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Pathways Recommended:	Protein Tyrosine Kinase/RTK

Results for "

Pim kinases

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Pim (48) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (12) Autophagy (5) c-Kit (1) Casein Kinase (3) Caspase (1) CDK (3) Checkpoint Kinase (Chk) (1) DAPK (1) DYRK (3) EGFR (1) ERK (1) Fluorescent Dye (1) GSK-3 (2) IRAK (1) MELK (2) mTOR (3) PKC (1) RIP kinase (2) Trk Receptor (2)
By Research Areas:	Cancer (47) Cardiovascular Disease (1) Inflammation/Immunology (4)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Targets Recommended: Pim

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W412264

Pim-1/2 kinase inhibitor 1	Pim	Cancer
Pim-1/2 kinase inhibitor 1 is an orally active **pim-1/2 kinase** inhibitor. Pim-1/2 kinase inhibitor 1 blocks the ability of **Pim kinases to phosphorylate peptides, and inhibits the pim protein kinase directed phosphorylation of 4E-BP1 and p27 ^Kip1*. Pim-1/2 kinase* inhibitor 1 can be used in study of cancer, especially prostate cancer .

HY-18095

CX-6258	Pim	Cancer
CX-6258 is a potent and kinase selective pan-Pim kinases inhibitor, with IC₅₀s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively .

HY-13287A

SGI-1776	Pim Apoptosis Autophagy	Inflammation/Immunology Cancer
SGI-1776 is an inhibitor of **Pim kinases, with IC₅₀*s of 7 nM, 363 nM, and 69 nM for Pim-1, Pim-2 and Pim*-3, respectively .

HY-135816

CK2/PIM1-IN-1	Casein Kinase Pim	Inflammation/Immunology Cancer
CK2/PIM1-IN-1 is an inhibitor of CK2 and *PIM1, with IC₅₀s of 3.787 μM and 4.327 μM for CK2 and PIM1, respectively. CK2/PIM1-IN-1 is developed for the research of proliferative disorders such as cancer, as well as other kinase*-associated conditions including inflammation, pain, vascular disorders, pathogenic infections and certain immunological disorders .

HY-123141

K00135	Pim	Cancer
K00135 is a potent and selective inhibitor of **PIM kinases*. K00135 inhibits survival and clonogenic growth of acute leukemia cells. K00135 inhibits the phosphorylation of PIM* downstream targets .

HY-147785

Pim-1 kinase inhibitor 2	Pim Apoptosis	Cancer
Pim-1 kinase inhibitor 2 (Compound 13) is a potent inhibitor of **Pim-1 kinase*. Pim-1 kinase* inhibitor 2 induces apoptosis. Pim-1 kinase inhibitor 2 has the potential for the research of cancer diseases .

HY-143295

Pim-1 kinase inhibitor 1	Pim Apoptosis	Cancer
Pim-1 kinase inhibitor 1 is a *Pim-1* kinase inhibitor with an IC₅₀ of 0.11 μM for Pim-1 kinase. Pim-1 kinase inhibitor 1 shows anticancer activity to several cancer cell lines by promotes cell apoptosis. Pim-1 kinase inhibitor 1 can be used for the research of cancer .

HY-162059

Pim-1 kinase inhibitor 10	Pim Apoptosis Caspase	Cancer
Pim-1 kinase inhibitor 10 (compound 13a) is a both competitive and non-competitive inhibitor of **PIM-1/2 kinase*. Pim-1 kinase* inhibitor 10 can induce cell apoptosis and exhibits anticancer activity. Pim-1 kinase inhibitor 10 also induces caspase 3/7 activation .

HY-163119

Pim-1 kinase inhibitor 9	Pim	Cancer
Pim-1 kinase inhibitor 9 (compound 8b) is a selective inhibitor against **Pim-1 kinase with IC₅₀** value of 0.24 µM. Pim-1 kinase inhibitor 9 inhibits cell cycle of T47D at S phase. Pim-1 kinase inhibitor 9 reveals antitumor activity .

