Search Result

Results for "

antiestrogenic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adhesion G Protein-coupled Receptors (AGPCRs) (1) Androgen Receptor (3) Apoptosis (2) Aryl Hydrocarbon Receptor (1) COX (3) Cytochrome P450 (4) Drug Metabolite (2) Endogenous Metabolite (3) Estrogen Receptor/ERR (38) HIF/HIF Prolyl-Hydroxylase (1) Isotope-Labeled Compounds (8) Mitochondrial Metabolism (2) Na+/K+ ATPase (2) Parasite (4) Potassium Channel (2) Progesterone Receptor (3) Reference Standards (3) Sodium Channel (2) Thyroid Hormone Receptor (3) VEGFR (1)
By Research Areas:	Cancer (27) Cardiovascular Disease (3) Endocrinology (24) Infection (4) Inflammation/Immunology (1) Metabolic Disease (8) Neurological Disease (2)

By Targets:

Adhesion G Protein-coupled Receptors (AGPCRs) (1)

Androgen Receptor (3)

Apoptosis (2)

Aryl Hydrocarbon Receptor (1)

COX (3)

Cytochrome P450 (4)

Drug Metabolite (2)

Endogenous Metabolite (3)

Estrogen Receptor/ERR (38)

HIF/HIF Prolyl-Hydroxylase (1)

Isotope-Labeled Compounds (8)

Mitochondrial Metabolism (2)

Na+/K+ ATPase (2)

Parasite (4)

Potassium Channel (2)

Progesterone Receptor (3)

Reference Standards (3)

Sodium Channel (2)

Thyroid Hormone Receptor (3)

VEGFR (1)

By Research Areas:

Cancer (27)

Cardiovascular Disease (3)

Endocrinology (24)

Infection (4)

Inflammation/Immunology (1)

Metabolic Disease (8)

Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113251

2-Hydroxyestrone 1 Publications Verification Catecholestrone	Endogenous Metabolite Estrogen Receptor/ERR	Endocrinology Cancer
2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic .

HY-N1507

Tracheloside	Estrogen Receptor/ERR	Cancer
Tracheloside is an antiestrogenic lignin. Tracheloside promotes keratinocyte proliferation through ERK1/2 stimulation. Tracheloside is a good candidate to promote wound healing .

HY-W087008

7-Hydroxyflavanone	Cytochrome P450	Endocrinology Cancer
7-Hydroxyflavanone is a potent inhibitor of aromatase (CYP19) activity with the IC₅₀ of 65 μM. 7-Hydroxyflavanone exerts various biological effects, including anticarcinogenic, antioxidant and (anti-)estrogenic effects, and modula

HY-B1617A

Zuclomiphene citrate 1 Publications Verification	Estrogen Receptor/ERR	Metabolic Disease Endocrinology
Zuclomiphene citrate is a cis isomer of Clomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent .

HY-123664

Trioxifene mesylate LY133314	Estrogen Receptor/ERR	Endocrinology
Trioxifene mesylate (LY133314) is an antiestrogenic compound. Trioxifene mesylate elicits mixed agonist-antagonist actions on estrogen target tissues .

HY-N3257

Millewanin G	Estrogen Receptor/ERR	Endocrinology
Millewanin G is a prenylated isoflavonoid with antiestrogenic activity (IC₅₀=29 μM). Millewanin G can be isolated from the leaves of M. pachycarpa cultivated in Japan .

HY-121441

Fispemifene	Estrogen Receptor/ERR	Inflammation/Immunology
Fispemifene, an orally active selective estrogen receptor modulator with anti-inflammatory and antiestrogenic action, attenuates glandular inflammation in an animal model of chronic nonbacterial prostatitis .

HY-147813

HIF-1α-IN-3	HIF/HIF Prolyl-Hydroxylase	Cancer
HIF-1α-IN-3 (Compound (S)-3f) is a hypoxia-selective HIF-1α inhibitor. HIF-1α-IN-3 shows strong antiestrogenic potency .

HY-N1507R

Tracheloside (Standard)	Reference Standards Estrogen Receptor/ERR	Cancer
Tracheloside (Standard) is the analytical standard of Tracheloside. This product is intended for research and analytical applications. Tracheloside is an antiestrogenic lignin. Tracheloside promotes keratinocyte proliferation through ERK1/2 stimulation. Tracheloside is a good candidate to promote wound healing .

