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tetrahydrofolate

" in MedChemExpress (MCE) Product Catalog:

31

Inhibitors & Agonists

1

Fluorescent Dye

1

Natural
Products

1

Recombinant Proteins

7

Isotope-Labeled Compounds

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-130569
    7-Hydroxymethotrexate

    		Drug Metabolite Inflammation/Immunology Cancer
    7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .
    7-Hydroxymethotrexate
  • HY-P2861
    Sarcosine oxidase, Bacillus

    SAO

    		 Endogenous Metabolite Others
    Sarcosine oxidase, Bacillus (SAO) can catalyze the oxidative demethylation of sarcosine to generate glycine, H2O2, 5,10-CH2-tetrahydrofolate, which are often used in biochemical reactions .
    Sarcosine oxidase, Bacillus
  • HY-153039
    Anhydroleucovorin

    		Drug Intermediate Others Cancer
    Anhydroleucovorin is a form of tetrahydrofolate and is a substrate for cyclohydrolase, which converts it to 10-formyltetrahydrofolate. Anhydroleucovorin can be used for research in the field of tumors .
    Anhydroleucovorin
  • HY-129246
    Cytembena

    		DNA/RNA Synthesis Cancer
    Cytembena is inhibitor for replicative DNA synthesis, purine synthesis and tetrahydrofolate formylase activity. Cytembena ameliorates ovarian or breast cancer, relieves the pain from skeletal metastases .
    Cytembena
  • HY-101943
    LY 345899
    5 Publications Verification

    		 Methylenetetrahydrofolate Dehydrogenase (MTHFD) Cancer
    LY 345899 is a Folate analog and is a methylene tetrahydrofolate dehydrogenase (MTHFD1; DC301) and MTHFD2 inbhibitor with IC50 values of 96 nM and 663 nM, respectively and a Ki of 18 nM for MTHFD1 .
    LY 345899
  • HY-133624
    1,1,3-Tribromoacetone

    		Drug Metabolite Cancer
    1,1,3-Tribromoacetone is an impurity of Methotrexate (HY-14519) . Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .
    1,1,3-Tribromoacetone
  • HY-121151
    (±)-Methotrexate

    (±)-Amethopterin; (±)-CL14377; (±)-WR19039

    		 Antifolate Others
    (±)-Methotrexate ((±)-Amethopterin) is a racemate of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of Folic acid into Tetrahydrofolate, and inhibiting DNA synthesis .
    (±)-Methotrexate
  • HY-E70399
    Formimino-L-glutamic acid Transferase, porcine liver

    5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase, FIGLU Enzymes; glutamate formimidoyltransferase

    		 Biochemical Assay Reagents Others
    Formimino-L-glutamic acid Transferase can convert aminomethyleneglutamic acid FIGLU and tetrahydrofolate THF into L-glutamic acid and 5-formimino-THF .
    Formimino-L-glutamic acid Transferase, porcine liver
  • HY-E70522
    Dihydrofolate reductase

    DHFR

    		 Others Others
    Dihydrofolate reductase is a key enzyme in folate metabolism and, therefore, in the production of thymidine. Its role in thymidine biosynthesis is the reduction of dihydrofolate to tetrahydrofolate using the cofactor NADPH .
    Dihydrofolate reductase
  • HY-118251
    PD130883

    		Antifolate Dihydrofolate reductase (DHFR) Cancer
    PD130883 is an antifolate DHFR inhibitor that directly inhibits thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site, reducing the net conversion of tetrahydrofolate cofactor to dihydrofolate.
    PD130883
  • HY-18062
    Pyrimethamine
    10+ Cited Publications