HY-149976

Pim-1 kinase inhibitor 4	Pim	Cancer
Pim-1 kinase inhibitor 4 (Compound 10f) is a **Pim-1 kinase** inhibitor (IC₅₀: 17.01 nM). Pim-1 kinase inhibitor 4 also has antioxidant activity and inhibits DPPH. Pim-1 kinase inhibitor 4 induces apoptosis in PC-3 cell, and inhibits PC-3 cell growth with an IC₅₀ of 16 nM. Pim-1 kinase inhibitor 4 can be used for research of prostate cancer .

HY-18095A

CX-6258 hydrochloride hydrate	Pim	Cancer
CX-6258 hydrochloride hydrate is a potent and kinase selective pan-Pim kinases inhibitor, with IC₅₀s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively .

HY-18095B

CX-6258 hydrochloride	Pim	Cancer
CX-6258 hydrochloride is a potent and kinase selective pan-Pim kinases inhibitor, with IC₅₀s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively .

HY-168071

Pim-1 kinase inhibitor 11	Pim	Cancer
Pim-1 kinase inhibitor 11 (10f) is a *PIM-1* inhibitor, with an IC₅₀ of 0.18 μM. Pim-1 kinase inhibitor 11 (10f) exhibits anticancer activity. Pim-1 kinase inhibitor 11 (10f) induces apoptosis and arrests cell cycle progression .

HY-150731

Pim-1 kinase inhibitor 3	Pim	Cancer
Pim-1 kinase inhibitor 3 (Compound H5) is a potent *Pim-1* kinase inhibitor with an IC₅₀ of 35.13 nM .

HY-162006

Pim-1 kinase inhibitor 8	PKC Pim	Cancer
Pim-1 kinase inhibitor 8 (compound 12) is a potent inhibitor of **Pim-1 kinase with an IC₅₀** of 14.3 nM. Pim-1 kinase inhibitor 8 has potent cytotoxicity against MCF-7 and HepG2 cells with IC₅₀s of 0.5 and 5.27 μM, respectively. Pim-1 kinase inhibitor 8 can used in study breast cancer .

HY-101126

TP-3654 3 Publications Verification	Pim	Cancer
TP-3654 is a second-generation *Pim* kinase inhibitor with K_i values of 5 and 42 nM for Pim-1 and Pim-3, respectively.

HY-149996

Pim-1 kinase inhibitor 6	Pim	Cancer
Pim-1 kinase inhibitor 6 (Compound 4d) is a potent Pim-1 kinase inhibitor with IC₅₀ value of 0.46 μM, and has significant cytotoxic effect on cancer cells .

HY-149995

Pim-1 kinase inhibitor 5	Pim	Cancer
Pim-1 kinase inhibitor 5 (Compound 4c) is a **Pim-1 kinase inhibitor (IC₅₀*: 0.61 μM). Pim-1 kinase* inhibitor 5 shows cytotoxicity against cancer cells, with IC₅₀s of 6.95-20.19 μM for HepG2, MCF-7, PC3, and HCT-116 cells .

HY-108605

PIM1-IN-2	Pim	Cancer
PIM1-IN-2 is a potent and ATP competitive *Pim-1* inhibitor with a K_i of 91 nM. PIM1-IN-2 targets the ATP-binding kinase hinge region not by forming classical hydrogen bonds .

HY-160006

PIM-IN-2	Pim	Cancer
PIM-IN-2 (Pim-2) is a *Pim* kinases inhibitor (IC₅₀ = 25 nM). PIM-IN-2 promotes cell survival, is antiapoptotic, and has exhibited an elevated level of expression in a variety of human tumors .

HY-157404

Pim-1/2 kinase inhibitor 2	Pim	Cancer
Pim-1/2 kinase inhibitor 2 (compound 5b) is a competitive *PIM-1* and **PIM-2 kinase inhibitor with IC₅₀*s of 1.31 μM and 0.67 μM, respectively. Pim-1/2 kinase* inhibitor 2 shows in-vitro low cytotoxicity against normal human lung fibroblast Wi-38 cell line and potent in-vitro anticancer activity against myeloid leukaemia (NFS-60), liver (HepG-2), prostate (PC-3), and colon (Caco-2) cancer cell lines .

