Search Result

Results for "

ocular hypertension

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (5) LIM Kinase (LIMK) (3) MMP (1) PKA (2) Potassium Channel (1) Prostaglandin Receptor (6) ROCK (5)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Endocrinology (11) Infection (1) Inflammation/Immunology (2) Neurological Disease (4)

Inhibitors & Agonists

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-137436

Cotosudil	ROCK	Endocrinology
Cotosudil is a ROCK kinase inhibitor, which can be used for glaucoma or ocular hypertension research .

HY-12659

LX7101 2 Publications Verification	LIM Kinase (LIMK) ROCK PKA	Endocrinology
LX7101 is a potent LIM-kinase, ROCK and PKA inhibitor with IC₅₀s of 24 nM, 1.6 nM, 10 nM and <1 nM for LIMK1, LIMK2, ROCK2 and PKA, respectively. LX7101 proves significantly selective for LIMK2 with IC₅₀ values of 4.3 nM and 32 nM for LIMK2 and LIMK1 at 2 μM ATP, respectively. LX7101 has the potential for ocular hypertension and associated glaucoma research .

HY-14227

LIMK-IN-1	LIM Kinase (LIMK) ROCK	Others
LIMK-IN-1 (Compound 14) is an inhibitor of LIM-Kinase (LIMK), with IC₅₀s of 0.5 nM and 0.9 nM for LIMK1 and LIMK2, respectively. LIMK-IN-1 can be used for ocular hypertension and associated glaucoma research .

HY-106916

Unoprostone	Potassium Channel	Neurological Disease
Unoprostone, a prostaglandin F2α analogs (PGAs), activates BK channels to reduce oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction. Unoprostone reduces intraocular pressure and is used topically for glaucoma or ocular hypertension .

HY-B0584

Travoprost 2 Publications Verification Fluprostenol isopropyl ester; AL6221; Flu-Ipr	Prostaglandin Receptor	Endocrinology
Travoprost (Fluprostenol isopropyl ester), an isopropyl ester proagent, is a high affinity, selective FP prostaglandin full receptor agonist. Travoprost has the ocular hypotensive efficacy and has the potential for glaucoma and ocular hypertension .

HY-12659B

LX7101 monohydrochloride	LIM Kinase (LIMK) ROCK PKA	Endocrinology
LX7101 monohydrochloride is a potent LIM-kinase, ROCK and PKA inhibitor with IC₅₀s of 24 nM, 1.6 nM, 10 nM and <1 nM for LIMK1, LIMK2, ROCK2 and PKA, respectively. LX7101 monohydrochloride proves significantly selective for LIMK2 with IC₅₀ values of 4.3 nM and 32 nM for LIMK2 and LIMK1 at 2 μM ATP, respectively. LX7101 monohydrochloride has the potential for ocular hypertension and associated glaucoma research .

HY-17494

Timolol (S)-L-714,465; MK 950 free base	Adrenergic Receptor	Cardiovascular Disease Inflammation/Immunology Cancer
Timolol is a β-blocker available for both topical and systemic administration. Topical Timolol is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect .

HY-17494B

Timolol hemimaleate (S)-L-714,465 hemimaleate; MK 950 hemimaleate	Adrenergic Receptor	Cardiovascular Disease Inflammation/Immunology Cancer
Timolol ((S)-L-714,465; MK 950) hemimaleate is a β-blocker available for both topical and systemic administration. Topical Timolol hemimaleate is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol hemimaleate can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect .

HY-151189

ROCK-IN-4	ROCK	Others
ROCK-IN-4 is a potent ROCK inhibitor maintaining NO releasing ability. ROCK-IN-4 reversibly depolymerizes F-actin, and suppresses mitochondrial respiration in human trabecular meshwork (HTM) cells. ROCK-IN-4 can be used for glaucoma or ocular hypertension research .

HY-B0584R

Travoprost (Standard) Fluprostenol isopropyl ester(Standard); AL6221(Standard); Flu-Ipr (Standard)	Prostaglandin Receptor	Endocrinology
Travoprost (Standard) is the analytical standard of Travoprost. This product is intended for research and analytical applications. Travoprost (Fluprostenol isopropyl ester), an isopropyl ester proagent, is a high affinity, selective FP prostaglandin full receptor agonist. Travoprost has the ocular hypotensive efficacy and has the potential for glaucoma and ocular hypertension .

HY-B0191S1

Bimatoprost-d4 AGN 192024-d₄	Prostaglandin Receptor	Endocrinology
Bimatoprost-d₄ is the deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.

HY-B0584A

5,6-trans-Travoprost 5,6-trans-Fluprostenol isopropyl ester; 5,6-trans-AL6221; 5,6-trans-Flu-Ipr	Others	Endocrinology
5,6-trans-Travoprost is the isomer of Travoprost (HY-B0584), and can be used as an experimental control. Travoprost (Fluprostenol isopropyl ester), an isopropyl ester proagent, is a high affinity, selective FP prostaglandin full receptor agonist. Travoprost has the ocular hypotensive efficacy and has the potential for glaucoma and ocular hypertension .

