Search Result
Results for "
antitussive
" in MedChemExpress (MCE) Product Catalog:
1
Biochemical Assay Reagents
3
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-B1032
-
|
(±)-Dropropizine; UCB-196
|
Others
|
Neurological Disease
|
|
Dropropizine ((±)-Dropropizine) belongs to the phenylpiperazine group of organic compounds. Dropropizine is a peripheral antitussive agent that acts by inhibiting cough reflex through its action on the peripheral receptors and their afferent conductors .
|
-
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- HY-B1895
-
-
-
- HY-B2090
-
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SKF 70230A; SQ 15874; Pipazetate
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GABA Receptor
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Others
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Pipazethate (SKF 70230A), a pyridobenzothiazine derivative, is a potent GABA antagonist. Pipazethate has antitussive activity. Pipazethate can be used in research in cough supressant .
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- HY-N10620
-
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Others
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Inflammation/Immunology
|
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Melitidin is a flavanone glycoside, that can be isolated from Citrus grandis 'Tomentosa'. Melitidin shows a good antitussive effect on cough induced by citric acid in Guinea pig .
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- HY-N7600
-
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25-Epieduardine; Puqiedinone
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Others
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Others
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Zhebeirine (Puqiedinone), a steroidal alkaloid, is isolated from the bulbs of Fritillaria puqiensis. Zhebeirine exhibits antitussive and expectorant properties .
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- HY-106495
-
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OR K-242
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Others
|
Neurological Disease
|
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Vadocaine (OR K-242), an orally active antitussive compound, is a local agent that can suppress or relieve pain .
|
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- HY-121644
-
-
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- HY-134006
-
-
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- HY-B1895R
-
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Histamine Receptor
|
Neurological Disease
Inflammation/Immunology
Endocrinology
|
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Levodropropizine (Standard) is the analytical standard of Levodropropizine. This product is intended for research and analytical applications. Levodropropizine (DF-526) is an orally active histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive agent .
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- HY-A0161
-
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Clofedanol; Calmotusin; NSC 113595
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Others
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Infection
|
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Chlophedianol (Clofedanol) is an orally active and potent antitussive agent. Chlophedianol can be used for the research of acute cough due to upper respiratory tract infections (URIs) .
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- HY-N3197
-
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(+)-Neostenine
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P-glycoprotein
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Cancer
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Neostenine is a stenine-type Stemona alkaloid, with antitussive activity. Neostenine is also a substrate of P-glycoprotein with high absorptive permeability in Caco-2 monolayer model. Neostenine also shows oral activity for intestinal application .
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- HY-121685
-
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Potassium Channel
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Neurological Disease
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Tipepidine reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine subsequently activates VTA dopamine neuron . Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect .
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- HY-A0161A
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Clofedanol hydrochloride; Calmotusin hydrochloride; NSC 113595 hydrochloride
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Others
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Infection
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Chlophedianol (Clofedanol) hydrochloride is an orally active and potent antitussive agent. Chlophedianol hydrochloride can be used for the research of acute cough due to upper respiratory tract infections (URIs) .
|
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- HY-13716
-
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(S,R)-Noscapine
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Opioid Receptor
Apoptosis
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Neurological Disease
Inflammation/Immunology
Cancer
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Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .
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- HY-B1551
-
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Benzononatine
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Sodium Channel
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Neurological Disease
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Benzonatate (Benzononatine) is a peripheral oral antitussive that dampens the activity of cough stretch receptors. Benzonatate has sodium channel-blocking properties and local anesthetic effects on the respiratory stretch receptors due to a tetracaine-like metabolite .
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- HY-13716R
-
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Opioid Receptor
Apoptosis
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Neurological Disease
Inflammation/Immunology
Cancer
|
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Noscapine (Standard) is the analytical standard of Noscapine. This product is intended for research and analytical applications. Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier [4] .
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- HY-B2078A
-
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Neurokinin Receptor
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Inflammation/Immunology
|
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Eprazinone dihydrochloride is a gent with mucolytic, secretolytic, antitussive, and bronchial antispasmodic properties. Eprazinone dihydrochloride is a neurokinin 1 receptor (NK1R) ligand. Eprazinone dihydrochloride has the potential for chronic bronchitis treatment that improved pulmonary function and arterial partial pressure of oxygen .
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- HY-106756
-
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U-62066
|
Opioid Receptor
|
Neurological Disease
|
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Spiradoline (U-62066), an arylacetamide, is a selective kappa opioid receptor (KOR) agonist with a Ki of 8.6 nM in guinea pig. The Ki values of Spiradoline for μ and δ receptors are 252 nM and 9400 nM, respectively. Spiradoline has potent diuretic, analgesic, antiarrythmic, antitussive, neuroprotective properties and easily penetrates the blood-brain barrier .