HY-101783

GNE-955	Pim	Cancer
GNE-955 is a potent and orally active pan **Pim kinase inhibitor with K_i*s of 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim*3, respectively.

HY-19322B

PIM-447 dihydrochloride 5+ Cited Publications LGH447 dihydrochloride	Pim Apoptosis	Cancer
PIM447 dihydrochloride (LGH447 dihydrochloride) is a potent, orally available, and selective pan-PIM kinase inhibitor, with K_i values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 dihydrochloride displays dual antimyeloma and bone-protective effects. PIM447 dihydrochloride induces apoptosis .

HY-19322

PIM447 5+ Cited Publications LGH447	Pim Apoptosis	Cancer
PIM447 (LGH447) is a potent, orally available, and selective pan-PIM *kinase* inhibitor, with K_i values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 displays dual antimyeloma and bone-protective effects. PIM447 induces apoptosis .

HY-13287

SGI-1776 free base 5+ Cited Publications	Pim Autophagy Apoptosis	Cancer
SGI-1776 free base is an inhibitor of *Pim* kinases, with IC₅₀s of 7 nM, 363 nM, and 69 nM for Pim-1, -2 and -3, respectively.

HY-142656

PIM-IN-1	Pim	Cancer
PIM-IN-1 is a pan-PIM kinase inhibitor (KG-1, EC₅₀ = 61 nM; pS6, EC₅₀ = 71 nM).

HY-101947

SMI-16a 4 Publications Verification Pim1/2 Kinase Inhibitor VI	Pim	Cancer
SMI-16a is a selective *Pim* kinase inhibitor with IC₅₀ values of 0.15, 0.02 and 48 μM for Pim1, Pim2 and PC3 cells, respectively.

HY-115837

DHPCC-9	Pim	Others
DHPCC-9 acts as an inhibitor of Pim kinase.

HY-12830

M-110	Pim	Cancer
M-110 is a highly selective, ATP-competitive inhibitor of **PIM kinases with a preference for PIM-3** (IC₅₀=47 nM). M-110 inhibits PIM-1 and PIM-2 with similar IC₅₀s of 2.5 μM. M-110 inhibits the proliferation of prostate cancer cell lines with IC₅₀s of 0.6 to 0.9 μM .

HY-16976

GDC-0339 2 Publications Verification	Pim	Cancer
GDC-0339 is a potent, orally bioavailable and well tolerated pan-Pim kinase inhibitor, with K_is of 0.03 nM, 0.1 nM and 0.02 nM for Pim1, Pim2 and Pim3, respectively. GDC-0339 is discovered as a potential treatment of multiple myeloma .

HY-101870B

Uzansertib phosphate INCB053914 phosphate	Pim	Cancer
Uzansertib (INCB053914) phosphate is an orally active, ATP-competitive pan-PIM *kinase* inhibitor with IC₅₀s of 0.24 nM, 30 nM, 0.12 nM for PIM1, PIM2, PIM3, respectively. Uzansertib phosphate has broad anti-proliferative activity against a variety of hematologic tumor cell lines .

HY-101870

Uzansertib INCB053914	Pim	Cancer
Uzansertib (INCB053914) is an orally active, ATP-competitive pan-PIM *kinase* inhibitor with IC₅₀s of 0.24 nM, 30 nM, 0.12 nM for PIM1, PIM2, PIM3, respectively. Uzansertib has broad anti-proliferative activity against a variety of hematologic tumor cell lines .

HY-15604

AZD1208 Maximum Cited Publications 16 Publications Verification	Pim Autophagy Apoptosis	Cancer
AZD1208 is an orally bioavailable, highly selective *PIM* kinases inhibitor .

HY-15604A

AZD1208 hydrochloride	Pim Autophagy Apoptosis	Cancer
AZD1208 hydrochloride is an orally bioavailable, highly selective *PIM* kinases inhibitor .

HY-10371

Pim1/AKK1-IN-1 5+ Cited Publications LKB1/AAK1 dual inhibitor	Pim	Cancer
Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with K_d values of 35 nM/53 nM/75 nM/380 nM for *Pim1/AKK1/MST2/LKB1* respectively, and also inhibits MPSK1 and TNIK.