HY-19518

Latanoprostene bunod NCX116; LBN	Others	Neurological Disease
Latanoprostene bunod (LBN), a nitric oxide (NO)-donating prostaglandin F2a analog, is a topical ophthalmic therapeutic for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension (OHT) .

HY-B0191S

Bimatoprost-d5 AGN 192024 d₅	Prostaglandin Receptor	Endocrinology
Bimatoprost-d₅ is a deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog and is a topical hypotensive agent frequently used for treating ocular hypertension and glaucoma. Bimatoprost also has an antiadipogenic effect[1][2].

HY-17494A

Timolol hemihydrate (S)-L-714,465 hemihydrate; MK 950 hemihydrate	Adrenergic Receptor	Infection
Timolol (hemihydrate) is a β-blocker available for both topical and systemic administration. Timolol (hemihydrate) is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension and Timolol (hemihydrate) also has cardioprotective effect .

HY-139419

Bimatoprost grenod NCX 470	Prostaglandin Receptor	Neurological Disease
Bimatoprost grenod (NCX 470) is a second-generation nitric oxide (NO)-donating prostaglandin analogue. Bimatoprost grenod effectively lowers intraocular pressure (IOP) in animal models of ocular hypertension and glaucoma by activating bimatoprost-mediated uveoscleral outflow and NO mediated conventional outflow. Bimatoprost grenod can be used for the research of cular hypertension and glaucoma .

HY-B0191A

5,6-trans-Bimatoprost 5,6-trans-AGN 192024	Others	Endocrinology Cancer
5,6-trans-Bimatoprost is the isomer of Bimatoprost (HY-B0191), and can be used as an experimental control. Bimatoprost is a prostaglandin analogue that can be used in studies of ocular hypertension and glaucoma and also has anti-fat formation effects.

HY-B0191

Bimatoprost AGN 192024	Prostaglandin Receptor MMP	Endocrinology
Bimatoprost is a prostaglandin analog that reduces intraocular pressure by regulating scleral and trabecular outflow. Bimatoprost is used in the study of open-angle glaucoma, ocular hypertension, and other forms of glaucoma. Topical application of bimatoprost induces fat atrophy and causes a deepening of the eyelid sulcus .

HY-19518R

Latanoprostene bunod (Standard)	Others	Neurological Disease
Latanoprostene bunod (Standard) is the analytical standard of Latanoprostene bunod. This product is intended for research and analytical applications. Latanoprostene bunod (LBN), a nitric oxide (NO)-donating prostaglandin F2a analog, is a topical ophthalmic therapeutic for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension (OHT) .

HY-114867

(15R)-Bimatoprost 15(R)-17-phenyl trinor PGF2α ethyl amide	Others	Endocrinology
(15R)-Bimatoprost (15(R)-17-phenyl trinor PGF2α ethyl amide) is a prostaglandin analog used to treat glaucoma and ocular hypertension. (15R)-Bimatoprost is an isomer of Bimatoprost with an inverted (β) hydroxyl group on C-15 .

HY-163994

Ibuterol hydrochloride KWD 2058 hydrochloride	Others	Others
Ibuterol (hydrochloride), a diester of Terbutaline (HY-B0802A), is an orally active, selective and effective β-stimulating agent with lipophilic activities. Ibuterol (hydrochloride) is also an orally active ocular hypotensive agent. Ibuterol (hydrochloride) relieves bronchial obstruction in asthma without causing circulatory effects. Ibuterol (hydrochloride) is proming for rasearch of intraocular hypertension, asthma and bronchitis .

HY-B1035

Levobunolol hydrochloride 1 Publications Verification l-Bunolol hydrochloride	Adrenergic Receptor	Others
Levobunolol (l-Bunolol) hydrochloride is a potent and nonselective β-adrenergic receptor antagonist. Levobunolol hydrochloride is an ocular hypotensive agent and lowers mean intraocular pressure (IOP). Levobunolol hydrochloride can be used for glaucoma and superior oblique myokymia (SOM) research .

HY-B1035A

Levobunolol l-Bunolol	Adrenergic Receptor	Others
Levobunolol (l-Bunolol) is a potent and nonselective β-adrenergic receptor antagonist. Levobunolol is an ocular hypotensive agent and lowers mean intraocular pressure (IOP). Levobunolol can be used for glaucoma and superior oblique myokymia (SOM) research .

Cat. No.	Product Name	Chemical Structure

HY-B0191S

Bimatoprost-d5
Bimatoprost-d₅ is a deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog and is a topical hypotensive agent frequently used for treating ocular hypertension and glaucoma. Bimatoprost also has an antiadipogenic effect[1][2].

HY-B0191S1

Bimatoprost-d4
Bimatoprost-d₄ is the deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Name
Email *

	Sorry, but the email address you supplied was invalid.