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Results for "

WRN Helicase Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA/RNA Synthesis (23)
By Research Areas:	Cancer (22)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153692

WRN inhibitor 1	DNA/RNA Synthesis	Cancer
WRN inhibitor 1 (example 7) is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor that inhibits *WRN* helicase domain activity. WRN inhibitor 1 has the potential to study cancer .

HY-110185

NSC 617145 2 Publications Verification	DNA/RNA Synthesis	Cancer
NSC 617145 is a selective werner syndrome helicase (WRN) helicase inhibitor with an IC₅₀ value of 230 nM. NSC 617145 inhibits WRN ATPase, and induces double-strand breaks (DSB) and chromosomal abnormalities. NSC 617145 shows selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases .

HY-128712

NCGC00029283	DNA/RNA Synthesis	Cancer
NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC₅₀s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively .

HY-160859

WRN inhibitor 8	DNA/RNA Synthesis	Cancer
WRN inhibitor 8 (Example 224) is a **WRN helicase** inhibitor with IC₅₀ value of 48 nM. WRN inhibitor 8 can be used in cancer research .

HY-163941

GSK_WRN2	DNA/RNA Synthesis	Cancer
GSK_WRN2 is a potent and selective covalent **WRN helicase** inhibitor that suppresses replication stress caused by DNA (TA)_n dinucleotide repeat expansions. GSK_WRN2 can be used to study microsatellite instability (MSI) cancers .

HY-169423

WRN inhibitor 17	DNA/RNA Synthesis	Cancer
WRN inhibitor 17 (Compound 250) is an orally active Werner Syndrome ATP dependent helicase enzyme (WRN) inhibitor, in particular inhibit *WRN* helicase domain activity. WRN inhibitor 17 is promising for research of cancers .

HY-168592

WRN inhibitor 12	DNA/RNA Synthesis	Cancer
WRN inhibitor 12 (compound 5) is an inhibitor of WRN helicase .

HY-164852

WRN inhibitor 13	DNA/RNA Synthesis	Others
WRN inhibitor 13 is a **WRN helicase** inhibitor with a pIC₅₀ of 6-7 .

HY-168583

WRN inhibitor 11	DNA/RNA Synthesis	Cancer
WRN inhibitor 11 (Example 17) is an orally active inhibitor of **WRN helicase, with the IC₅₀** of 63 nM .

HY-153973

WRN inhibitor 2	DNA/RNA Synthesis	Cancer
WRN inhibitor 2 (example 118) is a *WRN* (Werner Syndrome ATP dependent helicase enzyme) inhibitor, with pIC₅₀ ≥ 7.0 .

HY-156579

WRN inhibitor 3	DNA/RNA Synthesis	Cancer
WRN inhibitor 3 (example 110), a cyclic vinyl sulfone compound, is a Wemer Syndrome ATP dependent helicase enzyme *(WRN)* inhibitor. WRN inhibitor 3 can be used for the research of cancer .

HY-156580

WRN inhibitor 4	DNA/RNA Synthesis	Cancer
WRN inhibitor 4 (example 107), a cyclic vinyl sulfone compound, is a Wemer Syndrome ATP dependent helicase enzyme *(WRN)* inhibitor. WRN inhibitor 4 can be used for the research of cancer .

HY-156581

WRN inhibitor 5	DNA/RNA Synthesis	Cancer
WRN inhibitor 5 (example 157), a cyclic vinyl sulfone compound, is a Wemer Syndrome ATP dependent helicase enzyme *(WRN)* inhibitor. WRN inhibitor 5 can be used for the research of cancer .

HY-161386

WRN inhibitor 7	DNA/RNA Synthesis	Cancer
WRN inhibitor 7 (Compound h6) is a *WRN* inhibitor. WRN inhibitor 7 effectively inhibits WRN's helicase and ATPase activity (IC₅₀: 9.8 μM and 15.8 μM respectively). WRN inhibitor 7 can be used for research of microsatellite instable (MSI) cancers .

HY-149887

H3B-968 1 Publications Verification	DNA/RNA Synthesis	Cancer
H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) (IC₅₀=~10 nM)，which acts function as helicase，ATPase，and exonuclease. WRN exhibits synthetic lethal activity in cancer research. However，H3B-968 inhibits WRN helicase activity，competitively with ATP .

HY-163797

WRN inhibitor 10	DNA/RNA Synthesis	Cancer
WRN inhibitor 10 (Compound P24) is an inhibitor for the Werner helicase *WRN* with an IC₅₀ of 1.1 nM. WRN inhibitor 10 inhibits the proliferation of cancer cell SW48 with IC₅₀ of 39 nM. WRN inhibitor 10 exhibits good liver microsomal stability and film permeability. WRN inhibitor 10 exhibits good pharmacokinetic characteristics in CD-1 mice .

HY-148700

Werner syndrome RecQ helicase-IN-2	DNA/RNA Synthesis	Cancer
Werner syndrome RecQ helicase-IN-2 (example 57) is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research .

HY-148699

HRO761 2 Publications Verification Werner syndrome RecQ Helicase-IN-1	DNA/RNA Synthesis	Cancer
HRO761 (Werner syndrome RecQ helicase-IN-1) (example 42) is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research .

HY-158116

VVD-214 RO7589831; VVD-133214	DNA/RNA Synthesis	Cancer
VVD-214 is a synthetic lethal allosteric inhibitor of *WRN* helicase with an IC₅₀ of 0.1316 µM. VVD-214 covalently binds to cysteine 727 of WRN and inhibits ATP hydrolysis and *helicase* activity. VVD-214 is potent in causing double-stranded DNA breaks, nuclear swelling, and cell death in high microsatellite instability (MSI) cancers .

HY-163942

GSK_WRN4	DNA/RNA Synthesis	Cancer
GSK_WRN4 is a **WRN helicase** inhibitor (pIC₅₀=7.6) with anticancer activity. GSK_WRN4 selectively inhibits the growth of MSI tumor cells in vitro and in vivo by inducing DNA double-strand breaks, particularly at expanded TA repeats and DNA damage regions .

HY-148740

Werner syndrome RecQ helicase-IN-3	DNA/RNA Synthesis	Cancer
Werner syndrome RecQ helicase-IN-3 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC₅₀ value of 0.06 µM. Werner syndrome RecQ helicase-IN-3 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-3 shows anticancer activity .

HY-148741

Werner syndrome RecQ helicase-IN-4	DNA/RNA Synthesis	Cancer
Werner syndrome RecQ helicase-IN-4 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC₅₀ value of 0.06 µM. Werner syndrome RecQ helicase-IN-4 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-4 shows anticancer activity .

HY-162471

GSK_WRN3	DNA/RNA Synthesis	Cancer
GSK_WRN3 is a selective inhibitor of WRN protease (pIC₅₀ = 8.6). GSK_WRN3 displays a high degree of selectivity by forming a covalent binding to the Cys727 residue of the WRN protein. GSK_WRN3 reduces growth support for MSI tumor cells by inhibiting WRN protease activity, resulting in increased DNA double-strand breaks and cell growth inhibition .

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WRN Helicase Inhibitor

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