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tubulin polymerization activity

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By Targets:	Microtubule/Tubulin (70) ADC Cytotoxin (11) Antibiotic (2) Apoptosis (30) Autophagy (2) Bacterial (2) Caspase (1) COX (2) Drug-Linker Conjugates for ADC (4) Farnesyl Transferase (1) Fungal (1) HDAC (2) HIF/HIF Prolyl-Hydroxylase (2) Histone Demethylase (1) MMP (1) P-glycoprotein (1) Parasite (2) PARP (1) Proton Pump (1) Reactive Oxygen Species (3) Src (1) VEGFR (2)
By Research Areas:	Cancer (84) Infection (3) Inflammation/Immunology (3) Metabolic Disease (1)
Click Chemistry:	DBCO (1)

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Click Chemistry

Targets Recommended: Microtubule/Tubulin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155359

Tubulin polymerization-IN-55	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-55 is a potent inhibitor of **Tubulin Polymerization*. Tubulin* polymerization-IN-55 has antiproliferative activity against A549, K562, HepG2, MDA-MB-231 and HFL-1 with IC₅₀ s of 8, 3, 9, 24 and 62 nM, respectively .

HY-155841

Tubulin polymerization-IN-46	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-46 (compound 9q) is a microtubule/Tubulin inhibitor that inhibits tubulin polymerization and induces apoptosis. Tubulin polymerization-IN-46 inhibits mitosis and arrests MCF-7 cells in the G2/M phase. Tubulin polymerization-IN-46 has anti-proliferative activity against MCF-7 breast cancer cells with an IC₅₀ of 10 nM .

HY-122151

MPT0B002	Microtubule/Tubulin Apoptosis	Cancer
MPT0B002 is a potent microtubule inhibitor with anticancer activities. MPT0B002 disrupts tubulin polymerization, induces apoptosis, and arrests cell cycle at the G2/M phase .

HY-106265

9,10-trans-Dehydroepothilone D	P-glycoprotein	Cancer
9,10-trans-Dehydroepothilone D shows an antiproliferative activity against a paclitaxel-resistant cell lines overexpressing P-glycoprotein. 9,10-trans-Dehydroepothilone D also shows tubulin polymerization activity. 9,10-trans-Dehydroepothilone D is given by lactonization of Seco acid, which is promising for research of cancers .

HY-147896

Tubulin polymerization-IN-29	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-29 (compound 6g) is a potent tubulin polymerization inhibitor. Tubulin polymerization-IN-29 exhibits potent antiproliferative activity. Tubulin polymerization-IN-29 can induce HeLa cells arrest in G2/M phase .

HY-146164

Tubulin polymerization-IN-21	Microtubule/Tubulin	Metabolic Disease Cancer
Tubulin polymerization-IN-21 (compound 9a) is a **tubulin polymerization** inhibitor. Tubulin polymerization-IN-21 exhibits anti-cancer activity through disrupting cellular integrity and affecting glucose metabolism .

HY-147981

Tubulin polymerization-IN-31	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-31 (Compound 4c) is a **tubulin polymerization inhibitor with an IC₅₀** of 3.64 μM. Tubulin polymerization-IN-31 induces cancer cell apoptosis and shows antitumor activity .

HY-106423

Mivobulin NSC 613862; (S)-(-)-NSC 613862	Microtubule/Tubulin	Cancer
Mivobulin (NSC 613862) is a *tubulin* inhibitor, binds to tubulin in the region that overlaps the colchicine site, and inhibits tubulin polymerization. Mivobulin (NSC 613862) promotes the formation of abnormal polymers and a GTPase activity in the tubulin dimer. Anti-cancer activity .

HY-146211

Tubulin polymerization-IN-14	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-14 (Compound 20a) is a **tubulin polymerization inhibitor with an IC₅₀** of 3.15 μM. Tubulin polymerization-IN-14 shows potent anti-vascular and anticancer activities, induces cancer cell apoptosis .

HY-146209

Tubulin polymerization-IN-13	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-13 (Compound 4f) is a **tubulin polymerization inhibitor (IC₅₀*=0.37 μM). Tubulin* polymerization-IN-13 shows anti-proliferative activity against cancer cells, induces apoptosis and potential antivascular activity .

HY-155043

Tubulin polymerization-IN-42	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-42 (compound 10j), an indole-substituted furanone, is an inhibitor of tubulin polymerization with anti-cancer activity .

HY-146817

Tubulin polymerization-IN-11	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-11 is a potent **tubulin polymerization inhibitor with an IC₅₀** value of 3.4 µM. Tubulin polymerization-IN-11 shows antiproliferative activity. Tubulin polymerization-IN-11 induces Apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-11 decreases the expression of cyclin B1, p-cdc2, and Bcl-2 protein levels and increases the expression of cleaved PARP .

