2. Search Result
Search Result
Results for "

neuroleptic

" in MedChemExpress (MCE) Product Catalog:

45

Inhibitors & Agonists

1

Natural
Products

4

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-136280
    Panamesine

    EMD 57445

    		 Sigma Receptor Neurological Disease
    Panamesine (EMD 57445) is a sigma receptor ligand, which has a high affinity (IC50 6 nM) and selectivity for sigma binding sites. Panamesine is a potential atypical neuroleptic agent .
    Panamesine
  • HY-121276
    Benperidol
    1 Publications Verification

    		 Dopamine Receptor Neurological Disease
    Benperidol is a relatively old antipsychotic agent. Benperidol is a butyrophenone antipsychotic, with the highest neuroleptic potency in terms of D2 receptor blockade .
    Benperidol
  • HY-106587A
    Octoclothepin maleate salt

    Clorotepine maleate salt

    		 Dopamine Receptor Neurological Disease
    Octoclothepin maleate salt, an orally active neuroleptic agent, is a dual SR-2A and D2DR inhibitor. Octoclothepin maleate salt reveals an intensive central depressant action in a series of observational and instrumental procedures in rodents .
    Octoclothepin maleate salt
  • HY-14264
    Cyamemazine

    		5-HT Receptor Neurological Disease
    Cyamemazine is a neuroleptic agent that contains the phenothiazine chromophore. Cyamemazine is often used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki of 12 nM), 5-HT2A (Ki = 1.5 nM) and 5-HT2C (Ki of 75 nM) receptors antagonist with antipsychotic activity .
    Cyamemazine
  • HY-B1904
    Fluphenazine decanoate

    		Dopamine Receptor Neurological Disease
    Fluphenazine decanoate is a dopamine D2 receptor inhibitor, is a long-acting phenothiazine neuroleptic. Fluphenazine can be used for schizophrenia research .
    Fluphenazine decanoate
  • HY-122979
    (+)-Butaclamol hydrochloride

    		Dopamine Receptor Neurological Disease
    (+)-Butaclamol hydrochloride is a neuroleptic agent with dopamine receptor-blocking activity. (+)-Butaclamol hydrochloride is (+)- enantiomer of butaclamol .
    (+)-Butaclamol hydrochloride
  • HY-105710
    Tropatepine

    		Cholinesterase (ChE) Neurological Disease
    Tropatepine is an orally active, anticholinergic muscarinic antagonist and can be used as an antiparkinsonian agent . Tropatepine is used to combat against extrapyramidal syndrome induced by neuroleptic agents .
    Tropatepine
  • HY-B1196A
    Tiapride

    		Dopamine Receptor Neurological Disease
    Tiapride, an atypical neuroleptic agent, is a selective dopamine D2-receptor antagonist with little propensity for causing catalepsy and sedation. The IC50 values of Tiapride are 1440, 45.8, >100, and 11.7 μM for D1; D2; D3; D4, respectively .
    Tiapride
  • HY-101220
    RMI-61140

    		Dopamine Receptor Neurological Disease
    RMI-61140 is an orally active neuroleptics. RMI-61140 decreases spontaneous motility and muscle tone in mice. RMI-61140 increases barbit urate-induced sleep and causes eyelid ptosis. RMI-61140 can be used for schizophrenia research .
    RMI-61140
  • HY-B1904A
    Fluphenazine decanoate dihydrochloride

    		Dopamine Receptor Neurological Disease
    Fluphenazine decanoate dihydrochloride is a dopamine D2 receptor inhibitor, is a long-acting phenothiazine neuroleptic. Fluphenazine can be used for schizophrenia research .
    Fluphenazine decanoate dihydrochloride
  • HY-105545C
    Dexetimide hydrochloride

