METTL14

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) DNA Methyltransferase (1) Endogenous Metabolite (6) Enterovirus (2) Influenza Virus (1) METTL3 (2) PROTACs (2) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (5) Infection (3) Metabolic Disease (5)
Oligonucleotides:	Nucleosides and their Analogs (1) Pre-designed siRNA Sets (1) siRNAs (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153625

STM2120 1 Publications Verification	METTL3	Cancer
STM2120 is a *METTL3-METTL14* inhibitor with an IC₅₀ of 64.5 μM .

HY-160415A

WD6305 TFA	PROTACs Apoptosis	Cancer
WD6305 TFA is a potent METTL3-targeted PROTAC degrader. WD6305 TFA selectively reduces the METTL3 and METTL14 complex. WD6305 TFA inhibits m ⁶A modification and the proliferation of AML cells and promotes apoptosis. WD6305 TFA can be used for the research of leukemic .

HY-19528

SAH 5+ Cited Publications SAH (S-Adenosylhomocysteine)	Endogenous Metabolite	Metabolic Disease
SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine . SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC₅₀ of 0.9 µM .

HY-151926

Antiviral agent 24	Enterovirus	Infection
Antiviral agent 24 is a potent antiviral agent with EC₅₀ values of 0.101, 19.9, 91.2 µM for EV71, CVA21, EV68, respectively. Antiviral agent 24 inhibits METTL3/METTL14 activity in a dose-dependent manner .

HY-19528S

SAH-d4 SAH (S-Adenosylhomocysteine)-d₄	Endogenous Metabolite	Metabolic Disease
SAH-d₄ is the deuterium labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM[2].

HY-RS08355

METTL14 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
METTL14 Human Pre-designed siRNA Set A contains three designed siRNAs for METTL14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

METTL14 Human Pre-designed siRNA Set A METTL14 Human Pre-designed siRNA Set A

HY-160415

WD6305	PROTACs Apoptosis	Cancer
WD6305 is a potent METTL3-targeted PROTAC degrader. WD6305 selectively reduces the METTL3 and METTL14 complex. WD6305 inhibits m ⁶A modification and the proliferation of AML cells and promotes apoptosis. WD6305 can be used for the research of leukemic .

HY-P10387

RSM3	METTL3 Apoptosis	Cancer
RSM3, a stapled peptide, is a *METTL3-METTL14* inhibitor with an K_d of 3.10 μM. RSM3 inhibits tumor growth while induces cell apoptosis. RSM3 can be used for study of cancer .

HY-151924

Antiviral agent 23	Enterovirus	Infection
Antiviral agent 23 (compound 11b) is an antiviral agent to enterovirus 71 (EV71) with an EC₅₀ value of 94 nM. Antiviral agent 23 effectively suppresses the activity of METTL3/METTL14. Antiviral agent 23 can be used for the research of infection .

HY-19528S1

SAH-13C5 SAH (S-Adenosylhomocysteine)-¹³C₅	Endogenous Metabolite	Metabolic Disease
SAH- ¹³C₅ is the ¹³C-labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM[2].

HY-19528R

SAH (Standard)	Endogenous Metabolite	Metabolic Disease
SAH (Standard) is the analytical standard of SAH. This product is intended for research and analytical applications. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine . SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 μM .

HY-19528S2

SAH-13C10	Endogenous Metabolite	Metabolic Disease
SAH- ¹³C₁₀ is the ¹³C labeled SAH[1]. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[2]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 μM[3].

HY-162282

*PROTAC METTL3-14 degrader 1*	DNA Methyltransferase	Cancer
PROTAC METTL3-14 degrader 1 (compound 30) is a PROTAC degrader of *METTL3-14. PROTAC METTL3-14 degrader 1 shows a 50% or higher degradation of METTL3* and/or *METTL14* .

HY-N0086R

N6-Methyladenosine (Standard)	Influenza Virus Endogenous Metabolite	Infection
N6-Methyladenosine (Standard) is the analytical standard of N6-Methyladenosine. This product is intended for research and analytical applications. N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities. In Vitro: N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion . N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits .

Cat. No.	Product Name	Target	Research Area

HY-P10387

RSM3	METTL3 Apoptosis	Cancer
RSM3, a stapled peptide, is a *METTL3-METTL14* inhibitor with an K_d of 3.10 μM. RSM3 inhibits tumor growth while induces cell apoptosis. RSM3 can be used for study of cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-19528

SAH 5+ Cited Publications SAH (S-Adenosylhomocysteine)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Disease markers Metabolic Disease Amino acids Nervous System Disorder Endogenous metabolite Disease Research Fields	Endogenous Metabolite
SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine . SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC₅₀ of 0.9 µM .

HY-19528R

SAH (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Source classification Disease markers Amino acids Nervous System Disorder Endogenous metabolite	Endogenous Metabolite
SAH (Standard) is the analytical standard of SAH. This product is intended for research and analytical applications. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine . SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 μM .

HY-N0086R

N6-Methyladenosine (Standard)	Structural Classification Natural Products Microorganisms Source classification Endogenous metabolite	Influenza Virus Endogenous Metabolite
N6-Methyladenosine (Standard) is the analytical standard of N6-Methyladenosine. This product is intended for research and analytical applications. N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities. In Vitro: N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion . N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits .

Cat. No.	Compare	Product Name	Species	Source

HY-P703633

	METTL14-METTL3 Protein, Human (Sf9, His, Strep) KIAA1627	Human	Sf9 insect cells

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Cat. No.	Product Name	Chemical Structure

HY-19528S

SAH-d4
SAH-d₄ is the deuterium labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM[2].

HY-19528S2

SAH-13C10
SAH- ¹³C₁₀ is the ¹³C labeled SAH[1]. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[2]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 μM[3].

HY-19528S1

SAH-13C5
SAH- ¹³C₅ is the ¹³C-labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM[2].

Cat. No.	Product Name		Classification

HY-19528

SAH 5+ Cited Publications SAH (S-Adenosylhomocysteine)		Nucleosides and their Analogs
SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine . SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC₅₀ of 0.9 µM .

HY-RS08355

METTL14 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
METTL14 Human Pre-designed siRNA Set A contains three designed siRNAs for METTL14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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METTL14

Inhibitors & Agonists

Peptides

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Oligonucleotides

Natural
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