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Results for "

PNU159682

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

1

Fluorescent Dye

1

Biochemical Assay Reagents

1

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-16700
    PNU-159682

    		ADC Cytotoxin Topoisomerase Cancer
    PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome agent resistance.
    PNU-159682
  • HY-126666
    PNU-159682 carboxylic acid

    		ADC Cytotoxin Inflammation/Immunology Cancer
    PNU-159682 carboxylic acid (compound 53) is a potent ADCs cytotoxin and encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. PNU-159682 carboxylic acid has protein fold and diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response .
    PNU-159682 carboxylic acid
  • HY-126687
    Mal-PEG4-VC-PAB-DMEA-PNU-159682

    		Drug-Linker Conjugates for ADC Cancer
    Mal-PEG4-VC-PAB-DMEA-PNU-159682, a agent-linker conjugate for ADC, consists the ADC linker Mal-PEG4-VC-PAB and a potent ADC cytotoxin DMEA-PNU-159682. DMEA-PNU-159682 includes metabolites of nemorubicin (MMDX) from liver microsomes and ADC cytotoxin PNU-159682 .
    Mal-PEG4-VC-PAB-DMEA-PNU-159682
  • HY-126688
    Mal-C2-Gly3-EDA-PNU-159682

    		Drug-Linker Conjugates for ADC Cancer
    Mal-C2-Gly3-EDA-PNU-159682, a agent-linker conjugate for ADC, consists a cleavable ADC linker Mal-C2-Gly3-EDA and a potent ADC cytotoxin PNU-159682.
    Mal-C2-Gly3-EDA-PNU-159682
  • HY-126691
    DBCO-PEG4-VC-PAB-DMEA-PNU-159682

    		Drug-Linker Conjugates for ADC Cancer
    DBCO-PEG4-VC-PAB-DMEA-PNU-159682, a agent-linker conjugate for ADC, consists the ADC linker DBCO-PEG4-VC-PAB and a potent ADC cytotoxin DMEA-PNU-159682. DMEA-PNU-159682 includes metabolites of nemorubicin (MMDX) from liver microsomes and ADC cytotoxin PNU-159682. DBCO-PEG4-VC-PAB-DMEA-PNU-159682 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG4-VC-PAB-DMEA-PNU-159682
  • HY-16700G
    PNU-159682

    		ADC Cytotoxin Topoisomerase Cancer
    PNU-159682 GMP is a GMP grade PNU-159682 (HY-16700). PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome agent resistance.
    PNU-159682
  • HY-147093
    vc-PAB-DMEA-PNU159682

    		ADC Linker Cancer
    vc-PAB-DMEA-PNU159682 (compound I.47) can be used to synthesize the ADC molecule based on Sulfomaleimide-based Linker. vc-PAB-DMEA-PNU159682 has good serum stability .
    vc-PAB-DMEA-PNU159682
  • HY-126665
    DMEA-PNU-159682

    		ADC Cytotoxin Cancer
    DMEA-PNU-159682 (molecule D12) is a ADC cytotoxin molecule including metabolites of nemorubicin (MMDX) from liver microsomes and a potent ADCs cytotoxin PNU-159682 .
    DMEA-PNU-159682
  • HY-126665A
    DMEA-PNU-159682 dichloroacetate

    		ADC Cytotoxin Cancer
    DMEA-PNU-159682 (molecule D12) dichloroacetate is an ADC cytotoxin molecule including metabolites of nemorubicin (MMDX) from liver microsomes and a potent ADCs cytotoxin PNU-159682 .
    DMEA-PNU-159682 dichloroacetate
  • HY-126689
    Mal-Phe-C4-VC-PAB-DMEA-PNU-159682

    		Drug-Linker Conjugates for ADC Cancer
    Mal-Phe-C4-VC-PAB-DMEA-PNU-159682, a agent-linker conjugate for ADC, consists the ADC linker Mal-Phe-C4-VC-PAB and a potent ADC cytotoxin DMEA-PNU-159682. DMEA-PNU-159682 includes metabolites of nemorubicin (MMDX) from liver microsomes and ADC cytotoxin PNU-159682 .
    Mal-Phe-C4-VC-PAB-DMEA-PNU-159682
  • HY-145078
    PNU-EDA-Gly5

    		Drug-Linker Conjugates for ADC Cancer
    PNU-EDA-Gly5 is an oligo-glycine linker-payload for ADC synthesis, composed of a DNA topoisomerase I inhibitor PNU-159682 and a linker EDA-Gly5 .
    PNU-EDA-Gly5
  • HY-164761
    Anti-CD22-NMS249

    		Antibody-Drug Conjugates (ADCs) CD22 Cancer
    Anti-CD22-NMS249 is a CD22-targeting antibody-drug conjugate (ADC). Anti-CD22-NMS249 is composed of a humanized anti-CD22 antibody Pinatuzumab (HY-P99230), a cleavable linker (Mc-VC-PAB), and a DNA topoisomerase II inhibitor payload PNU-159682 (HY-16700). Anti-CD22-NMS249 can be used for research in non-Hodgkin lymphoma (NHL) .
    Anti-CD22-NMS249

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