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synaptic blocking

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) Calcium Channel (3) Endogenous Metabolite (1) iGluR (6) Interleukin Related (1) mAChR (1) nAChR (1) P2X Receptor (1) P2Y Receptor (1) Phosphatase (1) PKC (1) Potassium Channel (1) Pyroptosis (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Inflammation/Immunology (4) Neurological Disease (13)

Inhibitors & Agonists

Peptides

Natural
Products

Targets Recommended: Synaptic Vesicle Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P0062B

Ziconotide acetate SNX-111 acetate	Calcium Channel	Cardiovascular Disease Inflammation/Immunology Cancer
Ziconotide acetate (SNX-111 acetate), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide acetate reduces synaptic transmission, and can be used for chronic pain research .

HY-121964

cis-Piperidine-2,3-dicarboxylic acid	iGluR	Neurological Disease
Cis-piperidine-2,3-dicarboxylic acid is a non-specific antagonist of NMDA, AMPA and kainate ionotropic receptors and a partial agonist for NMDA receptors. Cis-piperidine-2,3-dicarboxylic acid can be used in blocking general excitatory synaptic transmissions .

HY-P2259

TAT-GluA2 3Y 1 Publications Verification	iGluR	Neurological Disease
TAT-GluA2 3Y, an interference peptide, blocks long-term depression (LTD) at glutamatergic synapses by disrupting the endocytosis of AMPAR. TAT-GluA2 3Y can alleviate Pentobarbital-induced spatial memory deficits and synaptic depression .

HY-100714B

L-AP5 L-APV; L-2-Amino-5-phosphonovaleric acid	iGluR	Neurological Disease
L-AP5 (L-APV; L-2-Amino-5-phosphonovaleric acid) is an NMDA antagonist and is the isomer of D-AP5 (HY-100714A). L-AP5 shows a relatively weak amino acid and synaptic blocking activity .

HY-107605

UBP296	iGluR	Neurological Disease
UBP296 is a potent and selective antagonist of GLU_K5-containing kainate receptor in the spinal cord. UBP296 reversibly blocks ATPA-induced depressions of synaptic transmission, and affects AMPA receptor-mediated synaptic transmission directly in rat hippocampal slices .

HY-P0062

Ziconotide SNX-111	Calcium Channel	Neurological Disease Inflammation/Immunology Cancer
Ziconotide (SNX-111), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide reduces synaptic transmission, and can be used for chronic pain research .

HY-P1054

pep2-EVKI YNVYGIEEVKI	PKC	Neurological Disease
pep2-EVKI (YNVYGIEEVKI) is an inhibitor peptide that selectively blocks PICK1 interactions, caused the opposite effects on synaptic AMPAR function to PICK1 expression .

HY-100785A

gamma-DGG acetate γDGG acetate; γ-D-Glutamylglycine acetate	iGluR	Neurological Disease
gamma-DGG acetate (γDGG acetate) is a competitive AMPA receptor blocker. gamma-DGG acetate is also a reversible *Excitatory post-synaptic* potentials** (e.p.s.p.s) antagonist .

HY-P0062A

Ziconotide TFA SNX-111 TFA	Calcium Channel	Neurological Disease Inflammation/Immunology Cancer
Ziconotide TFA (SNX-111 TFA), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide TFA reduces synaptic transmission, and can be used for chronic pain research .

HY-169871

Argiotoxin 636	iGluR	Neurological Disease
Argiotoxin 636 is a toxin and the non-specific, non-competitive, and potent ionotropic glutamate receptor (iGluR) antagonist. Argiotoxin 636 blocks excitatory synaptic transmission in neurons and has paralysis and muscle relaxation effects. Argiotoxin 636 can be used in the study of nervous system diseases .

HY-P10630

Pep63	Amyloid-β	Neurological Disease
Pep63 is a neuroprotective peptide (VFQVRARTVA). Pep63 has a neuroprotective effect on synaptic plasticity and memory. Pep63 can competitively bind with Aβ1-42 oligomers, and can block Aβ fiber formation. Pep63 can be used for Alzheimer’s disease (AD) research .

HY-103259

Sodium metatungstate 5+ Cited Publications Sodium polyoxotungstate; POM-1	Phosphatase P2X Receptor P2Y Receptor Pyroptosis Interleukin Related	Neurological Disease Inflammation/Immunology Cancer
Sodium metatungstate (Sodium polyoxotungstate) is a NTPDase inhibitor, with K_i values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively . Sodium metatungstate has anti-inflammatory and anti-cancer effect. Sodium metatungstate inhibits ATP breakdown but also blocks central synaptic transmission .

HY-P0099

Pentapeptide-3	nAChR	Others
Pentapeptide-3 is a pentapeptide fragment of neurotoxin waglerin-1, it can be extracted from the venom of Temple Viper. Pentapeptide-3 is a competitive antagonist of nicotinic acetylcholine receptors (nAChRs), it can blocks nerves at the post-synaptic membrane. Pentapeptide-3 has anti-aging effects and it can be used together with other cosmetic peptides .

