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Results for "

SP1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (2) Autophagy (1) Bacterial (4) Biochemical Assay Reagents (1) DNA/RNA Synthesis (1) Endogenous Metabolite (3) Glutathione S-transferase (2) HCV (1) HIV (2) HIV Protease (1) Neurokinin Receptor (1) NF-κB (1) NO Synthase (1) P2X Receptor (1) p38 MAPK (1) RAR/RXR (1) Small Interfering RNA (siRNA) (1) SphK (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Endocrinology (1) Infection (10) Inflammation/Immunology (4) Metabolic Disease (1) Neurological Disease (3)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-A0122

Plicamycin 30+ Cited Publications Mithramycin A	DNA/RNA Synthesis Bacterial Antibiotic Glutathione S-transferase	Infection Cancer
Plicamycin (Mithramycin A) is a selective specificity protein 1 (Sp1) inhibitor. Plicamycin inhibits the growth of various cancers by decreasing Sp1 protein. Plicamycin inhibits GSTM2 promoter activity and protein expression ^[1] .

HY-W100287

Murrayafoline A	NF-κB p38 MAPK	Neurological Disease Inflammation/Immunology
Murrayafoline A is a carbazole alkaloid that can be extracted from Murraya tetramera. Murrayafoline A directly targets Specificity protein 1 (Sp1), thereby inhibiting NF-κB and MAPK signaling pathways. Murrayafoline A has anti-neuroinflammatory activity ^[1].

HY-100008

Peretinoin 5 Publications Verification NIK333	RAR/RXR SphK Autophagy HCV	Infection Cancer
Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1 ^[1]. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression . Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC₅₀ of 9 μM .

HY-RS13600

SP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SP1 Human Pre-designed siRNA Set A contains three designed siRNAs for SP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SP1 Human Pre-designed siRNA Set A SP1 Human Pre-designed siRNA Set A

HY-150536

EP39	HIV HIV Protease	Infection
EP39 is a potent HIV-1 maturation inhibitor. EP39 interacts with the SP1 domain of Gag. EP39 decreases the dynamics of CA-SP1 junction, by binding to the QVT motif of the SP1 domain, and perturbs the natural coil-helix equilibrium on both sides of the SP1 domain by stabilizing the transient alpha helical structure. EP39 acts by arresting maturation of HIV-1 thereby blocking its infectivity ^[1].

HY-120764

PF-46396	HIV	Infection
PF-46396 is a potent *HIV-1* inhibitor with an EC₅₀ value of 0.206 µM. PF-46396 shows antiviral activity. PF-46396 inhibits the processing of capsid (CA)/spacer peptide 1 (SP1) (p25) Gag precursor proteins and blocks maturation of the viral core particle ^[1].

HY-123036

Renierone	Bacterial	Infection
Renierone is an antibacterial metabolite found in the sponge Reniera sp. .

HY-N8662

Primulic acid II	Others	Inflammation/Immunology
Primulic acid II is a saponin isolated from root extract of Primula sp .

HY-N13017

Bhimanone	Endogenous Metabolite	Others
Bhimanone is a bioinactive tetralone, which can be isolated from Streptomyces sp. .

HY-N13149

Tetromycin C1	Antibiotic Bacterial	Infection
Tetromycin C1 is an antibiotic bactericide isolated from Streptomyces sp. .

HY-N12266

12-Hydroxyalbrassitriol	Others	Others
12-Hydroxyalbrassitriol is a drimane sesquiterpenoid that can be isolated from Penicillium sp .

HY-N8391

Hydroxysulochrin	Others	Others
Hydroxysulochrin is a tea pollen growth inhibitor that can be isolated from Aureobasidium sp. .

HY-116077

AB 5046B	Others	Others
AB 5046B is a chlorosis-inducing substance can be isolated from Nodulisporium sp .

HY-20897A

5-Bromo-L-tryptophan	Endogenous Metabolite	Others
5-Bromo-L-tryptophan is an α-amino acid derivative that can be found in Semenospongia sp. .

HY-114585A

Sperabillin A dihydrochloride	Glutathione S-transferase	Others
Sperabillin A (dihydrochloride)is new inhibitors ofglutathione S-transferaseisolated from the culture broth ofStreptomyces sp .

HY-125458

Iromycin A	NO Synthase	Others
Iromycin A is a potent inhibitor of nitric oxide synthases (NO synthase) that can be isolated from Streptomyces sp. .

HY-120551

Fructigenine A	Others	Others
Fructigenine A (compound 4) is a active product that can be isolated from marine-derived Penicillium sp. .

HY-N6799

Neosolaniol	Others	Infection
Neosolaniol is a type A trichothecene mycotoxin from Fusarium sp . Neosolaniol evokes robust anorectic response .

