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diastereomer

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Antifolate (1) Cholinesterase (ChE) (1) Epigenetic Reader Domain (1) FKBP (2) GPR88 (1) Isotope-Labeled Compounds (1) LXR (2) Prostaglandin Receptor (1) PROTACs (2) Serotonin Transporter (1) TRP Channel (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Infection (2) Metabolic Disease (2) Neurological Disease (5)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-115867A

(S)-GSK852	Epigenetic Reader Domain	Cancer
(S)-GSK852 is a diastereomer of GSK852 (HY-115867). GSK852 is a BET inhibitor targeting BD2 (pIC₅₀=7.9) .

HY-134818

ML-SI1 5 Publications Verification	TRP Channel	Neurological Disease
ML-SI1, a racemic mixture of diastereomers, is a TRPML inhibitor with an IC₅₀ value of 15 μM for TRPML1 .

HY-107777A

LLY-284	Others	Cancer
LLY-284 is the diastereomer of LLY-283 with much less active. LLY-283 is a potent inhibitor of PRMT5. LLY-284 has the potential for the research of cancer diseases .

HY-N2078

Yamogenin Neodiosgenin	LXR	Metabolic Disease
Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin (Neodiosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin (Neodiosgenin) inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes .

HY-N7265

Epi-galantamine	Cholinesterase (ChE)	Neurological Disease
Epi-galantamine is a diastereomer of Galantamine. Epi-galantamine is an alkaloid isolated from the bulbs and flowers of Caucasian snowdrop (Galanthus woronowii). Epi-galantamine inhibits AChE with an EC₅₀ of 45.7 μM .

HY-126081

(8-epi)-BW 245C	Prostaglandin Receptor	Cardiovascular Disease
(8-epi)-BW 245C is the C-8 diastereomer of BW 245C (HY-101987). BW 245 C is a high affinity and selective PGD2 receptor agonist .

HY-117058

LY243246 (6S)-DDATHF	Antifolate	Cancer
LY243246 ((6S)-DDATHF), the 6S diastereomer of DDATHF, is a potent competitive inhibitor of 5’-phosphoribosylglycinamide formyltransferase (GAR transformylase). 6R- and 6S-diastereomers of DDATHF are remarkably similar and equiactive antimetabolites inhibitory to de novo purine synthesis .

HY-115871A

(Rac)-PDE4-IN-4	Others	Others
(Rac)-PDE4-IN-4 is the diastereomer mixture of PDE4-IN-4 (HY-115871). PDE4-IN-4 is a dual M3 (pIC₅₀ = 10.2) antagonist-PDE4 (pIC₅₀ = 8.8) inhibitor for the inhaled research of pulmonary diseases .

HY-147180

Dansyl-DL-valine cyclohexylammonium	Others	Others
Dansyl-DL-valine cyclohexylammonium is a salt form of Dansyl-DL-valine. Dansyl-DL-valine cyclohexylammonium can be used as analyte in chromatographic separation and separation column for the separation of enantiomers and diastereomers for dansyl amino acids, aromatic carboxylic acids, and isoxazolines .

HY-N2078R

Yamogenin (Standard)	LXR	Metabolic Disease
Yamogenin (Standard) is the analytical standard of Yamogenin. This product is intended for research and analytical applications. Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin (Neodiosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin (Neodiosgenin) inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes .

HY-W742256

N-Nitroso nebivolol (mixture of diastereomers)	Others	Cancer
N-Nitroso nebivolol (mixture of diastereomers) is a nitrosamine and mutagenic .

HY-153100

(R)-mchm5U	Others	Others
(R)-mchm5U is a diastereomer of (S)-mchm5U (HY-153100A) .

HY-152040S

Tenuazonic acid-(acetyl-13C2) (mixture of diastereomers) in methanol 3-(Acetyl-¹³C₂)-5-((S)-sec-butyl)-4-hydroxy-1,5-dihydro-2H-pyrrol-2-one	Isotope-Labeled Compounds	Others
Tenuazonic acid-(acetyl- ¹³C₂) (mixture of diastereomers) in methanol (3-(Acetyl- ¹³C₂)-5-((S)-sec-butyl)-4-hydroxy-1,5-dihydro-2H-pyrrol-2-one) is ¹³C labeled Tenuazonic acid-(acetyl) (mixture of diastereomers) in methanol .

HY-100540C

Golgicide A-1 GCA-1	Others	Infection
Golgicide A-1 (GCA-1) is a less active cis-diastereomer of Golgicide A (GCA). Golgicide A-1 weakly inhibits mosquito reproduction .

HY-145514A

dTAGV-1-NEG	PROTACs FKBP	Cancer
dTAGV-1-NEG is a diastereomer and as a heterobifunctional negative control of dTAGV-1. dTAGV-1 is an FKBP12 ^F36V-selective degrader .

