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Results for "

pan-KRAS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) E3 Ligase Ligand-Linker Conjugates (2) Isotope-Labeled Compounds (1) Ligands for Target Protein for PROTAC (1) PROTACs (4) Ras (23)
By Research Areas:	Cancer (25)
Click Chemistry:	Alkynes (3)

Inhibitors & Agonists

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148098

Pan KRas-IN-1 1 Publications Verification	Ras	Cancer
Pan KRas-IN-1 is a pan KRas inhibitor, can be used for agent resistance in cancer developed with KRas G12C inhibitors .

HY-168671

pan-KRAS ligand 1	Ligands for Target Protein for PROTAC Ras	Cancer
pan-KRAS ligand 1 is a Ligand for Target Protein for PROTAC. pan-KRAS ligand 1 can be used for synthesis PROTAC pan-KRAS degrader 4 (HY-168669) .

HY-162960

pan-KRAS degrader 1	Ras	Cancer
pan-KRAS degrader 1 (Compound 1) is a panKRAS degrader with a surface plasmon resonance (SPR) dissociation constant K_i value of 25 nM for KRAS ^G12V .pan-KRAS degrader 1 has antitumor activity .

HY-163488

pan-KRAS-IN-14	Ras	Cancer
pan-KRAS-IN-14 (compound 20) is a *Pan-KRAS* inhibitor (IC₅₀ =2.3 nM) .

HY-163489

pan-KRAS-IN-15	Ras	Cancer
pan-KRAS-IN-15 (compound 58) is a pan-KRAS inhibitor. pan-KRAS-IN-15 can be used in pancreatic cancer research .

HY-156555

pan-KRAS-IN-3	Ras	Cancer
pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor. pan-KRAS-IN-3 can be used for research of cancers . pan-KRAS-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-163299

pan-KRAS-IN-5	Ras Apoptosis	Cancer
pan-KRAS-IN-5 (compound 15a) is a pan-KRAS translation inhibitor by targeting 5′-UTR RNA G-quadruplexes (rG4s). pan-KRAS-IN-5 induces cell cycle arrest and promptes apoptosis in KRAS-driven cancer cells .

HY-162439

pan-KRAS-IN-6	Ras	Cancer
pan-KRAS-IN-6 (compound 12) is a potent pan KRAS inhibitor with IC₅₀ values of 9.79 nM (Kras G12D) and 6.03 nM (Kras G12V) .

HY-170785

pan-KRAS-IN-17	Ras	Cancer
pan-KRAS-IN-17 (Example 34) is an inhibitor of pan KRAS .

HY-164645

pan-KRAS-IN-16	Ras	Cancer
pan-KRAS-IN-16 (Compound 3344) is an anti-RAS small molecule derived from an intracellular antibody fragment with pan-RAS-effector protein-protein interaction inhibitor properties. pan-KRAS-IN-16 binds to a hydrophobic pocket near to the effector-binding switch regions of RAS. pan-KRAS-IN-16 prevents endogenous RAS-dependent signaling in tumor cell lines .

HY-162446

pan-KRAS-IN-13	Ras	Cancer
pan-KRAS-IN-13 (compound 2) is a potent inhibitor of KRAS, with IC₅₀s of 2.75 nM and 2.89 nM for G12D and G12V, respectively

HY-156528

pan-KRAS-IN-4	Ras	Cancer
pan-KRAS-IN-4 (compound 5) is a potent inhibitor of KRAS with IC₅₀s of 0.37 nM (Kras G12C), 0.19 nM (Kras G12V), respectively .

HY-162441

pan-KRAS-IN-8	Ras	Cancer
pan-KRAS-IN-8 (Compound 38) is an inhibitor for in human tumor mutated genes KRAS, which inhibits proliferation of KRAS mutated cells AsPC-1 (G12D mutant) and SW480 (G12V mutant) with IC₅₀ of 0.07 and 0.18 nM, respectively .

HY-162440

pan-KRAS-IN-7	Ras	Cancer
pan-KRAS-IN-7 (Compound 25) is an inhibitor for in human tumor mutated genes KRAS, which inhibits proliferation of KRAS mutated cells AsPC-1 (G12D mutant) and SW480 (G12V mutant) with IC₅₀ of 0.35 and 0.51 nM, respectively .

HY-162442

pan-KRAS-IN-9	Ras	Cancer
pan-KRAS-IN-9 (Compound 52) is an inhibitor for in human tumor mutated genes KRAS, which inhibits proliferation of KRAS mutated cells AsPC-1 (G12D mutant) and SW480 (G12V mutant) with IC₅₀ of 0.24 and 0.30 nM, respectively .