HY-125538

Deoxybrevianamide E	Endogenous Metabolite	Inflammation/Immunology
Deoxybrevianamide E, an indole alkaloid, is a biosynthetic precursor for advanced metabolites isolated from the marine-derived Aspergillus sp. .

HY-N12149

Axinysone B	Bacterial	Infection
Axinysone B can be isolated from Laurencia similis. Axinysone B has antibacterial activity against Staphylococcus sp. .

HY-N7078

Spiculisporic acid	Biochemical Assay Reagents	Others
Spiculisporic acid is a γ-butenolide isolated from the cultue of Aspergillus sp . Spiculisporic acid is a microbial biosurfactant and has anti-oxidative stress actions .

HY-W353469

2-O-(α-D-Glucopyranosyl)glycerol Glucosylglycerol	Others	Others
2-O-(α-D-Glucopyranosyl)glycerol (Glucosylglycerol) is a glycerol glycoside and can be isolated from the Marine Blue-green Alga Oscillatoria sp .

HY-N2657

Flavone, 5,7-dihydroxy-3,4',8-trimethoxy-, diacetate	Others	Others
Flavone, 5,7-dihydroxy-3,4',8-trimethoxy-, diacetate is a Flavonoids product that can be isolated from the herbs of Micromelum sp. .

HY-W010062

4-Chlorophenylacetic acid	Others	Metabolic Disease Cancer
4-Chlorophenylacetic acid is a compound belongs to a family of small aromatic fatty acids with anticancer properties. 4-Chlorophenylacetic acid can provide carbon and energy for Pseudomonas sp .

HY-N6799R

Neosolaniol (Standard)	Others	Infection
Neosolaniol (Standard) is the analytical standard of Neosolaniol. This product is intended for research and analytical applications. Neosolaniol is a type A trichothecene mycotoxin from Fusarium sp . Neosolaniol evokes robust anorectic response .

HY-N0980

1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid	Others	Others
1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid is a Alkaloids product that can be isolated from the herbs of Micromelum sp. .

HY-P1330

Purotoxin 1	P2X Receptor	Inflammation/Immunology
Purotoxin 1 is a P2X3 receptor inhibitor. Purotoxin 1 shows antinociceptive properties in animal models of inflammatory pain. Purotoxin 1 can be isolated from the venom of the wolf spider Geolycosa sp .

HY-P3805

[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11)	Neurokinin Receptor	Cardiovascular Disease Neurological Disease
[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) is a potent neurokinin NK1 antagonist. [D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) inhibits the effects of gold-protein-substance P (GPSP) and substance P (SP) .

Cat. No.	Product Name	Target	Research Area

HY-20897A

5-Bromo-L-tryptophan	Endogenous Metabolite	Others
5-Bromo-L-tryptophan is an α-amino acid derivative that can be found in Semenospongia sp. .

HY-P10603

*SP1*	Peptides	Infection
SP1 is an α-peptide encoded by the mating pheromone MFα1 gene in Candida albicans, which can induce cell growth arrest at the mating type locus MTLa in Candida albicans. SP1 can be used in the study of the prevention and treatment of Candida albicans infection ^[1].

HY-P10336

Serpinin	Peptides	Neurological Disease Endocrinology
Serpinin is an agonist of the protease inhibitor Nexin-1 (PN-1). Serpinin upregulates the expression of PN-1 through the cAMP-PKA-Sp1 signaling pathway, promoting granule biogenesis in endocrine cells. Serpinin is used in research related to the regulation of secretory function ^[1]. Serpinin is a selective agonist for β-adrenergic receptors. Serpinin interacts with β1-adrenergic receptors to activate the AC-cAMP-PKA pathway, which regulates myocardial systolic and diastolic function. pGlu-serpinin upregulates Bcl2 mRNA transcription and exerts neuroprotective effects .

HY-P5941

Bilaid C1	Peptides	Others
Bilaid C1 is a tetrapeptide isolated from Penicillium sp .

HY-P1330

Purotoxin 1	P2X Receptor	Inflammation/Immunology
Purotoxin 1 is a P2X3 receptor inhibitor. Purotoxin 1 shows antinociceptive properties in animal models of inflammatory pain. Purotoxin 1 can be isolated from the venom of the wolf spider Geolycosa sp .

HY-P3805

[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11)	Neurokinin Receptor	Cardiovascular Disease Neurological Disease
[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) is a potent neurokinin NK1 antagonist. [D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) inhibits the effects of gold-protein-substance P (GPSP) and substance P (SP) .