HY-151394

Tubulin polymerization-IN-33	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-33 is an inhibitor of [1,2]oxazoloisoindoles **tubulin polymerization*, exhibits high antiproliferative activity* against the NCI panel .

HY-162264

Tubulin polymerization/V-ATPase-IN-1	Microtubule/Tubulin Proton Pump Apoptosis	Inflammation/Immunology Cancer
Tubulin polymerization/V-ATPase-IN-1 (compound F10) is a **Tubulin polymerization/V-ATPase** inhibitor. Tubulin polymerization/V-ATPase-IN-1 shows robust antiproliferation activity against four human cancer cell lines, and exerts antiproliferative activity by inhibiting tubulin and V-ATPase. Tubulin polymerization/V-ATPase-IN-1 induces immunogenic cell death in addition to apoptosis, and inhibits tumor growth in an RM-1 homograft model with enhanced T lymphocyte infiltration .

HY-149016

Tubulin polymerization-IN-25	Microtubule/Tubulin Farnesyl Transferase	Cancer
Tubulin polymerization-IN-25 (compound 17f) is a dual inhibitor of **tubulin polymerization and farnesyl transferase (FTase) with IC₅₀*s of 1.11 μM and 0.39 μM, respectively. Tubulin* polymerization-IN-25 displays cytotoxicity and excellent antitumor activity .

HY-161338

Tubulin polymerization-IN-61	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-61 (Compound 9a) is a *tubulin* polymerization inhibitor. Tubulin polymerization-IN-61 destroys the microtubule skeleton, blocks the cell cycle in G2/M phase, induces Apoptosis, and inhibits cancer cell migration and colony formation. Tubulin polymerization-IN-61 shows antitumor activity in vivo against 4T1 xenograft model .

HY-163356

Tubulin polymerization-IN-60	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-60 (BF3) is a **tubulin polymerization** inhibitor with anticancer activity. Tubulin polymerization-IN-60 (BF3) belongs to the colchicine binding site inhibitors (CBSIs) and disturbs cell cycle progression leading to G2/M arrest and apoptosis .

HY-146718

Tubulin polymerization-IN-9	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-9 is a potent *tubulin* inhibitor with IC₅₀ of 1.82 μM. Tubulin polymerization-IN-9 causes cell cycle arrest at G2/M phase, and induces cell apoptosis and depolarized mitochondria of K562 cells. Tubulin polymerization-IN-9 has potent anti-vascular and antitumor activities .

HY-149021

Tubulin polymerization-IN-28	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-28 (compound-4) is a microtubule protein polymerization inhibitor with highly selective anticancer activity. Tubulin polymerization-IN-28 can be activated by NQO1 and effectively release combretastatin A-4 to kill tumor cells. Tubulin polymerization-IN-28 can induce cell apoptosis and be used in anti-cancer research .

HY-163983

Tubulin polymerization-IN-68	Microtubule/Tubulin Apoptosis PARP Caspase	Cancer
Tubulin polymerization-IN-68 (compound 32) is a *tubulin* inhibitor that can inhibit tubulin polymerization and destroy the cellular microtubule network. Tubulin polymerization-IN-68 can upregulate the expression of PARP-1 and caspase-3 and induce cell apoptosis, and has anticancer activity. Tubulin polymerization-IN-68 can effectively inhibit HepG2 (IC₅₀=93 nM) and significantly inhibit the growth of HepG2 xenograft tumors in nude mice by oral administration .

HY-144299

Tubulin polymerization-IN-5	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-5 (compound 20q) is a potent *tubulin* inhibitor with potential anticancer activities. Tubulin polymerization-IN-5 can arrest ESCC cells at G2/M phase and cause cells apoptosis .

HY-16777

Entasobulin 2 Publications Verification	Microtubule/Tubulin	Cancer
Entasobulin is a *β-tubulin* polymerization inhibitor with potential anticancer activity.

HY-143247

Tubulin polymerization-IN-2	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-2 is a potent anticancer agent targeting to *β-tubulin* with an IC₅₀ value of 0.92 μM. Tubulin polymerization-IN-2 shows promising activity against various leukemia, non-small lung, renal, prostate, and breast cancer cell lines .

HY-144748

Tubulin inhibitor 17	Microtubule/Tubulin Apoptosis	Cancer
Tubulin inhibitor 17 (Compound 3b) is a **tubulin polymerization inhibitor with an IC₅₀** of 12.38 µM. Tubulin inhibitor 17 has anticancer activities and induces cell apoptosis .