    (+)-Benzetimide hydrochloride; (S)-(+)-Dexetimide hydrochloride; Dexbenzetimide hydrochloride

    		 mAChR Neurological Disease
    Dexetimide hydrochloride ((+)-Benzetimide hydrochloride) is an antimuscarinic drug with the activity of suppressing neuroleptic-induced Parkinson's syndrome. Dexetimide hydrochloride is used to improve the symptoms of movement disorders caused by the use of neuroleptics. Dexetimide hydrochloride, as the (-)-enantiomer of (-)-Benzetimide, shows the ability to selectively inhibit cholinergic receptors .
    Dexetimide hydrochloride
  • HY-U00006
    Duoperone

    		Biochemical Assay Reagents Neurological Disease
    Duoperone is a neuroleptic agent and also a antiemetic agent in animal models.
    Duoperone
  • HY-B1904R
    Fluphenazine decanoate (Standard)

    		Dopamine Receptor Neurological Disease
    Fluphenazine decanoate (Standard) is the analytical standard of Fluphenazine decanoate. This product is intended for research and analytical applications. Fluphenazine decanoate is a dopamine D2 receptor inhibitor, is a long-acting phenothiazine neuroleptic. Fluphenazine can be used for schizophrenia research .
    Fluphenazine decanoate (Standard)
  • HY-160997
    Prosulpride

    GRI 1665

    		 Dopamine Receptor Neurological Disease
    Prosulpride (GRI 1665), a neuroleptics, can block selectively dopaminergic receptor .
    Prosulpride
  • HY-B1755
    Risocaine

    Propyl 4-aminobenzoate

    		 Biochemical Assay Reagents Neurological Disease
    Risocaine, also known as Propyl 4-aminobenzoate, with potential neuroleptic properties .
    Risocaine
  • HY-12542R
    Dantrolene (Standard)

    		Calcium Channel Autophagy Neurological Disease Inflammation/Immunology
    Dantrolene (Standard) is the analytical standard of Dantrolene. This product is intended for research and analytical applications. Dantrolene is an orally active, non-competitive glutathione reductase inhibitor with a Ki of 111.6 μM and an IC50 of 52.3 μM. Dantrolene is a ryanodine receptor (RyR) antagonist and Ca2+ signaling stabilizer. Dantrolene is a direct-acting skeletal muscle relaxant. Dantrolene can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome .
    Dantrolene (Standard)
  • HY-W103105
    R 29676

    		GABA Receptor Neurological Disease
    R 29676 is a neuroleptic agent and inhibits sodium-dependent GABA binding (GABA uptake) .
    R 29676
  • HY-12542AR
    Dantrolene (sodium hemiheptahydrate) (Standard)

    		Calcium Channel Autophagy Others
    Dantrolene (sodium hemiheptahydrate) (Standard) is the analytical standard of Dantrolene (sodium hemiheptahydrate). This product is intended for research and analytical applications. Dantrolene sodium hemiheptahydrate is an orally active, non-competitive glutathione reductase inhibitor with a Ki of 111.6 μM and an IC50 of 52.3 μM. Dantrolene sodium hemiheptahydrate is a ryanodine receptor (RyR) antagonist and Ca2+ signaling stabilizer. Dantrolene sodium hemiheptahydrate is a direct-acting skeletal muscle relaxant. Dantrolene sodium hemiheptahydrate can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome .
    Dantrolene (sodium hemiheptahydrate) (Standard)
  • HY-14543S
    Sertindole-d4

    		Isotope-Labeled Compounds 5-HT Receptor Dopamine Receptor Adrenergic Receptor Autophagy Neurological Disease Cancer
    Sertindole-d4 is the deuterium labeled Sertindole. Sertindole, a neuroleptic, is one of the newer antipsychotic medications available[1][2].
    Sertindole-d4
  • HY-W436270
    Bulbocapnine hydrochloride

    		Dopamine Receptor Neurological Disease Inflammation/Immunology
    Bulbocapnine hydrochloride, an aporphine alkaloid, is a dopamine receptor inhibitor. Bulbocapnine hydrochloride inhibits dopamine synthesis. Bulbocapnine hydrochloride also has neuroleptic-like, anticonvulsant and antinociceptive effects .
    Bulbocapnine hydrochloride
  • HY-A0163C
    trans-Clopenthixol dihydrochloride

