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Results for "

protein hydrolysis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Amyloid-β (1) Androgen Receptor (1) Antibiotic (2) Apoptosis (2) Bacterial (3) Biochemical Assay Reagents (5) Drug Metabolite (2) Endogenous Metabolite (5) Estrogen Receptor/ERR (2) Fluorescent Dye (2) HIV (1) mAChR (1) MAGL (1) Mitochondrial Metabolism (1) Penicillin-binding protein (PBP) (1) Phosphatase (2) Phospholipase (1) PKA (1) PKC (2) PROTACs (3) Ras (1)
By Research Areas:	Cancer (9) Endocrinology (1) Infection (5) Inflammation/Immunology (4) Metabolic Disease (3) Neurological Disease (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E70017

Peptidase, microorganism Erepsin; Peptidase (IMPa)	Others	Others
Peptidase (IMPa) (Erepsin) is catalytically active enzyme that cleaves peptide bonds in proteins and peptides by hydrolysis .

HY-153821

PROTAC KRAS G12C degrader-2	Ras PROTACs	Cancer
PROTAC KRAS G12C degrader-2 (compound 432) is a modulator of K-Ras protein hydrolysis. PROTAC KRAS G12C degrader-2 is a bifunctional compound, which contain on one end a cereblon inhibitor of apoptosis proteins (IAP) and on the other end a moiety which binds KRAS .

HY-P2973

Aspergillopepsin I Aspergillus acid protease	Others	Others
Aspergillopepsin I (Aspergillus acid protease) is an aspartic endopeptidase that catalyses the hydrolysis of peptide bonds in proteins, with broad specificity .

HY-W133898

Tryptone	Biochemical Assay Reagents	Others
Tryptone is a common component of biological media. Tryptone is the polypeptone derived from the protein hydrolysis of animal tissue (pancreas) and digested by pancreatic enzymes. The main components of Tryptone were the digestion of casein by trypsin, including the peptones, small peptides and amino acids generated from the hydrolysis of casein. Tryptone provides nutrients needed for bacterial growth, especially nitrogen and carbon sources.

HY-P2966

Protein-arginine deiminase	Endogenous Metabolite	Metabolic Disease
Protein-arginine deiminase is a unique family of enzymes that catalyzes the hydrolysis of peptidyl-arginine to form peptidyl-citrulline .

HY-E70095

T4 UvsY Protein	Others	Others
T4 UvsY Protein is an accessory protein for in vitro catalysis of strand exchange. T4 UvsY Protein enhances strand exchange by UvsX protein by interacting specifically with UvsX protein. UvsY protein enhances the rate of single-stranded-DNA-dependent ATP hydrolysis by UvsX protein .

HY-105549

Quinacillin	Antibiotic	Infection
Quinacillin is a compound that undergoes hydrolysis catalyzed by penicillinase. Quinacillin is irreversibly covalently bound to proteins via its β-lactam carboxyl group .

HY-137321

Estriol 3-glucuronide sodium salt Estriol 3-β-D-Glucuronide sodium salt	Endogenous Metabolite	Metabolic Disease
Estriol 3-glucuronide (Estriol 3-β-D-Glucuronide) sodium salt is a metabolite of Estriol. Estriol 3-glucuronide sodium salt competitively inhibits the hydrolysis of 4-methylumbelliferyl-β-D-glucuronide (4Mu-GlcU). Estriol 3-glucuronide sodium salt is a substrate for hydrolysis by Klotho-human IgG1 Fc protein (KLFc) .

HY-137613

Sp-TTPαS	HIV	Infection Inflammation/Immunology
Sp-TTPαS is a competitivesterile alpha motif and HD domain containing protein 1 (SAMHD1) catalysis inhibitor. Sp-TTPαS competitively inhibits TTP hydrolysis with a K_i value of 46 µM .

HY-P5723

Api137	Bacterial	Infection
Api137 is an antimicrobial peptide that interferes with bacterial growth by inhibiting translation. Api137 inhibits protein synthesis by trapping of release factors on the 70S ribosome following hydrolysis of the nascent polypeptide chain .

HY-P1376A

G-Protein antagonist peptide TFA	mAChR Adrenergic Receptor	Endocrinology
G-Protein antagonist peptide TFA is a truncated substance P-related peptide, competes with receptor for G protein binding. G-Protein antagonist peptide TFA inhibits the activation of G_i or G_o by M2 muscarinic cholinergic receptor (M2 mAChR) or of G_s by beta-adrenergic receptor in the reconstituted phospholipid vesicles, assayed by receptor-promoted GTP hydrolysis .

