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mild conditions

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By Targets:	ADC Linker (2) Biochemical Assay Reagents (79) EGFR (1) Endogenous Metabolite (1) Fluorescent Dye (2) Liposome (1) PROTAC Linkers (10) Radionuclide-Drug Conjugates (RDCs) (1)
By Research Areas:	Cancer (13) Cardiovascular Disease (1) Infection (1) Metabolic Disease (1)
Click Chemistry:	Azide (1)
Oligonucleotides:	Pegylated Lipids (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-121699

Kibdelone B	Biochemical Assay Reagents	Infection Metabolic Disease
Kibdelone B (Compound 2) is a bioactive heterocyclic polyketide that is found in Kibdelosporangium sp. Kibdelone B and C undergo a facile equilibration to Kibdelones A-C under mild conditions .

HY-W800830

DMG-Nitrophenyl carbonate	Biochemical Assay Reagents	Others
DMG-Nitrophenyl Carbonate is a short reagent featuring a DMG lipid headgroup and a nitrophenyl carbonate, which is readily displaced by amine nucleophiles to form carbamate bonds under mild conditions.

HY-E70422

Cyclomaltodextrinase	Biochemical Assay Reagents	Others
Cyclomaltodextrinase is a hydrolase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70451

Phosphopentomutase	Biochemical Assay Reagents	Others
Phosphopentomutase is an oxidase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70429

Ketohexokinases	Biochemical Assay Reagents	Others
Ketohexokinases is a transglutaminase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70446

Exolytic heparinase	Biochemical Assay Reagents	Others
Exolytic heparinase is a dehydrogenase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70448

Thimet oligopeptidase	Biochemical Assay Reagents	Others
Thimet oligopeptidase is a peptidase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70433

SaCas9	Biochemical Assay Reagents	Others
SaCas9 is a nuclease. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70425

Sucrose synthase	Biochemical Assay Reagents	Others
Sucrose synthase is a glycosyltransferase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70423

UDP-glucuronic acid decarboxylase	Biochemical Assay Reagents	Others
UDP-glucuronic acid decarboxylase is a decarboxylase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70438

Endoproteinase Pro-C	Biochemical Assay Reagents	Others
Endoproteinase Pro-C is a hydrolase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70442

Methionine aminopeptidase	Biochemical Assay Reagents	Others
Methionine aminopeptidase is a kinase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70428

D-Xylose dehydrogenase	Biochemical Assay Reagents	Others
D-Xylose dehydrogenase is a peptidase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70452

Microbial Transglutaminase MTG; MTGase; Protein-glutamine-γ-glutamyltransferase	Biochemical Assay Reagents	Others
Microbial Transglutaminase (MTG) is a transglutaminase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70430

N-Acylhexosamine oxidase	Biochemical Assay Reagents	Others
N-Acylhexosamine oxidase is an isomerase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70445

Chondroitinase AC II	Biochemical Assay Reagents	Others
Chondroitinase AC II is a hydrolase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70431

D-Xylonolactone lactonase	Biochemical Assay Reagents	Others
D-Xylonolactone lactonase is a peptidase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70444

Chondroitinase ABC II	Biochemical Assay Reagents	Others
Chondroitinase ABC II is a hydrolase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70440

L-Arabinose isomerase	Biochemical Assay Reagents	Others
L-Arabinose isomerase is a transglutaminase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70426

Polyphosphate kinase (RsPPK)	Biochemical Assay Reagents	Others
Polyphosphate kinase (RsPPK) is a kinase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70434

Dipeptidyl peptidase III (human)	Biochemical Assay Reagents	Others
Dipeptidyl peptidase III (human) is a hydrolase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70443

Chondroitinase ABC I	Biochemical Assay Reagents	Others
Chondroitinase ABC I is a hydrolase with high catalytic efficiency, high specificity, mild action conditions, etc., and can be used in the pharmaceutical industry, industrial production, food manufacturing, aquaculture and other industries .

HY-E70427

Dipeptidyl peptidase IX (human)	Biochemical Assay Reagents	Others
Dipeptidyl peptidase IX (human) is a hydrolase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70432

Dipeptidyl peptidase VII (human)	Biochemical Assay Reagents	Others
Dipeptidyl peptidase VII (human) is a peptidase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70436

Human keratinocyte transglutaminase TG1; TGase 1	Biochemical Assay Reagents	Others
Human keratinocyte transglutaminase (TG1) is a transglutaminase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70454

Human neuronal transglutaminase Neuronal Transglutaminase; TGy; TG6	Biochemical Assay Reagents	Others
Human epidermal transglutaminase (Neuronal Transglutaminase) is a transglutaminase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70439

Human epidermal transglutaminase TG3; TGase 3	Biochemical Assay Reagents	Others
Human epidermal transglutaminase (TG3) is a transferase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70435

Prolylendopeptidase, myxococcus xanthus PEP-Mx	Biochemical Assay Reagents	Others
Prolylendopeptidase, myxococcus xanthus (PEP-Mx) is an endopeptidase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70424

Glucose-1-phosphate thymidyltransferase	Biochemical Assay Reagents	Others
Glucose-1-phosphate thymidyltransferase is an endoprotease. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-D2367

Rhodamine B NHS ester	Fluorescent Dye	Others
Rhodamine B NHS ester is a fluorophore featuring an NHS ester. Rhodamine B is a fluorescent dye which is used in fluorescence-based assays in vivo. NHS esters are highly reactive towards amines, forming amides under mild conditions.

