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Results for "

terminal alkynes

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (2) Apoptosis (1) Bacterial (2) Biochemical Assay Reagents (33) Cytochrome P450 (1) Deubiquitinase (1) E3 Ligase Ligand-Linker Conjugates (2) Epigenetic Reader Domain (1) Fluorescent Dye (23) HSP (1) Liposome (2) PROTAC Linkers (2)
By Research Areas:	Cancer (8) Infection (2) Metabolic Disease (1)
Click Chemistry:	Labeling and Fluorescence Imaging (3) PROTAC Synthesis (2) Azide (16) Alkynes (17)
Oligonucleotides:	Cationic Lipids (1) Cholesterol (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Click Chemistry

Oligonucleotides

Targets Recommended: JNK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-159708

Ionizable lipid Az1	Liposome	Others
Ionizable lipid Az1is an ionizable lipid which can react with a variety of terminal alkynes under the CuAAC standard condition .

HY-D1664

BDP 558/568 alkyne	Fluorescent Dye	Others
BDP 558/568 alkyne is a borondipyrromethene dye. BDP 558/568 alkyne possesses high quantum yield. BDP 558/568 alkyne is a terminal alkyne for copper-catalyzed Click chemistry. (λ_ex=558 nm, λ_em=568 nm) .

HY-W615095

Biotin-PEG2-alkyne	Biochemical Assay Reagents	Others
Biotin-PEG2-alkyne is a short PEG linker featuring a biotin group and a terminal alkyne. Biotin is useful for affinity-based applications such as pull-down assays while terminal alkynes are used in copper (I) click chemistry with azides.

HY-132273

**Alkyne Phosphoramidite, 5'-terminal**	Biochemical Assay Reagents	Others
Alkyne Phosphoramidite, 5'-terminal (Compound 2) can be used for synthesis of oligo-nucleotides.

HY-151665

Alkyne-PEG2-iodide	ADC Linker	Others
Alkyne-PEG2-iodide is a click chemistry reagent with terminal alkyne and alkyl iodide groups.

HY-137018

27-Alkyne cholesterol	Biochemical Assay Reagents	Others
27-Alkyne cholesterol is a modified lipid containing an omega-terminal alkyne. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents, known as click chemistry, in the presence of a copper-containing catalyst. Alkyne cholesterol represents a versatile, sensitive, and easy-to-use tool for tracking cellular cholesterol metabolism and localization as it allows for manifold detection methods including mass spectrometry, and fluorescence microscopy.

HY-W615166

Thalidomide-NH-C2-alkyne	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-NH-C2-alkyne contains an E3 ligase ligand with an alkyl linker, and a terminal alkyne. Thalidomide-NH-C2-alkyne is ready for conjugation to target proteins for PROTAC R&D.

HY-W800840

Alkyne sphinganine	Biochemical Assay Reagents	Others
Alkyne Sphinganine a metabolic labeling reagent that contains a terminal alkyne moiety that allows for the subsequent tagging of protein?lipid complexes by click chemistry. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents, known as ‘click chemistry’, in the presence of a copper (Cu)-containing catalyst allowing for the visualization and proteomic profiling of protein?sphingolipid complexes in living cells.

HY-W674324

Thalidomide-5-NH-C-alkyne	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-5-NH-C-alkyne contains an E3 ligase ligand with a terminal alkyne. Thalidomide-5-NH-C-alkyne is ready for conjugation to target proteins for PROTAC.

HY-N1455

Falcarinol Panaxynol; Carotatoxin	HSP Apoptosis	Cancer
Falcarinol (Panaxynol) is a natural, orally active Hsp90 inhibitor targeting both the N-terminal and C-terminal of Hsp90 with limited toxicities. Falcarinol (Panaxynol) induces apoptosis . Falcarinol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-D1307A

Sulfo-cyanine7 alkyne potassium	Fluorescent Dye
Sulfo-cyanine7 alkyne potassium is a water-soluble near-infrared dye with a sulfonated terminal alkyne that can be used in copper-catalyzed click chemistry reactions to conjugate with azides in an aqueous environment.

HY-D1307

Sulfo-cyanine7 alkyne	Fluorescent Dye
Sulfo-cyanine7 alkyne is a water-soluble near-infrared dye with a sulfonated terminal alkyne that can be used in copper-catalyzed click chemistry reactions to conjugate with azides in an aqueous environment.

HY-D1333

BDP 630/650 alkyne	Fluorescent Dye	Others
DP 630/650 alkyne is a red fluorescent dye with λ_excitation of 630 nM and λ_emission of 650 nM. The terminal alkyne group can be conjugated with various azides by copper catalyzed Click chemistry. BDP 630/650 alkyne can be used for fluorescence polarization assays .

HY-W598193

[(5-Azidopentyl)oxy](1,1-dimethylethyl)dimethylsilane	Biochemical Assay Reagents	Others
[(5-Azidopentyl)oxy](tert-butyl)dimethylsilane is a silane compound with a terminal azide group. The trimethylsilane is commonly used for surface modifications. The terminal azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry.

