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Results for "

actin polymerization

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Arp2/3 Complex (11) Antibiotic (1) Apoptosis (2) CDK (1) Endogenous Metabolite (2) FAK (1) Fluorescent Dye (1) Fungal (3) HIV Protease (1) Isotope-Labeled Compounds (1) MMP (1) PI3K (1) Prostaglandin Receptor (2) Src (1) Topoisomerase (1) YAP (1)
By Research Areas:	Cancer (12) Infection (4) Inflammation/Immunology (5) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Arp2/3 Complex

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N6682

Cytochalasin D Maximum Cited Publications 48 Publications Verification Zygosporin A; NSC 209835	Arp2/3 Complex Antibiotic YAP	Infection
Cytochalasin D (Zygosporin A) is a potent **actin polymerization** inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap .

HY-16931

SMIFH2 2 Publications Verification	Arp2/3 Complex	Cancer
SMIFH2 is a formin specific inhibitor. SMIFH2 inhibits actin polymerization by Formins and affects the actin cytoskeleton .

HY-P0027

Jasplakinolide 5 Publications Verification	Arp2/3 Complex Fungal	Infection Cancer
Jasplakinolide is a potent **actin polymerization** inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a K_d of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity .

HY-101848

Latrunculin B	Fungal	Infection
Latrunculin B, an antimicrobial marine alkaloid, is an **actin polymerization** inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis. Antifungal and antiprotozoal activity .

HY-148683

EG-011	Arp2/3 Complex	Cancer
EG-011 is the first-in-class and potent Wiskott-Aldrich syndrome protein (WASP) activator. EG-011 activates the auto-inhibited form of WASP with strong actin polymerization. EG-011 has selective anti-tumor activity in lymphomas .

HY-D1425

DCVJ 9-(2,2-Dicyanovinyl)julolidine	Fluorescent Dye	Others
DCVJ (9-(2,2-Dicyanovinyl)julolidine), a molecular rotor and unique fluorescent dye, binds to tubulin and actin, and increases its fluorescence intensity drastically upon polymerization. DCVJ also binds to phospholipid bilayers and increases its fluorescence intensity. DCVJ can detect the kinetic process of degranulation of mast cells .

HY-104013

Aminopurvalanol A 1 Publications Verification	CDK Apoptosis	Cancer
Aminopurvalanol A is a potent, selective, and cell permeable inhibitor of Cyclins/Cdk complexes. Aminopurvalanol A preferentially targets the G2/M-phase transition inhibiting cancer cell differentiation. Aminopurvalanol A causes the inhibition of sperm fertilizing ability via the inhibition of physiological capacitation-dependent actin polymerization .

HY-127042

6,7-Epoxy-latrunculin A 6,7-Epoxy-LAT-A	Arp2/3 Complex	Others
6,7-Epoxy-latrunculin A can be isolated from the Red Sea sponge Negombata magnifica and is initially identified as an inhibitor of **actin polymerization** by its morphological effects .

HY-126989

19-O-Acetylchaetoglobosin A	Arp2/3 Complex	Cancer
19-O-Acetylchaetoglobosin A, a cytochalasan alkaloid, is a fungal metabolite originally isolated from C. globosum that has actin polymerization inhibitory and cytotoxic activities. 19-O-Acetylchaetoglobosin A is cytotoxic to HeLa cervical cancer cells .

HY-156403

AuM1Phe	Topoisomerase	Cancer
AuM1Phe, an N-Heterocyclic carbene (NHC) metal complexe, blocks the human topoisomerase I activity and actin polymerization reaction. AuM1Phe affects the growth of MDA-MB-231 breast cancer cells, with an IC₅₀ value of 1.2 μM .

HY-136808

Pfn1-IN-1	Others	Cancer
Pfn1-IN-1 (compound C1) is a Pfn1 inhibitor that inhibits the angiogenic capacity of endothelial cells (EC). Pfn1 is a regulator of the actin cytoskeleton, inducing actin polymerization and essential cellular activities. Pfn1-IN-1 inhibits Pfn1-Actin interaction and Actin polymerization.

HY-16929

Latrunculin A 5+ Cited Publications LAT-A	Arp2/3 Complex	Cancer
Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with K_ds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration .

HY-16928

Cytochalasin B 25+ Cited Publications Phomin	Arp2/3 Complex	Cancer
Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of *actin* filaments, disrupting the formation of actin polymers, with K_d value of 1.4-2.2 nM for F-actin. Cytochalasin B blocks cell migration.

HY-114657A

Benproperine phosphate	Arp2/3 Complex	Inflammation/Immunology Cancer
Benproperine phosphate is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of action polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate has the potential for a cough suppressant and suppresses cancer cell migration and tumor metastasis .

HY-15892

CK-636 1 Publications Verification CK-0944636	Arp2/3 Complex	Inflammation/Immunology Cancer
CK-636 is a cell permeable inhibitor of Arp2/3 complex, that could inhibit actin polymerization, with IC₅₀ values of 4 μM, 24 μM and 32 μM for human, fission yeast and bovine, respectively. CK636 blocks cell migration.

HY-N6773

Cytochalasin A	HIV Protease Fungal	Infection
Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC₅₀=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives .

HY-137308

15(R)-Prostaglandin D2 15R-PGD2	Prostaglandin Receptor	Inflammation/Immunology
15(R)-Prostaglandin D2 is a potential prostatic hormone DP(2) receptor (Prostaglandin Receptor) agonist with anti-inflammatory activity. 15(R)-Prostaglandin D2 increases actin polymerization in human eosinophils and increases cAMP levels in platelets .

HY-120213

YH-306	FAK Src PI3K MMP Apoptosis	Cancer
YH-306 is an antitumor agent. YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. YH-306 significantly inhibits the migration and invasion of colorectal cancer cells. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1 and the expression of MMP2 and MMP9. YH-306 also inhibita actin-related protein (Arp2/3) complex-mediated actin polymerization .

HY-125527

Resolvin D1 RvD1	Endogenous Metabolite	Inflammation/Immunology
Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages .

HY-137677B

GTPγS tetralithium Guanosine 5'-[γ-thio]triphosphate tetralithium	Others	Others
GTPγS (tetralithium) (Guanosine 5'-[γ-thio]triphosphate (tetralithium)) is a G-protein activator that protects proteins from proteolytic degradation, stimulates GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization. GTPγS (tetralithium) to couple with G- protein α, to study its effect on kinase activity. GTPγS (tetralithium) acts as a component of lysis buffer .

HY-125527S

Resolvin D1-d5 RvD1-d₅	Isotope-Labeled Compounds Endogenous Metabolite	Inflammation/Immunology
Resolvin D1-d₅ is the deuterium labeled Resolvin D1. Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages[1][2].

HY-12534

Wiskostatin 1 Publications Verification	Arp2/3 Complex	Neurological Disease
Wiskostatin is a potent and selective inhibitor of neuronal Wiskott-Aldrich syndrome protein (N-WASP)-mediated actin polymerization by stabilization of the closed, autoinhibited conformation, thereby preventing Arp2/3 complex activation. Wiskostatin is also a dynamin inhibitor with an IC₅₀ value of 20.7 μM and a potent inhibitor of clathrin-mediated endocytosis with an IC₅₀ value of 6.9 μM. Wiskostatin causes a rapid, profound, and irreversible decrease in cellular ATP levels. Wiskostatin also induces disassembly of podosomes in a murine monocyte cell line .

HY-125782

15(R)-15-Methyl prostaglandin D2 15(R)-15-Methyl PGD2	Prostaglandin Receptor	Metabolic Disease
15(R)-15-Methyl prostaglandin D2 (15(R)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2. The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1and CRTH2/DP2. 15(R)-15-Methyl prostaglandin D2 is a potent, selective agonist for the CRTH2/DP2 receptor. The EC₅₀ values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast the EC₅₀ for the DP1-mediated increase in platelet cAMP by 15(R)-15-methyl PGD2 is >10 μM.

Cat. No.	Product Name

HY-L060

Cytoskeleton Compound Library	1,372 compounds
The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, intracellular signal transduction, and many other functions that are essential for cellular homeostasis and survival. It accomplishes these tasks through three basic structures: F-actin, microtubules, and intermediate filaments (IFs). The cytoskeleton is a dynamic structure where the three major filaments and tubules are under the influence of proteins that regulate their length, state of polymerization, and level of cross-linking. Since cytoskeleton is involved in virtually all cellular processes, cytoskeletal protein aberrations are the underlying reason for many pathological phenotypes, including several cardiovascular disease syndromes, neurodegeneration, cancer, liver cirrhosis, pulmonary fibrosis, and blistering skin diseases. MCE designs a unique collection of 1,372 cytoskeleton-related compounds mainly focusing on the key targets in the cytoskeleton signal pathway and can be used in the research of cytoskeleton signal pathway and related diseases.

