Procyanidin A1 (Synonyms: Proanthocyanidin A1)

Name: Procyanidin A1
Brand: MedChemExpress
SKU: HY-N2344
Rating: 4.5 (1 reviews)

Cat. No.: HY-N2344 Purity: 99.19%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca²⁺ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects.

For research use only. We do not sell to patients.

Procyanidin A1 Chemical Structure

CAS No. : 103883-03-0

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 254	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 254	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Procyanidin A1:

Procyanidin B1 In-stock
Procyanidin B2 In-stock
Cyanidin Chloride Get quote
Procyanidin C1 Get quote
Procyanidin A2 Get quote
Procyanidin B3 Get quote
Procyanidin A1 (Standard) Get quote

1 Publications Citing Use of MCE Procyanidin A1

•Curr Top Nutraceutical Res. 2022 May 4.

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All PKC Isoform Specific Products:

View All Isoforms

PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Jurkat	IC₅₀	> 70 μM Compound: 5	Cytotoxicity against human Jurkat cells after 24 to 72 hrs by MTT assay Cytotoxicity against human Jurkat cells after 24 to 72 hrs by MTT assay	[PMID: 23268742]
MCF7	IC₅₀	> 70 μM Compound: 5	Cytotoxicity against human MCF7 cells after 24 to 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 24 to 72 hrs by MTT assay	[PMID: 23268742]
MT4	IC₅₀	14 μg/mL Compound: 8, proanthocyanidin A1	Antiviral activity against HIV infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against HIV infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 10425115]
MT4	CC₅₀	144.3 μg/mL Compound: 8, proanthocyanidin A1	Cytotoxicity against human MT4 cells by MTT assay Cytotoxicity against human MT4 cells by MTT assay	[PMID: 10425115]
PBMC	IC₅₀	25 μM Compound: 3	Immunomodulatory activity in PHA-stimulated human PBMC assessed as inhibition of IL2 production after 3 days by enzyme immuno assay Immunomodulatory activity in PHA-stimulated human PBMC assessed as inhibition of IL2 production after 3 days by enzyme immuno assay	[PMID: 11975489]
PBMC	IC₅₀	30.6 μM Compound: 3	Inhibition of PHA-stimulated human PBMC proliferation assessed as [3H]thymidine uptake after 3 days by scintillation counting Inhibition of PHA-stimulated human PBMC proliferation assessed as [3H]thymidine uptake after 3 days by scintillation counting	[PMID: 11975489]
PBMC	IC₅₀	5.1 μM Compound: 3	Immunomodulatory activity in PHA-stimulated human PBMC assessed as inhibition of IFN-gamma production after 3 days by enzyme immuno assay Immunomodulatory activity in PHA-stimulated human PBMC assessed as inhibition of IFN-gamma production after 3 days by enzyme immuno assay	[PMID: 11975489]

In Vivo

Procyanidin A1 suppress serum IgE and IgG1 levels in mice-immunized with ovalbumin^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

576.50

Formula

C₃₀H₂₄O₁₂

CAS No.

103883-03-0

Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=C4C(O[C@]5(C6=CC=C(O)C(O)=C6)OC7=CC(O)=CC(O)=C7[C@@]4([H])[C@H]5O)=CC(O)=C3C1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (173.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7346 mL	8.6730 mL	17.3461 mL
5 mM	0.3469 mL	1.7346 mL	3.4692 mL
10 mM	0.1735 mL	0.8673 mL	1.7346 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.34 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.34 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.34 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.19%

Select Batch:

Data Sheet (277 KB) SDS (393 KB)

COA (255 KB) HNMR (450 KB) RP-HPLC (165 KB) MS (185 KB)

Handling Instructions (2659 KB)

References

[1]. Tomochika K, et al. Effects of peanut-skin procyanidin A1 on degranulation of RBL-2H3 cells. Biosci Biotechnol Biochem. 2011;75(9):1644-8. [Content Brief]

[2]. Takano F, et al. Aqueous extract of peanut skin and its main constituent procyanidin A1 suppress serum IgE and IgG1 levels in mice-immunized with ovalbumin. Biol Pharm Bull. 2007 May;30(5):922-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7346 mL	8.6730 mL	17.3461 mL	43.3651 mL
	5 mM	0.3469 mL	1.7346 mL	3.4692 mL	8.6730 mL
	10 mM	0.1735 mL	0.8673 mL	1.7346 mL	4.3365 mL
	15 mM	0.1156 mL	0.5782 mL	1.1564 mL	2.8910 mL
	20 mM	0.0867 mL	0.4337 mL	0.8673 mL	2.1683 mL
	25 mM	0.0694 mL	0.3469 mL	0.6938 mL	1.7346 mL
	30 mM	0.0578 mL	0.2891 mL	0.5782 mL	1.4455 mL
	40 mM	0.0434 mL	0.2168 mL	0.4337 mL	1.0841 mL
	50 mM	0.0347 mL	0.1735 mL	0.3469 mL	0.8673 mL
	60 mM	0.0289 mL	0.1446 mL	0.2891 mL	0.7228 mL
	80 mM	0.0217 mL	0.1084 mL	0.2168 mL	0.5421 mL
	100 mM	0.0173 mL	0.0867 mL	0.1735 mL	0.4337 mL

Procyanidin A1 Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Procyanidin A1103883-03-0Proanthocyanidin A1Procyanidin A 1Procyanidin A-1Proanthocyanidin A 1Proanthocyanidin A-1PKCProtein kinase CInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

Procyanidin A1 (Synonyms: Proanthocyanidin A1)

Customer Review

Other Forms of Procyanidin A1:

Procyanidin A1 Related Antibodies

1 Publications Citing Use of MCE Procyanidin A1

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All PKC Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Procyanidin A1 Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report