HY-151705

Alkyne Cholesterol 1 Publications Verification	Liposome	Metabolic Disease
Alkyne Cholesterol, a modified lipid, is a click chemistry reagent containing an *alkyne* group. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents in the presence of a copper (Cu)-containing catalyst. Alkyne Cholesterol can be used for tracking cellular cholesterol metabolism and localization .

HY-Y1738

Tetrakis(triphenylphosphine)palladium Tetrakis(triphenylphosphine)palladium(0)	Biochemical Assay Reagents	Others
Tetrakis(triphenylphosphine)palladium is a catalyst. Tetrakis(triphenylphosphine)palladium catalyzes the highly regioselective addition of phenyl thiocyanate (PhSCN) to terminal alkynes .

HY-172296

Biotinamide-C3-PEG3-C-alkyne	Biochemical Assay Reagents	Others
Biotinamide-C3-PEG3-C-alkyne is a biotin PEG reagent containing a PEG3 chain linked to a terminal azide which can react with alkyne, BCN, DBCO via Click Chemistry.

HY-D1347

BDP 650/665 alkyne	Fluorescent Dye
BDP 650/665 alkyne is a bright boron dipyrromethene dye designed for use in the Cy5 channel of a variety of instruments. The terminal ethynyl group of the BDP 650/665 alkyne can be readily conjugated to various azides using copper-catalyzed click chemistry.

HY-34643

6-Heptynoic acid Hept-6-ynoic acid	Biochemical Assay Reagents	Others
6-Heptynoic acid (Hept-6-ynoic acid) is a reagent with an alkyne group and a carboxylic acid. The terminal carboxylic acid can form amide bond with primary amines (activation is needed). The alkyne can form triazole linkage with azide containing molecules via copper catalyzed reactions.

HY-147097A

EDA-DA TFA	Bacterial	Infection
EDA-DA is a N-terminally tagged dipeptide probe, can be used to label Peptidoglycan (PG) of bacteria. EDA-DA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .

HY-112789

(+)-JQ1 PA 1 Publications Verification	Epigenetic Reader Domain	Cancer
(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1, with an IC₅₀ of 10.4 nM. (+)-JQ1 PA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W800703

Alexa Fluor 594 azide	Fluorescent Dye	Others
Alexa Fluor 594 azide is a bright red fluorescent azide-activated probe that reacts with terminal alkynes via a copper-catalyzed click reaction (CuAAC) for single-molecule imaging .

HY-W591376

Azido-PEG19-azide	Biochemical Assay Reagents	Others
Azido-PEG19-azide is a click chemistry reagent with two terminal azide groups. The azide groups can react with alkyne, BCN, DBCO via Click Chemistry.

HY-115715A

EN219-alkyne	Fluorescent Dye	Cancer
EN219-alkyne is an alkyne-functionalized EN219 probe. EN219 (HY-P0287A) is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC₅₀ of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination . EN219-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W800807

R6G azide, 5-isomer	Fluorescent Dye	Others
R6G azide, 5-isomer is a xanthene dye with a terminal azide. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

HY-D1320

Cyanine5 azide chloride	Fluorescent Dye	Others
Cyanine5 azide chloride is a potent fluorescent dye. Cyanine5 azide chloride can be reacted with terminal alkynes via a copper-catalyzed click reaction (CuAAC). (λ_ex=646 nm, λ_em=662 nm) . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-W588704

4-Azidobutyric acid	Biochemical Assay Reagents	Others
4-Azidobutyric acid is a small molecule featuring an azide and a carboxylic acid. Carboxylic acids can be linked with alcohols or amides while azides can be used as click chemistry handles to react with terminal alkynes or strained cyclooctynes.

HY-D1321

Cy 5 amine hydrochloride Cyanine5 amine hydrochloride	Fluorescent Dye	Others
Cyanine5 amine hydrochloride is a potent fluorescent dye. Cyanine5 amine hydrochloride can be reacted with terminal alkynes via a copper-catalyzed click reaction (CuAAC). (λ_ex=646 nm, λ_em=662 nm) .

HY-W800706

Azidobutanamide-tri-(carboxyethoxymethyl)-methane	Biochemical Assay Reagents	Others
Azidobutanamide-tri-(carboxyethoxymethyl)-methane is a aqueous soluble PEG linker with an azide group with three terminal carboxylic acids. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-127112

Oleic acid alkyne	Cytochrome P450	Others
Oleic acid alkyne is oleic acid with an acetylene group. The terminal alkyne group can be used for click chemical ligation reactions. Oleic acid can be hydroxylated by a microsomal cytochrome P-450-dependent system (ω-OAH). Through click chemistry reactions, fluorescent or biotin-labeled oleic acid can be introduced to analyze its metabolism and biological activity.

