2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. Tubulysin B

Tubulysin B is a highly cytotoxic peptide and potent microtubule destabilizing agents isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties.Tubulysin B is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis.

For research use only. We do not sell to patients.

Tubulysin B Chemical Structure

Tubulysin B Chemical Structure

CAS No. : 205304-87-6

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5 mg USD 1750 In-stock
10 mg USD 2800 In-stock
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Based on 1 publication(s) in Google Scholar

Tubulysin B Related Antibodies

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Description

Tubulysin B is a highly cytotoxic peptide and potent microtubule destabilizing agents isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties[1].Tubulysin B is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis[2].

Cellular Effect
Cell Line Type Value Description References
KB IC50
2 nM
Compound: 2a
Growth inhibition of human KB cells by [3H]thymidine incorporation assay
Growth inhibition of human KB cells by [3H]thymidine incorporation assay
[PMID: 21974954]
In Vitro

Tubulysin B has IC50s of 0.6 and 0.9 nM against KB and A549 tumors cell lines, respectively.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulysin B Related Antibodies
Molecular Weight

830.04

Formula

C42H63N5O10S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(O[C@@H](C1=NC(C(N[C@H](C[C@H](C)C(O)=O)CC2=CC=C(O)C=C2)=O)=CS1)C[C@H](C(C)C)N(COC(CCC)=O)C([C@@]([C@@H](C)CC)([H])NC([C@@H](CCCC3)N3C)=O)=O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (120.48 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2048 mL 6.0238 mL 12.0476 mL
5 mM 0.2410 mL 1.2048 mL 2.4095 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2048 mL 6.0238 mL 12.0476 mL 30.1190 mL
5 mM 0.2410 mL 1.2048 mL 2.4095 mL 6.0238 mL
10 mM 0.1205 mL 0.6024 mL 1.2048 mL 3.0119 mL
15 mM 0.0803 mL 0.4016 mL 0.8032 mL 2.0079 mL
20 mM 0.0602 mL 0.3012 mL 0.6024 mL 1.5060 mL
25 mM 0.0482 mL 0.2410 mL 0.4819 mL 1.2048 mL
30 mM 0.0402 mL 0.2008 mL 0.4016 mL 1.0040 mL
40 mM 0.0301 mL 0.1506 mL 0.3012 mL 0.7530 mL
50 mM 0.0241 mL 0.1205 mL 0.2410 mL 0.6024 mL
60 mM 0.0201 mL 0.1004 mL 0.2008 mL 0.5020 mL
80 mM 0.0151 mL 0.0753 mL 0.1506 mL 0.3765 mL
100 mM 0.0120 mL 0.0602 mL 0.1205 mL 0.3012 mL
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Tubulysin B Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulysin B205304-87-6Microtubule/TubulinApoptosisInhibitorinhibitorinhibit

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