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procyanidins

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Androgen Receptor (2) Apoptosis (4) Bacterial (3) Endogenous Metabolite (1) Fungal (1) GLP Receptor (1) Histone Acetyltransferase (2) HIV (1) Notch (1) PKC (2) Reactive Oxygen Species (4) Toll-like Receptor (TLR) (4)
By Research Areas:	Cancer (10) Cardiovascular Disease (2) Infection (3) Inflammation/Immunology (13) Metabolic Disease (2)

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Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N9536

Cinnamtannin A2	GLP Receptor	Metabolic Disease
Cinnamtannin A2, a tetrameric procyanidin, can increases GLP-1 and insulin secretion in mice. Cinnamtannin A2 could upregulate the expression of corticotrophin releasing hormone. Cinnamtannin A2 exhibits antioxidant, anti-diabetic and nephroprotective effect .

HY-N0796R

Procyanidin B2 (Standard) Maximum Cited Publications 15 Publications Verification Proanthocyanidin B2 (Standard)	Reactive Oxygen Species	Cancer
Procyanidin B2 (Standard) is the analytical standard of Procyanidin B2. This product is intended for research and analytical applications. Procyanidin B2 is a natural flavonoid, with anti-cancer, antioxidant activities.

HY-N2344

Procyanidin A1 1 Publications Verification Proanthocyanidin A1	PKC	Inflammation/Immunology
Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca ²⁺ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects .

HY-N7935

Procyanidin B5	Reactive Oxygen Species	Inflammation/Immunology
Procyanidin B5 is an antioxidant agent with an IC₅₀ of 0.1 mM in mouse liver homogenate lipid peroxidation assay .

HY-N13174

*Peanut procyanidin* A**	Reactive Oxygen Species Apoptosis	Inflammation/Immunology
Peanut procyanidin A is a type of A-type procyanidin that can be extracted from peanut skins. Peanut procyanidin A can protect prostate DU145 cells from H₂O₂-induced oxidative stress damage through the MAPKs signaling pathway, alleviate cell cycle arrest, and reduce cell apoptosis. Peanut procyanidin A can also regulate gut microbiota and metabolism in mice with DSS (HY-116282)-induced ulcerative colitis .

HY-N2344R

Procyanidin A1 (Standard)	PKC	Inflammation/Immunology
Procyanidin A1 (Standard) is the analytical standard of Procyanidin A1. This product is intended for research and analytical applications. Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca2+ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects .

HY-N2342R

Procyanidin C1 (Standard)	Apoptosis	Cancer
Procyanidin C1 (Standard) is the analytical standard of Procyanidin C1. This product is intended for research and analytical applications. Procyanidin C1 (PCC1), a natural polyphenol with oral activity, causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. Procyanidin C1 shows senotherapeutic activity and increases lifespan in mice .

HY-N2343R

Procyanidin A2 (Standard)	Bacterial	Infection Inflammation/Immunology Cancer
Procyanidin A2 (Standard) is the analytical standard of Procyanidin A2. This product is intended for research and analytical applications. Procyanidin A2 is a flavonoid found in grapes, with anti-cancer, antioxidant, antimicrobial and anti-inflammation activity .

HY-N2345R

Procyanidin B3 (Standard)	Histone Acetyltransferase Toll-like Receptor (TLR) Androgen Receptor	Inflammation/Immunology Cancer
Procyanidin B3 (Standard) is the analytical standard of Procyanidin B3. This product is intended for research and analytical applications. Procyanidin B3 is a natural product with antioxidant activity and oral bioavailability, possessing good blood-brain barrier penetration. Procyanidin B3 is a selective inhibitor of histone acetyltransferase (HAT). By inhibiting p300 HAT-mediated acetylation of the androgen receptor (androgen receptor). Procyanidin B3 alleviates intervertebral disc degeneration (IVDD) by inhibiting the formation of the TLR4/MD-2 complex. Procyanidin B3 can be used in research on prostate cancer and arthritis .

HY-N9790

Procyanidin B2 3,3'-di-O-gallate	Notch	Others
Procyanidin B2, 3,3'-di-O-gallate is an active constituent. Procyanidin B2, 3,3'-di-O-gallate can be isolated from grape seed extract (GSE) procyanidin mix. Procyanidin B2, 3,3' -di-o-gallate target cancer stem cells (CSCs) in prostate cancer (PCa). Procyanidin B2, 3,3'-di-O-gallate targets both unsorted and sorted CSCs at lower doses. Procyanidin B2, 3,3'-di-O-gallate strongly suppresses the constitutive as well as Jagged1 (Notch1 ligand)-induced activated Notch1 pathway .