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- HY-124959
-
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U-62066 mesylate
|
Opioid Receptor
|
Neurological Disease
|
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Spiradoline mesylate (U-62066 mesylate), an arylacetamide, is a selective kappa opioid receptor (KOR) agonist with a Ki of 8.6 nM in guinea pig. The Ki values of Spiradoline mesylate for μ and δ receptors are 252 nM and 9400 nM, respectively. Spiradoline mesylate has potent diuretic, analgesic, antiarrythmic, antitussive, neuroprotective properties and easily penetrates the blood-brain barrier .
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- HY-114723
-
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Others
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Others
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NPD9948 is an antitussive agent with antitussive activity in a guinea pig antitussive test. Its half antitussive dose (AtD50) is 14.5 mg/kg and 22.6 mg/kg when injected intraperitoneally and orally, respectively.
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- HY-101828
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-
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- HY-N3945R
-
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Phosphodiesterase (PDE)
Calcium Channel
Adrenergic Receptor
Dopamine Receptor
Influenza Virus
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Infection
Inflammation/Immunology
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Glaucine (Standard) is the analytical standard of Glaucine. This product is intended for research and analytical applications. Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with Kis of 3.4 μM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a Ca2+ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities .
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- HY-B2215
-
-
-
- HY-N3163
-
-
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- HY-B0505
-
-
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- HY-106372A
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-
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- HY-N1471
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-
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- HY-N8197
-
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Others
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Cancer
|
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Epigambogic acid is a natural anti-tumor, antitussive, expectorant and anti-inflammatory compound .
|
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- HY-134004
-
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Carbetapentane
|
Sigma Receptor
mAChR
|
Neurological Disease
Inflammation/Immunology
|
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Pentoxyverine (Carbetapentane) is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membran σ1, respectively. Pentoxyverine is a muscarinic antagonist. Pentoxyverine is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance .
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- HY-N0413
-
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Others
|
Inflammation/Immunology
|
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Hupehenine, a bioactive isosteroidal alkaloid, is a main antitussive components present in most of Fritillaria hupehensis .
|
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- HY-B1055
-
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Carbetapentane citrate
|
Sigma Receptor
mAChR
|
Neurological Disease
Inflammation/Immunology
|
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Pentoxyverine (Carbetapentane) citrate is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membrane σ1, respectively. Pentoxyverine citrate is a muscarinic antagonist. Pentoxyverine citrate is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine citrate can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance .
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- HY-134004R
-
|
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Sigma Receptor
mAChR
|
Neurological Disease
Inflammation/Immunology
|
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Pentoxyverine (Standard) is the analytical standard of Pentoxyverine. This product is intended for research and analytical applications. Pentoxyverine (Carbetapentane) is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membran σ1, respectively. Pentoxyverine is a muscarinic antagonist. Pentoxyverine is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance .
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- HY-106873
-
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Others
|
Others
|
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Nepinalone, an alchilaminate derivative of β-tetralone and an orally active cough suppressant, possesses a non-opioid antitussive activity .
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- HY-106873A
-
|
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Others
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Others
|
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Nepinalone hydrochloride, an alchilaminate derivative of β-tetralone and an orally active cough suppressant, possesses a non-opioid antitussive activity .
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- HY-128418
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-
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- HY-B1055R
-
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Sigma Receptor
mAChR
|
Neurological Disease
Inflammation/Immunology
|
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Pentoxyverine (citrate) (Standard) is the analytical standard of Pentoxyverine (citrate). This product is intended for research and analytical applications. Pentoxyverine (Carbetapentane) citrate is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membrane σ1, respectively. Pentoxyverine citrate is a muscarinic antagonist. Pentoxyverine citrate is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine citrate can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance [4].
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- HY-N3196
-
|
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Bacterial
|
Infection
Inflammation/Immunology
|
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Neotuberostemonine, one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages .
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- HY-W742300
-
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SKF 70230A hydrochloride; SQ 15874 hydrochloride; Pipazetate hydrochloride
|
GABA Receptor
|
Inflammation/Immunology
|
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Pipazethate (SKF 70230A; SQ 15874) hydrochloride is a potent GABA antagonist. Pipazethate hydrochloride shows antitussive activity and can be used in research in cough suppressant .
|
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- HY-148144
-
-
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- HY-148144A
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-
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- HY-B1895S
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-
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- HY-13716S
-
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Isotope-Labeled Compounds
Apoptosis
Opioid Receptor
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Cancer
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Noscapine-13C,d3 is a deuterated labeled Noscapine . Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .
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- HY-W354753
-
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mAChR
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Others
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Homatropine hydrochloride is an orally active anticholinergic agent that rapidly dilates pupils and has cycloplegic effects. Homatropine hydrochloride also has antitussive activity. Homatropine hydrochloride can be used in research on eye diseases and coughs .
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- HY-N0808
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Camphor
2 Publications Verification
(±)-Camphor
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TRP Channel
Influenza Virus
|
Infection
Inflammation/Immunology
Cancer
|
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Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities . Camphor is a TRPV3 agonist .
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- HY-121388
-
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(+)-Ledol
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Fungal
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Infection
|
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Ledol ((+)-Ledol) is an antifungal agent that can be isolated from the essential oil fractions of Rhododendron tomentosum. Ledol is also the expectorant and antitussive agent, which is simultaneously responsible for adverse reactions such as dizziness, nausea and vomiting .
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- HY-B1038
-
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Others
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Inflammation/Immunology
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L-Cysteine methyl ester hydrochloride is an antitussive, phlegmolytic agent used to relieve breathing difficulties caused by large amounts of phlegm. L-Cysteine methyl ester hydrochloride is a copper corrosion inhibitor used in various industrial studies .
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- HY-B1032R
-
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(±)-Dropropizine (Standard); UCB-196 (Standard)
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Others
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Neurological Disease
|
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Dropropizine (Standard) is the analytical standard of Dropropizine. This product is intended for research and analytical applications. Dropropizine ((±)-Dropropizine) is a peripheral antitussive agent that acts by inhibiting cough reflex through its action on the peripheral receptors and their afferent conductors .
|
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- HY-N1377
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-
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- HY-N0829
-
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Others
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Inflammation/Immunology
|
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Shionone is the major triterpenoid isolated from Aster tataricus, has anti-tussive, anti-inflammatory activities . Shionone possesses a unique six-membered tetracyclic skeleton and 3-oxo-4-monomethyl structure .
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- HY-N10824
-
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Others
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Others
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2,3,5,6-Tetramethoxyaporphine is an antitussive agent, a medicinally valuable benzyl isoquinoline alkaloid. 2,3,5,6-Tetramethoxyaporphine can be isolated from the yellow hornpoppy, Glaucium flavum Cr. (Fam. Papaveraceae) .
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- HY-121685A
-
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Potassium Channel
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Neurological Disease
|
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Tipepidine hydrochloride reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine hydrochloride subsequently activates VTA dopamine neuron . Tipepidine hydrochloride, a non-narcotic antitussive, exerts an antidepressant-like effect .
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- HY-A0161S
-
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Clofedanol-13C6; Calmotusin-13C6; NSC 113595-13C6
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Isotope-Labeled Compounds
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Infection
|
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Chlophedianol- 13C6 is the 13C labeled Chlophedianol (HY-A0161). Chlophedianol is an orally active and potent antitussive agent. Chlophedianol can be used for the research of acute cough due to upper respiratory tract infections (URIs)[1][2][3].
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- HY-N0808R
-
|
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TRP Channel
Influenza Virus
|
Infection
Inflammation/Immunology
Cancer
|
|
Camphor (Standard) is the analytical standard of Camphor. This product is intended for research and analytical applications. Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities . Camphor is a TRPV3 agonist .
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- HY-N1377R
-
|
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Carboxylesterase
Bacterial
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Infection
Metabolic Disease
Inflammation/Immunology
|
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Nevadensin (Standard) is the analytical standard of Nevadensin. This product is intended for research and analytical applications. Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1 (hCE1) with an IC50 of 2.64 μM. Nevadensin has a variety of pharmacological effects such as anti-mycobacterium tuberculosis activities, antitussive, anti-inflammatory and anti-hypertensive .
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- HY-136026
-
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BLU-5937
|
P2X Receptor
|
Inflammation/Immunology
|
|
Camlipixant (BLU-5937) a potent, selective, non-competitive and orally active P2X3 homotrimeric receptor antagonist with an IC50 of 25 nM against hP2X3 homotrimeric. Camlipixant shows potent anti-tussive effect and no taste alteration. Camlipixant can be used for the research of unexplained, refractory chronic cough .
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- HY-103212A
-
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B-HT 933 hydrochloride; Oxazoloazepin hydrochloride
|
Adrenergic Receptor
|
Cardiovascular Disease
|
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Azepexole hydrochloride (B-HT 933 dihydrochloride; Oxazoloazepin dihydrochloride) is a selective agonist for α 2-adrenoceptor, with pKi of 8.3, 7.6, and 7.5 for α2A-, α2B- and α2C-adrenoceptor subtypes, resepctively. Azepexole dihydrochloride causes concentration-dependent inhibition of peristaltic contractions with IC50 of 78.72 nM. Azepexole hydrochloride exhibits antitussive and analgesic efficacy .
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- HY-N3945
-
|
O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396
|
Phosphodiesterase (PDE)
Calcium Channel
MMP
NF-κB
|
Inflammation/Immunology
Cancer
|
|
Glaucine (O,O-Dimethylisoboldine) is an alkaloid extracted from Glaucium flavum that possesses various activities, including cough relief, bronchodilation, anti-inflammatory effects, analgesia, antipyretic properties, and anticancer effects. Glaucine acts as a selective and orally active inhibitor of phosphodiesterase 4 (PDE4), with a Ki of 3.4 µM in human bronchial tissues and polymorphonuclear leukocytes. Glaucine induces relaxation of human isolated bronchi by antagonizing calcium channels. Additionally, Glaucine inhibits the activation of NF-κB, leading to a reduction in the expression of the MMP-9 gene, thereby suppressing the migration and invasion of breast cancer cells. Therefore, Glaucine holds potential for research in asthma and breast cancer .
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- HY-135976
-
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P2X Receptor
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Neurological Disease
Inflammation/Immunology
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P2X3 antagonist 34 is a potent, selective and orally active P2X3 homotrimeric receptor antagonist with IC50s of 25 nM, 92 nM and 126 nM for human P2X3, rat P2X3 and guinea pig P2X3 receptors, respectively. P2X3 antagonist 34 is less active against human, rat and guinea pig P2X2/3 heterotrimeric receptors. P2X3 antagonist 34 has strong anti-tussive effect .
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-
| Cat. No. |
Product Name |
Type |
-
- HY-W354753
-
|
|
Biochemical Assay Reagents
|
|
Homatropine hydrochloride is an orally active anticholinergic agent that rapidly dilates pupils and has cycloplegic effects. Homatropine hydrochloride also has antitussive activity. Homatropine hydrochloride can be used in research on eye diseases and coughs .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-N10620
-
-
-
- HY-N7600
-
-
-
- HY-13716
-
-
-
- HY-N3163
-
-
-
- HY-N1471
-
-
-
- HY-134006
-
-
-
- HY-N3197
-
-
-
- HY-13716R
-
|
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Structural Classification
Alkaloids
Source classification
Quinoline Alkaloids
Papaver somniferum Linn.
Plants
Papaveraceae
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Opioid Receptor
Apoptosis
|
|
Noscapine (Standard) is the analytical standard of Noscapine. This product is intended for research and analytical applications. Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier [4] .
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-
-
- HY-N3945R
-
-
-
- HY-N8197
-
-
-
- HY-N0413
-
-
-
- HY-N3196
-
-
-
- HY-N0808
-
-
-
- HY-121388
-
-
-
- HY-N1377
-
-
-
- HY-N0829
-
-
-
- HY-N10824
-
-
-
- HY-N0808R
-
-
-
- HY-N1377R
-
-
-
- HY-N3945
-
|
O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396
|
Infection
Alkaloids
Structural Classification
other families
Classification of Application Fields
Source classification
Plants
Isoquinoline Alkaloids
Glaucium flavum
Inflammation/Immunology
Disease Research Fields
Papaveraceae
|
Phosphodiesterase (PDE)
Calcium Channel
MMP
NF-κB
|
|
Glaucine (O,O-Dimethylisoboldine) is an alkaloid extracted from Glaucium flavum that possesses various activities, including cough relief, bronchodilation, anti-inflammatory effects, analgesia, antipyretic properties, and anticancer effects. Glaucine acts as a selective and orally active inhibitor of phosphodiesterase 4 (PDE4), with a Ki of 3.4 µM in human bronchial tissues and polymorphonuclear leukocytes. Glaucine induces relaxation of human isolated bronchi by antagonizing calcium channels. Additionally, Glaucine inhibits the activation of NF-κB, leading to a reduction in the expression of the MMP-9 gene, thereby suppressing the migration and invasion of breast cancer cells. Therefore, Glaucine holds potential for research in asthma and breast cancer .
|
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| Cat. No. |
Product Name |
Chemical Structure |
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- HY-B1895S
-
|
|
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Levodropropizine-d8 is deuterium labeled Levodropropizine. Levodropropizine (DF-526) is a histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive agent.
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-
-
- HY-13716S
-
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|
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Noscapine-13C,d3 is a deuterated labeled Noscapine . Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .
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-
- HY-A0161S
-
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|
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Chlophedianol- 13C6 is the 13C labeled Chlophedianol (HY-A0161). Chlophedianol is an orally active and potent antitussive agent. Chlophedianol can be used for the research of acute cough due to upper respiratory tract infections (URIs)[1][2][3].
|
-
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