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Results for "

Nedd4

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

1

Natural
Products

5

Recombinant Proteins

1

Antibodies

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-162809
    XMU-MP-9

    		Ras Cancer
    XMU-MP-9 is a bifunctional compound that binds to the C2 domain of Nedd4-1 and the allosteric site of K-Ras. XMU-MP-9 enhances the interaction between Nedd4-1 and K-Ras, induces conformational changes in the Nedd4-1/K-Ras complex, promotes the ubiquitination and degradation of multiple K-Ras mutants, and inhibits the proliferation of cells carrying K-Ras mutants. XMU-MP-9 can be used in cancer research .
    XMU-MP-9
  • HY-110204
    Heclin
    2 Publications Verification

    		 E1/E2/E3 Enzyme Akt MyD88 Others
    Heclin is a HECT E3 ubiquitin ligases inhibitor. Heclin inhibits Smurf2, Nedd4, WWP1 (IC50 values are 6.8, 6.3, 6.9 μM) and can be used for the research of gastric cancer .
    Heclin
  • HY-153178
    HECT E3-IN-1

    		E1/E2/E3 Enzyme Others
    HECT E3-IN-1 (compound 3) is a HECT E3 ligase inhibitor. HECT E3-IN-1 (compound 3) disrupts Ub binding to the noncovalent Ub-binding site of Nedd4-1 .
    HECT E3-IN-1
  • HY-110174
    NAB2

    		Others Neurological Disease
    NAB2 is a neuron-protective agent. NAB2 strongly and selectively protects diverse cell types from α-syn toxicity. NAB2 promots endosomal transport events dependent on the E3 ubiquitin ligase Rsp5/Nedd4. NAB2 identifies a agentgable node in the biology of α-syn that can correct multiple aspects of its underlying pathology, including dysfunctional endosomal and endoplasmic reticulum-to-Golgi vesicle trafficking .
    NAB2
  • HY-134417
    NSC2805
    1 Publications Verification

    		 Others Cancer
    NSC2805 is a WWP2 ubiquitin ligase inhibitor that can significant inhibit WWP2 activity with an IC50 of 0.38 μM. NSC2805 can be used for the research of cancer .
    NSC2805
  • HY-RS09179
    NEDD4 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    NEDD4 Human Pre-designed siRNA Set A contains three designed siRNAs for NEDD4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    NEDD4 Human Pre-designed siRNA Set A
    NEDD4 Human Pre-designed siRNA Set A
  • HY-RS09180
    NEDD4L Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    NEDD4L Human Pre-designed siRNA Set A contains three designed siRNAs for NEDD4L gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    NEDD4L Human Pre-designed siRNA Set A
    NEDD4L Human Pre-designed siRNA Set A
  • HY-N10159
    1-Benzyl-I3C

    		Others Cancer
    1-Benzyl-I3C is a NEDD4-1 inhibitor with significant anticancer activity. 1-Benzyl-I3C can directly inhibit the ubiquitination activity of NEDD4-1 with an IC50 of 12.3μM, which is significantly better than its precursor compound I3C of 284μM. 1-Benzyl-I3C and its analogs showed good effects in inhibiting the proliferation of human melanoma cells, which is roughly related to their potency as NEDD4-1 enzyme inhibitors. By combining in vitro ubiquitination experiments and thermal stability analysis, 1-Benzyl-I3C was shown to be able to bind to the catalytic HECT domain of NEDD4-1 .
    1-Benzyl-I3C
  • HY-122046
    Amb123203

    		Endogenous Metabolite Infection
    Amb123203 is an antiviral compound with the activity of inhibiting viral budding. Amb123203 exerts its effect by blocking the interaction between mVP40 and Nedd4 proteins. Amb123203 has a significant inhibitory effect on the budding of VP40 virus-like particles (VLPs) of Marburg (MARV) and Ebola viruses. Amb123203 can effectively target RNA viruses that rely on the PPxY L domain for efficient budding, showing broad-spectrum antiviral activity. The discovery of Amb123203 provides an important basis for the development of new broad-spectrum antiviral compounds .
    Amb123203

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