HY-16576A

SMI-4a 1 Publications Verification TCS-Pim-1-4a	Pim	Cancer
SMI-4a (TCS-PIM-1-4a) is a poten, selective, cell-permeable and ATP-competitive *Pim-1* inhibitor with an IC₅₀ of 24 μM and a K_i of 0.6 μM. SMI-4a also inhibits *Pim-2* (IC₅₀ of 100 μM), and does not significantly inhibit the other serine/threonine- or tyrosine-kinases. SMI-4a has anticancer activity .

HY-164460

AZD1897	Pim	Cancer
AZD1897 is a *PIM1, PIM2, and PIM3* inhibitor with IC₅₀ values of less than 3 nM for these three PIM kinases. AZD1897 exhibits anticancer activity and synergistically inhibits the activity of acute myeloid leukemia (AML) cells in combination with Capivasertib (HY-15431). This synergistic inhibitory effect is achieved through the inhibition of the mTOR and MCL1 pathways .

HY-N4149

Quercetagetin 3 Publications Verification 6-Hydroxyquercetin	Pim	Inflammation/Immunology Cancer
Quercetagetin (6-Hydroxyquercetin) is a flavonoid . Quercetagetin is a moderately potent and selective, cell-permeable *pim-1* kinase inhibitor (IC₅₀, 0.34 μM) . Anti-inflammatory and anticancer properties.

HY-P1404

R8-T198wt	Pim	Cancer
R8-T198wt is a cell-permeable carboxyl-terminal p27 ^Kip1 peptide exhibits anti-tumor activity by inhibiting **Pim-1 kinase** .

HY-N4149R

Quercetagetin (Standard)	Pim	Inflammation/Immunology Cancer
Quercetagetin (Standard) is the analytical standard of Quercetagetin. This product is intended for research and analytical applications. Quercetagetin (6-Hydroxyquercetin) is a flavonoid . Quercetagetin is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50, 0.34 μM) . Anti-inflammatory and anticancer properties.

HY-133850

10-DEBC	Pim	Cancer
10-DEBC is a selective Akt inhibitor. 10-DEBC shows strong inhibitory activity against Moloney murine leukemia virus (Pim) kinase-1 (IC₅₀=1.28 μM) .

HY-155717

NDBM	Autophagy Pim	Cancer
NDBM is a probe and binds to tumor-specific **Pim-1 kinase, releases strong fluorescence, and produces cytotoxicity, thus achieving cell screening and killing effects. NDBM can specifically target lysosomes and sensitively respond to pH. NDBM can be used to track the pH changes in the intracellular environment under conditions of autophagy** and external stimulation .

HY-122665

HTH-01-091	MELK DYRK Pim mTOR CDK GSK-3 RIP kinase	Cancer
HTH-01-091 is a potent and selective *maternal embryonic leucine zipper kinase* (MELK) inhibitor, with an IC₅₀ of 10.5 nM. HTH-01-091 also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2**. HTH-01-091 can be uesd for breast cancer research .

HY-122665A

HTH-01-091 TFA	MELK DYRK Pim mTOR CDK GSK-3 RIP kinase	Cancer
HTH-01-091 TFA is a potent and selective *maternal embryonic leucine zipper kinase* (MELK) inhibitor, with an IC₅₀ of 10.5 nM. HTH-01-091 TFA also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2**. HTH-01-091 TFA can be uesd for breast cancer research .

HY-D2415

BODIPY-FL staurosporine	Fluorescent Dye	Others
BODIPY-FL staurosporine (Compound 8a) is a fluorescence probe based on staurosporine, exhibiting high specificity towards tyrosine kinases (TK) and tyrosine kinase-like (TKL) family kinases. BODIPY-FL staurosporine has the potential to develop binding assays for kinases that are not recommended for use with Kinase Tracer 236, such as PIM3, CDC42BPG, MAP2K7, TXK, and SIK3. BODIPY-FL staurosporine can be a powerful tool for analyzing kinase selectivity in kinase drug discovery .

