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Results for "

pyrazoles

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apelin Receptor (APJ) (1) Apoptosis (3) Arrestin (1) Aurora Kinase (2) AUTACs (2) Autophagy (4) Bacterial (3) Biochemical Assay Reagents (16) COX (4) Deubiquitinase (1) EGFR (1) Endogenous Metabolite (3) Ephrin Receptor (1) Epigenetic Reader Domain (1) Epoxide Hydrolase (1) Estrogen Receptor/ERR (2) Fungal (1) Histamine Receptor (3) Isotope-Labeled Compounds (2) Kallikrein (1) Lactate Dehydrogenase (1) Lipoxygenase (1) p38 MAPK (2) PKA (1) Proteasome (1) SHMT (1) SHP2 (1) SphK (1) TGF-β Receptor (1) TRP Channel (1) VEGFR (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (4) Endocrinology (1) Infection (3) Inflammation/Immunology (12) Metabolic Disease (9) Neurological Disease (1)

By Targets:

Apelin Receptor (APJ) (1)

Apoptosis (3)

Arrestin (1)

Aurora Kinase (2)

AUTACs (2)

Autophagy (4)

Bacterial (3)

Biochemical Assay Reagents (16)

COX (4)

Deubiquitinase (1)

EGFR (1)

Endogenous Metabolite (3)

Ephrin Receptor (1)

Epigenetic Reader Domain (1)

Epoxide Hydrolase (1)

Estrogen Receptor/ERR (2)

Fungal (1)

Histamine Receptor (3)

Isotope-Labeled Compounds (2)

Kallikrein (1)

Lactate Dehydrogenase (1)

Lipoxygenase (1)

p38 MAPK (2)

PKA (1)

Proteasome (1)

SHMT (1)

SHP2 (1)

SphK (1)

TGF-β Receptor (1)

TRP Channel (1)

VEGFR (1)

By Research Areas:

Cancer (16)

Cardiovascular Disease (4)

Endocrinology (1)

Infection (3)

Inflammation/Immunology (12)

Metabolic Disease (9)

Neurological Disease (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145551

Atinvicitinib	Others	Inflammation/Immunology
Atinvicitinib is a kind of pyrazole compound. Atinvicitinib has the potential for the research of atopic dermatitis (extracted from patent WO2021123094A1) .

HY-118810

BIO-013077-01	TGF-β Receptor	Cancer
BIO-013077-01 is a pyrazole TGF-β inhibitor .

HY-A0273

Propyphenazone 4-Isopropylantipyrine; Isopropylphenazone	COX	Inflammation/Immunology
Propyphenazone (4-Isopropylantipyrine) is an orally active nonacidic pyrazole nonsteroidal anti-inflammatory drug (NSAID). Propyphenazone is a weak nonselective COX inhibitor. Propyphenazone has the effect of reducing pain and antipyretic activity with minimal anti-inflammatory activity .

HY-145568

Feniralstat KVD-824	Kallikrein	Cardiovascular Disease Metabolic Disease
Feniralstat (compound 30), a pyrazole derivative, is a potent kallikrein inhibitor with an IC₅₀ of 6.7 nM for Human plasma kallikrein (pKal). Feniralstat has no inhibition on Human KLKl, Human FXIa, Human Factor Xlla (all IC₅₀>40 μM).

HY-W002328

Pyrazole-3-carboxylic acid	Biochemical Assay Reagents	Others
Pyrazole-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-131062

yGsy2p-IN-1	Others	Metabolic Disease
yGsy2p-IN-1 is a potent inhibitor for yeast glycogen synthase 2 (yGsy2p). yGsy2p-IN-1 is a competitive human glycogen synthase 1 (hGYS1) inhibitor with an IC₅₀ of 2.75 µM and a K_i of 1.31 µM for wild-type hGYS1. yGsy2p-IN-H23 a pyrazole inhibitor, is used for glycogen storage diseases (GSDs) .

HY-19408

Pyr10 3 Publications Verification	TRP Channel	Others
Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor. Pyr10 inhibits Ca ²⁺ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with an IC₅₀ of 0.72 μM (IC₅₀ of 13.08 μM for store operated Ca ²⁺ entry in BRL-2H3 cells). Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels .

HY-A0273R

Propyphenazone (Standard)	COX	Inflammation/Immunology
Propyphenazone (Standard) is the analytical standard of Propyphenazone. This product is intended for research and analytical applications. Propyphenazone (4-Isopropylantipyrine) is an orally active nonacidic pyrazole nonsteroidal anti-inflammatory drug (NSAID). Propyphenazone is a weak nonselective COX inhibitor. Propyphenazone has the effect of reducing pain and antipyretic activity with minimal anti-inflammatory activity .

HY-127133

Methylpiperidino pyrazole MPP	Estrogen Receptor/ERR	Endocrinology
Methylpiperidino pyrazole (MPP) is a potent and selective ER (estrogen receptor) modulator. Methylpiperidino pyrazole induces significant apoptosis in the endometrial cancer and oLE cell lines. Methylpiperidino pyrazole reverses the the positive effects of beta-estradiol. Methylpiperidino pyrazole has mixed agonist/antagonist action on murine uterine ERalpha in vivo .

HY-132518S

Pyrazole N-Demethyl Sildenafil-d3	Isotope-Labeled Compounds	Others
Pyrazole N-Demethyl Sildenafil-d₃ is the deuterium labeled Pyrazole N-Demethyl Sildenafil[1].

HY-76228

1H-pyrazole Pyrazole	Endogenous Metabolite	Metabolic Disease
1H-pyrazole is an endogenous metabolite.

HY-B1850

Halosulfuron-methyl Inpool; MON 12000; Manage	Others	Others
Halosulfuron-methyl is a pyrazole sulfonylurea herbicide .

HY-12564

Phthalazinone pyrazole	Aurora Kinase Apoptosis	Cancer
Phthalazinone pyrazole is a potent, selective, and orally active inhibitor of Aurora-A kinase with an IC₅₀ of 0.031 μM. Phthalazinone pyrazole can arrests mitosis and subsequently inhibit tumor growth via apoptosis of proliferating cells. Phthalazinone pyrazole suppresses the epithelial-mesenchymal transition (EMT) during the differentiation of hepatocyte-like cells (HLCs) from human embryonic stem cells .

HY-128546

Flupranone	Others	Inflammation/Immunology
Flupranone is a pyrazole derivatives with antiinflammatory and antihypertensive properties .

HY-W007997R

*Ethyl 3-amino-1H-pyrazole-4-carboxylate (Standard)*	Biochemical Assay Reagents	Others
Ethyl 3-amino-1H-pyrazole-4-carboxylate (Standard) is the analytical standard of Ethyl 3-amino-1H-pyrazole-4-carboxylate. This product is intended for research and analytical applications. Ethyl 3-amino-1H-pyrazole-4-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-17475

Nifenazone	Others	Inflammation/Immunology
Nifenazone is a pyrazole agent which can be used in the in the treatment of a variety of rheumatic disorders.

HY-100689

*Propyl pyrazole* triol** Maximum Cited Publications 15 Publications Verification PPT	Estrogen Receptor/ERR	Cancer
Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%) .

HY-10179

Danusertib 5+ Cited Publications PHA-739358	Aurora Kinase Autophagy	Cancer
Danusertib is a pyrrolo-pyrazole and aurora kinase inhibitor with IC₅₀ of 13, 79, and 61 nM for Aurora A, B, and C, respectively.

HY-139994

XN methyl pyrazole XP	Others	Metabolic Disease Cancer
XN methyl pyrazole improves diet-induced obesity and induces energy expenditure in high-fat diet-fed mice .

HY-133726

Bixafen	Others	Infection
Bixafen, a member of the pyrazole class of fungicides, serves as a broad-spectrum agent for controlling pathogens in cereal crops by functioning as a succinate dehydrogenase inhibitor.

HY-B1850R

Halosulfuron-methyl (Standard)	Others	Others
Halosulfuron-methyl (Standard) is the analytical standard of Halosulfuron-methyl. This product is intended for research and analytical applications. Halosulfuron-methyl is a pyrazole sulfonylurea herbicide .

