2. Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Apoptosis Reactive Oxygen Species
  4. SFI003

SFI003 is a novel SRSF3 inhibitor, and shows anticancer activity by inducing ROS-mediated cell apoptosis against colorectal cancer.

For research use only. We do not sell to patients.

SFI003 Chemical Structure

SFI003 Chemical Structure

CAS No. : 2361332-90-1

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Based on 1 publication(s) in Google Scholar

SFI003 Related Antibodies

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Description

SFI003 is a novel SRSF3 inhibitor, and shows anticancer activity by inducing ROS-mediated cell apoptosis against colorectal cancer[1].

In Vitro

SFI003 (0-2.5  μM, 72 h) inhibits the proliferation of HCT-116 and SW480 cells with IC50 values of 8.78 µM and 48.67 µM, respectively[1].
SFI003 (10, 20 and 50  μM, 72 h) induces cell apoptosis in HCT-116 and SW480 cells [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SFI003 Related Antibodies
In Vivo

SFI003 (subcutaneous injection, 100 and 200 mg/kg for two continuous weeks) inhibits tumor growth in HCT-116 and SW480 xenografts SCID mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

363.44

Formula

C19H17N5OS
CAS No.
SMILES

COC(C=C1)=CC=C1C2=CSC(N/N=C(C3=NC4=CC=CC=C4N3)\C)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SFI003 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SFI0032361332-90-1SFI 003SFI-003ApoptosisReactive Oxygen SpeciesHCT-116SW480colorectal cancerInhibitorinhibitorinhibit

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