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Results for "

QC

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (2) Apoptosis (1) CD47 (2) Histone Acetyltransferase (1) Histone Demethylase (3) Huntingtin (1) Ligands for Target Protein for PROTAC (1) PROTACs (2) Small Interfering RNA (siRNA) (1) Tau Protein (1)
By Research Areas:	Cancer (6) Metabolic Disease (1) Neurological Disease (4)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Recombinant Proteins

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103391

Qc1	Others	Metabolic Disease
Qc1 is a reversible and noncompetitive threonine dehydrogenase (TDH) inhibitor. Qc1 can be used for the research of Metabolic disease .

HY-104048

QC6352 5 Publications Verification	Histone Demethylase	Cancer
QC6352 is an orally active KDM4 inhibitor with anti-tumor and anti-proliferative activity. QC6352 has in vivo inhibitory effects on PDX models of breast and colon cancer and reduces the number of chemoresistant cell populations. QC6352 inhibits KDM4 different isoforms with IC₅₀s of 104 nM (KDM4A), 56 nM (KDM4B), 35 nM (KDM4C), and 104 nM (KDM4D), respectively. QC6352 has moderate inhibitory activity against KDM5 with an IC₅₀ of 750 nM (KDM5B) .

HY-134850

QC-01–175	PROTACs Tau Protein	Neurological Disease
QC-01-175 is a heterobifunctional molecule, which degrades aberrant tau. QC-01-175 reduces the levels of A152T and P301L mutant tau protein and protects neurons from tau-mediated toxicity and improve cell survival (Pink: ligand for target protein Aberrant tau ligand 1 (HY-W453397); Black: linker NH2-PEG3 (HY-W007545); Blue: ligand for E3 ligase Pomalidomide (HY-10984)) .

HY-148807

Zavondemstat QC8222 free base; TACH 101 free base	Histone Demethylase	Cancer
Zavondemstat (QC8222; TACH 101) is an inhibitor of histone lysine demethylase 4D (KDM4D) with antineoplastic activity .

HY-151132

Glutaminyl cyclases-IN-1 IsoQC-IN-1	CD47	Cancer
Glutaminyl cyclases-IN-1 (IsoQC-IN-1) is a potent glutaminyl cyclases (QC) inhibitor with IC₅₀ values of 12 nM and 73 nM for human QC and isoQC, respectively. Glutaminyl cyclases-IN-1 can selectively interfere with the interaction of CD47/SIRPα through isoQC inhibition, and enhances the increased phagocytic activity of both THP-1 and U937 macrophages .

HY-162259

QC-182	PROTACs Histone Acetyltransferase	Cancer
QC-182 is a potent PROTAC degrader of p300/CBP. QC-182 reduces p300 protein in the SK-HEP-1 cells (DC₅₀ = 93nM). QC-182 potently and effectively inhibits cell growth in the SK-HEP-1 and JHH7 cell lines with IC₅₀ values of 0.733 and 0.477 μM, respectively. QC-182 can be used for the research of hepatocellular carcinoma (HCC) .

HY-148807A

Zavondemstat L-lysine QC8222; TACH 101	Histone Demethylase	Cancer
Zavondemstat (QC8222; TACH 101) (L-lysine) is an inhibitor of histone lysine demethylase 4D (KDM4D) with antineoplastic activity .

HY-RS01721

C1QC Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
C1QC Human Pre-designed siRNA Set A contains three designed siRNAs for C1QC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

C1QC Human Pre-designed siRNA Set A C1QC Human Pre-designed siRNA Set A

HY-W453397

Aberrant tau ligand 1	Ligands for Target Protein for PROTAC	Neurological Disease
Aberrant tau ligand 1 is a ligand for tau proteins with abnormal forms. Aberrant tau ligand 1 can be used for synthesis of PROTAC aberrant Tau degrader QC-01-175 (HY-134850) .

HY-152031

Glutaminyl Cyclase Inhibitor 5	Amyloid-β	Neurological Disease
Glutaminyl Cyclase Inhibitor 5 (Compound 71) is a potent and selective human glutaminyl cyclase (hQC) inhibitor with an IC₅₀ of 3.2 nM .

HY-136780

SEN177	Amyloid-β Apoptosis CD47 Huntingtin	Neurological Disease Cancer
SEN177 is an orally effect glutamine cyclase (QC) inhibitor. The K_i of SEN177 for human glutamine cyclase (hQC) is 20 nM, and the IC₅₀ is 13 nM. SEN177 interferes with the interaction between CD47 and SIRRPα, and has anti-tumor activity. SEN177 reduces aggregation and apoptosis caused by HTT mutation in Huntington model, and can be used in the study of neurodegenerative diseases .

HY-148807B

(S)-Zavondemstat (S)-QC8222 free base; (S)-TACH 101 free base	Others	Others
(S)-Zavondemstat is the S-enantiomer of Zavondemstat (HY-148807). Zavondemstat is an inhibitor of histone lysine demethylase 4D (KDM4D) with antineoplastic activity ^{[1] ^.}

Species:	Human (1) Mouse (1) E.coli (1)
Tag:	His (3) Myc (1)
Source:	HEK293 (1) Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P71670

	QPCT Protein, Mouse (HEK293, His) Qpct; Glutaminyl-peptide cyclotransferase; EC 2.3.2.5; Glutaminyl cyclase; QC; Glutaminyl-tRNA cyclotransferase	Mouse	HEK293
	The QPCT protein plays a key role in pyroglutamyl peptide biosynthesis and exhibits substrate preference for N-terminal glutamine residues while showing specificity for residues near the N-terminus. Notably, its catalytic activity is independent of chain length beyond the second residue, emphasizing the importance of QPCT in the precise biosynthesis of pyroglutamyl peptides with diverse N-termini, contributing to various biological background. QPCT Protein, Mouse (HEK293, His) is the recombinant mouse-derived QPCT protein, expressed by HEK293 , with N-His, N-Myc labeled tag.

HY-P76560

	QPCT Protein, Human (sf9, His) Glutaminyl-peptide cyclotransferase; QC; Glutamyl cyclase; EC	Human	Sf9 insect cells
	QPCT Protein synthesizes pyroglutamyl peptides, favoring N-terminal glutaminyl residue over adjacent acidic and tryptophan residues. It catalyzes N-terminal pyroglutamate formation, particularly [Glu-3]-amyloid-beta in APP peptides. In lab settings, it aids pyroglutamate formation in truncated amyloid-beta peptides. QPCT Protein may contribute to N-terminal pyroglutamate formation in peptides linked to amyloid-related plaque development. QPCT Protein, Human (sf9, His) is the recombinant human-derived QPCT protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P70247

	LacI Protein, E.coli (Q360QC, His) rE.coLactose operon repressor/LacI, His; Lactose operon repressor; LacI	E.coli	E. coli
	LacI, the lactose operon repressor, regulates lactose metabolism by binding to the operator region and repressing gene transcription. The presence of the inducer, allolactose, alters its binding affinity, derepressing the operon. As a homotetramer, LacI finely tunes lactose metabolism, orchestrating regulatory mechanisms in response to the cellular environment. LacI Protein, E.coli (Q360QC, His) is the recombinant E. coli-derived LacI protein, expressed by E. coli , with N-10*His labeled tag and Q360QC mutation.

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C1QC Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
C1QC Human Pre-designed siRNA Set A contains three designed siRNAs for C1QC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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