HY-111108

LDH-IN-1 1 Publications Verification	Lactate Dehydrogenase	Cancer
LDH-IN-1 is a novel pyrazole-based inhibitor of human lactate dehydrogenase (LDH) with IC₅₀s of 32 and 27 nM for LDHA and LDHB, respectively.

HY-Y1298

Methyl acetylacetate 1 Publications Verification Acetoacetate methyl ester; Methyl 3-oxobutanoate; Methyl acetoacetate	Endogenous Metabolite	Metabolic Disease
Methyl acetylacetate is a chemical reagent used in the synthesis of pharmaceuticals for the synthesis of α-substituted acetoacetate and cyclic compounds such as pyrazole, pyrimidine, and coumarin derivatives .

HY-B1137

Ramifenazone Isopropylaminoantipyrine	Bacterial	Inflammation/Immunology
Ramifenazone (Isopropylaminoantipyrine) is a pyrazole derivative and acts as a non-steroidal anti-inflammatory agent (NSAID). Ramifenazone has analgesic, antipyretic, anti-inflammatory and antimicrobial activities .

HY-W017032

*1H-Pyrazole-1-carboximidamide hydrochloride*	Biochemical Assay Reagents	Others
1H-Pyrazole-1-carboximidamide hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W002461

3-Phenylpyrazole	Biochemical Assay Reagents	Others
3-Phenyl-1H-pyrazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W002458

4-Nitropyrazole	Biochemical Assay Reagents	Others
4-Nitro-1H-pyrazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W004212

4-(Trifluoromethyl)-1H-pyrazole	Biochemical Assay Reagents	Others
4-(Trifluoromethyl)-1H-pyrazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-I0314

*1H-Pyrazole-4-boronic acid pinacol ester*	Biochemical Assay Reagents	Others
1H-Pyrazole-4-boronic acid pinacol ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-69052

*1-Methyl-1H-pyrazole-4-carboxaldehyde*	Biochemical Assay Reagents	Others
1-Methyl-1H-pyrazole-4-carboxaldehyde is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-34603

*1-Methyl-1H-pyrazole-3-carboxylic acid*	Biochemical Assay Reagents	Others
1-Methyl-1H-pyrazole-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-I0308

*1-Methyl-1H-pyrazole-4-boronic acid pinacol ester*	Biochemical Assay Reagents	Others
1-Methyl-1H-pyrazole-4-boronic acid pinacol ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-34027

*Ethyl 5-methyl-1H-pyrazole-3-carboxylate*	Biochemical Assay Reagents	Others
Ethyl 5-methyl-1H-pyrazole-3-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W007997

*Ethyl 3-amino-1H-pyrazole-4-carboxylate* 3-Amino-4-ethoxycarbonylpyrazole	Biochemical Assay Reagents	Others
Ethyl 3-amino-1H-pyrazole-4-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W004978

*1,5-Dimethyl-1H-pyrazole-3-carboxylic acid*	Biochemical Assay Reagents	Others
1,5-Dimethyl-1H-pyrazole-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-11087

SD 0006 SD-06	p38 MAPK Autophagy	Inflammation/Immunology
SD 0006 (SD-06) is an orally active, selective, ATP-competitive and potent diaryl pyrazole inhibitor of p38α MAP kinase, with an IC₅₀ of 110 nM for p38α .

HY-W002351

*Ethyl 1,5-dimethyl-1H-pyrazole-3-carboxylate*	Biochemical Assay Reagents	Others
Ethyl 1,5-dimethyl-1H-pyrazole-3-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-120122

PK7088	Others	Cancer
PK7088 is a pyrazole and a specific peptide. PK7088 supports the reactivation of mutant p53 by converting it to a form exhibiting wild-type properties. PK7088 exhibit anticancer activity in cancer research .

