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OAT

" in MedChemExpress (MCE) Product Catalog:

By Targets:	OAT (15) 11β-HSD (1) Acetolactate Synthase (ALS) (2) Acyltransferase (2) BCRP (2) Drug Metabolite (1) Endogenous Metabolite (1) Fluorescent Dye (1) Fungal (1) GLUT (1) HIV (3) HIV Integrase (3) Small Interfering RNA (siRNA) (1) URAT1 (6)
By Research Areas:	Cancer (1) Infection (7) Inflammation/Immunology (5) Metabolic Disease (11)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Natural
Products

Oligonucleotides

Targets Recommended: OAT

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15592A

Cabotegravir sodium Maximum Cited Publications 8 Publications Verification GSK-1265744 sodium; S/GSK1265744 sodium	OAT HIV HIV Integrase	Infection
Cabotegravir (GSK-1265744) sodium is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC₅₀ values of 2.5 nM, 0.41 μM and 0.81 μM for HIV_ADA, OAT3 and OAT1, respectively. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir sodium can be used to research AIDS .

HY-15592

Cabotegravir Maximum Cited Publications 8 Publications Verification GSK-1265744; S/GSK1265744	OAT HIV HIV Integrase	Infection
Cabotegravir (GSK-1265744) is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC₅₀ values of 2.5 nM, 0.41 μM and 0.81 μM for HIV_ADA, OAT3 and OAT1, respectively. Cabotegravir is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir can be used to research AIDS .

HY-15258

Lesinurad 2 Publications Verification RDEA594	OAT URAT1	Metabolic Disease
Lesinurad is a URAT1 and *OAT* inhibitor, is determined to be a substrate for the kidney transporters *OAT1* and *OAT3* with K_m values of 0.85 and 2 µM, respectively.

HY-15258A

Lesinurad sodium 2 Publications Verification RDEA-594 sodium	OAT URAT1	Metabolic Disease
Lesinurad sodium is a URAT1 and *OAT* inhibitor, is determined to be a substrate for the kidney transporters *OAT1* and *OAT3* with K_m values of 0.85 and 2 µM, respectively.

HY-N12007

OAT1/3-IN-1	OAT	Metabolic Disease
OAT1/3-IN-1 (compound 7) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-1 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-1 can be used to study mercury-induced kidney damage .

HY-N12008

OAT1/3-IN-2	OAT	Metabolic Disease
OAT1/3-IN-2 (compound 8) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-2 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-2 can be used to study mercury-induced kidney damage .

HY-125279

OAT-2068	Others	Inflammation/Immunology
OAT-2068 is a selective, high activity and orally active inhibitor of mouse chitotriosidase (mCHIT1) (IC₅₀=29 nM) and displays 143-fold selectivity over m AMCase (IC₅₀=4170 nM). OAT-2068 displays a good pharmacokinetic profile and is an ideal tool to study the role of CHIT1 in biological systems, including animal models of human diseases .

HY-RS09731

OAT Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
OAT Human Pre-designed siRNA Set A contains three designed siRNAs for OAT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

OAT Human Pre-designed siRNA Set A OAT Human Pre-designed siRNA Set A

HY-15592R

Cabotegravir (Standard)	OAT HIV HIV Integrase	Infection
Cabotegravir (Standard) is the analytical standard of Cabotegravir. This product is intended for research and analytical applications. Cabotegravir (GSK-1265744) is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC₅₀ values of 2.5 nM, 0.41 μM and 0.81 μM for HIV_ADA, OAT3 and OAT1, respectively. Cabotegravir is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir can be used to research AIDS .

HY-N4103A

Δ5-Avenasterol	Others	Cancer
Δ5-Avenasterol, belongs to the components of oat grain , exhibits propounding antioxidant effectiveness .

HY-W740244

4’-Hydroxy Trazodone	OAT	Metabolic Disease
4’-hydroxy Trazodone is a metabolite of the antidepressant and sedative trazodone. It is an inhibitor of organic anion transporter 3 (OAT3; Ki=16.9 μM) and is selective for OAT3 over OAT1 (Ki=>200 μM).

HY-122009

Indican Indoxyl-β-D-glucoside	Fluorescent Dye OAT	Others
Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4 .