HY-112607

Tubulin inhibitor 1	Microtubule/Tubulin Apoptosis	Cancer
Tubulin inhibitor 1 is a *tubulin* inhibitor, inhibits tubulin polymerization. Tubulin inhibitor 1 shows potent anti-tumor activity, casues cellular mitotic arrest in the G2/M phase, and induces cellular apoptosis .

HY-143251

Tubulin inhibitor 13	Microtubule/Tubulin Apoptosis	Cancer
Tubulin inhibitor 13 (E27) is a potent *tubulin* inhibitor with an IC₅₀ value of 16.1 μM for the tubulin polymerization inhibition. Tubulin inhibitor 13 inhibits migration and invasion of cancer cells, induces apoptosis and has anticancer activity .

HY-146711

Tubulin inhibitor 24	Microtubule/Tubulin	Cancer
Tubulin inhibitor 24 is a potent *tubulin* inhibitor. Tubulin inhibitor 24 inhibits tubulin polymerization. Tubulin inhibitor 24 induces cell cycle arrest at the G2/M phase in a concentration-dependent manner. Tubulin inhibitor 24 shows antitumor activity with no obvious toxicity .

HY-149252

Tubulin inhibitor 32	Apoptosis Microtubule/Tubulin	Cancer
Tubulin inhibitor 32 is a potent and orally active *tubulin* inhibitor. Tubulin inhibitor 32 shows anti-proliferative activity and inhibits microtubule polymerization. Tubulin inhibitor 32 induces Apoptosis and cell cycle arrest at G2/M phase. Tubulin inhibitor 32 shows anti-tumor activity .

HY-149364

Tubulin inhibitor 34	Microtubule/Tubulin Apoptosis	Cancer
Tubulin inhibitor 34 (compound b5) is a potent anticancer agent. Tubulin inhibitor 34 can inhibit **tubulin polymerization and induce G2/M arrest and apoptosis*. Tubulin* inhibitor 34 exhibits significant antivascular and antitumor activity .

HY-N2415

Podophyllotoxone	Microtubule/Tubulin	Cancer
Podophyllotoxone is isolated from the roots of Dysosma versipellis and has anti-cancer activities.Podophyllotoxone is able to inhibit the *tubulin* polymerization .

HY-N9842

Violanone	Microtubule/Tubulin	Infection
Violanone, an isoflavanone compound, can inhibit tubulin polymerization. Violanone also exhibits larvicidal activity against A. aegypti .

HY-N3950

Glochidiol	Microtubule/Tubulin	Cancer
Glochidiol is an orally active **tubulin polymerization inhibitor with an IC₅₀** of 2.76 μM. Glochidiol shows anti-cancer activity .

HY-15482

D-64131 1 Publications Verification	Microtubule/Tubulin	Cancer
D-64131 is an orally active *tubulin* inhibitor, with an IC₅₀ of 0.53 μM for tubulin polymerization. D-64131 has antimitotic activity. D-64131 can be used for cancer research .

HY-146506

isoCA-4	Microtubule/Tubulin	Cancer
isoCA-4, a Combretastatin A4 derivative, is a **tubulin polymerization** inhibitor. isoCA-4 has anti-proliferative activities .

HY-152030

Tubulin/MMP-IN-2	Microtubule/Tubulin MMP Apoptosis	Cancer
Tubulin/MMP-IN-2 is dual inhibitor of tubulin and matrix metalloproteinases. Tubulin/MMP-IN-2 can strongly inhibit tubulin polymerization and induces cell apoptosis. Tubulin/MMP-IN-2 has inhibitory activities against MMP-2, MMP-3 and MMP-9 with IC₅₀ values of 24.95 μM, 31.60 μM and 22.37 μM, respectively. Tubulin/MMP-IN-2 can be used for the research of cancer .

HY-149578

Tubulin/HDAC-IN-3	Microtubule/Tubulin HDAC	Cancer
Tubulin/HDAC-IN-3 (compound 12a) is a potent *tubulin/HDAC* dual inhibitor. Tubulin/HDAC-IN-3 effectively disrupts tubulin polymerization (IC₅₀: 5.4 μM). Tubulin/HDAC-IN-3 exhibits potent HDAC1/8 inhibitory activities, with IC₅₀ values of 0.155 and 0.177 μM, respectively. Tubulin/HDAC-IN-3 works through blocking cellular cycle, inducing apoptosis and inhibiting colony formation .

HY-N8745

α-Peltatin	Fungal	Others
α-Peltatin is an aryl lignan. α-Peltatin has anticancer and antifungal activity. α-Peltatin inhibits DNA topoisomerase and tubulin polymerization .