HY-D1349

Bodipy TR alkyne	Fluorescent Dye
Bodipy TR alkyneis one of a boron dipyrromethene fluorophore for the ROX (Texas Red) channel. This is a versatile fluorophore that can be used in microscopy, fluorescence polarization measurements, and other applications. This derivative is a terminal alkyne of copper-catalyzed click chemistry.

HY-W190786

Bromoacetamido-PEG2-azide	Biochemical Assay Reagents	Others
Bromoacetamido-PEG2-azide is a heterobifunctional PEG linker containing a reactive bromoacetamido and a terminal azide.The bromoacetamidogroup is a very reactive group for nucleophilic substitution. The azide group can react with alkyne, BCN, DBCO via Click Chemistry.

HY-W190836

N3-PEG2-Tos	Biochemical Assay Reagents	Others
Azide-PEG2-Tos is a small PEG linker featuring an azide and a tosylate. Tosylates are good leaving groups which are easily displaced by nucleophiles while azide is a click chemistry handle which is used to react with terminal alkynes or strained cyclooctynes.

HY-W190738

Azide-PEG8-Tos	Biochemical Assay Reagents	Others
Azide-PEG8-Tos is a small PEG linker featuring an azide and a tosylate. Tosylates are good leaving groups which are easily displaced by nucleophiles while azide is a click chemistry motif which is used to react with terminal alkynes or strained cyclooctynes.

HY-D2161

AF 594 azide	Fluorescent Dye	Others
AF 594 azide is an azide derivative of the red fluorescent dye AF 594, which has high fluorescence quantum yield and high photostability (maximum absorption wavelength of 586 nm, maximum emission wavelength of 613 nm). AF 594 azide forms stable adducts by reaction of the azide group with alkynyl derivatives (terminal alkynes and cyclooctyne). It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .

HY-151678

N3-L-Lys(Mtt)-OH	ADC Linker	Others
N3-L-Lys(Mtt)-OH is a click chemistry reagent containing an azide group. N3-L-Lys(Mtt)-OH can introduce azide functions into the amino acid building block of peptide sequences at the N-terminal position. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-129832

Biotin-azide 2 Publications Verification N-(3-Azidopropyl)biotinamide	Biochemical Assay Reagents	Others
Biotin-azide (N-(3-Azidopropyl)biotinamide) is a form of biotin with a terminal azide group. Biotin-azide can be used to prepare various biotinylated conjugates via Click Chemistry . Biotin-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-W591975

Alkyne maleimide	Biochemical Assay Reagents	Others
Alkyne maleimide is a bifunctional linker reagent with a terminal malimide group and a propargyl group. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The propargyl group can be linked to azide-containing biomolecules via Click Chemistry.

HY-W592010

C18-PEG4-Azide	Biochemical Assay Reagents	Others
C18-PEG4-Azide is a hybrid linker featuring a hydrophobic C18 chain, a hydrophilic PEG4 spacer, and an azide. The azide is reactive with terminal alkynes or strained cyclooctynes such as DBCO or BCN through click chemistry.

HY-147097

EDA-DA	Bacterial	Infection
EDA-DA, a N-terminally tagged dipeptide probe, can be used to label Peptidoglycan (PG) of bacteria. Peptidoglycan (PG), an essential structure in the cell walls of the vast majority of bacteria, is critical for division and maintaining cell shape and hydrostatic pressure . EDA-DA is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-D1721

Fluorescein-12-dATP	Fluorescent Dye	Others
Fluorescein-12-dATP is a fluorescent dye acting as the detection probe. Fluorescein-12-dATP can be used to label the thrombin-binding aptamers by catalytic polymerization of TdT (terminal deoxynucleotidyl transferase) . Fluorescein-12-dATP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W336992

2-(7-Octyn-1-yl)-1H-isoindole-1,3-dione	Biochemical Assay Reagents	Others
2-(7-Octyn-1-yl)-1H-isoindole-1,3-dione is a phthalimide with a terminal propargyl group connected by a 6-carbon linker. The alkyne can participate in copper-catalyzed Click Chemistry.

HY-W598194

1-((4-Azidobutoxy)methyl)-4-methoxybenzene	Biochemical Assay Reagents	Others
1-((4-Azidobutoxy)methyl)-4-methoxybenzene is a compound with a methyl phenol group and a butyl tail ending in a terminal azide. The azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

HY-W598199

Ethyl 4-azidobutyrate	Biochemical Assay Reagents	Others
Ethyl 4-azidobutyrate comprises an ethyl ester and a terminal azide group with a 3-carbon linker. The azide can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The methyl ester groups can be hydrolyzed, reduced, or substituted under different conditions.

HY-W197430

Ethyl 6-azidohexanoate	Biochemical Assay Reagents	Others
Ethyl 6-azidohexanoate comprises an ethyl ester and a terminal azide group with a 5-carbon linker. The azide can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The methyl ester groups can be hydrolyzed, reduced, or substituted under different conditions.