HY-P5723A

Api137 TFA	Bacterial	Infection
Api137 TFA is an antimicrobial peptide that interferes with bacterial growth by inhibiting translation. Api137 TFA inhibits protein synthesis by trapping of release factors on the 70S ribosome following hydrolysis of the nascent polypeptide chain .

HY-11000A

CaMKP inhibitor sodium	Phosphatase	Cancer
CaMKP inhibitor sodium (compound 5) is an inhibitor of Ca ²⁺/neutral protein-dependent protein concentration (CaMKP) and its nuclear type (CaMKP-N) (IC50: 6.4 μM, CaMKP; 6.6 μM, CaMKP-N). CaMKP is one type of Ser/Thr protein, which can be passed through to remove the oxidized oxidized protein (CaMK). CaMKP inhibitor sodium inhibits CaMKP mediated phospho-CaMKI hydrolysis, unaffectes protein phosphoric acid 2C (PP2C) and calcineurin (CaN) .

HY-137135A

Cantharidic acid disodium	Phosphatase Apoptosis	Cancer
Cantharidic acid disodium is the hydrolysis product of the acid anhydride Cantharidin that induces apoptosis in various human cancer cells. Cantharidic acid disodium is a selective protein phosphatase 2 (PP2A) and PP1 inhibitor withIC₅₀ values of 50 nM and 600 nM, respectively .

HY-116022

4-Nitrophenyl phosphate p-Nitrophenyl phosphate	Biochemical Assay Reagents	Others
4-Nitrophenyl phosphate (p-Nitrophenyl phosphate) is widely used as a small molecule phosphotyrosine-like substrate in activity assays for protein tyrosine phosphatases.4-Nitrophenyl phosphate is a colorless substrate that upon hydrolysis is converted to a yellow 4-nitrophenolate ion that can be monitored by absorbance at 405 nm .

HY-P3028

Ficain Ficin	Biochemical Assay Reagents	Others Metabolic Disease
Ficain is an enzyme extract composed of several proteases that can be isolated from Ficus hispida L. and the latex of fig (Ficus carica). Ficain has different specificities in different proportions during fruit ripening. Ficain is widely used in protein hydrolysis, food, production of bioactive peptides and antibody fragments .

HY-116022A

4-Nitrophenyl phosphate disodium hexahydrate 3 Publications Verification p-Nitrophenyl phosphate disodium hexahydrate	Biochemical Assay Reagents	Others
4-Nitrophenyl phosphate (p-nitrophenyl phosphate) disodium hexahydrate is widely used as a small molecule phosphotyrosine-like substrate in activity assays for protein tyrosine phosphatases. 4-Nitrophenyl phosphate disodium hexahydrate is a colorless substrate that upon hydrolysis is converted to a yellow 4-nitrophenolate ion that can be monitored by absorbance at 405 nm .

HY-P10628

β Amyloid (1-14), human	Amyloid-β	Neurological Disease
β Amyloid (1-14), human is a peptide fragment of β-amyloid protein (Aβ), which is obtained by hydrolysis of Aβ1-40 peptide by catalytic antibody light chain #7TR. β Amyloid (1-14), human can be used for Alzheimer's disease research .

HY-129099

N-Desmethyltamoxifen	PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite	Cancer
N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .

HY-129099A

N-Desmethyltamoxifen hydrochloride	PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite	Cancer
N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .

HY-D1688

Flubida-2	Fluorescent Dye	Others
Flubida-2 is a cell permeable dye which can be hydrolyzed to Fubi-2 by endoesterases in cells (after hydrolysis, Ex=492 nm, Em=517 nm). Flubida-2 can be used to detect pH at a specific site in a cell organelle by directing the probe to where avidin fusion proteins are located .

HY-152261

MS6105	PROTACs	Cancer
MS6105 is an LDH protein hydrolysis-targeted chimera (PROTAC) that effectively degrades LDHA and LDHB in a time- and ubiquitin-proteasome system-dependent manner and has anticancer activity . MS6105 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-121329

Carumonam AMA-1080; Ro 17-2301	Penicillin-binding protein (PBP) Antibiotic Bacterial	Infection
Carumonam (AMA-1080; Ro 17-2301) is a sulfonated monocyclic β-Lactam Antibiotic, targeting to *penicillin-binding protein* (PBP)*. Carumonam exerts highly activity against Enterobacteriaceae, Pseudomonas aeruginosa, and Haemophilus influenzae, while it weakly and even inactively inhibits Streptococcus pneumoniae* and Staphylococcus aureus. Carumonam is resistant to beta-lactamase-mediated hydrolysis .