HY-33046

N-Boc-dolaproine (2R,3R)-BOC-dolaproine	Others	Cancer
N-Boc-dolaproine (Dap) is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .

HY-43304

N-Boc-dolaproine-methyl	Others	Cancer
N-Boc-dolaproine-methyl is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .

HY-162319

Tubulin/HDAC-IN-4	Apoptosis HDAC Microtubule/Tubulin Reactive Oxygen Species	Cancer
Tubulin/HDAC-IN-4 (compound 9n) is a dual *Tubulin* and HDAC inhibitor with IC₅₀ values of 0.73, 0.43, 0.62, 2.34 µM for HDAC1, HDAC2, HDAC6, HDAC7, respectively. Tubulin/HDAC-IN-4 inhibits the tubulin polymerization by targeting the colchicine binding site. Tubulin/HDAC-IN-4 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin/HDAC-IN-4 induces a significant elevation of intracellular ROS levels. Tubulin/HDAC-IN-4 shows anti-angiogenesis activity and anticancer activity .

HY-163105

Tubulin/NEDDylation-IN-1	Microtubule/Tubulin	Cancer
Tubulin/NEDDylation-IN-1 (compound C11) is a dual inhibitor of *tubulin* (Microtubule/Tubulin)-NEDDylation (IC₅₀ for tubulin=2.40 μM), which has strong anti-proliferative activity. Neddylation is a protein post-translational modification that covalently tags the ubiquitin-like protein NEDD8 to target proteins. Tubulin/NEDDylation-IN-1 forms hydrogen bonds with residues of tubulin and E1 NEDD8 activating enzyme (NAE) through methoxy and dithiocarbamate groups and inhibits NEDDylation and microtubulin in an ATP-dependent manner. tube polymerization .

HY-149374

Tubulin inhibitor 36	Microtubule/Tubulin	Cancer
Tubulin inhibitor 36 (Compound 10) is a novel and potent *tubulin* inhibitor and inhibits the polymerization of microtubular protein then induces apoptosis with an IC₅₀ value of 1.5±0.1 μM. Tubulin inhibitor 36 (Compound 10) has significant anti-mitotic effect and exhibits activities against glioblastoma cells. Tubulin inhibitor 36 (Compound 10) has anti-tumor effects and can be used for glioblastoma multiforme (GBM) research .

HY-42912

N-Boc-dolaproine-OH ((+)-phenylethylamine)	Others	Cancer
N-Boc-dolaproine-OH ((+)-phenylethylamine) is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .

HY-42912A

N-Boc-dolaproine-OH dicyclohexylamine	Others	Cancer
N-Boc-dolaproine-OH dicyclohexylamine is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .

HY-136317

MC-betaglucuronide-MMAE-1	Drug-Linker Conjugates for ADC	Cancer
MC-betaglucuronide-MMAE-1 is a agent-linker conjugate for ADC with potent antitumor activity by using MMAE (a tubulin polymerization inhibitor), linked via the cleavable ADC linker MC-betaglucuronide.

HY-130233

S516	Microtubule/Tubulin	Cancer
S516 (Compound 22) is an active metabolite of CKD-516 and a potent **tubulin polymerization inhibitor with an IC₅₀** of 4.29 μM. S516 has marked antitumor activity .

HY-136321

MC-betaglucuronide-MMAE-2	Drug-Linker Conjugates for ADC	Cancer
MC-betaglucuronide-MMAE-2 is a agent-linker conjugate for ADC with potent antitumor activity by using MMAE (a tubulin polymerization inhibitor), linked via the cleavable ADC linker MC-betaglucuronide.

HY-33046A

N-Boc-dolaproine dicyclohexylamine (2R,3R)-BOC-dolaproine dicyclohexylamine	Others	Cancer
N-Boc-dolaproine dicyclohexylamine is an amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity. And contains dicyclohexylamine .

HY-49053

N-Boc-dolaproine-amide-Me-Phe	Others	Cancer
N-Boc-dolaproine-amide-Me-Phe is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .

HY-162089

MY-1442	Microtubule/Tubulin Apoptosis	Cancer
MY-1442 (I-3) is a microtubulin polymerization inhibitor. MY-875 inhibits tubulin polymerization by targeting colchicine binding sites. MY-1442 has anticancer activity. MY-1442 can induce apoptosis of MGC-803 cells and inhibit cell migration .

Cat. No.	Product Name		Classification

HY-133492

DBCO-PEG4-MMAF		DBCO
DBCO-PEG4-MMAF is a agent-linker conjugate for ADC with potent antitumor activity by using the tubulin polymerization inhibitor, MMAF, linked via the cleavable linker DBCO-PEG4. DBCO-PEG4-MMAF is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

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tubulin polymerization activity

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