HY-N11787

Cimicifuga racemosa extract	Estrogen Receptor/ERR	Metabolic Disease
Cimicifuga racemosa extract is a herbal remedy with antiestrogenic properties found in the plant Cimicifuga racemosa, commonly used to alleviate menopausal symptoms and relieve symptoms such as hot flashes and night sweats .

HY-121149

Droloxifene 1 Publications Verification 3-Hydroxytamoxifen	Estrogen Receptor/ERR Apoptosis	Cancer
Droloxifene, a Tamoxifen derivative, is an orally active and selective estrogen receptor modulator. Droloxifene shows antiestrogenic and anti-implantation effects. Droloxifene induces p53 expression and apoptosis in MCF-7 cells. Droloxifene prevents bone loss in ovariectomized rats .

HY-B2158

Chlorotrianisene	Estrogen Receptor/ERR COX	Cardiovascular Disease Endocrinology
Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood .

HY-13556

Arzoxifene LY353381; SERM III	Estrogen Receptor/ERR	Metabolic Disease Cancer
Arzoxifene (LY353381) is an orally active selective estrogen receptor modulator with a fixed ring structure similar to raloxifene. Arzoxifene has minimal side effects with powerful antiestrogenic effects on breast cancer and endometrium, with equally strong favorable estrogenic effects on bone and lipid profile .

HY-B2158R

Chlorotrianisene (Standard)	Reference Standards Estrogen Receptor/ERR COX	Cardiovascular Disease Endocrinology
Chlorotrianisene (Standard) is the analytical standard of Chlorotrianisene. This product is intended for research and analytical applications. Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood .

HY-119437

FLTX1 2 Publications Verification	Estrogen Receptor/ERR	Cancer
FLTX1 is a fluorescent Tamoxifen derivative that can specifically label intracellular Tamoxifen-binding sites (estrogen receptors) under permeabilized and non-permeabilized conditions. FLTX1 exhibits the potent antiestrogenic properties of Tamoxifen in breast cancer cells. FLTX1 is devoid of the estrogenic agonistic effect on the uterus .

HY-B1095

Chlormadinone acetate 1 Publications Verification	Progesterone Receptor	Endocrinology
Chlormadinone acetate is a steroidal progestin, with antiandrogen and antiestrogenic effects.

HY-B1095S2

Chlormadinone acetate-d3	Isotope-Labeled Compounds Progesterone Receptor	Endocrinology
Chlormadinone acetate-d₃ is the deuterium labeled Chlormadinone acetate. Chlormadinone acetate is a steroidal progestin, with antiandrogen and antiestrogenic effects .

HY-122411

Panomifene EGIS 5650; GYKI-13504	Estrogen Receptor/ERR	Cancer
Panomifene (EGIS 5650) is a tamoxifen (HY-13757A) analog with an antiestrogenic activity. Panomifene can be used in the research of breast cancer .

HY-18719D

Endoxifen (E-isomer) E-Endoxifen	Estrogen Receptor/ERR	Cancer
Endoxifen E-isomer (E-Endoxifen), an E-isomer of Endoxifen, is an impurity in Endoxifen Z-isomer agent substance. Endoxifen E-isomer exhibits antiestrogenic effects .

HY-18719A

Endoxifen Z-isomer hydrochloride 3 Publications Verification	Estrogen Receptor/ERR Potassium Channel	Cancer
Endoxifen Z-isomer hydrochloride is the most important Tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα).

HY-18719C

Endoxifen E-isomer hydrochloride E-Endoxifen hydrochloride	Estrogen Receptor/ERR	Cancer
Endoxifen E-isomer hydrochloride (E-Endoxifen hydrochloride), an E-isomer of Endoxifen, is an impurity in Endoxifen Z-isomer agent substance. Endoxifen E-isomer hydrochloride exhibits antiestrogenic effects .

HY-N3981

Guajadial	Others	Cancer
Guajadial, a caryophyllene-based meroterpenoid, has anti-estrogenic and anticancer effect. Guajadial reverses multidrug resistance in cancer. Guajadial can be isolated from Psidium guajava leaves .

HY-105634

Nomegestrol	Progesterone Receptor	Endocrinology Cancer
Nomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a K_d of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity.

HY-113251S

2-Hydroxyestrone-d4 Catecholestrone-d₄	Isotope-Labeled Compounds Endogenous Metabolite Estrogen Receptor/ERR	Endocrinology Cancer
2-Hydroxyestrone-d₄ is the deuterium labeled 2-Hydroxyestrone. 2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic .

HY-113251S1

2-Hydroxyestrone-13C6 Catecholestrone-¹³C₆	Isotope-Labeled Compounds Endogenous Metabolite Estrogen Receptor/ERR	Endocrinology Cancer
2-Hydroxyestrone- ¹³C₆ is the ¹³C-labeled 2-Hydroxyestrone. 2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic .

HY-N1581

Quassin Nigakilactone D	Parasite	Infection Endocrinology
Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits *P. falciparum* with an IC₅₀ of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity .

HY-148225

Fulvestrant 3-β-D-Glucuronide	Drug Metabolite	Cancer
Fulvestrant 3-β-D-Glucuronide, a metabolite, is glucuronide and sulfate conjugates of Fulvestrant (HY-13636), a pure anti-estrogenic steroid. Fulvestrant 3-β-D-Glucuronide can be used for the research of breast cancer .

HY-122411A

(E/Z)-Panomifene hydrochloride (E/Z)-EGIS 5650 hydrochloride; (E/Z)-GYKI-13504 hydrochloride	Estrogen Receptor/ERR	Cancer
(E/Z)-Panomifene (hydrochloride) is an orally active tamoxifen (TMX) (HY-13757A) analog. (E/Z)-Panomifene (hydrochloride) is a selective *anti-estrogenic* compound. (E/Z)-Panomifene (hydrochloride) has anti-tumor activity and can be used in breast cancer research .

HY-B1617AS

Zuclomiphene-d4 citrate	Estrogen Receptor/ERR	Metabolic Disease Endocrinology
Zuclomiphene-d₄ (citrate) is a deuterium labeled Zuclomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent .

HY-B2158S

Chlorotrianisene-d9	Isotope-Labeled Compounds Estrogen Receptor/ERR COX	Cardiovascular Disease Endocrinology
Chlorotrianisene-d₉ is the deuterium labeled Chlorotrianisene. Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood .

HY-18719

Endoxifen (Z-isomer) 3 Publications Verification	Estrogen Receptor/ERR Potassium Channel	Cancer
Endoxifen Z-isomer is an oral active Tamoxifen (HY-13757A) metabolite, inducing an anti-estrogenic effect in breast cancer cells expressing ERα. Endoxifen Z-isomer inhibits hERG. This effect is concentration-dependent, with an IC₅₀ value of 1.6 μM .

HY-117038

Anordiol	Estrogen Receptor/ERR	Endocrinology
Anordiol is an antiestrogenic compound with weak estrogenic activity. It can reduce the parameters of uterine growth (including uterine wet weight, soluble protein content, and DNA content) induced by estradiol in rats and can also regulate the estrous cycle in rats. Anordiol holds potential application value in the research of antiestrogen-related diseases .

HY-125263

OP-1074	Estrogen Receptor/ERR	Cancer
OP-1074, a pure anti-estrogen drug, is a selective ER degrader (PA-SERD) with specific anti-estrogenic activity against ERα and ERβ, inhibiting 17β-estradiol (E2)-stimulated transcription with IC₅₀ values of 1.6 and 3.2 nM, respectively.

HY-B1617AS2

Zuclomiphene d10 Citrate salt	Isotope-Labeled Compounds Estrogen Receptor/ERR	Metabolic Disease Endocrinology
Zuclomiphene d₁₀ Citrate salt is deuterium labeled Zuclomiphene (citrate). Zuclomiphene citrate is a cis isomer of Clomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent .

HY-N1581R

Quassin (Standard) Nigakilactone D (Standard)	Reference Standards Parasite	Infection Endocrinology
Quassin (Standard) is the analytical standard of Quassin. This product is intended for research and analytical applications. Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits P. falciparum with an IC₅₀ of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity .

HY-W106688

Triisopropyl phosphate	Estrogen Receptor/ERR	Endocrinology
Triisopropyl phosphate inhibits TFF1 and EGR3 gene expression, exhibits anti-estrogenic activity that inhibits Estradiol (HY-B0141)-induced MCF-7 cell proliferation with an EC₅₀ of 341 μM. Triisopropyl phosphate inhibits the estrogen response element (ERE)-stimulated luciferase activity in MVLN cells with an EC₅₀ of 900 μM .

HY-B1617AS1

Zuclomiphene-d5 citrate	Estrogen Receptor/ERR	Endocrinology
Zuclomiphene-d₅ (citrate) is the deuterium labeled Zuclomiphene citrate . Zuclomiphene citrate is a cis isomer of Clomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent .

HY-135671

AhR modulator-1	Aryl Hydrocarbon Receptor VEGFR Estrogen Receptor/ERR	Endocrinology Cancer
AhR modulator-1 (compound 6-MCDF) is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. AhR modulator-1 inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. AhR modulator-1 also possess anti-estrogenic properties in rat uterus .

HY-16023B

(Rac)-Acolbifene EM-343; (Rac)-EM-652	Estrogen Receptor/ERR	Cancer
(Rac)-Acolbifene (EM-343; (Rac)-EM-652) is the racemic form of EM652 (estrogen receptor?antagonist), has anti-estrogenic and estrogenic activities. (Rac)-Acolbifene (EM-343; (Rac)-EM-652) contains a piperidine ring, shows good pharmacological profile,relative binding affinity (RBA)=380 .

HY-B0887

Permethrin 1 Publications Verification NRDC-143	Parasite Mitochondrial Metabolism Sodium Channel Na+/K+ ATPase	Infection Neurological Disease
Permethrin (NRDC-143) is an insecticide, acaricide and a high selectively inhibitor of the Mitochondrial complex I, found in sediment and water samples. Permethrin shows *estrogenic* in vivo and anti-estrogenic activity in vitro. Permethrin also acts as a neurotoxin affecting neuron membranes by prolonging Sodium channel activation. Permethrin decreases resistance to bacterial infections in medaka (Oryzias latipes) .

HY-125263B

(R)-OP-1074	Estrogen Receptor/ERR	Cancer
(R)-OP-1074 is an isomer of OP-1074 (HY-125263) and can serve as a control compound in experiments. OP-1074, a pure anti-estrogen drug, is a selective ER degrader (PA-SERD) with specific anti-estrogenic activity against ERα and ERβ, inhibiting 17β-estradiol (E2)-stimulated transcription with IC₅₀ values of 1.6 and 3.2 nM, respectively.

HY-125091

LY2066948	Estrogen Receptor/ERR	Cancer
LY2066948 is a selective and orally active estrogen receptor modulator (SERM). LY2066948 has high affinity for estrogen receptors ERα and ERβ (K_i: 0.51 and 1.36 nM respectively) and shows potent antiestrogenic activity. LY2066948 blocks uterine weight gain induced by Ethynyl estradiol (HY-B0216) in immature rats. LY2066948 can be used for research of uterine fibroids and myomas .

HY-W774926

Permethrin-d6 NRDC-143-d₆	Isotope-Labeled Compounds Na+/K+ ATPase Parasite Sodium Channel Mitochondrial Metabolism	Infection Neurological Disease
Permethrin-d₆ (NRDC-143-d₆) is deuterium labeled Permethrin. Permethrin (NRDC-143) is an insecticide, acaricide and a high selectively inhibitor of the Mitochondrial complex I, found in sediment and water samples. Permethrin shows *estrogenic* in vivo and anti-estrogenic activity in vitro. Permethrin also acts as a neurotoxin affecting neuron membranes by prolonging Sodium channel activation. Permethrin decreases resistance to bacterial infections in medaka (Oryzias latipes) .

HY-16023

Acolbifene hydrochloride 2 Publications Verification EM-652 hydrochloride; SCH 57068 hydrochloride	Estrogen Receptor/ERR	Cancer
Acolbifene (EM-652) hydrochloride, an active metabolite of EM800, is an orally active, cancer-preventing *selective estrogen* receptor modulator (SERM)*. Acolbifene (EM-652) hydrochloride inhibits estradiol (E2)-induced transcriptional activity of ERα (IC₅₀=2 nM) and ERβ (IC₅₀=0.4 nM). Acolbifene (EM-652) hydrochloride exerts a potent and pure antiestrogenic* action in the mammary gland and uterus. Anticarcinogenic properties .

HY-B1234

Octinoxate Octyl methoxycinnamate	Androgen Receptor Estrogen Receptor/ERR Thyroid Hormone Receptor Cytochrome P450	Metabolic Disease Endocrinology
Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an *anti-estrogenic* and *anti-androgenic* effect in vitro and in vivo .