HY-P2734

Phosphorylase a, rabbit muscle	Biochemical Assay Reagents	Others
Phosphopentomutase (EC 5.4.2.7) is an isomerase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-P2728A

Murine Antithrombin III	Biochemical Assay Reagents	Cardiovascular Disease
Murine Antithrombin III is a blood coagulation inhibitory enzyme with high catalytic efficiency, high specificity, mild action conditions, etc., and can be used in the pharmaceutical industry, industrial production, food manufacturing, aquaculture and other industries .

HY-E70437

Guinea pig liver transglutaminase Tissue-type transglutaminase; TG2; TGase 2	Biochemical Assay Reagents	Others
Guinea pig liver transglutaminase (Tissue-type transglutaminase) is an exoenzyme. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-W092176

1,9-Bis-boc-1,5,9-triazanonane	Biochemical Assay Reagents	Others
1,9-Bis-Boc-1,5,9-triazanonane is a linker containing two Boc-protected amino groups. The Boc groups can be deprotected under mild acidic conditions to form the free amines.

HY-155500

Digoxigenin NHS ester	Biochemical Assay Reagents	Others
Digoxigenin NHS ester is an activated ester which readily reacts with amino groups under mild conditions, attaching the digoxigenin (HY-B1025) moiety to proteins or amino-. Digoxigenin NHS ester can be used to label proteins and oligonucleotides .

HY-W052066

tert-Butyl (3-chloropropyl)carbamate	Biochemical Assay Reagents	Others
tert-Butyl (3-chloropropyl)carbamate is a compound with a t-butyl and a terminal choloride. The cholorine (Cl) is a good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-144011

DSPE-PEG-Cyanur	Liposome	Others
DSPE-PEG-Cyanur is a PEG derivative containing cyanur functional group. DSPE-PEG-Cyanur can be used for PEGylation of protein under mild basic conditions. DSPE-PEG-Cyanur can be used for nanostructured lipid carrier .

HY-P2950B

α-(1-2,3,6) Mannosidase	Biochemical Assay Reagents	Others
α-(1-2,3,6) Mannosidase is a glycosidase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-W053842

tert-Butyl 3-iodopropylcarbamate	Biochemical Assay Reagents	Others
tert-Butyl 3-iodopropylcarbamate is a compound with a t-butyl and a terminal iodine. The iodine (I) is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-134106

N-Boc-erythro-sphingosine	Biochemical Assay Reagents	Others
N-Boc-erythro-sphingosine is composed of t-butyl ester protected N-acetylsphingosine with a fatty acid tail. The hydroxy group enables further derivatization or replacement with other reactive functional groups. The t-butyl group can be deprotected under mild acidic conditions.

HY-W800660

endo-BCN-PEG4-Boc-amine	Biochemical Assay Reagents	Others
endo-BCN-PEG4-Boc-amine is a PEG linker containing a BCN group and a Boc-protected amine. The protected amine can be deprotected under mild acidic conditions. The BCN group can react with azide-tagged biomolecules.

HY-44370

Boc-Gly-Gly-Gly-Gly-Gly	ADC Linker	Cancer
(tert-Butoxycarbonyl)glycyl-glycyl-glycyl-glycyl-glycine is a protease cleavable ADC linker with a Boc group on the N terminus, and it is used for the development of antibody-drug conjugates (ADCs). The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-W598191

tert-Butyl (3-azidopropyl)carbamate	Biochemical Assay Reagents	Others
tert-Butyl (3-azidopropyl)carbamate is a reagent containing an azide group and Boc-protected amino group. It is reactive with alkyne, BCN, DBCO via Click Chemistry. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-172511

m-PEG9-4-Nitrophenyl carbonate	Biochemical Assay Reagents	Others
m-PEG9-4-nitrophenyl carbonate serves as a PEG linker containing a nitrophenyl carbonate, which is readily displaced by amine nucleophiles to form carbamate bonds under mild conditions. The PEG9 chain bolsters the water solublity of the compound.

HY-N11019

Erinacine P	Others	Others
Erinacine P (compoud 1) is a parental metabolite of luteolin. Erinacine P can be isolated from the mycelia of basidiomycetous Hericium erinaceum YB4-6237. Under mild conditions, Erinacine P is able to be chemically converted to Erinacine B and then to Erinacine A .