    (E)-Clopenthixol dihydrochloride

    		 Antibiotic Bacterial Parasite Infection
    trans-Clopenthixol ((E)-Clopenthixol) dihydrochloride is an antibiotic agent, without neuroleptic effect. trans-Clopenthixol can be used to inhibit Pseudomonas aeruginosa and Plasmodium falciparum in vitro .
    trans-Clopenthixol dihydrochloride
  • HY-119595
    Haloperidide

    R3201

    		 Others Neurological Disease
    Haloperidide (R3201) is a neuroleptic compound. Haloperidide is a potent and selective anti-emetic agent. Haloperidide antagonizes Apomorphine (HY-12723)-induced emesis in dogs .
    Haloperidide
  • HY-B1470
    Azaperone

    R-1929

    		 Dopamine Receptor Neurological Disease
    Azaperone (R-1929) acts as a dopamine antagonist but also has some antihistaminic and anticholinergic properties. Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic agent with antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine.
    Azaperone
  • HY-121276R
    Benperidol (Standard)

    		Dopamine Receptor Neurological Disease
    Benperidol (Standard) is the analytical standard of Benperidol. This product is intended for research and analytical applications. Benperidol is a relatively old antipsychotic agent. Benperidol is a butyrophenone antipsychotic, with the highest neuroleptic potency in terms of D2 receptor blockade .
    Benperidol (Standard)
  • HY-B1196
    Tiapride hydrochloride

    		Dopamine Receptor Neurological Disease
    Tiapride hydrochloride is a selective and orally active D2 and D3 dopamine receptors antagonist with IC50 values of 110-320 nM and 180 nM, respectively. Tiapride hydrochloride shows anti-dyskinetic activity and anxiolytic activity. Tiapride hydrochloride is a neuroleptic agent .
    Tiapride hydrochloride
  • HY-101349A
    L 741742 hydrochloride

    		Dopamine Receptor Neurological Disease
    L 741742 hydrochloride is an orally active and selective antagonist of hD4 receptors. L 741742 hydrochloride has a good brain penetration. L 741742 hydrochloride can be used in study nervous system disorders, particularly schizophrenia .
    L 741742 hydrochloride
  • HY-B1470S
    Azaperone-d4

    R-1929-d4

    		 Isotope-Labeled Compounds Dopamine Receptor Neurological Disease
    Azaperone-d4 is the deuterium labeled Azaperone. Azaperone (R-1929) acts as a dopamine antagonist but also has some antihistaminic and anticholinergic properties. Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic agent with antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine.
    Azaperone-d4
  • HY-B1470R
    Azaperone (Standard)

    		Dopamine Receptor Neurological Disease
    Azaperone (Standard) is the analytical standard of Azaperone. This product is intended for research and analytical applications. Azaperone (R-1929) acts as a dopamine antagonist but also has some antihistaminic and anticholinergic properties. Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic agent with antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine.
    Azaperone (Standard)
  • HY-136281
    DuP 734

    		Sigma Receptor Neurological Disease
    DuP 734 is a sigma receptor antagonist. DuP 734 is a selective and potent sigma and 5-HT2 receptor ligand with weak affinity for D2 receptors. DuP 734 may have antipsychotic activity without the liability of motor side effects typical of neuroleptics .
    DuP 734
  • HY-103415
    Nemonapride

    YM-09151-2; Emonapride

    		 Dopamine Receptor 5-HT Receptor Neurological Disease
    Nemonapride is a highly potent dopamine D2 receptor antagonist with a Ki of 0.06 nM. Nemonapride also activates 5-HT1A receptor with an IC50 of 34 nM. Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals .
    Nemonapride
  • HY-100930
    L-693403 maleate