HY-153342

Luxdegalutamide ARV-766	PROTACs Androgen Receptor	Cancer
Luxdegalutamide (ARV-766) is an orally active protein hydrolysis targeted chimeric (PROTAC) targeting androgen receptor (AR), which can degrade AR resistance related mutants, including T878/H875/L702 mutants. Luxdegalutamide has anti-tumor activity and can be used in the study of castration resistant prostate cancer .

HY-134283

8-Benzylthio-cAMP	PKA Apoptosis	Others
8-Benzylthio-cAMP is a derivative of cyclic adenosine monophosphate (cAMP). 8-Bn-cAMP is a site-selective activator of *cAMP-dependent protein* kinases*. Compared with cyclic adenosine monophosphate, it is more stable to phosphodiesterase (PDE) hydrolysis* and has higher membrane permeability. 8-Bn-cAMP can be used to study the role of cAMP in regulating cell proliferation, differentiation and apoptosis .

HY-143678

Citrulline-specific probe-biotin	Biochemical Assay Reagents	Others
Citrulline-specific probe-biotin is a biotinylated probe for detection of citrulline. Citrulline is the hydrolysis product of arginine catalyzed by protein arginine deiminase (PAD). PAD is abnormally activated in many diseases, leading to increased citrulline levels. Citrulline-specific probe-biotin is a biological probe that can identify diseases showing abnormal increases in PAD activity and may be effectively used in animal models of ulcerative colitis .

HY-D1377

Citrulline-specific probe-rhodamine hydrate	Fluorescent Dye	Others
Citrulline-specific probe-rhodamine hydrate is a specific probe for citrulline (Citrulline) combined with a rhodamine fluorescent group. Citrulline is the hydrolysis product of arginine catalyzed by protein arginine deiminase (PAD). PAD is abnormally activated in many diseases, leading to increased citrulline levels. Citrulline-specific probe-rhodamine hydrate is a biological probe that can identify diseases showing abnormal increases in PAD activity and may be effectively used in animal models of ulcerative colitis .

HY-116141

7-Hydroxycoumarinyl arachidonate 7-HCA; Umbelliferyl Arachidonate; 7-HC-arachidonate	Phospholipase MAGL	Others
7-Hydroxycoumarinyl arachidonate (7-HCA) is a fluorogenic substrate of cytosolic phospholipase A2 (PLA2). 7-Hydroxycoumarinyl arachidonate is also a fluorogenic substrate for monoacylglycerol lipase (MAGL). MAGL protein catalyzes the hydrolysis of 7-Hydroxycoumarinyl arachidonat to generate Arachidonic acid (AA) and the highly fluorescent 7-hydroxyl coumarin (7-HC; HY-N0573). Release of 7-HC can be measured using a fluorometer .

HY-149677

ZK53	Mitochondrial Metabolism	Cancer
ZK53 is a selective activator of mitochondrial caseinolytic protease P (HsClpP) (EC₅₀: 1.37?μM for α-casein hydrolysis by HsClpP). ZK53 is is inactive toward bacterial ClpP proteins. ZK53 induces apoptosis in H1703, H520 and SK-MES-1 cells. ZK53 induces dysregulation of mitochondrial functions in lung squamous cell carcinoma (LUSC) cells. ZK53 inhibits tumor growth in H1703 xenograft mouse model .

HY-108548

Rp-8-Br-PET-cGMPS sodium Rp-8-Bromo-PET-cGMPS	Others	Inflammation/Immunology
Rp-8-bromo-PET-Cyclic GMPS (Rp-8-bromo-PET-cGMPS) is an analog of cyclic GMP (cGMP). It is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP (Kis=35 and 30 nM). It less potently inhibits protein kinase A (Ki=11 μM) and cGMP-induced activation of cyclic nucleotide-gated channels (IC₅₀=25 μM). In the absence of cGMP stimulation, Rp-8-bromo-PET-cGMPS can act as a partial agonist of cGKI (Ki=1 μM). Rp-8-bromo-PET-cGMPS is resistant to hydrolysis by phosphodiesterase 11.