HY-111345

Epaminurad UR-1102; URC-102	OAT URAT1	Metabolic Disease Inflammation/Immunology
Epaminurad (UR-1102) is an orally active, potent and selective URAT1 (urate transporter 1) inhibitor, with a K_i of 0.057 μM. Epaminurad quite modestly inhibits *OAT1* and *OAT3* (organic anion transporter). Epaminurad is a uricosuric agent. Epaminurad can be used for gout and hyperuricemia research .

HY-111345A

Epaminurad hydrochloride UR-1102 hydrochloride; URC-102 hydrochloride	OAT URAT1	Metabolic Disease Inflammation/Immunology
Epaminurad (UR-1102) hydrochloride is an orally active, potent and selective URAT1 (urate transporter 1) inhibitor, with a K_i of 0.057 μM. Epaminurad hydrochloride quite modestly inhibits *OAT1* and *OAT3* (organic anion transporter). Epaminurad hydrochloride is a uricosuric agent. Epaminurad hydrochloride can be used for gout and hyperuricemia research .

HY-136367

Diclofop-methyl	Others	Others
Diclofop-methyl, a common post-emergence herbicide, is widely used in agriculture production. Diclofop-methyl increases the proton permeability of isolated oat-root tonoplast .

HY-126987

Mesosulfuron-methyl	Acetolactate Synthase (ALS)	Others
Mesosulfuron-methyl is a sulfonylurea herbicide that inhibits acetolactate synthase (ALS) and is used in research for post-emergence control of ryegrass and Avena spp. (wild oat) in wheat fields .

HY-163431

URAT1 inhibitor 10	URAT1	Inflammation/Immunology
URAT1 inhibitor 10 (Compound 23a) is a URAT1 inhibitor. URAT1 inhibitor 10 has oral efficacy and low cytotoxicity. URAT1 inhibitor 10 has high selectivity for *OAT1* .

HY-154021A

5-Fluoromethylornithine dihydrochloride 5-FMOrn dihydrochloride	OAT	Metabolic Disease
5-Fluoromethylornithine (5-FMOrn) dihydrochloride is a specific irreversible inhibitor of L-ornithine:2-oxoacid aminotransferase (OAT). 5-Fluoromethylornithine dihydrochloride can be used in the study of gyrate atrophy of choroid and retina .

HY-126987R

Mesosulfuron-methyl (Standard)	Acetolactate Synthase (ALS)	Others
Mesosulfuron-methyl (Standard) is the analytical standard of Mesosulfuron-methyl. This product is intended for research and analytical applications. Mesosulfuron-methyl is a sulfonylurea herbicide that inhibits acetolactate synthase (ALS) and is used in research for post-emergence control of ryegrass and Avena spp. (wild oat) in wheat fields .

HY-136367R

Diclofop-methyl (Standard)	Others	Others
Diclofop-methyl (Standard) is the analytical standard of Diclofop-methyl. This product is intended for research and analytical applications. Diclofop-methyl, a common post-emergence herbicide, is widely used in agriculture production. Diclofop-methyl increases the proton permeability of isolated oat-root tonoplast .

HY-148682

18β-Glycyrrhetyl-3-O-sulfate Glycyrrhetic acid 3-O-hydrogen sulfate	OAT 11β-HSD Drug Metabolite	Metabolic Disease Inflammation/Immunology
18β-Glycyrrhetyl-3-O-sulfate (Glycyrrhetic acid 3-O-(hydrogen sulfate)) is a potent type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) inhibitor with an IC₅₀ of 0.10 µM using rat kidney microsome. 18β-Glycyrrhetyl-3-O-sulfate is the major metabolite of Glycyrrhetinic acid (GA). 18β-Glycyrrhetyl-3-O-sulfate is the substrate of organic anion transporter (OAT) 1 and OAT3. 18β-Glycyrrhetyl-3-O-sulfate has anti-inflammatory effects and has the potential for pseudohyperaldosteronism research .

HY-W714171

Propoxycarbazone sodium BAY MKH 6561	Others	Others
Propoxycarbazone sodium (BAY MKH 6561) is a herbicide. Propoxycarbazone sodium controls shepherd’s purse (Capsella bursa-pastoris L. Medicus), tumble mustard (Sisymbrium altissimum L.), field pennycress (Thlaspi arvense L.), and several Bromus species. Propoxycarbazone sodium also inhibits the growth of jointed goatgrass, wild oat (Avena fatua L.), and quackgrass (Elytrigia repens L. Nevski) .