    		Sigma Receptor Neurological Disease
    L-693403 maleate is a high affinity and selective σ ligand. L-693403 maleate has the potential for physiological disease research .
    L-693403 maleate
  • HY-B1196R
    Tiapride (hydrochloride) (Standard)

    		Dopamine Receptor Neurological Disease
    Tiapride (hydrochloride) (Standard) is the analytical standard of Tiapride (hydrochloride). This product is intended for research and analytical applications. Tiapride hydrochloride is a selective and orally active D2 and D3 dopamine receptors antagonist with IC50 values of 110-320 nM and 180 nM, respectively. Tiapride hydrochloride shows anti-dyskinetic activity and anxiolytic activity. Tiapride hydrochloride is a neuroleptic agent .
    Tiapride (hydrochloride) (Standard)
  • HY-115895
    Trebenzomine

    CI-686 free base

    		 Dopamine Receptor Adrenergic Receptor Neurological Disease
    Trebenzomine (CI-686 free base) is a centrally acting psychotropic compound. Trebenzomine has both neuroleptic and stimulant activity. Trebenzomine potentiates Methamphetamine-induced self-stimulation. Trebenzomine reduces septal hyperirritability, suppression of conditioned avoidance behavior, blocks Apomorphine (HY-12723)-induced emesis in dogs .
    Trebenzomine
  • HY-B1693R
    Levomepromazine (Standard)

    Methotrimeprazine (Standard)

    		 5-HT Receptor Dopamine Receptor Autophagy Histamine Receptor Enterovirus Calcium Channel Infection Neurological Disease Inflammation/Immunology
    Levomepromazine (Standard) is the analytical standard of Levomepromazine. This product is intended for research and analytical applications. Levomepromazine (Methotrimeprazine) is an orally active antipsychotic compound and Ca 2+ release inducer. Levomepromazine inhibits SERCA pump and induces an increase in cytoplasmic Ca 2+ levels. Levomepromazine has antagonistic effects on a variety of neurotransmitter receptors, including dopamine, cholinergic, serotonin, and histamine receptors. Levomepromazine can induce adaptive ER stress and autophagy. In addition, Levomepromazine has antiviral, anti-inflammatory, neuroprotective and analgesic, sedative and anti-injurious activities. Levomepromazine can be used in the study psychiatric disorders and relieving nausea and vomiting .
    Levomepromazine (Standard)
  • HY-19489
    (±)-Levomepromazine

    (±)-Methotrimeprazine; dl-Methotrimeprazine

    		 Drug Isomer Neurological Disease
    (±)-Levomepromazine is the racemate of Levomepromazine. Levomepromazine is an orally active and potent antipsychotic agent .
    (±)-Levomepromazine
  • HY-B1371
    Spiperone
    1 Publications Verification

    Spiroperidol

    		 Dopamine Receptor 5-HT Receptor Wnt Neurological Disease
    Spiperone (Spiroperidol) is a potent dopamine D2, serotonin 5-HT1A, and serotonin 5-HT2A antagonist. Spiperone is also a labelled ligand for neuroleptic receptors. Spiperone enhances intracellular calcium level and inhibits the Wnt signaling pathway. Spiperone has the potential for the research of neurology diseases .
    Spiperone
  • HY-14264S
    Cyamemazine-d6

    		Isotope-Labeled Compounds 5-HT Receptor Neurological Disease
    Cyamemazine-d6 is the deuterium labeled Cyamemazine. Cyamemazine is a neuroleptic agent that contains the phenothiazine chromophore. Cyamemazine is often used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki of 12 nM), 5-HT2A (Ki = 1.5 nM) and 5-HT2C (Ki of 75 nM) receptors antagonist with antipsychotic activity[1][2].
    Cyamemazine-d6
  • HY-12542S
    Dantrolene-13C3