HY-W002736

*N,N'-Di-Boc-1H-pyrazole-1-carboximidamide*	Biochemical Assay Reagents	Others
N,N'-Di-Boc-1H-pyrazole-1-carboximidamide (Compound 1) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-22365

*1-Ethyl-3-methyl-1H-pyrazole-5-carboxylic acid*	Biochemical Assay Reagents	Others
1-Ethyl-3-methyl-1H-pyrazole-5-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-148037

Thrombin inhibitor 5	Proteasome	Cardiovascular Disease
Thrombin inhibitor 5 (compound 385) is a thrombin inhibitor, with IC₅₀s ranging from 0.1 μM to 1 μM. Thrombin inhibitor 5 can be used for research of venous thromboembolism .

HY-B1137S

Ramifenazone-d7	Isotope-Labeled Compounds Bacterial	Inflammation/Immunology
Ramifenazone-d₇ is the deuterium labeled Ramifenazone. Ramifenazone (Isopropylaminoantipyrine) is a pyrazole derivative and acts as a non-steroidal anti-inflammatory agent (NSAID). Ramifenazone has analgesic, antipyretic, anti-inflammatory and antimicrobial activities[1][2].

HY-Y1298R

Methyl acetylacetate (Standard) Acetoacetate methyl ester (Standard); Methyl 3-oxobutanoate (Standard); Methyl acetoacetate (Standard)	Endogenous Metabolite	Metabolic Disease
Methyl acetylacetate (Standard) is the analytical standard of Methyl acetylacetate. This product is intended for research and analytical applications. Methyl acetylacetate is a chemical reagent used in the synthesis of pharmaceuticals for the synthesis of α-substituted acetoacetate and cyclic compounds such as pyrazole, pyrimidine, and coumarin derivatives .

HY-143296

SphK1-IN-1	SphK	Cancer
SphK1-IN-1 (compound 48) is a SphK1 inhibitor with effective antitumor activity. SphK1-IN-1 inhibits SphK1 ATPase with an IC₅₀ value of 4.02 μM. SphK1-IN-1 can be used for the research of cancer .

HY-149530

EGFR-IN-86	EGFR Apoptosis	Cancer
EGFR-IN-86 (compound 4i) is an EGFR inhibitor (IC₅₀: 1.5 nM) with high activity against glioblastoma. EGFR-IN-86 induces apoptosis and arrests the U87 cell cycle in the G2/M phase .

HY-B1557

Betazole 1 Publications Verification Ametazole	Histamine Receptor	Metabolic Disease
Betazole (Ametazole), a pyrazole analogue of histamine, is an orally active histamine H2 receptor agonist. Betazole induces gastric acid secretion and causes an immediate and significant increase in common bile duct pressure. Betazole is used as a diagnostic agent known as histalog for investigating gastric acid secretory capacity .

HY-B1557A

Betazole dihydrochloride Ametazole dihydrochloride	Histamine Receptor	Metabolic Disease
Betazole (Ametazole) dihydrochloride, a pyrazole analogue of histamine, is an orally active H2 receptor agonist. Betazole dihydrochloride induces gastric acid secretion, and causes an immediate and significant increase in common bile duct pressure. Betazole dihydrochloride has been used as a diagnostic agent known as histalog, for investigating gastric acid secretory capacity .

HY-158985

Amino-PEG3-2G degrader-1	AUTACs Autophagy	Cancer
Amino-PEG3-2G degrader-1 (compound ) is a conjugate of a PEG Linker and a pyrazole-linked FBnG tag for ubiquitin-proteasome system (UPS) induction. Amino-PEG3-2G degrader-1 can be used to synthesize autophagy-targeting chimeras (AUTACs) .

HY-151618

Antitumor agent-79	Apoptosis	Cancer
Antitumor agent-79 shows good antiproliferative activities against hepatocellular carcinoma and breast cancer cells with IC₅₀ values of 0.7-7.9 μM. Antitumor agent-79 induces cancer cells apoptosis and shows in vivo antitumor effects. Antitumor agent-79 can be used for the research of cancer .

HY-148481

USP7-IN-10	Deubiquitinase	Cancer
USP7-IN-10 (compound 1) is a potent ubiquitin-specific protease 7 (USP7) inhibitor, with an IC₅₀ of 13.39 nM .

Cat. No.	Product Name	Category	Target	Chemical Structure