HY-N0795R

Procyanidin B1 (Standard)	Toll-like Receptor (TLR)	Inflammation/Immunology
Procyanidin B1 (Standard) is the analytical standard of Procyanidin B1. This product is intended for research and analytical applications. Procyanidin B1 is a polyphenolic flavonoid isolated from commonly eaten fruits, binds to TLR4/MD-2 complex, and has anti-inflammatory activity.

HY-N2342

Procyanidin C1 4 Publications Verification PCC1	Apoptosis	Cancer
Procyanidin C1 (PCC1), a natural polyphenol with oral activity, causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. Procyanidin C1 shows senotherapeutic activity and increases lifespan in mice .

HY-N2345

Procyanidin B3	Histone Acetyltransferase Toll-like Receptor (TLR) Androgen Receptor	Inflammation/Immunology Cancer
Procyanidin B3 is a natural product with antioxidant activity and oral bioavailability, possessing good blood-brain barrier penetration. Procyanidin B3 is a selective inhibitor of histone acetyltransferase (HAT). By inhibiting p300 HAT-mediated acetylation of the androgen receptor (androgen receptor). Procyanidin B3 alleviates intervertebral disc degeneration (IVDD) by inhibiting the formation of the TLR4/MD-2 complex. Procyanidin B3 can be used in research on prostate cancer and arthritis .

HY-N11101

Procyanidin A5'	Others	Others
Procyanidin A5' is A dimerized proanthocyanidin type A .

HY-N7709

Cinchonain IIb	Others	Cardiovascular Disease
Cinchonain IIb is a proanthocyanidin. Cinchonain IIb has the effect of rational utilization of decreased cardiac function. Cinchonain IIb is isolated from natural hawthorn (Crataegus spp. ) .

HY-N0796

Procyanidin B2 Maximum Cited Publications 15 Publications Verification Proanthocyanidin B2	Reactive Oxygen Species	Cancer
Procyanidin B2 is a natural flavonoid, with anti-cancer, antioxidant activities.

HY-N9777

Procyanidin B-5 3,3'-di-O-gallate	Others	Metabolic Disease
Procyanidin B-5 3,3'-di-O-gallate is a potent inhibitor of squalene epoxidase with an IC₅₀ of 0.55 μM. Procyanidin B-5 3,3'-di-O-gallate reduces cholesterol by inhibiting squalene epoxidase activity .

HY-107208

Procyanidol B4 (-)-Procyanidin B4	HIV	Inflammation/Immunology
Procyanidol B4 ((-)-Procyanidin B4) is a flavanol. Anti-inflammatory properties .

HY-N7521

Procyanidin C2 Procyanidine C2	Others	Others
Procyanidin C2 is a phenol glycoside derived from Fagopyrum dibotrys (D. Don) Hara .

HY-N2343

Procyanidin A2 1 Publications Verification	Bacterial	Infection Inflammation/Immunology Cancer
Procyanidin A2 is a flavonoid found in grapes, with anti-cancer, antioxidant, antimicrobial and anti-inflammation activity .

HY-N0795

Procyanidin B1 4 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
Procyanidin B1 is a polyphenolic flavonoid isolated from commonly eaten fruits, binds to TLR4/MD-2 complex, and has anti-inflammatory activity.

HY-107208R

Procyanidol B4 (Standard)	Others	Inflammation/Immunology
Procyanidol B4 (Standard) is the analytical standard of Procyanidol B4. This product is intended for research and analytical applications. Procyanidol B4 ((-)-Procyanidin B4) is a flavanol. Anti-inflammatory properties .

HY-N0794

Proanthocyanidins 3 Publications Verification	Bacterial Fungal	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Proanthocyanidin (Procyanidin) are a class of polyphenolic that are widely distributed in higher plants, consisted of an electrophilic flavanyl unit. Proanthocyanidin can be used as antioxidant and anti-cancers agent. Proanthocyanidin also exhibit anti-inflammatory, cardioprotective, antibacterial and antifungal properties, which can be used in the treatment of chronic venous insufficiency, capillary fragility, sunburn and retinopathy. .

HY-113056A

N1-Acetylspermidine hydrochloride	Endogenous Metabolite Apoptosis	Cancer
N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamines and a substrate for polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride can promote Apoptosis in combination with Procyanidins. N1-Acetylspermidine hydrochloride has a certain cleavage efficiency at apurinic sites of DNA. N1-Acetylspermidine hydrochloride can be used in colorectal cancer research .