HY-15847

HS38 1 Publications Verification	DAPK	Cardiovascular Disease
HS38 is a potent, selective, and ATP-competitive inhibitor of *death-associated protein kinase* 1 (DAPK1) and zipper-interacting protein kinase (ZIPK, also called DAPK3), with K_ds of 300 nM and 280 nM, respectively. HS38 is also a PIM3 inhibitor with an IC₅₀** of 200 nM. HS38 can be used for the research of smooth muscle related disorders .

HY-120561

PC-046	Trk Receptor IRAK Pim Apoptosis	Cancer
PC-046 is a multi-target inhibitor for *tyrosine receptor kinase* B (TrkB), IRAK-4 and Pim-1, with IC₅₀ of 13.4 μM, 15.4 μM and 19.1 μM, respectively. PC-046 exhibits cytotoxicity against pancreatic cancer cell BxPC3 with IC₅₀ of 7.5-130 nM. PC-046 induces apoptosis** and arrests cell cycle at G2/M phase in BxPC3. PC-046 exhibits antitumor efficacy and exhibits good pharmacokinetic characteristics in mice .

HY-15901A

LGB321 monohydrochloride	Pim mTOR	Cancer
LGB321 monohydrochloride is a potent, selective, orally active and ATP competitive inhibitor of all three *PIM* kinases. LGB321 monohydrochloride inhibits proliferation, mTOR-C1 signaling and phosphorylation of BAD in a number of cell lines derived from diverse hematologic malignancies. LGB321 monohydrochloride can be used for the research of hematologic malignancies .

HY-156470

*Multi-kinase-IN-6*	Trk Receptor Anaplastic lymphoma kinase (ALK) c-Kit EGFR Pim Casein Kinase Checkpoint Kinase (Chk) CDK Apoptosis	Cancer
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that shows good enzyme inhibitory activity against TrkA, ALK2, c-KIT, EGFR, *PIM1, CK2α, CHK1, and CDK2. Multi-kinase-IN-6 reveals antiproliferative activity against MCF7, HCT116 and EKVX with IC₅₀* values of 3.36 μM, 1.40 μM and 3.49 μM, respectively. Multi-kinase-IN-6 shows cell cycle arrest at the G1/S phase and G1 phase in MCF7 and HCT116 cells with good apoptotic effect .

HY-135906

CK2/ERK8-IN-1	Casein Kinase ERK Pim DYRK Apoptosis	Cancer
CK2/ERK8-IN-1 is a dual *casein kinase* 2 (CK2) (K_i of 0.25 µM) and ERK8 (MAPK15, ERK7) inhibitor with IC₅₀s of 0.50 μM. CK2/ERK8-IN-1 also binds to PIM1, HIPK2 (homeodomain-interacting protein kinase 2), and DYRK1A with K_is of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. CK2/ERK8-IN-1 has pro-apoptotic** efficacy .

Cat. No.	Product Name	Type

HY-D2415

BODIPY-FL staurosporine

Fluorescent Dyes/Probes

BODIPY-FL staurosporine (Compound 8a) is a fluorescence probe based on staurosporine, exhibiting high specificity towards tyrosine kinases (TK) and tyrosine kinase-like (TKL) family kinases. BODIPY-FL staurosporine has the potential to develop binding assays for kinases that are not recommended for use with Kinase Tracer 236, such as PIM3, CDC42BPG, MAP2K7, TXK, and SIK3. BODIPY-FL staurosporine can be a powerful tool for analyzing kinase selectivity in kinase drug discovery .

Cat. No.	Product Name	Target	Research Area

HY-P1404

R8-T198wt	Pim	Cancer
R8-T198wt is a cell-permeable carboxyl-terminal p27 ^Kip1 peptide exhibits anti-tumor activity by inhibiting **Pim-1 kinase** .

HY-P10042

S6K Substrate	Peptides	Others
S6K Substrate is a substrate for active protein kinases, including CLK2, MRCKalpha, MRCKbeta, p70S6K, ROCK1, ROCK2, RSK1, RSK3, PIM1 .

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