Murrayafoline A	Structural Classification Alkaloids Murraya tetramera C. C. Huang Source classification Rutaceae Carbazole Alkaloids Plants	NF-κB p38 MAPK
Murrayafoline A is a carbazole alkaloid that can be extracted from Murraya tetramera. Murrayafoline A directly targets Specificity protein 1 (Sp1), thereby inhibiting NF-κB and MAPK signaling pathways. Murrayafoline A has anti-neuroinflammatory activity ^[1].

5-Bromo-L-tryptophan	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
5-Bromo-L-tryptophan is an α-amino acid derivative that can be found in Semenospongia sp. .

Primulic acid II	Structural Classification Natural Products other families Classification of Application Fields Source classification Coniogramme japonica (Thunb.) Diels Plants Inflammation/Immunology Disease Research Fields Saccharides	Others
Primulic acid II is a saponin isolated from root extract of Primula sp .

Bhimanone	Structural Classification Natural Products Microorganisms Source classification	Endogenous Metabolite
Bhimanone is a bioinactive tetralone, which can be isolated from Streptomyces sp. .

Tetromycin C1	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Antibiotic Bacterial
Tetromycin C1 is an antibiotic bactericide isolated from Streptomyces sp. .

12-Hydroxyalbrassitriol	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Others
12-Hydroxyalbrassitriol is a drimane sesquiterpenoid that can be isolated from Penicillium sp .

Hydroxysulochrin	Structural Classification Microorganisms Source classification Phenols Polyphenols	Others
Hydroxysulochrin is a tea pollen growth inhibitor that can be isolated from Aureobasidium sp. .

AB 5046B	Structural Classification Natural Products Microorganisms Source classification	Others
AB 5046B is a chlorosis-inducing substance can be isolated from Nodulisporium sp .

Sperabillin A dihydrochloride	Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Other Diseases Disease Research Fields Other Antibiotics	Glutathione S-transferase
Sperabillin A (dihydrochloride)is new inhibitors ofglutathione S-transferaseisolated from the culture broth ofStreptomyces sp .

Iromycin A	Structural Classification Natural Products Microorganisms Source classification	NO Synthase
Iromycin A is a potent inhibitor of nitric oxide synthases (NO synthase) that can be isolated from Streptomyces sp. .

Species:	Human (1) Mouse (1)
Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P702524

	Matriptase/ST14 Catalytic Domain Protein, Mouse (His) EC 3.4.21; Epithin; HAI; Matriptase; Membrane-type serine protease 1; MTSP1; MT-SP1EC 3.4.21.109; prostamin; PRSS14; Serine protease 14; Serine protease TADG-15; SNC19; SNC19MTSP1; ST14; suppressor of tumorigenicity 14 protein; TADG15; TADG-15; TMPRSS14; tumor associated differentially expressed gene 15 protein; Tumor-associated differentially-expressed gene 15 protein	Mouse	E. coli
	The Matriptase/ST14 catalytic domain protein exhibits serine-type endopeptidase activity and is critical in processes as diverse as placental branching and neural tube closure. It is an extrinsic component of the plasma membrane and is expressed in structures such as the digestive system, early concepts, genitourinary system, pituitary gland, and sense organs. Matriptase/ST14 Catalytic Domain Protein, Mouse (His) is the recombinant mouse-derived Matriptase/ST14 Catalytic Domain protein, expressed by E. coli , with N-6*His labeled tag.

HY-P702523

	Matriptase/ST14 Catalytic Domain Protein, Human (His) EC 3.4.21; Epithin; HAI; Matriptase; Membrane-type serine protease 1; MTSP1; MT-SP1EC 3.4.21.109; prostamin; PRSS14; Serine protease 14; Serine protease TADG-15; SNC19; SNC19MTSP1; ST14; suppressor of tumorigenicity 14 protein; TADG15; TADG-15; TMPRSS14; tumor associated differentially expressed gene 15 protein; Tumor-associated differentially-expressed gene 15 protein	Human	E. coli
	The Matriptase/ST14 catalytic domain protein originates from epithelial cells, forms a complex with HAI-1, and is activated by sphingosine-1-phosphate. It cleaves and activates hepatocyte growth factor/scatter factor and urokinase plasminogen activator, suggesting its role as an activator of other proteases and potential growth factors. Matriptase/ST14 Catalytic Domain Protein, Human (His) is the recombinant human-derived Matriptase/ST14 Catalytic Domain protein, expressed by E. coli , with N-6*His labeled tag.

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HY-P80336

	SP1 Antibody	WB, ICC/IF, IHC-P	Human
	SP1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 81 kDa, targeting to SP1. It can be used for WB,ICC/IF,IHC-P assays with tag free, in the background of Human.

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Cat. No.	Product Name		Classification

HY-RS13600

SP1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
SP1 Human Pre-designed siRNA Set A contains three designed siRNAs for SP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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SP1

Inhibitors & Agonists

Peptides

NaturalProducts

Recombinant Proteins

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