    Pirimecidan; Pirimetamin; RP 4753

    		 Antifolate Parasite Infection Cancer
    Pyrimethamine (Pirimecidan) is a potent, orally active dihydrofolate reductase (DHFR) inhibitor. Pyrimethamine is an antimalarial agent. Pyrimethamine affects the nucleoprotein metabolism of malarial parasites by interference in the folic–folinic acid systems and affects cell division by inhibiting the conversion of dihydrofolate to tetrahydrofolate .
    Pyrimethamine
  • HY-14519
    Methotrexate
    Maximum Cited Publications
    49 Publications Verification

    Amethopterin; CL14377; WR19039

    		 Antifolate DNA/RNA Synthesis ADC Cytotoxin Apoptosis Bacterial Inflammation/Immunology Cancer
    Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .
    Methotrexate
  • HY-14519D
    Methotrexate monohydrate

    Amethopterin monohydrate; CL14377 monohydrate; WR19039 monohydrate

    		 Antifolate DNA/RNA Synthesis ADC Cytotoxin Apoptosis Bacterial Inflammation/Immunology Cancer
    Methotrexate (Amethopterin) monohydrate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate monohydrate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .
    Methotrexate monohydrate
  • HY-14519A
    Methotrexate disodium
    Maximum Cited Publications
    49 Publications Verification

    Amethopterin disodium; CL14377 disodium; WR19039 disodium

    		 Antifolate DNA/RNA Synthesis ADC Cytotoxin Apoptosis Bacterial Inflammation/Immunology Cancer
    Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .
    Methotrexate disodium
  • HY-130569S1
    7-Hydroxymethotrexate-d3

    		Drug Metabolite Metabolic Disease
    7-Hydroxymethotrexate-d3 is the deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1][2].
    7-Hydroxymethotrexate-d3
  • HY-130569S
    7-Hydroxymethotrexate-d3 sodium

    		Isotope-Labeled Compounds Drug Metabolite Inflammation/Immunology Cancer
    7-Hydroxymethotrexate-d3 (sodium) is deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1][2].
    7-Hydroxymethotrexate-d3 sodium
  • HY-W654227
    7-Hydroxy methotrexate-d3 ammonium salt

    		Isotope-Labeled Compounds Drug Metabolite Inflammation/Immunology
    7-Hydroxy methotrexate-d3 (ammonium salt) is deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .
    7-Hydroxy methotrexate-d3 ammonium salt
  • HY-18062R
    Pyrimethamine (Standard)

    		Antifolate Parasite Infection
    Pyrimethamine (Standard) is the analytical standard of Pyrimethamine. This product is intended for research and analytical applications. Pyrimethamine (Pirimecidan) is a potent, orally active dihydrofolate reductase (DHFR) inhibitor. Pyrimethamine is an antimalarial agent. Pyrimethamine affects the nucleoprotein metabolism of malarial parasites by interference in the folic–folinic acid systems and affects cell division by inhibiting the conversion of dihydrofolate to tetrahydrofolate .
    Pyrimethamine (Standard)
  • HY-130569S2
    7-Hydroxymethotrexate-d3 ammonium

    		Drug Metabolite Metabolic Disease
    7-Hydroxymethotrexate-d3 (ammonium) is the deuterium labeled 7-Hydroxymethotrexate ammonium. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1][2].
    7-Hydroxymethotrexate-d3 ammonium
  • HY-14519S1
    Methotrexate-d3 diammonium

    		Isotope-Labeled Compounds Metabolic Disease Inflammation/Immunology Cancer
    Methotrexate-d3 diammonium is the deuterium labeled Methotrexate diammonium. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .
    Methotrexate-d3 diammonium
  • HY-113046S
    5-Methyltetrahydrofolic acid-13C5

    5-Methyl THF-13C5; 5-MTHF-13C,d5

    		 Endogenous Metabolite Metabolic Disease
    5-Methyltetrahydrofolic acid- 13C5 is the 13C-labeled 5-Methyltetrahydrofolic acid. 5-Methyltetrahydrofolic acid (5-Methyl THF) is a biologically active form of folic acid. 5-Methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. 5-Methyltetrahydrofolic acid is the predominant natural dietary folate and the principal form of folate in plasma and cerebrospinal fluid[1].
    5-Methyltetrahydrofolic acid-13C5
  • HY-154508
    FdUMP triethylammonium