HY-W598198

Ethyl 3-azidopropanoate	Biochemical Assay Reagents	Others
Ethyl 3-azidopropanoate comprises an ethyl ester and a terminal azide group with a 2-carbon linker. The azide can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The methyl ester groups can be hydrolyzed, reduced, or substituted under different conditions.

HY-D1649

BDP R6G amine	Fluorescent Dye	Others
BDP R6G amine is a fluorophore based on borondipyrromethene scaffold. BDP R6G amine is a BDP linker containing an amine group. BDP R6G amine is a terminal alkyne for copper-catalyzed Click chemistry. (λ_ex=530 nm, λ_em=548 nm).

HY-130598

N-(Azido-PEG3)-N-Boc-PEG4-acid	PROTAC Linkers	Cancer
N-(Azido-PEG3)-N-Boc-PEG4-acid is a PEG-based PROTAC linker with a terminal azide group and is used in the synthesis of PROTACs N-(Azido-PEG3)-N-Boc-PEG4-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-151774

TAMRA hydrazide (6-isomer)	Fluorescent Dye	Others
TAMRA hydrazide (6-isomer) is a click chemistry reagent that can be coupled to carbonyl compounds. The dye hydrazide in TAMRA hydrazide (6-isomer) labels carbonyl compounds such as aldehydes and ketones. TAMRA in TAMRA hydrazide (6-isomer) is a xanthene red fluorophore that reacts with terminal alkynes .

HY-W800691

BP Fluor 350 picolyl azide	Fluorescent Dye	Others
BP Fluor 350 Picolyl Azide is a blue-fluorescent azide-activated probe that reacts with terminal alkynes via a copper-catalyzed click reaction (CuAAC). It also reacts with strained cyclooctyne via a copper-free click chemistry reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures.

Cat. No.	Product Name

HY-L908

Lead-like Covalent Screening Library

1,049 compounds

Small molecule covalent inhibitors, or irreversible inhibitors, are a type of inhibitors that exert their biological functions by irreversibly binding to target through covalent bonds. Compared with non-covalent inhibitors, covalent inhibitors have obvious advantages in bioactivity, such that covalent warheads can target rare residues of a particular target protein, thus leading to the development of highly selective inhibitors and achieving a more complete and continued target occupancy in living systems. In recent years, the distinct strengths of covalent inhibitors in overcoming drug resistance had been recognized. However, toxicity can be a real challenge related to this class of therapeutics due to their potential for off-target reactivity and has led to these drugs being disfavored as a drug class. The drug design and optimization of covalent inhibitors has become a hot spot in drug discovery.

MCE Lead-like Covalent Screening Library offers a valuable resource of 1,049 lead-like compounds with commonly used covalent warheads. These warheads, such as acrylamide, activated terminal alkyne, acyloxymethyl ketone, and boronic acid, are capable of reacting with specific amino acid residues, including cysteine, lysine, serine, and histidine. The inclusion of these reactive warheads in the library allows researchers to explore the potential of covalent inhibition, a powerful approach in drug discovery.

Cat. No.	Product Name	Type

HY-D1320

Cyanine5 azide chloride

Dyes

Cyanine5 azide chloride is a potent fluorescent dye. Cyanine5 azide chloride can be reacted with terminal alkynes via a copper-catalyzed click reaction (CuAAC). (λ_ex=646 nm, λ_em=662 nm) . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-D1664

BDP 558/568 alkyne	Fluorescent Dyes/Probes
BDP 558/568 alkyne is a borondipyrromethene dye. BDP 558/568 alkyne possesses high quantum yield. BDP 558/568 alkyne is a terminal alkyne for copper-catalyzed Click chemistry. (λ_ex=558 nm, λ_em=568 nm) .

HY-D1307A

Sulfo-cyanine7 alkyne potassium	Fluorescent Dyes/Probes
Sulfo-cyanine7 alkyne potassium is a water-soluble near-infrared dye with a sulfonated terminal alkyne that can be used in copper-catalyzed click chemistry reactions to conjugate with azides in an aqueous environment.

HY-D1307

Sulfo-cyanine7 alkyne	Fluorescent Dyes/Probes
Sulfo-cyanine7 alkyne is a water-soluble near-infrared dye with a sulfonated terminal alkyne that can be used in copper-catalyzed click chemistry reactions to conjugate with azides in an aqueous environment.

HY-D1347

BDP 650/665 alkyne	Fluorescent Dyes/Probes
BDP 650/665 alkyne is a bright boron dipyrromethene dye designed for use in the Cy5 channel of a variety of instruments. The terminal ethynyl group of the BDP 650/665 alkyne can be readily conjugated to various azides using copper-catalyzed click chemistry.

HY-W800807

R6G azide, 5-isomer	Fluorescent Dyes/Probes
R6G azide, 5-isomer is a xanthene dye with a terminal azide. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

HY-D1321

Cy 5 amine hydrochloride Cyanine5 amine hydrochloride	Dyes
Cyanine5 amine hydrochloride is a potent fluorescent dye. Cyanine5 amine hydrochloride can be reacted with terminal alkynes via a copper-catalyzed click reaction (CuAAC). (λ_ex=646 nm, λ_em=662 nm) .

HY-D1349

Bodipy TR alkyne	Fluorescent Dyes/Probes
Bodipy TR alkyneis one of a boron dipyrromethene fluorophore for the ROX (Texas Red) channel. This is a versatile fluorophore that can be used in microscopy, fluorescence polarization measurements, and other applications. This derivative is a terminal alkyne of copper-catalyzed click chemistry.

HY-D2161

AF 594 azide

Fluorescent Dyes/Probes

AF 594 azide is an azide derivative of the red fluorescent dye AF 594, which has high fluorescence quantum yield and high photostability (maximum absorption wavelength of 586 nm, maximum emission wavelength of 613 nm). AF 594 azide forms stable adducts by reaction of the azide group with alkynyl derivatives (terminal alkynes and cyclooctyne). It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .

HY-D1649

BDP R6G amine	Fluorescent Dyes/Probes
BDP R6G amine is a fluorophore based on borondipyrromethene scaffold. BDP R6G amine is a BDP linker containing an amine group. BDP R6G amine is a terminal alkyne for copper-catalyzed Click chemistry. (λ_ex=530 nm, λ_em=548 nm).

HY-151774

TAMRA hydrazide (6-isomer)	Fluorescent Dyes/Probes
TAMRA hydrazide (6-isomer) is a click chemistry reagent that can be coupled to carbonyl compounds. The dye hydrazide in TAMRA hydrazide (6-isomer) labels carbonyl compounds such as aldehydes and ketones. TAMRA in TAMRA hydrazide (6-isomer) is a xanthene red fluorophore that reacts with terminal alkynes .

HY-D2161A

AF 594 azide triethylamine	Fluorescent Dyes/Probes
AF 594 azide (triethylamine) is an azide derivative of the red fluorescent dye AF 594, which has high fluorescence quantum yield and high photostability (maximum absorption wavelength of 586 nm, maximum emission wavelength of 613 nm). AF 594 azide (triethylamine) forms stable adducts by reaction of the azide group with alkynyl derivatives (terminal alkynes and cyclooctyne) .

HY-D2769

Oregon green 488 azide Difluorocarboxyfluorescein azide, 6-isomer	Fluorescent Dyes/Probes
Oregon green 488 azide (Difluorocarboxyfluorescein azide, 6-isomer) is a bright, green-fluorescent azide-activated probe that reacts with terminal alkynes via a copper-catalyzed click reaction (CuAAC). It also reacts with strained cyclooctyne via a copper-free click chemistry reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures.

HY-D2750

Sulfo-Cy5 picolyl azide	Fluorescent Dyes/Probes
Sulfo-Cy5 Picolyl Azide is a fluorophore featuring a sulfonate group and an azide. Azide groups are click chemistry handles which are reactive towards terminal alkynes and strained cyclooctynes such as BCN or DBCO. Cy5 is a cyanine dye with excitation and emission maxima at 651 nm and 670 nm respectively. The sulfonate group on the Cy5 dye increases this compound’s water solubility.

HY-D1726

8RK59	Fluorescent Dyes/Probes
8RK59, a Bodipy probe, is a potent UCHL1 (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC₅₀ close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 (HY-148254) using copper(I)-mediated click chemistry, resulting in compound 8RK59 .

HY-W800696

BP Fluor 430 azide

Fluorescent Dyes/Probes

BP Fluor 430 Azide is a water-soluble, green-fluorescent, azide-activated probe that reacts with terminal alkynes via a copper-catalyzed click reaction (CuAAC). It also reacts with strained cyclooctyne via a copper-free click chemistry reaction to form a stable triazole and does not require a Cu-catalyst or elevated temperatures. BP Fluor 430 is a bright, photostable, green-fluorescent probe with excitation near its absorption maximum at 432 nm and emission maximum at 539 nm. This probe is water soluble and pH-insensitive from pH 4 to pH 10. A next generation probe, BP Fluor 430 Picolyl Azide, is also available for detection of low abundance alkyne-tagged biomolecules.

HY-D2759

Cyanine3B azide

Fluorescent Dyes/Probes

Cyanine3B azide for click chemistry conjugation with terminal alkynes via a copper-catalyzed click reaction or strained cyclooctynes via a copper-free click reaction. Cyanine3B is a yellow-emitting cyanine dye that is an improved version of the Cyanine3 fluorophore with significantly higher fluorescence quantum yield and photostability. Due to the fixed conformation, Cyanine3B has the highest emission quantum yield compared to other dyes of this wavelength. This is a non-sulfonated dye that requires an organic co-solvent (DMF, DMSO, or other) for efficient labeling in water.

HY-W800692

BP Fluor 350 azide

Fluorescent Dyes/Probes

BP Fluor 350 Azide is a blue-fluorescent, azide-activated probe that reacts with terminal alkynes via a copper-catalyzed click reaction (CuAAC). It also reacts with strained cyclooctyne via a copper-free click chemistry reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures. BP Fluor 350 is a water-soluble, moderately photostable, blue-fluorescent probe optimally excited by the 350 nm laser line. It is routinely used for generation of stable signal in imaging and flow cytometry. The brightness and photostability of blue dyes are best suited to direct imaging of high-abundance targets.

HY-W800702

BP Fluor 555 azide

Fluorescent Dyes/Probes

BP Fluor 555 Azide is a water-soluble, bright orange-fluorescent dye with excitation ideally suited for the 532 nm or 555 nm laser lines and visualized with TRITC (tetramethylrhodamine) filter sets. BP Fluor 555 conjugates of antibodies, peptides, and proteins are pH insensitive from pH 4 to pH 10. AF 555 conjugates ideally suited for detection of low abundance targets. BP Fluor 555 Azide can be reacted with terminal alkynes via a copper-catalyzed click reaction (CuAAC). It also reacts with strained cyclooctyne via a copper-free “click chemistry” reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures. The brightness and photostability of this dye are best suited to direct imaging of low-abundance targets.

Cat. No.	Product Name	Type

HY-151705

Alkyne Cholesterol 1 Publications Verification	Drug Delivery
Alkyne Cholesterol, a modified lipid, is a click chemistry reagent containing an *alkyne* group. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents in the presence of a copper (Cu)-containing catalyst. Alkyne Cholesterol can be used for tracking cellular cholesterol metabolism and localization .

HY-Y1738

Tetrakis(triphenylphosphine)palladium Tetrakis(triphenylphosphine)palladium(0)	Biochemical Assay Reagents
Tetrakis(triphenylphosphine)palladium is a catalyst. Tetrakis(triphenylphosphine)palladium catalyzes the highly regioselective addition of phenyl thiocyanate (PhSCN) to terminal alkynes .

HY-129832

Biotin-azide

2 Publications Verification

N-(3-Azidopropyl)biotinamide

Biochemical Assay Reagents

Biotin-azide (N-(3-Azidopropyl)biotinamide) is a form of biotin with a terminal azide group. Biotin-azide can be used to prepare various biotinylated conjugates via Click Chemistry . Biotin-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-W440949

Stearic acid-PEG-Mal (MW 1000)	Drug Delivery
Azide-PEG-Silane, MW 2000 is a click reagent which can react with a terminal alkyne via CuAAC or with a cyclooctyne (DBCO/BCN) via SPAAC to form a triazole bond. Silane is a surface modification moiety which can react with hydroxyl group of surface, such as glass, nanoparticles, etc. Reagent grade, for research use only.

HY-W440951

Stearic acid-PEG-Mal (MW 3400)	Drug Delivery
Azide-PEG-Silane, MW 5000 is a heterobifunctional polyPEG for surface grafting through reaction between hydroxyl and ethoxyl silane. The polymer through its azide moiety can react with a terminal alkyne via CuAAC or with a cyclooctyne (DBCO/BCN) via SPAAC to form a covalent triazole bond. Reagent grade, for research use only.

Cat. No.	Product Name		Classification

HY-151705

Alkyne Cholesterol 1 Publications Verification		Alkynes Labeling and Fluorescence Imaging
Alkyne Cholesterol, a modified lipid, is a click chemistry reagent containing an *alkyne* group. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents in the presence of a copper (Cu)-containing catalyst. Alkyne Cholesterol can be used for tracking cellular cholesterol metabolism and localization .

HY-159708

Ionizable lipid Az1		Azide
Ionizable lipid Az1is an ionizable lipid which can react with a variety of terminal alkynes under the CuAAC standard condition .

HY-151665

Alkyne-PEG2-iodide		Alkynes
Alkyne-PEG2-iodide is a click chemistry reagent with terminal alkyne and alkyl iodide groups.

HY-137018

27-Alkyne cholesterol		Alkynes
27-Alkyne cholesterol is a modified lipid containing an omega-terminal alkyne. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents, known as click chemistry, in the presence of a copper-containing catalyst. Alkyne cholesterol represents a versatile, sensitive, and easy-to-use tool for tracking cellular cholesterol metabolism and localization as it allows for manifold detection methods including mass spectrometry, and fluorescence microscopy.

HY-W615166

Thalidomide-NH-C2-alkyne		Alkynes
Thalidomide-NH-C2-alkyne contains an E3 ligase ligand with an alkyl linker, and a terminal alkyne. Thalidomide-NH-C2-alkyne is ready for conjugation to target proteins for PROTAC R&D.

HY-W674324

Thalidomide-5-NH-C-alkyne		Alkynes
Thalidomide-5-NH-C-alkyne contains an E3 ligase ligand with a terminal alkyne. Thalidomide-5-NH-C-alkyne is ready for conjugation to target proteins for PROTAC.

HY-D1307A

Sulfo-cyanine7 alkyne potassium		Alkynes
Sulfo-cyanine7 alkyne potassium is a water-soluble near-infrared dye with a sulfonated terminal alkyne that can be used in copper-catalyzed click chemistry reactions to conjugate with azides in an aqueous environment.

HY-D1307

Sulfo-cyanine7 alkyne		Alkynes
Sulfo-cyanine7 alkyne is a water-soluble near-infrared dye with a sulfonated terminal alkyne that can be used in copper-catalyzed click chemistry reactions to conjugate with azides in an aqueous environment.

HY-W598193

[(5-Azidopentyl)oxy](1,1-dimethylethyl)dimethylsilane		Azide
[(5-Azidopentyl)oxy](tert-butyl)dimethylsilane is a silane compound with a terminal azide group. The trimethylsilane is commonly used for surface modifications. The terminal azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry.

HY-172296

Biotinamide-C3-PEG3-C-alkyne		Alkynes
Biotinamide-C3-PEG3-C-alkyne is a biotin PEG reagent containing a PEG3 chain linked to a terminal azide which can react with alkyne, BCN, DBCO via Click Chemistry.

HY-D1347

BDP 650/665 alkyne		Alkynes
BDP 650/665 alkyne is a bright boron dipyrromethene dye designed for use in the Cy5 channel of a variety of instruments. The terminal ethynyl group of the BDP 650/665 alkyne can be readily conjugated to various azides using copper-catalyzed click chemistry.

HY-147097A

EDA-DA TFA		Alkynes
EDA-DA is a N-terminally tagged dipeptide probe, can be used to label Peptidoglycan (PG) of bacteria. EDA-DA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .

HY-112789

(+)-JQ1 PA 1 Publications Verification		Alkynes
(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1, with an IC₅₀ of 10.4 nM. (+)-JQ1 PA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W800703

Alexa Fluor 594 azide		Azide
Alexa Fluor 594 azide is a bright red fluorescent azide-activated probe that reacts with terminal alkynes via a copper-catalyzed click reaction (CuAAC) for single-molecule imaging .

HY-115715A

EN219-alkyne		Alkynes
EN219-alkyne is an alkyne-functionalized EN219 probe. EN219 (HY-P0287A) is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC₅₀ of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination . EN219-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-D1320

Cyanine5 azide chloride		Azide Labeling and Fluorescence Imaging
Cyanine5 azide chloride is a potent fluorescent dye. Cyanine5 azide chloride can be reacted with terminal alkynes via a copper-catalyzed click reaction (CuAAC). (λ_ex=646 nm, λ_em=662 nm) . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-127112

Oleic acid alkyne		Alkynes
Oleic acid alkyne is oleic acid with an acetylene group. The terminal alkyne group can be used for click chemical ligation reactions. Oleic acid can be hydroxylated by a microsomal cytochrome P-450-dependent system (ω-OAH). Through click chemistry reactions, fluorescent or biotin-labeled oleic acid can be introduced to analyze its metabolism and biological activity.

HY-D1349

Bodipy TR alkyne		Alkynes
Bodipy TR alkyneis one of a boron dipyrromethene fluorophore for the ROX (Texas Red) channel. This is a versatile fluorophore that can be used in microscopy, fluorescence polarization measurements, and other applications. This derivative is a terminal alkyne of copper-catalyzed click chemistry.

HY-W190836

N3-PEG2-Tos		Azide
Azide-PEG2-Tos is a small PEG linker featuring an azide and a tosylate. Tosylates are good leaving groups which are easily displaced by nucleophiles while azide is a click chemistry handle which is used to react with terminal alkynes or strained cyclooctynes.

HY-D2161

AF 594 azide		Azide
AF 594 azide is an azide derivative of the red fluorescent dye AF 594, which has high fluorescence quantum yield and high photostability (maximum absorption wavelength of 586 nm, maximum emission wavelength of 613 nm). AF 594 azide forms stable adducts by reaction of the azide group with alkynyl derivatives (terminal alkynes and cyclooctyne). It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .

HY-151678

N3-L-Lys(Mtt)-OH		Azide
N3-L-Lys(Mtt)-OH is a click chemistry reagent containing an azide group. N3-L-Lys(Mtt)-OH can introduce azide functions into the amino acid building block of peptide sequences at the N-terminal position. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-129832

Biotin-azide 2 Publications Verification N-(3-Azidopropyl)biotinamide		Azide Labeling and Fluorescence Imaging
Biotin-azide (N-(3-Azidopropyl)biotinamide) is a form of biotin with a terminal azide group. Biotin-azide can be used to prepare various biotinylated conjugates via Click Chemistry . Biotin-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-147097

EDA-DA		Alkynes
EDA-DA, a N-terminally tagged dipeptide probe, can be used to label Peptidoglycan (PG) of bacteria. Peptidoglycan (PG), an essential structure in the cell walls of the vast majority of bacteria, is critical for division and maintaining cell shape and hydrostatic pressure . EDA-DA is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130598