HY-16950A

(E/Z)-4-Hydroxytamoxifen 1 Publications Verification Afimoxifene; 4-OHT	Estrogen Receptor/ERR Adhesion G Protein-coupled Receptors (AGPCRs) Drug Metabolite	Metabolic Disease Cancer
(E/Z)-4-Hydroxytamoxifen (Afimoxifene) is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. (E/Z)-4-Hydroxytamoxifen is a selective estrogen receptor modulator with mixed estrogenic and antiestrogenic activity, which is also an active metabolite of Tamoxifen (HY-13757A). (E/Z)-4-Hydroxytamoxifen is an agonist of the G protein-coupled estrogen receptor (GPER) with relatively low affinity (100-1000 nM). (E/Z)-4-Hydroxytamoxifen is promising for research of cyclical mastalgia, such as breast pain, tenderness, and nodularity .

HY-121149B

(E/Z)-Droloxifene (E/Z)-3-Hydroxytamoxifen	Estrogen Receptor/ERR Apoptosis	Cancer
(E/Z)-Droloxifene is a mixture of (E)-droloxifene (a selective estrogen receptor modulator) and (Z)-droloxifene. (E)-Droloxifene binds to the estrogen receptor (ER) with an IC₅₀ value of 24 nM in rabbit uterine homogenates. (E)-Droloxifene increases uterine weight in immature rats, and reduces estradiol-induced increases in uterine weight in juvenile rats. (E)-Droloxifene also inhibits 17β-estradiol-stimulated growth of MCF-7, ZR-75-1, and T47D human breast cancer cells. (Z)-Droloxifene binds weakly to ER and has no estrogenic or antiestrogenic activity .

HY-B1234S

Octinoxate-13C,d3	Cytochrome P450 Thyroid Hormone Receptor Androgen Receptor Estrogen Receptor/ERR Isotope-Labeled Compounds	Metabolic Disease Endocrinology
Octinoxate-13C,d3 is the deuterium labeled Octinoxate (HY-W245806). Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an *anti-estrogenic* and *anti-androgenic* effect in vitro and in vivo .

HY-W713284

2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate	Isotope-Labeled Compounds Cytochrome P450 Estrogen Receptor/ERR Androgen Receptor Thyroid Hormone Receptor	Endocrinology
2-Ethylhexyl (E)-3-(4-(methoxy-d₃)phenyl)acrylate is the deuterium labeled Octinoxate (HY-B1234). Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113251

2-Hydroxyestrone 1 Publications Verification Catecholestrone	Structural Classification Other disease Classification of Application Fields Disease markers Endogenous metabolite Disease Research Fields Endocrinology Steroids Cancer	Endogenous Metabolite Estrogen Receptor/ERR
2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic .

HY-N1507

Tracheloside	Structural Classification other families Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Disease Research Fields Cancer	Estrogen Receptor/ERR
Tracheloside is an antiestrogenic lignin. Tracheloside promotes keratinocyte proliferation through ERK1/2 stimulation. Tracheloside is a good candidate to promote wound healing .

HY-W087008

7-Hydroxyflavanone	Dalbergia cochinchinensis Monophenols Source classification Papilionaceae Phenols Plants Disease Research Fields Endocrinology Cancer	Cytochrome P450
7-Hydroxyflavanone is a potent inhibitor of aromatase (CYP19) activity with the IC₅₀ of 65 μM. 7-Hydroxyflavanone exerts various biological effects, including anticarcinogenic, antioxidant and (anti-)estrogenic effects, and modula

HY-N1581

Quassin Nigakilactone D	Triterpenes Structural Classification Simaroubaceae Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Picrasma quassioides(D．Don)Benn． Endocrinology	Parasite
Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits *P. falciparum* with an IC₅₀ of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity .

HY-B1234

Octinoxate Octyl methoxycinnamate	Structural Classification Natural Products other families Classification of Application Fields Source classification Other Diseases Cosmetic Research Plants Disease Research Fields	Androgen Receptor Estrogen Receptor/ERR Thyroid Hormone Receptor Cytochrome P450
Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an *anti-estrogenic* and *anti-androgenic* effect in vitro and in vivo .

HY-N3257

Millewanin G	Structural Classification Flavonoids Leguminosae Millettia pachycarpa Benth. Source classification Plants Isoflavones	Estrogen Receptor/ERR
Millewanin G is a prenylated isoflavonoid with antiestrogenic activity (IC₅₀=29 μM). Millewanin G can be isolated from the leaves of M. pachycarpa cultivated in Japan .

HY-N1507R

Tracheloside (Standard)	Structural Classification other families Source classification Lignans Phenylpropanoids Plants	Reference Standards Estrogen Receptor/ERR
Tracheloside (Standard) is the analytical standard of Tracheloside. This product is intended for research and analytical applications. Tracheloside is an antiestrogenic lignin. Tracheloside promotes keratinocyte proliferation through ERK1/2 stimulation. Tracheloside is a good candidate to promote wound healing .