    2’-Deoxy-5-Fluorouridine 5’-phosphate triethylammonium

    		 Nucleoside Antimetabolite/Analog Thymidylate Synthase Cancer
    FdUMP triethylammonium is the intracellular active form of 5-fluorouracil (5-FU). 5-FU is converted to FdUMP after being transported into the cell by various enzymes. FdUMP forms a ternary complex with thymidylate synthase and its cofactor 5,10-methylene tetrahydrofolate, inhibiting the activity of thymidylate synthase, which in turn leads to the suppression of DNA synthesis.
    FdUMP triethylammonium
  • HY-14519R
    Methotrexate (Standard)

    		Antifolate DNA/RNA Synthesis ADC Cytotoxin Apoptosis Bacterial Inflammation/Immunology Cancer
    Methotrexate (Standard) is the analytical standard of Methotrexate. This product is intended for research and analytical applications. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .
    Methotrexate (Standard)
  • HY-14519S
    Methotrexate-d3

    		Antifolate DNA/RNA Synthesis ADC Cytotoxin Apoptosis Inflammation/Immunology Cancer
    Methotrexate-d3 (Amethopterin-d3) is the deuterium labeled Methotrexate. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3].
    Methotrexate-d3
  • HY-B0510C
    Trimethoprim lactate
    5+ Cited Publications

    		 Antifolate Bacterial Antibiotic Infection Cancer
    Trimethoprim lactate is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim lactate is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim lactate has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim lactate can inhibit infection of Influenza A virus in chick embryo when combinated with zinc .
    Trimethoprim lactate
  • HY-B0510A
    Trimethoprim sulfate

    		Antifolate Bacterial Antibiotic Influenza Virus Infection Cancer
    Trimethoprim sulfate is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim sulfate is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim sulfate has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim sulfate can inhibit infection of Influenza A virus in chick embryo when combinated with zinc .
    Trimethoprim sulfate
  • HY-B0510CR
    Trimethoprim (lactate) (Standard)

    		Antifolate Bacterial Antibiotic Infection Cancer
    Actein (Standard) is the analytical standard of Actein. This product is intended for research and analytical applications. Actein, a triterpene glycoside, shows an inhibitory effect on cancer cells, which is isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in bladder cancer. Actein has little toxicity in vivo .
    Trimethoprim (lactate) (Standard)
  • HY-D2435
    MTX-PEG-Cy3

    		Fluorescent Dye Inflammation/Immunology Cancer
    CDDP-PEG-Cy3 is a MTX-PEG conjugate labeled with Cy3 (HY-D0822). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. The maximum emission wavelength of Cy3 is approximately 562-570 nm. Methotrexate (Amethopterin; MTX) (HY-14519), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .
    MTX-PEG-Cy3
  • HY-B0510R
    Trimethoprim (Standard)

    		Antifolate Bacterial Antibiotic Influenza Virus Infection
    Trimethoprim (Standard) is the analytical standard of Trimethoprim. This product is intended for research and analytical applications. Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim can inhibit infection of Influenza A virus in chick embryo when combinated with zinc .
    Trimethoprim (Standard)
  • HY-B0510
    Trimethoprim
    5+ Cited Publications

    		 Antifolate Bacterial Antibiotic Influenza Virus Infection Cancer
    Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim can inhibit infection of Influenza A virus in chick embryo when combinated with zinc .
    Trimethoprim
  • HY-B0510B
    Trimethoprim hydrochloride

    		Antifolate Bacterial Antibiotic Influenza Virus Infection Cancer
    Trimethoprim hydrochloride is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim hydrochloride is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim hydrochloride has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim hydrochloride can inhibit infection of Influenza A virus in chick embryo when combinated with zinc .
    Trimethoprim hydrochloride

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