HY-144305

KPH2f	URAT1 GLUT	Infection
KPH2f is a safe, orally active, and effective dual URAT1/GLUT9 inhibitor with IC₅₀s of 0.24 μM and 9.37 μM for URAT1 and GLUT9, respectively. KPH2f shows little effects on OAT1 and ABCG2 (IC₅₀=32.14 and 26.74 μM) .

HY-W714171R

Propoxycarbazone sodium (Standard)	Others	Others
Propoxycarbazone (sodium) (Standard) is the analytical standard of Propoxycarbazone (sodium). This product is intended for research and analytical applications. Propoxycarbazone sodium (BAY MKH 6561) is a herbicide. Propoxycarbazone sodium controls shepherd’s purse (Capsella bursa-pastoris L. Medicus), tumble mustard (Sisymbrium altissimum L.), field pennycress (Thlaspi arvense L.), and several Bromus species. Propoxycarbazone sodium also inhibits the growth of jointed goatgrass, wild oat (Avena fatua L.), and quackgrass (Elytrigia repens L. Nevski) .

HY-16278

Pradigastat 2 Publications Verification LCQ-908	Acyltransferase BCRP OAT	Infection Metabolic Disease
Pradigastat (LCQ-908) is a selective and orally effective diacylglyceryl acyltransferase 1 (DGAT1) inhibitor with IC₅₀ at 0.157 µM. Pradigastat is primarily used to study diseases associated with abnormal triglyceride metabolism. Pradigastat has anti-obesity and anti-diabetic effects. Pradigastat inhibited BCRP, OATP1B1, OATP1B3 and OAT3 activities with IC₅₀ of 5 µM, 1.66µM, 3.34µM and 0.973µM, respectively. In addition, Pradigastat has antiviral activity and can inhibit hepatitis C virus replication in vitro .

HY-16278A

Pradigastat sodium LCQ 908 sodium	Acyltransferase BCRP OAT	Infection Metabolic Disease
Pradigastat sodium (LCQ 908 sodium) is a selective and orally effective diacylglyceryl acyltransferase 1 (DGAT1) inhibitor with IC₅₀ at 0.157 µM. Pradigastat is primarily used to study diseases associated with abnormal triglyceride metabolism. Pradigastat has anti-obesity and anti-diabetic effects. Pradigastat inhibited BCRP, OATP1B1, OATP1B3 and OAT3 activities with IC₅₀ of 5 µM, 1.66µM, 3.34µM and 0.973µM, respectively. In addition, Pradigastat has antiviral activity and can inhibit hepatitis C virus replication in vitro .

HY-N7723

Avenacin A-1	Fungal Endogenous Metabolite	Infection
Avenacin A-1 exhibits antifungal activity, which inhibits growth of Culvularia sp, Drechslera victoriae, Rhizoctonia solani, Fusarium spp.. Avenacin A-1 affects the bilayer permeability .

Indican Indoxyl-β-D-glucoside	Alkaloids Structural Classification Classification of Application Fields Leguminosae Source classification Other Diseases Plants Disease Research Fields Indole Alkaloids Indigofera	Fluorescent Dye OAT
Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4 .

OAT1/3-IN-1	Quinones Structural Classification Cassia obtusifolia L. Anthraquinones Source classification Caesalpiniaceae Plants	OAT
OAT1/3-IN-1 (compound 7) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-1 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-1 can be used to study mercury-induced kidney damage .

OAT1/3-IN-2	Quinones Structural Classification Cassia obtusifolia L. Anthraquinones Source classification Caesalpiniaceae Plants	OAT
OAT1/3-IN-2 (compound 8) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-2 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-2 can be used to study mercury-induced kidney damage .

Δ5-Avenasterol	Structural Classification Natural Products Classification of Application Fields Source classification Euphorbiaceae Hevea brasiliensis (Willd. ex A. Juss.) Muell. Arg. Plants Disease Research Fields Cancer	Others
Δ5-Avenasterol, belongs to the components of oat grain , exhibits propounding antioxidant effectiveness .

Avenacin A-1	Structural Classification Avena sativa Linn. Terpenoids Gramineae Source classification Plants Pentacyclic Triterpenoids	Fungal Endogenous Metabolite
Avenacin A-1 exhibits antifungal activity, which inhibits growth of Culvularia sp, Drechslera victoriae, Rhizoctonia solani, Fusarium spp.. Avenacin A-1 affects the bilayer permeability .

OAT Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
OAT Human Pre-designed siRNA Set A contains three designed siRNAs for OAT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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OAT

Inhibitors & Agonists

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Natural
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