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serotonin uptake

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-118166
    Gentisein

    NSC 329491; 1,3,7-Trihydroxyxanthone

    		 5-HT Receptor Neurological Disease
    Gentisein (NSC 329491), the major metabolite of Mangiferin, shows the most potent serotonin uptake inhibition with an IC50 value of 4.7 µM .
    Gentisein
  • HY-32126
    1-Fluoronaphthalene

    		Others Others
    1-Fluoronaphthalene is an organofluorine compound derived from naphthalene derivatives and fluorinated aromatics. 1-Fluoronaphthalene can be used to synthesize LY248686, a potent inhibitor of serotonin and noradrenaline uptake .
    1-Fluoronaphthalene
  • HY-107128
    Ampreloxetine hydrochloride

    TD-9855 hydrochloride

    		 Serotonin Transporter Neurological Disease
    Ampreloxetine (TD-9855) hydrochloride is an orally active and CNS-penetrant inhibitor of Norepinephrine transporter (NET) and Serotonin 5-HT uptake transporter (SERT), but not Dopamine transporter (DAT). Ampreloxetine hydrochloride binds norepinephrine transporters (NET) and serotonin transporters (SERT) with EC50 values of 11.7 ng/mL and 50.8 ng/mL, respectively, in plasma .
    Ampreloxetine hydrochloride
  • HY-110023
    Zimelidine dihydrochloride

    		5-HT Receptor Serotonin Transporter Neurological Disease
    Zimelidine dihydrochloride is a potent and selective inhibitor of serotonin 5-HT uptake and SERT. Zimelidine dihydrochloride is an antidepressant .
    Zimelidine dihydrochloride
  • HY-129682
    LY125180

    		5-HT Receptor Dopamine Receptor Adrenergic Receptor Neurological Disease
    LY125180 is a serotonin uptake inhibitor. LY125180 competitively inhibits the uptake of serotonin and norepinephrine by cortical synaptosomes and of dopamine by striatal synaptosomes, with Ki values of 0.06 μM, 2.2 μM and 2.5 μM respectively .
    LY125180
  • HY-123199
    Serotonin azidobenzamidine

    SABA

    		 Serotonin Transporter Neurological Disease
    Serotonin azidobenzamidine is an arylazido derivative of 5-hydroxytryptamine (HY-B1473A). Serotonin azidobenzamide competitively inhibits [3H]5-hydroxytryptamine uptake by rat cortical synaptosomes in the dark with a Ki of 130 nM .
    Serotonin azidobenzamidine
  • HY-32126R
    1-Fluoronaphthalene (Standard)

    		Others Others
    1-Fluoronaphthalene (Standard) is the analytical standard of 1-Fluoronaphthalene. This product is intended for research and analytical applications. 1-Fluoronaphthalene is an organofluorine compound derived from naphthalene derivatives and fluorinated aromatics. 1-Fluoronaphthalene can be used to synthesize LY248686, a potent inhibitor of serotonin and noradrenaline uptake .
    1-Fluoronaphthalene (Standard)
  • HY-105521A
    Dexnafenodone hydrochloride

    (S)-Nafenodone; LU-43706

    		 Others Neurological Disease
    Dexnafenodone hydrochloride ((S)-Nafenodone) as an antidepressant compound, is a potent and selective inhibitor of the synaptosomal uptake of noradrenaline, but has a less potent effect on serotonin uptake and a negligible effect on dopamine uptake.
    Dexnafenodone hydrochloride
  • HY-135556
    Norfluoxetine

    		Drug Metabolite Neurological Disease
    Norfluoxetine is the active metabolite of antidepressant Fluoxetine (HY-B0102). Norfluoxetine is a selective inhibitor for serotonin uptake .
    Norfluoxetine
  • HY-118835
    Zimelidine

    		5-HT Receptor Serotonin Transporter Neurological Disease
    Zimelidine is a potent and selective inhibitor of serotonin 5-HT uptake and SERT. Zimelidine is an antidepressant .
    Zimelidine
  • HY-105699
    Napamezole

    		Adrenergic Receptor Neurological Disease
    Napamezole is an α2A adrenergic receptor antagonist and a serotonin/norepinephrine uptake inhibitor. Napamezole increases the levels of monoamines in the brain by blocking monoamine uptake, which gives it antidepressant activity .
    Napamezole
  • HY-101753A
    Cianopramine hydrochloride

    Cyanimipramine hydrochloride; Ro 11-2465 hydrochloride

    		 5-HT Receptor Neurological Disease
    Cianopramine hydrochloride (Cyanimipramine hydrochloride; Ro 11-2465 hydrochloride) is the hydrochloride form of Cianopramine (HY-101753). Cianopramine hydrochloride is an antidepressant, which selectively inhibits the serotonin uptake into synaptosomes .
    Cianopramine hydrochloride
  • HY-101753
    Cianopramine

    Cyanimipramine; Ro 11-2465

    		 5-HT Receptor Neurological Disease
    Cianopramine (Cyanimipramine) is a tricyclic antidepressant, and a potent inhibitor of neuronal serotonin (5-HT) uptake. Cianopramine blocks central and peripheral 5-HT receptors .
    Cianopramine
  • HY-B1287
    Citalopram hydrobromide
    5+ Cited Publications

    (±)-Citalopram hydrobromide; Lu 10-171

    		 Serotonin Transporter Autophagy Neurological Disease Cancer
    Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI). Citalopram hydrobromide inhibits 5-HT uptake into synaptosomes with an IC50 of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC50 of 14 nM. Antidepressant effect .
    Citalopram hydrobromide
  • HY-B0773
    Paroxetine mesylate

    BRL29060 mesylate

    		 Serotonin Transporter Adrenergic Receptor Neurological Disease
    Paroxetine mesylate, a phenylpiperidine derivative, is a potent and selective serotonin reuptake inhibitor (SSRI). Paroxetine mesylate is a very weak inhibitor of norepinephrine (NE) uptake but it is still more potent at this site than the other SSRIs .
    Paroxetine mesylate
  • HY-133732
    Alaproclate hydrochloride

    GEA 654 hydrochloride; A03 hydrochloride

    		 Serotonin Transporter 5-HT Receptor iGluR Neurological Disease
    Alaproclate (GEA 654) hydrochloride is a selective and orally active serotonin re-uptake inhibitor (SSRI). Alaproclate hydrochloride also acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow .
    Alaproclate hydrochloride
  • HY-18610
    Diclofensine hydrochloride

    Ro 8-4650 hydrochloride

    		 Dopamine Transporter Neurological Disease
    Diclofensine hydrochloride (Ro-8-4650 hydrochloride) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively.
    Diclofensine hydrochloride
  • HY-18610A
    Diclofensine

    Ro 8-4650

    		 Dopamine Transporter Neurological Disease
    Diclofensine(Ro-8-4650) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively.
    Diclofensine
  • HY-108256
    Melitracen hydrochloride

    		5-HT Receptor Neurological Disease
    Melitracen hydrochloride is an orally active biphasic antidepressant and antianxiety agent. Melitracen hydrochloride can inhibit the uptake of Norepinephrine and 5-HT (serotonin) through the presynaptic membrane inducing the increase of monoamine transmitters in synaptic space .
    Melitracen hydrochloride
  • HY-129985
    Clovoxamine

    DU23811

    		 Serotonin Transporter 5-HT Receptor Neurological Disease
    Clovoxamine (DU23811) (Compound 35) has binding affinity for serotonin transporter (SERT) (Ki: 61 nM). Clovoxamine is a 5-HT and norepinephrine reuptake (NE) re-uptake inhibitor. Clovoxamine is an antidepressant .
    Clovoxamine
  • HY-N0749
    Jatrorrhizine

    		Cholinesterase (ChE) 5-HT Receptor Bacterial Neurological Disease
    Jatrorrhizine is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .
    Jatrorrhizine
  • HY-N0740
    Jatrorrhizine chloride
    1 Publications Verification

    		 Cholinesterase (ChE) 5-HT Receptor Bacterial Neurological Disease Inflammation/Immunology
    Jatrorrhizine chloride is an alkaloid isolated from?Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine chloride is a potent and orally active inhibitor of?AChE?(IC50=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine chloride reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .
    Jatrorrhizine chloride
  • HY-W587542
    (1S,4S)-N-Desmethyl Sertraline hydrochloride

    		Serotonin Transporter Others
    (1S,4S)-N-Desmethyl Sertraline (hydrochloride) is a metabolite of Sertraline. (1S,4S)-N-Desmethyl Sertraline (hydrochloride) is a selective serotonin uptake blocker with antidepressant properties .
    (1S,4S)-N-Desmethyl Sertraline hydrochloride
  • HY-12390
    Lofepramine

    Lopramine

    		 Others Neurological Disease
    Lofepramine (Lopramine) is a potent tricyclic antidepressant and is extensively metabolised to Desipramine. The antidepressant activity of Lofepramine stems from the facilitation of noradrenergic neurotransmission by uptake inhibition. Lofepramine may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase. Lofepramine has significant anxiolytic efficacy in addition to its antidepressant properties .
    Lofepramine
  • HY-12390A
    Lofepramine hydrochloride

    Lopramine hydrochloride

    		 Others Neurological Disease
    Lofepramine (Lopramine) hydrochloride is a potent tricyclic antidepressant and is extensively metabolised to Desipramine. The antidepressant activity of Lofepramine hydrochloride stems from the facilitation of noradrenergic neurotransmission by uptake inhibition. Lofepramine hydrochloride may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase. Lofepramine hydrochloride has significant anxiolytic efficacy in addition to its antidepressant properties .
    Lofepramine hydrochloride
  • HY-N0749A
    Jatrorrhizine hydroxide
    1 Publications Verification

    		 Cholinesterase (ChE) 5-HT Receptor Bacterial Neurological Disease Inflammation/Immunology
    Jatrorrhizine hydroxide is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine hydroxide is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine hydroxide reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .
    Jatrorrhizine hydroxide
  • HY-12394
    Dothiepin

    Dosulepin; Dothep

    		 Histamine Receptor 5-HT Receptor Neurological Disease
    Dothiepin (Dosulepin; Dothep) is an antidepressant agent with sedative/anxiolytic activity. Dothiepin is an inhibitor preferring of noradrenaline uptake than serotonin uptake. Dothiepin facilitates noradrenergic neurotransmission via inhibiting the neuronal uptake. Dothiepin is also an antagonist of histamine H1-receptor without cardiotoxicity. Dothiepin exhibits significant analgesic activity in psychogenic facial pain，idiopathic fibromyalgia syndrome or rheumatoid arthritis .
    Dothiepin
  • HY-126158
    SRI-29574

    		Dopamine Transporter Serotonin Transporter Neurological Disease
    SRI-29574 is an allosteric modulator of the dopamine transporter (DAT). SRI-29574 partially inhibits the uptake of the DAT (IC50=2.3 nM) and also partially inhibits the uptake of the serotonin transporter (SERT) and norepinephrine transporter (NET). SRI-29574 may serve as a useful probe to study the function and regulatory mechanisms of DAT .
    SRI-29574
  • HY-B1287R
    Citalopram hydrobromide (Standard)

    (±)-Citalopram hydrobromide(Standard); Lu 10-171 (Standard)

    		 Serotonin Transporter Autophagy Neurological Disease Cancer
    Citalopram (hydrobromide) (Standard) is the analytical standard of Citalopram (hydrobromide). This product is intended for research and analytical applications. Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI). Citalopram hydrobromide inhibits 5-HT uptake into synaptosomes with an IC50 of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC50 of 14 nM. Antidepressant effect .
    Citalopram hydrobromide (Standard)
  • HY-122272S2
    Paroxetine-d6-1

    BRL29060-d6-1

    		 Isotope-Labeled Compounds Adrenergic Receptor Serotonin Transporter Neurological Disease
    Paroxetine-d6-1 is a deuterated labeled Paroxetine . Paroxetine, a phenylpiperidine derivative, is a potent and selective serotonin reuptake inhibitor (SSRI). Paroxetine is a very weak inhibitor of norepinephrine (NE) uptake but it is still more potent at this site than the other SSRIs .
    Paroxetine-d6-1
  • HY-N0740R
    Jatrorrhizine chloride (Standard)

    		Cholinesterase (ChE) 5-HT Receptor Bacterial Neurological Disease Inflammation/Immunology
    Jatrorrhizine (chloride) (Standard) is the analytical standard of Jatrorrhizine (chloride). This product is intended for research and analytical applications. Jatrorrhizine chloride is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine chloride is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine chloride reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .
    Jatrorrhizine chloride (Standard)
  • HY-108256S
    Melitracen-d6 hydrochloride

    		Isotope-Labeled Compounds 5-HT Receptor Neurological Disease
    Melitracen-d6 (hydrochloride) is the deuterium labeled Melitracen hydrochloride. Melitracen hydrochloride is an orally active biphasic antidepressant and antianxiety agent. Melitracen hydrochloride can inhibit the uptake of Norepinephrine and 5-HT (serotonin) through the presynaptic membrane inducing the increase of monoamine transmitters in synaptic space[1][2].
    Melitracen-d6 hydrochloride
  • HY-165378
    (E)-Dothiepin hydrochloride

    (E)-Dosulepin hydrochloride; (E)-Dothep hydrochloride

    		 Histamine Receptor Neurological Disease
    (E)-Dothiepin ((E)-Dosulepin;(E)-Dothep) hydrochloride is an antidepressant agent with sedative/anxiolytic activity. (E)-Dothiepin hydrochloride is an inhibitor preferring of noradrenaline uptake than serotonin uptake. (E)-Dothiepin hydrochloride facilitates noradrenergic neurotransmission via inhibiting the neuronal uptake. (E)-Dothiepin hydrochloride is also an antagonist of histamine H1-receptor without cardiotoxicity. (E)-Dothiepin hydrochloride exhibits significant analgesic activity in psychogenic facial pain，idiopathic fibromyalgia syndrome or rheumatoid arthritis .
    (E)-Dothiepin hydrochloride
  • HY-108256R
    Melitracen hydrochloride (Standard)

    		5-HT Receptor Neurological Disease
    Melitracen (hydrochloride) (Standard) is the analytical standard of Melitracen (hydrochloride). This product is intended for research and analytical applications. Melitracen hydrochloride is an orally active biphasic antidepressant and antianxiety agent. Melitracen hydrochloride can inhibit the uptake of Norepinephrine and 5-HT (serotonin) through the presynaptic membrane inducing the increase of monoamine transmitters in synaptic space .
    Melitracen hydrochloride (Standard)
  • HY-12390S
    Lofepramine-d3

    		Isotope-Labeled Compounds Neurological Disease
    Lofepramine-d3 (Lopramine-d3) is the deuterium labeled Lofepramine. Lofepramine (Lopramine) is a potent tricyclic antidepressant and is extensively metabolised to Desipramine. The antidepressant activity of Lofepramine stems from the facilitation of noradrenergic neurotransmission by uptake inhibition. Lofepramine may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase. Lofepramine has significant anxiolytic efficacy in addition to its antidepressant properties[1].
    Lofepramine-d3
  • HY-14201
    Lazabemide

    Ro 19-6327

    		 Monoamine Oxidase Neurological Disease
    Lazabemide (Ro 19-6327) is a selective, reversible inhibitor of monoamine oxidase B (MAO-B) (IC50=0.03 μM) but less active for MAO-A (IC50>100 μM). Lazabemide ?inhibits monoamine uptake at high concentrations, the IC50 values are 86 μM, 123 μM and >500 μM for noradrenalin, serotonin and dopamine uptake, respectively. Lazabemide can be used for the research of parkinson and?alzheimer′s disease .
    Lazabemide
  • HY-14202
    Lazabemide hydrochloride

    Ro 19-6327 hydrochloride

    		 Monoamine Oxidase Neurological Disease
    Lazabemide hydrochloride (Ro 19-6327 hydrochloride) is a selective, reversible inhibitor of monoamine oxidase B (MAO-B) (IC50=0.03 μM) but less active for MAO-A (IC50>100 μM). Lazabemide  inhibits monoamine uptake at high concentrations, the IC50 values are 86 μM, 123 μM and >500 μM for noradrenalin, serotonin and dopamine uptake, respectively. Lazabemide can be used for the research of parkinson and alzheimer′s disease .
    Lazabemide hydrochloride
  • HY-117223
    GEA 857