    F 368-13C3

    		 Isotope-Labeled Compounds Glutathione Reductase (GR) Neurological Disease Inflammation/Immunology
    Dantrolene- 13C3 is the 13C3 labeled Dantrolene. Dantrolene (F368), a muscle relaxant, non-competitively inhibits human erythrocyte glutathione reductase. Ki and IC50 values are 111.6 μM and 52.3 μM, respectively. Dantrolene is a ryanodine receptor antagonist and Ca2+ signaling stabilizer. Dantrolene can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome.
    Dantrolene-13C3
  • HY-14325
    L-745870
    3 Publications Verification

    		 Dopamine Receptor Neurological Disease
    L-745870 is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors .
    L-745870
  • HY-14325B
    L-745870 hydrochloride
    3 Publications Verification

    		 Dopamine Receptor Neurological Disease
    L-745870 hydrochloride is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 hydrochloride shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors .
    L-745870 hydrochloride
  • HY-B1482A
    Mesoridazine

    TPS-23

    		 Potassium Channel Neurological Disease
    Mesoridazine (TPS-23) , a metabolite of Thioridazine (HY-B0965A), acts as an orally active phenothiazine antipsychotic agent. Mesoridazine is a potent and rapid open-channel blocker of human ether-a-go-go related gene (hERG) channels and blocks hERG currents with an IC50 of 550 nM (at 0 mV) in human embryonic kidney 293 cells .Mesoridazine can be used for the research of schizophrenia, as well as certain other psychiatric disorders .
    Mesoridazine
  • HY-B1482
    Mesoridazine benzenesulfonate

    TPS-23 benzenesulfonate

    		 Potassium Channel Neurological Disease
    Mesoridazine (TPS-23) benzenesulfonate, a metabolite of Thioridazine (HY-B0965A), acts as an orally active phenothiazine antipsychotic agent. Mesoridazine benzenesulfonate is a potent and rapid open-channel blocker of human ether-a-go-go related gene (hERG) channels and blocks hERG currents with an IC50 of 550 nM (at 0 mV) in human embryonic kidney 293 cells .Mesoridazine benzenesulfonate can be used for the research of schizophrenia, as well as certain other psychiatric disorders .
    Mesoridazine benzenesulfonate
  • HY-N5159
    Ampullosporin A

    		iGluR Neurological Disease
    Ampullosporin A is a peptaibol-type polypeptide that can be isolated from the fungus Sepedonium ampullosporum HKI-0053, exhibiting neuroleptic-like activity. Ampullosporin A can inhibit hyperactivity induced by NMDA receptor antagonist MK-801 (HY-15084B) and ameliorate social behavior abnormalities caused by subchronic drug treatment. Ampullosporin A alters the activity of glutamate receptors without affecting dopamine D1 and D2 receptors .
    Ampullosporin A
  • HY-12542
    Dantrolene
    Maximum Cited Publications
    9 Publications Verification

    F 368

    		 Calcium Channel Reactive Oxygen Species Apoptosis Cardiovascular Disease Neurological Disease Inflammation/Immunology
    Dantrolene is an orally active, non-competitive glutathione reductase inhibitor with a Ki of 111.6 μM and an IC50 of 52.3 μM. Dantrolene is also a calcium channel protein inhibitor. Dantrolene inhibits the release of Ca 2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties .
    Dantrolene
  • HY-12542A
    Dantrolene sodium hemiheptahydrate
    Maximum Cited Publications
    9 Publications Verification

    Dantrolene sodium hydrate

    		 Calcium Channel Reactive Oxygen Species Apoptosis Cardiovascular Disease Neurological Disease Metabolic Disease
    Dantrolene sodium hemiheptahydrate is an orally active, non-competitive glutathione reductase inhibitor with a Ki of 111.6 μM and an IC50 of 52.3 μM. Dantrolene sodium hemiheptahydrate is also a calcium channel protein inhibitor. Dantrolene sodium hemiheptahydrate inhibits the release of Ca 2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene sodium hemiheptahydrate offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties .
    Dantrolene sodium hemiheptahydrate

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: