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Results for "

crosslinking agent

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (5) Apoptosis (10) Autophagy (1) Biochemical Assay Reagents (9) Cholinesterase (ChE) (2) DNA Alkylator/Crosslinker (23) DNA/RNA Synthesis (1) Drug Metabolite (1) Drug-Linker Conjugates for ADC (2) E1/E2/E3 Enzyme (1) Endogenous Metabolite (1) Ferroptosis (1) FKBP (1) Fluorescent Dye (1) Isotope-Labeled Compounds (3) Lipoxygenase (1) Pyroptosis (1)
By Research Areas:	Cancer (31) Inflammation/Immunology (2) Neurological Disease (2)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W012887

Oxalyldihydrazide	Biochemical Assay Reagents	Others
Oxalyldihydrazide is a crosslinking agent in proteomics research. Oxalyldihydrazide can capture carbonylated proteins on the surface of a microchip .

HY-W010756

FMOC-AM	Others	Others
FMOC-AM is a protein cross-linking agent.

HY-W017831

2-Maleimido acetic acid	Others	Others
2-Maleimido acetic acid is a protein cross-linking agent.

HY-W009034

Fmoc-Suberol	Others	Others
Fmoc-Suberol is a protein cross-linking agent.

HY-159008

NHSF	Biochemical Assay Reagents	Others
NHSF is a protein cross-linking agent .

HY-W011123

N-Succinimidyl 4-[4-maleimidophenyl]butyrate	DNA Alkylator/Crosslinker	Cancer
N-Succinimidyl 4-[4-maleimidophenyl]butyrate is a crosslinking agent.

HY-139635

Anticancer agent 11	DNA Alkylator/Crosslinker	Cancer
Anticancer agent 11 is a broad-spectrum anticancer agent that inhibits angiogenesis and induces DNA cross-links.

HY-130170

Disuccinimidyl tartrate Di(N-succinimidyl) L-tartrate	DNA Alkylator/Crosslinker	Cancer
Disuccinimidyl tartrate (Di(N-succinimidyl) L-tartrate) is a crosslinking agent.

HY-W040113

6-(N-Boc)caproic acid NHS	Others	Others
6-(N-Boc)caproic acid NHS is a protein cross-linking agent.

HY-130545

3-(Pyridin-2-yldisulfanyl)propanehydrazide	DNA Alkylator/Crosslinker	Cancer
3-(Pyridin-2-yldisulfanyl)propanehydrazide is a crosslinking agent.

HY-76214

Dibenzyl hydrazodicarboxylate Dibenzyl hydrazine-1,2-dicarboxylate	Others	Others
Dibenzyl hydrazodicarboxylate (Dibenzyl hydrazine-1,2-dicarboxylate) is a protein cross-linking agent.

HY-W013538

1,2-Bis(maleimido)ethane N,N'-Ethylenedimaleimide	Others	Others
1,2-Bis(maleimido)ethane (N,N'-Ethylenedimaleimide) is a protein cross-linking agent.

HY-D1423

Dibromobimane	Fluorescent Dye	Others
Dibromobimane is a thiol-selective fluorescent imaging agent. Dibromobimane is used to crosslink cysteine- and homocysteine-containing peptides .

HY-101127

SGD-1882 PBD dimer	ADC Cytotoxin	Cancer
SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.

HY-138287

4'-Aminomethyl-4,5',8-trimethylpsoralen	Biochemical Assay Reagents	Others
4'-Aminomethyl-4,5',8-trimethylpsoralen is a photoreactive agent for crosslinking nucleic acids .

HY-W008575

N-Fmoc-N-methoxy-3-aminopropionic acid	Others	Others
N-Fmoc-N-methoxy-3-aminopropionic acid, a Weinreb amide linker, is a protein cross-linking agent .

HY-117112

Hexamethoxymethylmelamine Hexakis(methoxymethyl)melamine; HMMM	Biochemical Assay Reagents	Others
Hexamethoxymethylmelamine (Hexakis(methoxymethyl)melamine; HMMM) is a crosslinking agent, which can be used with polyester resins to produce thermosetting coating .

HY-13567S

Bendamustine-d4 SDX-105-d₄ free base	Isotope-Labeled Compounds DNA Alkylator/Crosslinker	Cancer
Bendamustine-d₄ is the deuterium labeled Bendamustine. Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties.

HY-14573

SJG-136 2 Publications Verification NSC-694501	DNA Alkylator/Crosslinker ADC Cytotoxin	Cancer
SJG-136 is a DNA cross-linking agent, with an XL₅₀ of 45 nM for pBR322 DNA. SJG-136 has potent antitumor activity.

HY-B0245

Busulfan 10+ Cited Publications	DNA Alkylator/Crosslinker Apoptosis	Inflammation/Immunology Cancer
Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

HY-17394

Cisplatin Maximum Cited Publications 464 Publications Verification cis-Platinum; CDDP; cis-Diaminodichloroplatinum	DNA Alkylator/Crosslinker Ferroptosis Autophagy Pyroptosis Lipoxygenase	Cancer
Cisplatin (CDDP) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates ferroptosis and induces autophagy .

HY-16046

Rimiducid 30+ Cited Publications AP1903	FKBP Apoptosis	Cancer
Rimiducid (AP1903) is a dimerizer agent that acts by cross-linking the FKBP domains. Rimiducid (AP1903) dimerizes the Caspase 9 suicide switch and rapidly induces apoptosis.

HY-101162

SGD-1910	Drug-Linker Conjugates for ADC	Cancer
SGD-1910 is a agent-linker conjugate for ADC by using the antitumor antibiotic, pyrrolobenzodiazepine (PBD, a cytotoxic DNA crosslinking), linked via the cleavable linker MC-Val-Ala .

HY-B0245S

Busulfan-d8	DNA Alkylator/Crosslinker Apoptosis	Inflammation/Immunology Cancer
Busulfan-d₈ is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent[1][2][3].

HY-B0077

Bendamustine hydrochloride 4 Publications Verification SDX-105	DNA Alkylator/Crosslinker Apoptosis	Cancer
Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .

HY-111397

Bizelesin NSC 615291; U-77779	DNA Alkylator/Crosslinker	Cancer
Bizelesin (NSC 615291; U-77779) is an AT-specific DNA alkylating agent that can generate DNA interstrand crosslinks, effectively inhibit DNA replication, and has potential anticancer activity .

HY-W106487

(+)-N,N'-Diallyl-L-tartardiamide	Biochemical Assay Reagents	Others
(+)-N,N'-Diallyl-L-tartardiamide is a cross-linking agent used in the preparation of hydrogels. (+)-N,N'-Diallyl-L-tartardiamide is a kind of biological materials or organic compounds that are widely used in life science research .

HY-136610

Chlorpyrifos-oxon	Cholinesterase (ChE)	Neurological Disease
Chlorpyrifos-oxon, an active metabolite of Chlorpyrifos, is a potent phosphorylating agent that potently inhibits AChE. Chlorpyrifos-oxon can induce cross-linking between subunits of tubulin and disrupt microtubule function .

HY-13567

Bendamustine 4 Publications Verification SDX-105 free base	DNA Alkylator/Crosslinker Apoptosis	Cancer
Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties .

HY-402091

SJG-136 intermediate-1	ADC Cytotoxin	Others
SJG-136 intermediate-1 (compound 19) is an intermediate for synthesizing SJG-136. SJG-136 is a DNA cross-linking agent, with an XL₅₀ of 45 nM for pBR322 DNA .

HY-402090

SJG-136 intermediate-2	ADC Cytotoxin	Others
SJG-136 intermediate-2 (compound 141) is an intermediate for synthesizing SJG-136. SJG-136 is a DNA cross-linking agent, with an XL₅₀ of 45 nM for pBR322 DNA .

HY-13703A

Nimustine hydrochloride 1 Publications Verification ACNU	DNA/RNA Synthesis DNA Alkylator/Crosslinker Apoptosis	Cancer
Nimustine hydrochloride (ACNU) is a DNA cross-linking and DNA alkylating agent, which induces DNA replication blocking lesions and DNA double-strand breaks and inhibits DNA synthesis, commonly used in chemotherapy for glioblastomas .

HY-126539

UBE2T/FANCL-IN-1	E1/E2/E3 Enzyme	Cancer
UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation that sensitizes cells to the DNA cross-linking agent, Carboplatin .

HY-W105731

1,10-Diiododecane Decamethylene diiodide	Others	Others
1,10-Diiododecane (Decamethylene diiodide) serves as a crosslinking reagent for tetrabutylammonium polygalacturonic acid and acts as an alkylating agent in the synthesis of both symmetrical and unsymmetrical bis-cryptophanes, in addition to being utilized for the production of decane at a temperature of 20°C.

HY-B0077S1

Bendamustine-d8 hydrochloride SDX-105-d₈	Isotope-Labeled Compounds DNA Alkylator/Crosslinker Apoptosis	Cancer
Bendamustine-d₈ (hydrochloride) is deuterium labeled Bendamustine (hydrochloride). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties[1].

HY-114577

Palifosfamide tromethamine Isophosphoramide mustard tromethamine; IPM tromethamine; ZIO-201 tromethamine	DNA Alkylator/Crosslinker	Cancer
Palifosfamide (tromethamine) is a synthetic alkylating agent with potential antineoplastic activity. As the stabilized active metabolite of ifosfamide, palifosfamide (tromethamine) irreversibly alkylates and crosslinks DNA through GC base pairs. This leads to an inhibition of DNA replication and ultimately cell death. Compared to ifosfamide, palifosfamide (tromethamine) is less toxic.

HY-B0077R

Bendamustine hydrochloride (Standard)	DNA Alkylator/Crosslinker Apoptosis	Cancer
Bendamustine (hydrochloride) (Standard) is the analytical standard of Bendamustine (hydrochloride). This product is intended for research and analytical applications. Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .

HY-16406

PR-104 sodium	DNA Alkylator/Crosslinker	Cancer
PR-104 (sodium) is a selective hypoxia-activated DNA cross-linking agent and can be used for the research of multiple tumor xenograft models. PR-104 (sodium), as a nitrogen mustard pre-proagent, is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A .

HY-16405

PR-104	DNA Alkylator/Crosslinker	Cancer
PR-104 is a selective hypoxia-activated DNA cross-linking agent and can be used for the research of multiple tumor xenograft models. PR-104, as a nitrogen mustard pre-proagent, is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A .

HY-147740

WEHI-150	DNA Alkylator/Crosslinker	Cancer
WEHI-150 is a replica of mitoxantrone, is a portent DNA interstrand crosslinkagent with an adduct half-lives of 12.5 h. WEHI-150 forms covalent adducts at CpG sequences and exhibits a preference for methylated CpG sites. Formaldehyde-activated WEHI-150 induces DNA interstrand crosslinks. Formaldehyde-activated WEHI-150 shows Concentration-dependent transcription blockages. WEHI-150 can mediate covalent adducts that are independent of interactions with the N-2 of guanine and is capable of adduct formation at novel DNA sequences .

HY-136610S

Chlorpyrifos-oxon-d10	Cholinesterase (ChE)	Neurological Disease
Chlorpyrifos-oxon-d₁₀ is the deuterium labeled Chlorpyrifos-oxon. Chlorpyrifos-oxon, an active metabolite of Chlorpyrifos, is a potent phosphorylating agent that potently inhibits AChE. Chlorpyrifos-oxon can induce cross-linking between subunits of tubulin and disrupt microtubule function[1][2][3][4].

HY-13567S1

Bendamustine-d8 SDX-105-d₈ free base	DNA Alkylator/Crosslinker Apoptosis	Cancer
Bendamustine-d₈ is the deuterium labeled Bendamustine[1]. Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties[2].

HY-117909

CEP-40125 RXDX-107	Apoptosis	Cancer
CEP-40125 (RXDX-107) is a modified form of Bendamustine (HY-13567), a DNA cross-linking agent that may cause DNA damage and cell apoptosis. CEP-40125 (RXDX-107) is formed by encapsulating the alkyl ester form of Bendamustine in human serum albumin .

