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Isoforms Recommended:	mGluR2

Results for "

mGlu2 receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	mGluR (33)
By Research Areas:	Inflammation/Immunology (1) Neurological Disease (32)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18760

LY2812223	mGluR	Neurological Disease
LY2812223 is a highly potent, functionally selective **mGlu₂ receptor** agonist with mGlu₂ binding affinity for mGlu₂ and mGlu₃ (K_i=144 nM and 156 nM, respectively) .

HY-18941

Eglumegad 3 Publications Verification LY354740; Eglumetad	mGluR	Neurological Disease
Eglumegad (LY354740) is a highly potent and selective group II (mGlu2/3) receptor agonist with IC₅₀s of 5 nM and 24 nM on transfected human *mGlu2* and *mGlu3* receptors, respectively.

HY-18941B

(rel)-Eglumegad (rel)-LY354740; (rel)-Eglumetad	mGluR	Neurological Disease
(rel)-Eglumegad ((rel)-LY354740) is a relative configuration of Eglumegad (HY-18941). Eglumegad is a highly potent and selective group II (mGlu2/3) receptor agonist with EC₅₀s of 5 and 24 nM for transfected human mGlu2 and mGlu3 receptors, respectively .

HY-13239

LY2979165	mGluR	Neurological Disease
LY2979165 is the alanine proagent of 2812223, a selective and potent orthosteric *mGlu2* receptor agonist .

HY-18941C

Eglumegad hydrochloride 3 Publications Verification LY354740 hydrochloride; Eglumetad hydrochloride	mGluR	Neurological Disease
Eglumegad (LY354740) hydrochloride is a highly potent and selective group II (mGlu2/3) receptor agonist with IC₅₀s of 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively. Eglumegad hydrochloride protects neurons from NMDA toxicity. Eglumegad hydrochloride has anxiolytic- and antipsychotic-like effects .

HY-124372

JNJ-46356479	mGluR	Neurological Disease
JNJ-46356479 is a selective and orally bioavailable **mGlu2 receptor positive allosteric modulator (PAM), with the EC₅₀** of 78 nM. JNJ-46356479 shows active in vivo .

HY-103551

(±)-LY395756	mGluR	Neurological Disease
(±)-LY395756 is an agonist of **mGlu2 receptor and an antagonist of mGlu3 receptor*. (±)-LY395756 can distinguish the native mGlu2* and mGlu3 receptors .

HY-120717

VU6001966	mGluR	Others
VU6001966 (compound 15m) is a potent and cross the blood-brain barrier mGlu2 (metabotropic glutamate receptor 2) negative allosteric modulator with IC₅₀s of 78 nM and >30 µM for mGlu2 and mGlu3, respectively. VU6001966 can serve as an mGlu2 PET tracer .

HY-116855

TASP0433864	mGluR	Neurological Disease
TASP0433864 is a selective positive allosteric modulator (PAM) of metabotropic glutamate 2 (mGlu2) receptor with EC₅₀ values of 199 nM and 206 nM against human and rat mGlu2 receptors, respectively. TASP0433864 has antipsychotic activity .

HY-123433

JNJ-40068782	mGluR	Neurological Disease
JNJ-40068782 is a potent positive allosteric modulator of the **mGlu2 receptor, with the IC₅₀** of 38 nM .

HY-18162

JNJ-42153605	mGluR	Neurological Disease
JNJ-42153605 is a positive allosteric modulator of the metabotropic glutamate 2 (mGlu2) receptor with an EC₅₀ of 17 nM.

HY-13239A

LY2979165 free base	mGluR	Neurological Disease
LY2979165 free base is the alanine proagent of 2812223, a selective and potent orthosteric *mGlu2* receptor agonist .

HY-103558

LY379268	mGluR	Neurological Disease
LY379268 is a potent, selective and brain-penetrant *mGlu2/3R* agonist with EC₅₀ values of 2.69 nM (mGlu2) and 4.48 nM (mGlu3). LY379268 has no activity on human mGlu 1a, 4a, 5a or 7a receptors. LY379268 has antioxidant and neuroprotective effects .

HY-162117

LBG30300	mGluR	Neurological Disease
LBG30300 is a subtype-selective *mGlu₂* receptor agonist EC₅₀ 0.6 nM. LBG30300 is blood-brain barrier permeable .

HY-131336

MGS0274	mGluR	Neurological Disease
MGS0274, an ester-based lipophilic proagent of a metabotropic glutamate (mGlu)2 and **mGlu3 receptor** agonist MGS0008, shows improved oral bioavailability. MGS0274 has the potential for the research of schizophrenia .

HY-131287

MGS0028	mGluR	Neurological Disease
MGS0028 is a selective metabotropic glutamate 2/3 (mGlu2/3) receptor agonist. MGS0028 can be used for psychiatric disorders research .

HY-105040C

Pomaglumetad methionil hydrochloride LY2140023 hydrochloride	mGluR	Neurological Disease
Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. Pomaglumetad methionil hydrochloride has the potential for schizophrenia research .

HY-14554

Pomaglumetad methionil anhydrous LY2140023	mGluR	Neurological Disease
Pomaglumetad methionil anhydrous (LY2140023) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. LY2140023 has the potential for schizophrenia research .

HY-117606

LY3027788	mGluR	Neurological Disease
LY3027788, a diester analog of LY3020371 which is an **mGlu2/3 receptor** antagonist, is a potent and orally active prodrug of LY3020371. LY3027788 has antidepressant efficacy .