HY-B1789

Telenzepine	mAChR	Neurological Disease
Telenzepine is an antimuscarinic agent with Kis of 0.94 nM (M1 mAChR) and 17.8 nM (M2 mAChR) binding to muscarinic receptors. Telenzepine effectively blocks synaptic transmission promoted by muscarinic or M1 receptor agonists. Thus, Telenzepine can reduce the amplitude of extracellular slow excitatory postsynaptic potentials (EC50=38 nM) and slow inhibitory postsynaptic potentials (EC50=253 nM) .

HY-108578

RuBi-4AP	Potassium Channel	Neurological Disease
RuBi-4AP, a derivative of 4-aminopyridine (4AP; HY-B0604), is a caged K_v channel blocker. RuBi-4AP contains a photolabile protecting group, allowing its effect to be controlled precisely in both space and time with light. RuBi-4AP can be used for the research of neuronal excitability, synaptic transmission, and signal propagation .

HY-134356

AICA-riboside, 5′-phosphate AICAR-5'-MP	Endogenous Metabolite	Others
AICA-riboside, 5′-phosphate is AICA riboside with a phosphate group. The functions of AICA riboside include: 1) conversion into AMP mimetic to selectively activate AMPK; 2) competition with adenosine for the uptake of nucleoside transporters, reversible blocking of adenosine reuptake, increasing extracellular adenosine concentration, and indirectly activating adenosine A1 receptors. AICA riboside is involved in metabolic regulation (promoting catabolism and inhibiting anabolism) and adenosine-dependent neuroprotection (inhibiting excitatory synaptic transmission). AICA riboside can be used in the study of metabolic diseases (such as diabetes and obesity) and neurological diseases (such as ischemia and epilepsy), and has central nervous system protective activity .

Cat. No.	Product Name	Target	Research Area

HY-P0062B

Ziconotide acetate SNX-111 acetate	Calcium Channel	Cardiovascular Disease Inflammation/Immunology Cancer
Ziconotide acetate (SNX-111 acetate), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide acetate reduces synaptic transmission, and can be used for chronic pain research .

HY-P2259

TAT-GluA2 3Y 1 Publications Verification	iGluR	Neurological Disease
TAT-GluA2 3Y, an interference peptide, blocks long-term depression (LTD) at glutamatergic synapses by disrupting the endocytosis of AMPAR. TAT-GluA2 3Y can alleviate Pentobarbital-induced spatial memory deficits and synaptic depression .

HY-P0099

Pentapeptide-3	nAChR	Others
Pentapeptide-3 is a pentapeptide fragment of neurotoxin waglerin-1, it can be extracted from the venom of Temple Viper. Pentapeptide-3 is a competitive antagonist of nicotinic acetylcholine receptors (nAChRs), it can blocks nerves at the post-synaptic membrane. Pentapeptide-3 has anti-aging effects and it can be used together with other cosmetic peptides .

HY-P0062

Ziconotide SNX-111	Calcium Channel	Neurological Disease Inflammation/Immunology Cancer
Ziconotide (SNX-111), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide reduces synaptic transmission, and can be used for chronic pain research .

HY-P1054

pep2-EVKI YNVYGIEEVKI	PKC	Neurological Disease
pep2-EVKI (YNVYGIEEVKI) is an inhibitor peptide that selectively blocks PICK1 interactions, caused the opposite effects on synaptic AMPAR function to PICK1 expression .

HY-P0062A

Ziconotide TFA SNX-111 TFA	Calcium Channel	Neurological Disease Inflammation/Immunology Cancer
Ziconotide TFA (SNX-111 TFA), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide TFA reduces synaptic transmission, and can be used for chronic pain research .

HY-P10630

Pep63	Amyloid-β	Neurological Disease
Pep63 is a neuroprotective peptide (VFQVRARTVA). Pep63 has a neuroprotective effect on synaptic plasticity and memory. Pep63 can competitively bind with Aβ1-42 oligomers, and can block Aβ fiber formation. Pep63 can be used for Alzheimer’s disease (AD) research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-134356

AICA-riboside, 5′-phosphate AICAR-5'-MP	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
AICA-riboside, 5′-phosphate is AICA riboside with a phosphate group. The functions of AICA riboside include: 1) conversion into AMP mimetic to selectively activate AMPK; 2) competition with adenosine for the uptake of nucleoside transporters, reversible blocking of adenosine reuptake, increasing extracellular adenosine concentration, and indirectly activating adenosine A1 receptors. AICA riboside is involved in metabolic regulation (promoting catabolism and inhibiting anabolism) and adenosine-dependent neuroprotection (inhibiting excitatory synaptic transmission). AICA riboside can be used in the study of metabolic diseases (such as diabetes and obesity) and neurological diseases (such as ischemia and epilepsy), and has central nervous system protective activity .

HY-169871

Argiotoxin 636	Structural Classification Animals Source classification Phenols Polyphenols Animal Venoms	iGluR
Argiotoxin 636 is a toxin and the non-specific, non-competitive, and potent ionotropic glutamate receptor (iGluR) antagonist. Argiotoxin 636 blocks excitatory synaptic transmission in neurons and has paralysis and muscle relaxation effects. Argiotoxin 636 can be used in the study of nervous system diseases .

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synaptic blocking

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