Cinnamtannin A2	Structural Classification Cinnamomum cassia (L.) D. Don Classification of Application Fields Source classification Metabolic Disease Plants Flavanonols Flavonoids Phenols Polyphenols Lauraceae Biflavones Disease Research Fields	GLP Receptor
Cinnamtannin A2, a tetrameric procyanidin, can increases GLP-1 and insulin secretion in mice. Cinnamtannin A2 could upregulate the expression of corticotrophin releasing hormone. Cinnamtannin A2 exhibits antioxidant, anti-diabetic and nephroprotective effect .

Procyanidin B2 (Standard) Maximum Cited Publications 15 Publications Verification Proanthocyanidin B2 (Standard)	Structural Classification Flavonoids other families Functional Molecules Classification of Application Fields Source classification Research of Health Products Phenols Plants Disease Research Fields Cancer	Reactive Oxygen Species
Procyanidin B2 (Standard) is the analytical standard of Procyanidin B2. This product is intended for research and analytical applications. Procyanidin B2 is a natural flavonoid, with anti-cancer, antioxidant activities.

Procyanidin A1 1 Publications Verification Proanthocyanidin A1	Structural Classification Classification of Application Fields Source classification Plants Flavonoids other families Functional Molecules Research of Health Products Phenols Polyphenols Biflavones Inflammation/Immunology Disease Research Fields	PKC
Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca ²⁺ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects .

Procyanidin B5	Structural Classification Aronia melanocarpa Source classification Rosaceae Phenols Polyphenols Plants	Reactive Oxygen Species
Procyanidin B5 is an antioxidant agent with an IC₅₀ of 0.1 mM in mouse liver homogenate lipid peroxidation assay .

*Peanut procyanidin* A**	Structural Classification Arachis hypogaea L. Leguminosae Source classification Phenols Polyphenols Plants	Reactive Oxygen Species Apoptosis
Peanut procyanidin A is a type of A-type procyanidin that can be extracted from peanut skins. Peanut procyanidin A can protect prostate DU145 cells from H₂O₂-induced oxidative stress damage through the MAPKs signaling pathway, alleviate cell cycle arrest, and reduce cell apoptosis. Peanut procyanidin A can also regulate gut microbiota and metabolism in mice with DSS (HY-116282)-induced ulcerative colitis .

Procyanidin A1 (Standard)	Structural Classification Flavonoids other families Source classification Phenols Polyphenols Plants Biflavones	PKC
Procyanidin A1 (Standard) is the analytical standard of Procyanidin A1. This product is intended for research and analytical applications. Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca2+ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects .

Procyanidin C1 (Standard)	Structural Classification Flavonoids Source classification Rosaceae Phenols Polyphenols Crataegus pinnatifida Bge. Plants Biflavones	Apoptosis
Procyanidin C1 (Standard) is the analytical standard of Procyanidin C1. This product is intended for research and analytical applications. Procyanidin C1 (PCC1), a natural polyphenol with oral activity, causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. Procyanidin C1 shows senotherapeutic activity and increases lifespan in mice .

Procyanidin A2 (Standard)	Structural Classification Flavonoids other families Source classification Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae Biflavones	Bacterial
Procyanidin A2 (Standard) is the analytical standard of Procyanidin A2. This product is intended for research and analytical applications. Procyanidin A2 is a flavonoid found in grapes, with anti-cancer, antioxidant, antimicrobial and anti-inflammation activity .

Procyanidin B3 (Standard)	Structural Classification Flavonoids other families Source classification Phenols Polyphenols Plants Biflavones	Histone Acetyltransferase Toll-like Receptor (TLR) Androgen Receptor
Procyanidin B3 (Standard) is the analytical standard of Procyanidin B3. This product is intended for research and analytical applications. Procyanidin B3 is a natural product with antioxidant activity and oral bioavailability, possessing good blood-brain barrier penetration. Procyanidin B3 is a selective inhibitor of histone acetyltransferase (HAT). By inhibiting p300 HAT-mediated acetylation of the androgen receptor (androgen receptor). Procyanidin B3 alleviates intervertebral disc degeneration (IVDD) by inhibiting the formation of the TLR4/MD-2 complex. Procyanidin B3 can be used in research on prostate cancer and arthritis .

Procyanidin B2 3,3'-di-O-gallate	Structural Classification Source classification Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae	Notch
Procyanidin B2, 3,3'-di-O-gallate is an active constituent. Procyanidin B2, 3,3'-di-O-gallate can be isolated from grape seed extract (GSE) procyanidin mix. Procyanidin B2, 3,3' -di-o-gallate target cancer stem cells (CSCs) in prostate cancer (PCa). Procyanidin B2, 3,3'-di-O-gallate targets both unsorted and sorted CSCs at lower doses. Procyanidin B2, 3,3'-di-O-gallate strongly suppresses the constitutive as well as Jagged1 (Notch1 ligand)-induced activated Notch1 pathway .