HY-W051391

1,4,7-Trimethyl-1,4,7-triazonane Me3TACN	Biochemical Assay Reagents	Others
1,4,7-Trimethyl-1,4,7-triazonane, also known as TMT or trimethylenetris(aziridine), is a cyclic organic compound. TMT is commonly used as a crosslinking agent and a precursor for polymer and resin synthesis. In addition, it is used as a stabilizer in the production of polyurethane foam and as a curing agent for epoxy resins. Due to its high reactivity and stability, TMT is considered to be a versatile and efficient reagent in various applications.

HY-W010342

6-Aminonicotinamide 5+ Cited Publications	Others	Cancer
6-Aminonicotinamide, a potent antimetabolite of nicotinamide, is competitive NADP ⁺-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) inhibitor (K_i=0.46 μM). 6-Aminonicotinamide resultis ATP depletion and synergizes with DNA-crosslinking chemotherapy agents, such as Cisplatin, in killing cancer cells .

HY-W127344

Oleoyl Chloride	Biochemical Assay Reagents	Others
Oleoyl chloride A pungent-smelling liquid commonly used as a reagent in organic synthesis, especially for the production of a variety of organic compounds, including pharmaceuticals and agrochemicals. In addition, it can also be used as a cross-linking agent or surfactant in polymer chemistry. Its unique chemical properties make it an important ingredient in a variety of industrial processes, including petrochemical refining and materials science.

HY-137265

Aminomethyltrioxsalen hydrochloride	Biochemical Assay Reagents	Others
Aminomethyltrioxsalen hydrochloride is a derivative of Psoralen (HY-N0053). Aminomethyltrioxsalen hydrochloride penetrate intact cells and form interstrand crosslinks between pyrimidine residues of nucleic acid helices upon irradiation with ultraviolet light as a bifunctional nucleic acid intercalating agent, which can be used as a probe for double-stranded regions in heterogeneous nuclear RNA (hnRNA) to detect the secondary structure of hnRNA .

HY-W781133

cDPCP cis-[Pt(NH3)2(N1-pyridine)Cl]Cl	Others	Cancer
cDPCP (cis-[Pt(NH3)2(N1-pyridine)Cl]Cl) is a DNA crosslinking agent and also a substrate for OCT1 and OCT2. DPCP exhibits anticancer activity and can improve the survival rate of sarcoma-180 mice. cDPCP is suitable for the research of colorectal cancer and cancers with appropriate cation transporters .

HY-14572

PR-104A SN 27858	DNA Alkylator/Crosslinker Drug Metabolite	Cancer
PR-104A (SN 27858) is the alcohol metabolite of phosphate proagent PR-104. PR-104A is a hypoxia-selective DNA cross-linking agent/DNA-damaging agent and cytotoxin. Antitumor Activity . PR-104A is metabolized under hypoxia by the 1-electron NADPH:cytochrome P450 oxidoreductase. PR-104A can be used for the research of relapsed/refractory T-lineage acute lymphoblastic leukemia (T-ALL) .

HY-13543

Tretazicar CB 1954	DNA Alkylator/Crosslinker	Cancer
Tretazicar (CB 1954), an antitumor proagent, is highly selective against the Walker 256 rat tumour line. Tretazicar is enzymatically activated to generate a bifunctional agent, which can form DNA-DNA interstrand cross-links. Tretazicar in rat cells involves the reduction of its 4-nitro group to a 4-hydroxylamine by the enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1) .

Cat. No.	Product Name	Type

HY-D1423

Dibromobimane	Fluorescent Dyes/Probes
Dibromobimane is a thiol-selective fluorescent imaging agent. Dibromobimane is used to crosslink cysteine- and homocysteine-containing peptides .

Cat. No.	Product Name	Type

HY-W012887

Oxalyldihydrazide	Biochemical Assay Reagents
Oxalyldihydrazide is a crosslinking agent in proteomics research. Oxalyldihydrazide can capture carbonylated proteins on the surface of a microchip .

HY-W051391

1,4,7-Trimethyl-1,4,7-triazonane

Me3TACN

Biochemical Assay Reagents

1,4,7-Trimethyl-1,4,7-triazonane, also known as TMT or trimethylenetris(aziridine), is a cyclic organic compound. TMT is commonly used as a crosslinking agent and a precursor for polymer and resin synthesis. In addition, it is used as a stabilizer in the production of polyurethane foam and as a curing agent for epoxy resins. Due to its high reactivity and stability, TMT is considered to be a versatile and efficient reagent in various applications.

HY-W142308

Diammonium dithiodiglycolate

Biochemical Assay Reagents

Diammonium dithiodiglycolate is a film-forming polymer used as a crosslinking agent, with the activity of promoting crosslinking of materials and enhancing their stability. Diammonium dithiodiglycolate plays a key role in biomedical applications, especially in the preparation of biocompatible materials. The unique chemical properties of Diammonium dithiodiglycolate make it an ideal choice to achieve high-performance polymer properties.

HY-W106487

(+)-N,N'-Diallyl-L-tartardiamide	Drug Delivery
(+)-N,N'-Diallyl-L-tartardiamide is a cross-linking agent used in the preparation of hydrogels. (+)-N,N'-Diallyl-L-tartardiamide is a kind of biological materials or organic compounds that are widely used in life science research .

HY-W127344

Oleoyl Chloride

Surfactants

Oleoyl chloride A pungent-smelling liquid commonly used as a reagent in organic synthesis, especially for the production of a variety of organic compounds, including pharmaceuticals and agrochemicals. In addition, it can also be used as a cross-linking agent or surfactant in polymer chemistry. Its unique chemical properties make it an important ingredient in a variety of industrial processes, including petrochemical refining and materials science.

HY-W250309

Pentaerythritol tetra(3-mercaptopropionate)

Biochemical Assay Reagents

Pentaerythritol tetra(3-mercaptopropionate)It is a class of organic compounds containing both pentaerythritol and mercaptopropionate groups. It is commonly used as a stabilizer and crosslinking agent in various chemical and industrial applications. Pentaerythritol tetra(3-mercaptopropionate)Has a variety of properties that make it suitable for these applications, including the ability to increase the mechanical strength, thermal stability and weatherability of polymers and coatings. Additionally, it can be used as a feedstock for the production of other specialty chemicals and materials.

Cat. No.	Product Name	Chemical Structure

HY-B0245S

Busulfan-d8
Busulfan-d₈ is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent[1][2][3].

HY-13567S

Bendamustine-d4
Bendamustine-d₄ is the deuterium labeled Bendamustine. Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties.

HY-B0077S1

Bendamustine-d8 hydrochloride
Bendamustine-d₈ (hydrochloride) is deuterium labeled Bendamustine (hydrochloride). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties[1].

HY-136610S

Chlorpyrifos-oxon-d10
Chlorpyrifos-oxon-d₁₀ is the deuterium labeled Chlorpyrifos-oxon. Chlorpyrifos-oxon, an active metabolite of Chlorpyrifos, is a potent phosphorylating agent that potently inhibits AChE. Chlorpyrifos-oxon can induce cross-linking between subunits of tubulin and disrupt microtubule function[1][2][3][4].

HY-13567S1

Bendamustine-d8
Bendamustine-d₈ is the deuterium labeled Bendamustine[1]. Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties[2].

HY-W011188S

Glycidyl stearate-d5

Glycidyl stearate-d₅ is a deuterium labeled Glycidyl stearate (HY-W011188). Oxiran-2-ylmethyl stearate is a compound belonging to the class of esters. It contains reactive oxirane or epoxy groups that give the molecule its unique properties. Oxiran-2-ylmethyl stearate is derived from stearic acid and epichlorohydrin, which are naturally occurring substances. Glycidyl stearate is commonly used in various industrial applications such as the production of coatings, adhesives and surfactants. It can also be used as a crosslinking agent in the manufacture of polymers and resins.

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