2. Antibody-drug Conjugate/ADC Related Cytoskeleton Cell Cycle/DNA Damage
  3. ADC Cytotoxin Microtubule/Tubulin
  4. Tubulysin M

Tubulysin M is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin M can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin M displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Tubulysin M inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis.

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Tubulysin M Chemical Structure

Tubulysin M Chemical Structure

CAS No. : 936691-46-2

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Tubulysin M Related Antibodies

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Description

Tubulysin M is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin M can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin M displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Tubulysin M inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis[1][2][3].

Cellular Effect
Cell Line Type Value Description References
DU-145 GI50
0.71 nM
Compound: 1
Cytotoxicity against human DU145 cells incubated for 72 hrs by alamar blue abased assay
Cytotoxicity against human DU145 cells incubated for 72 hrs by alamar blue abased assay
[PMID: 27809515]
HCT-116 GI50
0.62 nM
Compound: 1
Cytotoxicity against human HCT116 cells incubated for 72 hrs by alamar blue abased assay
Cytotoxicity against human HCT116 cells incubated for 72 hrs by alamar blue abased assay
[PMID: 27809515]
KB IC50
0.33 nM
Compound: 1; N-14-desacetoxytubulysin H
Cytotoxicity against MDR1 deficient human KB cells assessed as decrease in cell viability after 4 days by MTS assay
Cytotoxicity against MDR1 deficient human KB cells assessed as decrease in cell viability after 4 days by MTS assay
[PMID: 27882198]
L-428 EC50
0.04 nM
Compound: 2; TubM
Antiproliferative against human L428 cells incubated for 96 hrs by cellTiter-Glo assay
Antiproliferative against human L428 cells incubated for 96 hrs by cellTiter-Glo assay
[PMID: 32527543]
L-540 EC50
0.08 nM
Compound: 2; TubM
Antiproliferative against human L540cy cells incubated for 96 hrs by cellTiter-Glo assay
Antiproliferative against human L540cy cells incubated for 96 hrs by cellTiter-Glo assay
[PMID: 32527543]
MDA-MB-231 GI50
1.14 nM
Compound: 1
Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by alamar blue abased assay
Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by alamar blue abased assay
[PMID: 27809515]
MDA-MB-361 IC50
0.13 nM
Compound: 1; N-14-desacetoxytubulysin H
Cytotoxicity against human MDA-MB-361/DYT2 cells assessed as decrease in cell viability after 4 days by MTS assay
Cytotoxicity against human MDA-MB-361/DYT2 cells assessed as decrease in cell viability after 4 days by MTS assay
[PMID: 27882198]
NCI-N87 IC50
0.46 nM
Compound: 1; N-14-desacetoxytubulysin H
Cytotoxicity against human NCI-N87 cells assessed as decrease in cell viability after 4 days by MTS assay
Cytotoxicity against human NCI-N87 cells assessed as decrease in cell viability after 4 days by MTS assay
[PMID: 27882198]
Molecular Weight

727.95

Formula

C38H57N5O7S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(N[C@@H]([C@@H](C)CC)C(N(C)[C@@H](C(C)C)C[C@@H](OC(C)=O)C1=NC(C(N[C@@H](CC2=CC=CC=C2)C[C@H](C)C(O)=O)=O)=CS1)=O)[C@@H]3N(C)CCCC3
Structure Classification
Initial Source

Archangium gephyra
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥96.0%

SDS (251 KB)

COA (249 KB)

Handling Instructions (2659 KB)
References
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Tubulysin M Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulysin M936691-46-2ADC CytotoxinMicrotubule/TubulinADC PayloadInhibitorinhibitorinhibit

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