Procyanidin B1 (Standard)	Structural Classification Flavonoids other families Source classification Phenols Polyphenols Plants Biflavones	Toll-like Receptor (TLR)
Procyanidin B1 (Standard) is the analytical standard of Procyanidin B1. This product is intended for research and analytical applications. Procyanidin B1 is a polyphenolic flavonoid isolated from commonly eaten fruits, binds to TLR4/MD-2 complex, and has anti-inflammatory activity.

Procyanidin C1 4 Publications Verification PCC1	Structural Classification Classification of Application Fields Source classification Rosaceae Crataegus pinnatifida Bge. Plants Flavonoids Functional Molecules Research of Health Products Phenols Polyphenols Biflavones Disease Research Fields Cancer	Apoptosis
Procyanidin C1 (PCC1), a natural polyphenol with oral activity, causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. Procyanidin C1 shows senotherapeutic activity and increases lifespan in mice .

Procyanidin B3	Structural Classification Classification of Application Fields Source classification Plants Flavonoids other families Functional Molecules Research of Health Products Phenols Polyphenols Biflavones Disease Research Fields Cancer	Histone Acetyltransferase Toll-like Receptor (TLR) Androgen Receptor
Procyanidin B3 is a natural product with antioxidant activity and oral bioavailability, possessing good blood-brain barrier penetration. Procyanidin B3 is a selective inhibitor of histone acetyltransferase (HAT). By inhibiting p300 HAT-mediated acetylation of the androgen receptor (androgen receptor). Procyanidin B3 alleviates intervertebral disc degeneration (IVDD) by inhibiting the formation of the TLR4/MD-2 complex. Procyanidin B3 can be used in research on prostate cancer and arthritis .

Procyanidin A5'	Structural Classification Prunus spinosa L. Source classification Rosaceae Phenols Polyphenols Plants	Others
Procyanidin A5' is A dimerized proanthocyanidin type A .

Cinchonain IIb	Structural Classification Crataegus monogyna Jacq. Source classification Rosaceae Phenols Polyphenols Plants	Others
Cinchonain IIb is a proanthocyanidin. Cinchonain IIb has the effect of rational utilization of decreased cardiac function. Cinchonain IIb is isolated from natural hawthorn (Crataegus spp. ) .

Procyanidin B2 Maximum Cited Publications 15 Publications Verification Proanthocyanidin B2	Structural Classification Classification of Application Fields Source classification Plants Flavonoids other families Functional Molecules Research of Health Products Phenols Polyphenols Biflavones Disease Research Fields Cancer	Reactive Oxygen Species
Procyanidin B2 is a natural flavonoid, with anti-cancer, antioxidant activities.

Procyanidin B-5 3,3'-di-O-gallate	Structural Classification Rheum palmatum L. Polygonaceae Source classification Phenols Polyphenols Plants	Others
Procyanidin B-5 3,3'-di-O-gallate is a potent inhibitor of squalene epoxidase with an IC₅₀ of 0.55 μM. Procyanidin B-5 3,3'-di-O-gallate reduces cholesterol by inhibiting squalene epoxidase activity .

Procyanidol B4 (-)-Procyanidin B4	Structural Classification Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Biflavones Inflammation/Immunology Disease Research Fields	HIV
Procyanidol B4 ((-)-Procyanidin B4) is a flavanol. Anti-inflammatory properties .

Procyanidin C2 Procyanidine C2	Structural Classification Polygonaceae Source classification Phenols Polyphenols Fagopyrum dibotrys (D. Don) Hara Plants	Others
Procyanidin C2 is a phenol glycoside derived from Fagopyrum dibotrys (D. Don) Hara .

Procyanidin A2 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Vitis vinifera cv. Zalema Plants Vitaceae Infection Flavonoids other families Functional Molecules Research of Health Products Phenols Polyphenols Biflavones Inflammation/Immunology Disease Research Fields	Bacterial
Procyanidin A2 is a flavonoid found in grapes, with anti-cancer, antioxidant, antimicrobial and anti-inflammation activity .

Procyanidin B1 4 Publications Verification	Structural Classification Classification of Application Fields Source classification Plants Flavonoids other families Functional Molecules Research of Health Products Phenols Polyphenols Biflavones Inflammation/Immunology Disease Research Fields	Toll-like Receptor (TLR)
Procyanidin B1 is a polyphenolic flavonoid isolated from commonly eaten fruits, binds to TLR4/MD-2 complex, and has anti-inflammatory activity.

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