    		Potassium Channel Neurological Disease
    GEA 857 is a structural analog of the Serotonin (HY-B1473A) uptake blocker Alaproclate (HY-164011). GEA 857 enhances responses induced by muscarinic receptor agonists by inhibiting certain calcium-dependent potassium channels on membranes, a blockade that can enhance or prolong the muscarinic cholinergic effects. GEA 857 can be used in research on neurodegenerative diseases .
    GEA 857
  • HY-116062
    JNJ-7925476 hydrochloride

    		Others Others
    JNJ-7925476 (hydrochloride) is a triple monoamine uptake inhibitor with the ability to regulate neurotransmitter levels and antidepressant activity. JNJ-7925476 (hydrochloride) can be rapidly absorbed into the plasma in rats, with a higher concentration in the brain than in plasma. It can induce an increase in the levels of extracellular serotonin, dopamine, and norepinephrine in the rat cerebral cortex, and exhibits antidepressant activity in the mouse tail suspension test.
    JNJ-7925476 hydrochloride
  • HY-14472
    Tesofensine

    NS-2330

    		 Dopamine Transporter Serotonin Transporter Metabolic Disease
    Tesofensine (NS-2330) is a triple monoamine reuptake inhibitor inducing a potent inhibition of the re-uptake process in the synaptic cleft of the neurotransmitters dopamine (DA; IC50=6.5 nM), norepinephrine (NE;IC50=1.7 nM), and serotonin (5-HT;IC50=11 nM), and with potentials as an anti-obesity agent . Tesofensine is a CNS acting anti-obesity agent .
    Tesofensine
  • HY-106617A
    Etoperidone hydrochloride

    		5-HT Receptor Adrenergic Receptor Neurological Disease
    Etoperidone hydrochloride, an antidepressant agent, is an orally active serotonin and nor-adrenaline re-uptake antagonist. Etoperidone hydrochloride shows Kd values of 36 nM, 38 nM, 85 nM, and 570 nM for 5-HT2 receptor, α1-adrenergic receptor, 5-HT1A receptor, and α2-adrenergic receptor, respectively .
    Etoperidone hydrochloride
  • HY-W011235
    Norfluoxetine hydrochloride

    		5-HT Receptor Calcium Channel Drug Metabolite Neurological Disease
    Norfluoxetine hydrochloride is an active N-demethylated metabolite of Fluoxetine. Fluoxetine is a selective serotonin (5-HT) reuptake inhibitor that is metabolized to Norfluoxetine hydrochloride by cytochrome P450 (CYP) 2D6, CYP2C19, and CYP3A4. Norfluoxetine hydrochloride inhibits 5-HT uptake and inhibits CaV3.3 T current (IC50 = 5 μM). Norfluoxetine hydrochloride has anticonvulsant activity .
    Norfluoxetine hydrochloride
  • HY-117542
    D595

    		Others Neurological Disease
    D595 is a phenylethylamine calcium channel blocker with potent negative inotropic activity. D595 has shown significant efficacy in its corresponding pharmacological studies, especially in inhibiting the uptake of monoamine neurotransmitters. D595 has high affinity in binding to the dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET). Structural adjustments of D595, especially changes in the hydroxyl stereochemistry, significantly affect its interaction with the transporters, showing a specific preference for stereoisomers .
    D595
  • HY-W020111
    7-Chloro-4-(piperazin-1-yl)quinoline

    		Sirtuin Parasite Infection
    7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry. 7-Chloro-4-(piperazin-1-yl)quinolone is a potent sirtuin inhibitor and also inhibits the serotonin uptake (IC50 of 50 μM). 7-Chloro-4-(piperazin-1-yl)quinolone exhibits antimalarial activity on D10 and K1 strains of P. falciparum with IC50s of 1.18 μM and 0.97 μM, respectively .
    7-Chloro-4-(piperazin-1-yl)quinoline

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