HY-100013A1

(1R,2R)-2-PCCA hydrochloride 1 Publications Verification	GPR88	Neurological Disease
(1R,2R)-2-PCCA hydrochloride is a diastereomer of 2-PCCA, and acts as a potent GPR88 receptor agonist, with an EC₅₀ of 3 nM in cell-free assay, and 603 nM in cell assay.

HY-145514B

dTAGV-1-NEG TFA	PROTACs FKBP	Cancer
dTAGV-1-NEG TFA is a diastereomer and as a heterobifunctional negative control of dTAGV-1. dTAGV-1-NEG TFA is an FKBP12 ^F36V-selective degrader .

HY-125932A

9β-Debilon	Serotonin Transporter	Neurological Disease
9β-Debilon is a sesquiterpenoid compound found in Nardostachys chinensis and may possess SERT regulatory activity. Structurally, 9β-Debilon is a diastereomer of Debilon (HY-125932). 9β-Debilon holds potential for research into neurological disorders .

HY-154959A

(9R,12aR)-AZD4747	Others	Cancer
(9R,12aR)-AZD4747 is a diastereomer of AZD4747 (HY-154959). AZD4747 is a selective mutant GTPase KRAS ^G12C inhibitor with blood-brain barrier permeability. AZD4747 has the potential to study cancer .

HY-100013B1

(1S,2S)-2-PCCA hydrochloride	Others	Neurological Disease
(1S,2S)-2-PCCA hydrochloride is a less active diastereomer of 2-PCCA. 2-PCCA is a GPR88 receptor agonist, and inhibits GPR88-mediated cAMP production, with an EC₅₀ of 116 nM in HEK293 cells.

HY-121120

Isosulfazecin	Antibiotic	Infection
Isosulfazecin (iSZ) is a novel β-lactam antibiotic produced by Pseudomonas acidophilus sp., synthesized in a nutrient solution supplemented with glycerol and sodium thiosulfate under aerobic conditions in parallel with bacterial growth. It is purified by chromatography and crystallization from aqueous methanol. Physicochemical analysis determined its molecular formula to be C12H20N4O9S, showing a structure with a β-lactam ring, methoxyl and sulfonate groups. Acid hydrolysis yields L-alanine and D-glutamic acid. iSZ is a diastereomer of sulfadiazine and exhibits moderate activity against both gram-positive and gram-negative bacteria, but potent activity against bacteria resistant to β-lactam antibiotics .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2078

Yamogenin Neodiosgenin	Structural Classification other families Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields Steroids	LXR
Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin (Neodiosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin (Neodiosgenin) inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes .

HY-N7265

Epi-galantamine	Alkaloids other families Source classification Plants	Cholinesterase (ChE)
Epi-galantamine is a diastereomer of Galantamine. Epi-galantamine is an alkaloid isolated from the bulbs and flowers of Caucasian snowdrop (Galanthus woronowii). Epi-galantamine inhibits AChE with an EC₅₀ of 45.7 μM .

HY-N2078R

Yamogenin (Standard)	Structural Classification other families Source classification Plants Steroids	LXR
Yamogenin (Standard) is the analytical standard of Yamogenin. This product is intended for research and analytical applications. Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin (Neodiosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin (Neodiosgenin) inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes .

HY-125932A

9β-Debilon	Structural Classification Terpenoids Sesquiterpenes Source classification Nardostachys jatamansi (D. Don) DC. Plants Valerianaceae	Serotonin Transporter
9β-Debilon is a sesquiterpenoid compound found in Nardostachys chinensis and may possess SERT regulatory activity. Structurally, 9β-Debilon is a diastereomer of Debilon (HY-125932). 9β-Debilon holds potential for research into neurological disorders .

HY-121120

Isosulfazecin	Structural Classification Microorganisms Antibiotics Source classification Beta-lactam Antibiotics	Antibiotic
Isosulfazecin (iSZ) is a novel β-lactam antibiotic produced by Pseudomonas acidophilus sp., synthesized in a nutrient solution supplemented with glycerol and sodium thiosulfate under aerobic conditions in parallel with bacterial growth. It is purified by chromatography and crystallization from aqueous methanol. Physicochemical analysis determined its molecular formula to be C12H20N4O9S, showing a structure with a β-lactam ring, methoxyl and sulfonate groups. Acid hydrolysis yields L-alanine and D-glutamic acid. iSZ is a diastereomer of sulfadiazine and exhibits moderate activity against both gram-positive and gram-negative bacteria, but potent activity against bacteria resistant to β-lactam antibiotics .

Cat. No.	Product Name	Chemical Structure

HY-152040S

Tenuazonic acid-(acetyl-13C2) (mixture of diastereomers) in methanol
Tenuazonic acid-(acetyl- ¹³C₂) (mixture of diastereomers) in methanol (3-(Acetyl- ¹³C₂)-5-((S)-sec-butyl)-4-hydroxy-1,5-dihydro-2H-pyrrol-2-one) is ¹³C labeled Tenuazonic acid-(acetyl) (mixture of diastereomers) in methanol .

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diastereomer

Inhibitors & Agonists

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Isotope-Labeled Compounds

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