HY-P2797B

Chitinase	Biochemical Assay Reagents	Others
Chitinase is a hydrolase that can convert chitin into N-acetyl-D-glucosamine. Enzymes have high catalytic efficiency, high specificity, mild action conditions, etc., and can be used in the pharmaceutical industry, industrial production, food manufacturing, aquaculture and other industries .

HY-W154175

Boc-DODA	Biochemical Assay Reagents	Others
Boc-DODA is a linker containing a Boc-protected amino group and a terminal amine. The Boc group can be deprotected under mild acidic conditions to form the free amine. The terminal amine is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

HY-W591971

5-((tert-Butoxycarbonyl)amino)pentyl 4-methylbenzenesulfonate	Biochemical Assay Reagents	Others
5-((tert-Butoxycarbonyl)amino)pentyl 4-methylbenzenesulfonate is a PEG linker containing a Boc protected amine and a tosyl group. The protected amine can be deprotected under mild acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

HY-W071967

Alloc-Val-Ala-pAB	ADC Linker	Cancer
Alloc-Val-Ala-PAB is a peptide cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). The Val-Ala will specifically be cleaved by Cathepsin B. The Alloc group is stable to treatment with piperidine and TFA, but can be easily removed under mild conditions by palladium catalyzed allyl transfer.

HY-W591973

OTs-C6-NHBoc	Biochemical Assay Reagents	Others
OTs-C6-NHBoc is a six carbon linker containing a tosyl group and Boc-protected amine group. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form a free amine.

Cat. No.	Product Name	Type

HY-D1840

Tyramide Amplification Buffer

Dyes

Tyramide Amplification Buffer is a ready-to-use buffer primarily intended for immunostaining of cells and tissues by the technique of tyramide signal amplification (TSA). TSA Technology is based on a tyrosinase labeling system that reacts a tyrosine-labeled antibody with a fluorescently labeled tyramide using peroxidase to form a highly amplified fluorescent signal. For example, horseradish peroxidase (HRP) can catalyze the reaction of tyrosine and hydrogen peroxide under milder conditions to generate epoxy groups. Epoxy groups promote the binding of tyramide to adjacent amino acids to form fluorescently labeled products .

HY-D2367

Rhodamine B NHS ester	Dyes
Rhodamine B NHS ester is a fluorophore featuring an NHS ester. Rhodamine B is a fluorescent dye which is used in fluorescence-based assays in vivo. NHS esters are highly reactive towards amines, forming amides under mild conditions.

HY-131030

Janelia Fluor® 669, SE JF669, SE; JF669, NHS	Fluorescent Dyes/Probes
Janelia Fluor 669, SE (JF669, SE), a red fluorescent dye, can be directly reacted with the available thiol-containing HaloTag ligand under mild conditions (DIEA, DMF) to afford a JF669HaloTag ligand in a single step (Ex = 669 nm; Em = 682 nm) . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

Cat. No.	Product Name	Type

HY-144011

DSPE-PEG-Cyanur	Drug Delivery
DSPE-PEG-Cyanur is a PEG derivative containing cyanur functional group. DSPE-PEG-Cyanur can be used for PEGylation of protein under mild basic conditions. DSPE-PEG-Cyanur can be used for nanostructured lipid carrier .

HY-W1048542A

Fmoc-NH-PEG-COOH (MW 2000)	Drug Delivery
Fmoc-NH-PEG-COOH (MW 2000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 2000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .

HY-W1048542D

Fmoc-NH-PEG-COOH (MW 5000)	Drug Delivery
Fmoc-NH-PEG-COOH (MW 5000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 5000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .

HY-W1048542I

Fmoc-NH-PEG-COOH (MW 40000)	Drug Delivery
Fmoc-NH-PEG-COOH (MW 40000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 40000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .

HY-W1048542E

Fmoc-NH-PEG-COOH (MW 10000)	Drug Delivery
Fmoc-NH-PEG-COOH (MW 10000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 10000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .

HY-W1048542C

Fmoc-NH-PEG-COOH (MW 3400)	Drug Delivery
Fmoc-NH-PEG-COOH (MW 3400) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 3400) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .

HY-W1048542H

Fmoc-NH-PEG-COOH (MW 20000)	Drug Delivery
Fmoc-NH-PEG-COOH (MW 20000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 20000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .

Cat. No.	Product Name		Classification

HY-W457953

tert-Butyl N-(4-azidobutyl)carbamate		Azide
tert-Butyl N-(4-azidobutyl)carbamate is N-Boc protected crosslinker. tert-Butyl N-(4-azidobutyl)carbamate can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Cat. No.	Product Name		Classification

HY-144011

DSPE-PEG-Cyanur		Pegylated Lipids
DSPE-PEG-Cyanur is a PEG derivative containing cyanur functional group. DSPE-PEG-Cyanur can be used for PEGylation of protein under mild basic conditions. DSPE-PEG-Cyanur can be used for nanostructured lipid carrier .

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mild conditions

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

NaturalProducts

Click Chemistry

Oligonucleotides

Natural
Products