HY-N11787

Cimicifuga racemosa extract	Structural Classification Natural Products Ranunculaceae Source classification Cimicifuga foetida Linn. Plants	Estrogen Receptor/ERR
Cimicifuga racemosa extract is a herbal remedy with antiestrogenic properties found in the plant Cimicifuga racemosa, commonly used to alleviate menopausal symptoms and relieve symptoms such as hot flashes and night sweats .

HY-N3981

Guajadial	Structural Classification Natural Products Source classification Psidium guajava Linn. Myrtaceae Plants	Others
Guajadial, a caryophyllene-based meroterpenoid, has anti-estrogenic and anticancer effect. Guajadial reverses multidrug resistance in cancer. Guajadial can be isolated from Psidium guajava leaves .

HY-N1581R

Quassin (Standard) Nigakilactone D (Standard)	Triterpenes Structural Classification Simaroubaceae Terpenoids Source classification Plants Picrasma quassioides(D．Don)Benn．	Reference Standards Parasite
Quassin (Standard) is the analytical standard of Quassin. This product is intended for research and analytical applications. Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits P. falciparum with an IC₅₀ of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity .

HY-16950A

(E/Z)-4-Hydroxytamoxifen 1 Publications Verification Afimoxifene; 4-OHT	Structural Classification Alkaloids Monophenols Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields Cancer	Estrogen Receptor/ERR Adhesion G Protein-coupled Receptors (AGPCRs) Drug Metabolite
(E/Z)-4-Hydroxytamoxifen (Afimoxifene) is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. (E/Z)-4-Hydroxytamoxifen is a selective estrogen receptor modulator with mixed estrogenic and antiestrogenic activity, which is also an active metabolite of Tamoxifen (HY-13757A). (E/Z)-4-Hydroxytamoxifen is an agonist of the G protein-coupled estrogen receptor (GPER) with relatively low affinity (100-1000 nM). (E/Z)-4-Hydroxytamoxifen is promising for research of cyclical mastalgia, such as breast pain, tenderness, and nodularity .

Cat. No.	Product Name	Chemical Structure

HY-113251S

2-Hydroxyestrone-d4
2-Hydroxyestrone-d₄ is the deuterium labeled 2-Hydroxyestrone. 2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic .

HY-B1617AS

Zuclomiphene-d4 citrate
Zuclomiphene-d₄ (citrate) is a deuterium labeled Zuclomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent .

HY-W713284

2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate

2-Ethylhexyl (E)-3-(4-(methoxy-d₃)phenyl)acrylate is the deuterium labeled Octinoxate (HY-B1234). Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo .

HY-B1095S2

Chlormadinone acetate-d3
Chlormadinone acetate-d₃ is the deuterium labeled Chlormadinone acetate. Chlormadinone acetate is a steroidal progestin, with antiandrogen and antiestrogenic effects .

HY-113251S1

2-Hydroxyestrone-13C6
2-Hydroxyestrone- ¹³C₆ is the ¹³C-labeled 2-Hydroxyestrone. 2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic .

HY-B2158S

Chlorotrianisene-d9
Chlorotrianisene-d₉ is the deuterium labeled Chlorotrianisene. Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood .

HY-B1617AS2

Zuclomiphene d10 Citrate salt
Zuclomiphene d₁₀ Citrate salt is deuterium labeled Zuclomiphene (citrate). Zuclomiphene citrate is a cis isomer of Clomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent .

HY-B1617AS1

Zuclomiphene-d5 citrate
Zuclomiphene-d₅ (citrate) is the deuterium labeled Zuclomiphene citrate . Zuclomiphene citrate is a cis isomer of Clomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent .

HY-W774926

Permethrin-d6

Permethrin-d₆ (NRDC-143-d₆) is deuterium labeled Permethrin. Permethrin (NRDC-143) is an insecticide, acaricide and a high selectively inhibitor of the Mitochondrial complex I, found in sediment and water samples. Permethrin shows estrogenic in vivo and anti-estrogenic activity in vitro. Permethrin also acts as a neurotoxin affecting neuron membranes by prolonging Sodium channel activation. Permethrin decreases resistance to bacterial infections in medaka (Oryzias latipes) .

HY-B1234S

Octinoxate-13C,d3

Octinoxate-13C,d3 is the deuterium labeled Octinoxate (HY-W245806). Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

antiestrogenic

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products