Cytoskeleton Compound Library

1,372 compounds

The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, intracellular signal transduction, and many other functions that are essential for cellular homeostasis and survival. It accomplishes these tasks through three basic structures: F-actin, microtubules, and intermediate filaments (IFs). The cytoskeleton is a dynamic structure where the three major filaments and tubules are under the influence of proteins that regulate their length, state of polymerization, and level of cross-linking. Since cytoskeleton is involved in virtually all cellular processes, cytoskeletal protein aberrations are the underlying reason for many pathological phenotypes, including several cardiovascular disease syndromes, neurodegeneration, cancer, liver cirrhosis, pulmonary fibrosis, and blistering skin diseases.

MCE designs a unique collection of 1,372 cytoskeleton-related compounds mainly focusing on the key targets in the cytoskeleton signal pathway and can be used in the research of cytoskeleton signal pathway and related diseases.

Cat. No.	Product Name	Target	Research Area

HY-P0027

Jasplakinolide 5 Publications Verification	Arp2/3 Complex Fungal	Infection Cancer
Jasplakinolide is a potent **actin polymerization** inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a K_d of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6682

Cytochalasin D Maximum Cited Publications 48 Publications Verification Zygosporin A; NSC 209835	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Arp2/3 Complex Antibiotic YAP
Cytochalasin D (Zygosporin A) is a potent **actin polymerization** inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap .

HY-P0027

Jasplakinolide 5 Publications Verification	Structural Classification Antifungal Classification of Application Fields Marine natural products Source classification Disease Research Other Antibiotics Infection Monophenols Animals Antibiotics Cyclopeptides Phenols Sponge Anticancer Disease Research Fields	Arp2/3 Complex Fungal
Jasplakinolide is a potent **actin polymerization** inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a K_d of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity .

HY-101848

Latrunculin B	Infection Animals Classification of Application Fields Marine natural products Sponge Disease Research Fields	Fungal
Latrunculin B, an antimicrobial marine alkaloid, is an **actin polymerization** inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis. Antifungal and antiprotozoal activity .

HY-16929

Latrunculin A 5+ Cited Publications LAT-A	Structural Classification Macrolide Antibiotics Animals Classification of Application Fields Antibiotics Marine natural products Source classification Other Diseases Sponge Disease Research Anticancer Disease Research Fields	Arp2/3 Complex
Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with K_ds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration .

HY-16928

Cytochalasin B 25+ Cited Publications Phomin	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	Arp2/3 Complex
Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of *actin* filaments, disrupting the formation of actin polymers, with K_d value of 1.4-2.2 nM for F-actin. Cytochalasin B blocks cell migration.

HY-N6773

Cytochalasin A	Infection Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields	HIV Protease Fungal
Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC₅₀=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives .

HY-125527

Resolvin D1 RvD1	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Inflammation/Immunology	Endogenous Metabolite
Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages .

HY-127042

6,7-Epoxy-latrunculin A 6,7-Epoxy-LAT-A	Structural Classification Natural Products Microorganisms Source classification	Arp2/3 Complex
6,7-Epoxy-latrunculin A can be isolated from the Red Sea sponge Negombata magnifica and is initially identified as an inhibitor of **actin polymerization** by its morphological effects .

HY-126989

19-O-Acetylchaetoglobosin A	Alkaloids Structural Classification Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	Arp2/3 Complex
19-O-Acetylchaetoglobosin A, a cytochalasan alkaloid, is a fungal metabolite originally isolated from C. globosum that has actin polymerization inhibitory and cytotoxic activities. 19-O-Acetylchaetoglobosin A is cytotoxic to HeLa cervical cancer cells .

Cat. No.	Product Name	Chemical Structure

HY-125527S

Resolvin D1-d5
Resolvin D1-d₅ is the deuterium labeled Resolvin D1. Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages[1][2].

Resolvin D1-d5

Resolvin D1-d₅ is the deuterium labeled Resolvin D1. Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages[1][2].

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actin polymerization

Inhibitors & Agonists

Screening Libraries

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