N-(Azido-PEG3)-N-Boc-PEG4-acid		PROTAC Synthesis Azide
N-(Azido-PEG3)-N-Boc-PEG4-acid is a PEG-based PROTAC linker with a terminal azide group and is used in the synthesis of PROTACs N-(Azido-PEG3)-N-Boc-PEG4-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-D2769

Oregon green 488 azide Difluorocarboxyfluorescein azide, 6-isomer		Azide
Oregon green 488 azide (Difluorocarboxyfluorescein azide, 6-isomer) is a bright, green-fluorescent azide-activated probe that reacts with terminal alkynes via a copper-catalyzed click reaction (CuAAC). It also reacts with strained cyclooctyne via a copper-free click chemistry reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures.

HY-D2750

Sulfo-Cy5 picolyl azide		Azide
Sulfo-Cy5 Picolyl Azide is a fluorophore featuring a sulfonate group and an azide. Azide groups are click chemistry handles which are reactive towards terminal alkynes and strained cyclooctynes such as BCN or DBCO. Cy5 is a cyanine dye with excitation and emission maxima at 651 nm and 670 nm respectively. The sulfonate group on the Cy5 dye increases this compound’s water solubility.

HY-W591360

Iodoacetamido-PEG6-azide		Azide
Iodoacetamido-PEG6-azide is an aqueous soluble PEG linker containing an azide and a terminal Iodoacetamido group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Iodoacetamido moiety is commonly used to bind covalently with the thiol group of cysteine so the protein cannot form disulfide bonds.

HY-W782122

Photoclick cholesterol		Alkynes
Photoclick cholesterol is a sterol lipid cholesterol analog that contains a clickable terminal alkyne moiety and a photoactivatable diaziridine group. Photoclick cholesterol has the ability to photoaffinity label the mitochondrial outer membrane transport protein (TSPO) and is able to specifically bind cholesterol to TSPO. However, using excessive amounts of Photoclick cholesterol will reduce the photolabeling of total mitochondrial proteins and TSPO .

HY-130312

N-(Azido-PEG4)-N-Boc-PEG4-NHS ester		PROTAC Synthesis Azide
N-(Azido-PEG4)-N-Boc-PEG4-NHS ester is a PEG-based PROTAC linker with a terminal azide group. N-(Azido-PEG4)-N-Boc-PEG4-NHS ester is used in the synthesis of PROTACs N-(Azido-PEG4)-N-Boc-PEG4-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-129084

Propargylcholine bromide		Alkynes
Propargylcholine bromide is a choline analogue containing terminal propargyl that can be incorporated into all classes of Choline-containing phospholipids such as phosphatidylcholine and sphingomyelin, labeling Choline-containing phospholipids. Propargylcholine bromide-labeled phospholipid molecules can be visualized in cells with high sensitivity and spatial resolution. Propargylcholine bromide can be used as a molecular tool to study the biochemical and metabolic processes of Choline-containing phospholipids in cells . Propargylcholine (bromide) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W800664

5-(Azido-PEG4)-pent-2-yn-1-ol		Azide
5-(Azido-PEG4)-pent-2-yn-1-Ol is a PEG linker containing an azide group and a terminal hydroxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

HY-D2759

Cyanine3B azide		Azide
Cyanine3B azide for click chemistry conjugation with terminal alkynes via a copper-catalyzed click reaction or strained cyclooctynes via a copper-free click reaction. Cyanine3B is a yellow-emitting cyanine dye that is an improved version of the Cyanine3 fluorophore with significantly higher fluorescence quantum yield and photostability. Due to the fixed conformation, Cyanine3B has the highest emission quantum yield compared to other dyes of this wavelength. This is a non-sulfonated dye that requires an organic co-solvent (DMF, DMSO, or other) for efficient labeling in water.

HY-W591390

6-Azidohexanoic acid STP ester		Azide
6-Azidohexanoic Acid STP Ester is an amine-reactive, water-soluble labeling reagent with an azide group and a terminal 4-Sulfo-2,3,5,6-tetrafluorophenyl (STP) group. 6-Azidohexanoic Acid STP Ester is used to modify proteins, antibodies, and other amine-containing biopolymers in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. STP esters can react with primary amines, forming covalent amide bonds, and typically display much better stability toward hydrolysis in aqueous media, resulting in more efficiency and better reproducible labeling of biopolymers.

Cat. No.	Product Name		Classification

HY-151705

Alkyne Cholesterol 1 Publications Verification		Cholesterol
Alkyne Cholesterol, a modified lipid, is a click chemistry reagent containing an *alkyne* group. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents in the presence of a copper (Cu)-containing catalyst. Alkyne Cholesterol can be used for tracking cellular cholesterol metabolism and localization .

HY-159708

Ionizable lipid Az1		Cationic Lipids
Ionizable lipid Az1is an ionizable lipid which can react with a variety of terminal alkynes under the CuAAC standard condition .

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