HY-113225B

Guanosine triphosphate tritris GTP tritris	Endogenous Metabolite	Cancer
Guanosine triphosphate tritris (GTP tritris) serves as a vital enhancer of myogenic cell differentiation and plays a critical role in modulating miRNA-myogenic regulator factors. It also facilitates the release of exosomes enriched with guanosine and guanosine-derived molecules, and is regarded as an activated precursor for RNA synthesis. In mitochondrial function, GTP participates in the import of proteins into the matrix, which is essential for various regulated pathways, and is involved in initiating peptide synthesis through the binding of formylmethionyl-tRNA to the ribosome, as well as polypeptide chain elongation. Additionally, GTP acts as a phosphate and pyrophosphate carrier that channels chemical energy into specific biosynthetic pathways. It activates signal transducing G proteins that regulate cellular processes such as proliferation and differentiation, and its hydrolysis by small GTPases, including Ras and Rho, is integral to both proliferation and apoptosis. Furthermore, the small GTPase Rab is instrumental in vesicle docking, fusion, and formation. Beyond signal transduction, GTP is an energy-rich precursor in the enzymatic biosynthesis of DNA and RNA.

HY-135115

Oleuropein Aglycone 3,4-DHPEA-EA	Others	Inflammation/Immunology
Oleuropein aglycone is a polyphenol and an aglycone form of Oleuropein (HY-N0292) that has been found in extra virgin olive oil and has diverse biological activities. It is formed from oleuropein via enzymatic, acidic, or acetyl hydrolysis. Dietary administration of oleuropein aglycone (50 mg/kg of food) increases the number of neuronal autophagic vesicles and reverses cognitive deficits in a TgCRND8 transgenic mouse model of Alzheimer’s disease. It also decreases cortical and hippocampal levels of histone deacetylase 2 (HDAC2) and restores long-term potentiation in the same model. Oleuropein aglycone increases urinary norepinephrine, as well as interscapular brown adipose tissue epinephrine and UCP1 protein levels, and decreases plasma leptin levels and total abdominal cavity adipose tissue weight in a rat model of high-fat diet-induced obesity. It also reduces lung neutrophil infiltration, lipid peroxidation, and IL-1β levels in a mouse model of carrageenan-induced pleurisy.

Cat. No.	Product Name	Type

HY-D1688

Flubida-2	Fluorescent Dyes/Probes
Flubida-2 is a cell permeable dye which can be hydrolyzed to Fubi-2 by endoesterases in cells (after hydrolysis, Ex=492 nm, Em=517 nm). Flubida-2 can be used to detect pH at a specific site in a cell organelle by directing the probe to where avidin fusion proteins are located .

HY-D1377

Citrulline-specific probe-rhodamine hydrate	Fluorescent Dyes/Probes
Citrulline-specific probe-rhodamine hydrate is a specific probe for citrulline (Citrulline) combined with a rhodamine fluorescent group. Citrulline is the hydrolysis product of arginine catalyzed by protein arginine deiminase (PAD). PAD is abnormally activated in many diseases, leading to increased citrulline levels. Citrulline-specific probe-rhodamine hydrate is a biological probe that can identify diseases showing abnormal increases in PAD activity and may be effectively used in animal models of ulcerative colitis .

Citrulline-specific probe-rhodamine hydrate

Fluorescent Dyes/Probes

Citrulline-specific probe-rhodamine hydrate is a specific probe for citrulline (Citrulline) combined with a rhodamine fluorescent group. Citrulline is the hydrolysis product of arginine catalyzed by protein arginine deiminase (PAD). PAD is abnormally activated in many diseases, leading to increased citrulline levels. Citrulline-specific probe-rhodamine hydrate is a biological probe that can identify diseases showing abnormal increases in PAD activity and may be effectively used in animal models of ulcerative colitis .

Cat. No.	Product Name	Type

HY-W133898

Tryptone	Microbial Culture
Tryptone is a common component of biological media. Tryptone is the polypeptone derived from the protein hydrolysis of animal tissue (pancreas) and digested by pancreatic enzymes. The main components of Tryptone were the digestion of casein by trypsin, including the peptones, small peptides and amino acids generated from the hydrolysis of casein. Tryptone provides nutrients needed for bacterial growth, especially nitrogen and carbon sources.

Tryptone

Microbial Culture

Tryptone is a common component of biological media. Tryptone is the polypeptone derived from the protein hydrolysis of animal tissue (pancreas) and digested by pancreatic enzymes. The main components of Tryptone were the digestion of casein by trypsin, including the peptones, small peptides and amino acids generated from the hydrolysis of casein. Tryptone provides nutrients needed for bacterial growth, especially nitrogen and carbon sources.