HY-162443

pan-KRAS-IN-10	Ras	Cancer
pan-KRAS-IN-10 (Compound 58) is an inhibitor for in human tumor mutated genes KRAS, which inhibits proliferation of KRAS mutated cells AsPC-1 (G12D mutant) and SW480 (G12V mutant) with IC₅₀ of 0.7 and 0.24 nM, respectively .

HY-156529

pan-KRAS-IN-2	Ras	Cancer
pan-KRAS-IN-2 (compound 6) is a pan inhibitor of with IC₅₀s ≤10 nM for KRAS WT and mutants (G12D, G12C, G12V, G12S, G12A, Q61H), and ＞10 μM for KRAS G13D, respectively .

HY-168678

*PROTAC K-Ras* Degrader-6**	PROTACs Ras	Cancer
pan-KRAS degrader 5 (compound 102) is a potent cereblon-based KRAS PROTAC degrader, with a DC50 of <100 nM. pan-KRAS degrader 5 shows anticancer effects. (Pink: ligand for target protein (HY-168679); Black: linker (HY-168670); Blue: E3 ligase ligand (HY-W580113)) .

HY-168669

*PROTAC K-Ras* Degrader-5**	PROTACs Ras	Cancer
pan-KRAS degrader 4 (compound 69) is a potent cereblon-based KRAS PROTAC degrader, with a DC50 of <100 nM. pan-KRAS degrader 4 shows anticancer effects. (Pink: ligand for target protein (HY-168671); Black: linker (HY-168670); Blue: E3 ligase ligand (HY-W733895)) .

HY-168672

E3 Ligase Ligand-linker Conjugate 133	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 133 is a conjugate of E3 ligase ligand and linker that serve as a key intermediate for the synthesis of complete PROTAC molecule pan-KRAS degrader 4 (HY-168669) .

HY-168680

E3 Ligase Ligand-linker Conjugate 135	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 135 is a conjugate of E3 ligase ligand and linker that serve as a key intermediate for the synthesis of complete PROTAC molecule pan-KRAS degrader 5 (HY-168678) .

HY-153723

BI-2493	Ras	Cancer
BI-2493 is a structural analogue of BI-2865 and a highly selective and orally active pan-KRAS inhibitor. BI-2493 can attenuate tumor growth. BI-2493 can be used for cancer iseases research .

HY-162445S

KRASG12D-IN-3-d3	Isotope-Labeled Compounds	Others
pan-KRAS-IN-5-d₃ is deuterated labeled pan-KRAS-IN-5.

HY-153724

BI-2865 5 Publications Verification	Ras	Cancer
BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 binds to WT, G12C, G12D, G12V and G13D mutant KRAS with K_Ds of 6.9, 4.5, 32, 26, 4.3 nM respectively. BI-2865 inhibits the proliferation of G12C, G12D or G12V mutant KRAS expressing BaF3 cells (mean IC₅₀: roughly 140 nM) .

HY-157228

ACBI3	PROTACs Ras	Cancer
ACBI3 (compound 7) is a PROTAC targeting KRAS. ACBI3 is composed of PROTAC target protein ligand pan-KRAS degrader 1 (HY-162960) (red part), E3 ligase ligand E3 ligase Ligand 43 (HY-401613) (blue part) and PROTAC Linker 1-Bromo-4-(ethynyloxy)butane (HY-169992) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is E3 Ligase Ligand-linker Conjugate 143 (HY-169995). ACBI3 achieves in vivo degradation of oncogenic KRAS, resulting in durable pathway modulation and tumor regressions in KRAS mutant xenograft mouse models .

HY-164365

*PROTAC K-Ras* Degrader-2**	PROTACs Ras	Cancer
PROTAC K-Ras degrader-2 (compound 48) is a pan-KRAS-mutant PROTAC degrader with an IC₅₀ of ≤200 nM for KRAS G12V/RAF1. PROTAC K-Ras degrader-2 degrades SW620 KRAS G12D with a DC₅₀ of ≤200 nM. PROTAC K-Ras degrader-2 inhibits cell growth of SW620 3D cell with an IC₅₀ of ≤20 nM. (Pink: KRAS inhibitor-30 (HY-164366)) .

KRASG12D-IN-3-d3
pan-KRAS-IN-5-d₃ is deuterated labeled pan-KRAS-IN-5.

Cat. No.	Product Name		Classification

HY-163488

pan-KRAS-IN-14		Alkynes
pan-KRAS-IN-14 (compound 20) is a *Pan-KRAS* inhibitor (IC₅₀ =2.3 nM) .

HY-156555

pan-KRAS-IN-3		Alkynes
pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor. pan-KRAS-IN-3 can be used for research of cancers . pan-KRAS-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-162446

pan-KRAS-IN-13		Alkynes
pan-KRAS-IN-13 (compound 2) is a potent inhibitor of KRAS, with IC₅₀s of 2.75 nM and 2.89 nM for G12D and G12V, respectively

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