HY-117606A

LY3027788 hydrochloride	mGluR	Neurological Disease
LY3027788 hydrochloride, a diester analog of LY3020371 which is an **mGlu2/3 receptor** antagonist, is a potent and orally active prodrug of LY3020371. LY3027788 hydrochloride has antidepressant efficacy .

HY-107505

CBiPES hydrochloride	mGluR	Neurological Disease
CBiPES hydrochloride is a **mGlu2 receptor positive allosteric modulator (EC₅₀**: 92.8 nM). CBiPES hydrochloride attenuates stress-induced hyperthermia and PCP-induced hyperlocomotor activity. CBiPES hydrochloride can be used for research of neurological disease .

HY-105040

Pomaglumetad methionil LY2140023 hydrate	mGluR	Neurological Disease
Pomaglumetad methionil (LY2140023 hydrate) is an oral methionine prodrug of the potent specific **mGlu2/3 receptor** agonist LY404039 (HY-50906). Pomaglumetad methionil is well-tolerated and has a distinct safety profile, and can be used for schizophrenia .

HY-123820

LY3020371 hydrochloride	mGluR	Neurological Disease
LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with K_i of 5.3 and 2.5 nM, potently blocks cAMP formation with IC₅₀ of 16.2 nM . LY3020371 hydrochloride exerts an antidepressant-like signature in vivo .

HY-103551A

LY 541850	mGluR	Neurological Disease
LY 541850 is claimed from human ionotropic and metabotropic glutamate (mGlu) receptors expressed in non-neuronal cells. LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC₅₀ values of 0.161 μM and 0.038 μM, respectively .

HY-70059

LY341495 Maximum Cited Publications 9 Publications Verification	mGluR	Neurological Disease
LY341495 is a *metabotropic glutamate receptor* (mGluR) antagonist with IC₅₀*s of 21 nM, 14 nM, 7.8 μM, 8.2 μM, 170 nM, 990 nM, 22 μM for mGlu2, mGlu3, mGlu1a, mGlu5a, mGlu8, mGlu7, and mGlu4 receptors*, respectively .

HY-103552

LY487379 hydrochloride	mGluR	Neurological Disease
LY487379 hydrochloride is a selective human mGluR2 positive allosteric modulator (PAM). LY487379 hydrochloride potentiates glutamate-stimulated [ ³⁵S]GTPγS binding with EC₅₀ values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 hydrochloride promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 hydrochloride can be used for schizophrenia research .

HY-101311

UPF-523 AIDA	mGluR	Inflammation/Immunology
UPF-523 (AIDA), a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors *(mGlu1a)* with an IC₅₀ of 214 μM. But UPF-523 has no effect on group II (mGlu2), group III (mGlu4) receptors or ionotropic glutamate receptors. UPF-523 has the potential for the research of the acute arthritis .

HY-129274

RO4988546	mGluR	Neurological Disease
RO4988546 is a negative allosteric modulator (NAM) that targets metabotropic glutamate receptors 2 and 3 (mGlu2, *mGlu3). RO4988546 can reduce the binding of [ ³h]-LY354740 at the positive binding site, while affecting the receptor*'s G protein coupling and intracellular signaling. RO4988546 can be used in the development of antidepressants and cognitive enhancers .

HY-70059A

(Rac)-LY341495	Others	Neurological Disease
(Rac)-LY341495 is the isomer of LY341495 (HY-70059), and can be used as an experimental control. LY341495 is a *metabotropic glutamate receptor* (mGluR) antagonist with IC₅₀*s of 21 nM, 14 nM, 7.8 μM, 8.2 μM, 170 nM, 990 nM, 22 μM for mGlu2, mGlu3, mGlu1a, mGlu5a, mGlu8, mGlu7, and mGlu4 receptors*, respectively .

HY-122255

LY487379	mGluR	Neurological Disease
LY487379 is a selective human mGluR2 positive allosteric modulator (PAM). LY487379 potentiates glutamate-stimulated [ ³⁵S]GTPγS binding with EC₅₀ values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 can be used for schizophrenia research .

HY-131289

LY3020371	mGluR	Neurological Disease
LY3020371 is a potent and selective antagonist of glutamate (mGlu) 2/3 receptor, with K_is of 5.26 and 2.50 nM for hmGluR2 and hmGluR3, respectively. LY3020371 can be used for the research of depression .

HY-15748

JNJ-40411813 ADX-71149	mGluR	Neurological Disease
JNJ-40411813 (ADX-71149) is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC₅₀ of 147 nM. JNJ-40411813 has orally bioactivity and penetrate the blood-brain barriers. JNJ-40411813 has the potential property of anti-depression .

HY-130630

mGluR2 modulator 1	mGluR	Neurological Disease
mGluR2 modulator 1 (compound 95) is a potent and BBB-penetrated mGluR2 (metabotropic glutamate receptor-2) positive allosteric modulator, with an EC₅₀ of 0.03 μM. mGluR2 modulator 1 can be used for psychosis research .

HY-101335

DCG-IV	mGluR	Neurological Disease
DCG-IV is a potent agonist of group II mGluRs with EC₅₀s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC₅₀: mGlu1R/5R=389/630 μM) and III receptors (IC₅₀: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects .

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mGlu2 receptor

Inhibitors & Agonists