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Results for "

indazole

" in MedChemExpress (MCE) Product Catalog:

17

Inhibitors & Agonists

6

Biochemical Assay Reagents

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-60298
    6-Bromo-1H-indazole

    		Biochemical Assay Reagents Others
    6-Bromo-1H-indazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    6-Bromo-1H-indazole
  • HY-33849
    5-Amino-1H-indazole

    		Biochemical Assay Reagents Others
    5-Amino-1H-indazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    5-Amino-1H-indazole
  • HY-155362
    Tubulin polymerization-IN-56

    		Microtubule/Tubulin Apoptosis Cancer
    Tubulin polymerization-IN-56 (compound 8l), an indazole derivative, is a potent tubulin polymerization inhibitor through interacting with the colchicine site, resulting in cell cycle arrest and cellular apoptosis. polymerization-IN-56 reduces cell migration and leads to more potent inhibition of tumor growth in vivo .
    Tubulin polymerization-IN-56
  • HY-40294
    Indazole

    		Monoamine Oxidase GSK-3 LRRK2 Cardiovascular Disease Neurological Disease Cancer
    Indazole, also called isoindazole, a heterocyclic aromatic organic compound. Its derivatives display a broad variety of biological activities including anti-inflammatory, antibacterial, anti-HIV, antiarrhythmic, antifungal and antitumour properties. Indazole and its derivatives can be used for research of cancer, neurological disorders, cardiovascular diseases, gastrointestinal diseases .
    Indazole
  • HY-W002518
    Indazole-3-carboxylic acid

    		Biochemical Assay Reagents Others
    Indazole-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Indazole-3-carboxylic acid
  • HY-137004
    Indazole-Cl

    Ind-Cl

    		 Estrogen Receptor/ERR COX Inflammation/Immunology
    Indazole-Cl (Ind-Cl) is an Estrogen receptor (ER)-β-specific agonist with inflammatory effect. Indazole-Cl inhibits cyclooxygenase-2 exression reduction induced by hypoxia. And Indazole-Cl inhibits ROS production. Indazole-Cl also inhibits cell migration and invasion by hypoxia increased by hypoxia. Indazole-Cl is potent inhibitor of hypoxia-induced inflammation in vascular smooth muscle cells (VSMCs) .
    Indazole-Cl
  • HY-W007927R
    1-Methyl-1H-indazole-3-carboxylic acid (Standard)

    		Biochemical Assay Reagents Others
    1-Methyl-1H-indazole-3-carboxylic acid (Standard) is the analytical standard of 1-Methyl-1H-indazole-3-carboxylic acid. This product is intended for research and analytical applications. 1-Methyl-1H-indazole-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    1-Methyl-1H-indazole-3-carboxylic acid (Standard)
  • HY-69085
    4-Bromo-1H-indazole

    		Biochemical Assay Reagents Others
    4-Bromo-1H-indazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    4-Bromo-1H-indazole
  • HY-W007927
    1-Methyl-1H-indazole-3-carboxylic acid

    		Biochemical Assay Reagents Others
    1-Methyl-1H-indazole-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    1-Methyl-1H-indazole-3-carboxylic acid
  • HY-116730
    CHS-111

    		Reactive Oxygen Species Others
    CHS-111 is a benzyl indazole inhibitor of superoxide anion O 2- generation. CHS-111 inhibits the cell migration, and reduces the formyl-Met-Leu-Phe- but not phorbol ester-stimulated phospholipase D activity, with the IC50 of 3.9 μM .
    CHS-111
  • HY-146366
    Tubulin inhibitor 26

    		Microtubule/Tubulin Cancer
    Tubulin inhibitor 26 (compound 3c) is a potent inhibitor of tubulin. Tubulin inhibitor 26 is an indazole derivative compound. Tubulin inhibitor 26 shows noteworthy low nanomolar potency against HepG2, HCT116, SW620, HT29 and A549 cancer cell lines. Tubulin inhibitor 26 arrests tumor cell in G2/M phase and induced cell apoptosis. Tubulin inhibitor 26 suppresses tumor growth in vivo without affecting the mice body weight .
    Tubulin inhibitor 26
  • HY-100194
    FKK

    		Others Cardiovascular Disease Inflammation/Immunology
    FKK is an indazole derivative and also a novel bronchodilator.
    FKK
  • HY-116781
    PD 114595

    		Others Others
    PD 114595 is a Benzothiopyrano-indazole compound .
    PD 114595
  • HY-123035
    Gamendazole

    		HSP Akt EGFR Endocrinology
    Gamendazole, an indazole carboxylic acid (ICA), is an orally active, selective HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A) inhibitor. Gamendazole binds to the C-terminal nucleotide binding pocket of HSP90 and cause downregulation of clients AKT1 and ERBB2, but stabilizes the HSP90 heterocomplex. Gamendazole specifically inhibits the actin bundling function of EEF1A1, but does not bind to the nucleotide docking pocket nor inhibits the ribosome charging or protein translation functions of EEF1A1. Gamendazole, an antispermatogenic compound with antifertility effects, has the potential for reversible non-hormonal male contraceptive agent research .
    Gamendazole
  • HY-128781
    Glucagon receptor antagonists-5

    		GCGR Metabolic Disease
    Glucagon receptor antagonists-5 (compound 13K) is a potent and orally bioavailable indazole-based glucagon receptor antagonist (Ki=32 nM). Glucagon receptor antagonists-5 has potential for the treatment of type 2 diabetes mellitus (T2DM) .
    Glucagon receptor antagonists-5
  • HY-149311
    PPO-IN-2

    		Others Others
    PPO-IN-2 is an inhibitor of protoporphyrinogen IX oxidase with an Ki of 16 nM .
    PPO-IN-2
  • HY-118046
    GSK2163632A

    		G Protein-coupled Receptor Kinase (GRK) Cardiovascular Disease
    GSK2163632A is a selective G protein-coupled receptor kinase (GRK) inhibitor that may serve as a probe for studying heart failure and Parkinson's disease. Screening of known protein kinase inhibitors by differential scanning fluorescence method revealed that the melting points of GRK2 and GRK5 increased. Enzymatic assays of the 14 most stable hits revealed that three exhibited nanomolar inhibitory potency against a single GRK, with some showing significant selectivity. Most of the identified compounds can be divided into two categories: indazole/dihydropyrimidine compounds selectively inhibit GRK2, and pyrrolopyrimidine compounds effectively inhibit GRK1 and GRK5 but with modest selectivity. The two most inhibitory representative compounds, GSK180736A and GSK2163632A, are co-crystals with GRK2 and GRK1, respectively, and their atomic structures were determined to 2.6 and 1.85 ? distances, respectively. GSK180736A, as an inhibitor of Rho-related coiled-coil protein kinase, binds to GRK2 in a manner similar to paroxetine, while GSK2163632A, as an inhibitor of insulin-like growth factor 1 receptor, occupies a novel region of the GRK active site cleft and may be used to achieve more Selectivity. However, both compounds inhibited GRK no more potently than their original targets. These data provide a basis for the rational design of more effective and selective GRK inhibitors in the future .
    GSK2163632A

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