Sibiricaxanthone B

Name: Sibiricaxanthone B
Brand: MedChemExpress
SKU: HY-N2171
Rating: 4.5 (1 reviews)

Cat. No.: HY-N2171 Purity: 99.12%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Sibiricaxanthone B is a xanthone isolated from Polygala tenuifolia.

For research use only. We do not sell to patients.

Sibiricaxanthone B Chemical Structure

CAS No. : 241125-81-5

Size	Price	Stock	Quantity
5 mg	USD 170	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Sibiricaxanthone B is a xanthone isolated from Polygala tenuifolia^[1].

In Vivo

Sibiricaxanthone B, tenuifolin, sibiricose A5, sibiricose A6, tenuifoliside A, ginsenoside Re and ginsenoside Rb1 are oral administered after Kai-Xin-San, The results indicated that Sibiricaxanthone B shows no significant differences in pharmacokinetic parameters in normal and AD rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

538.45

Formula

C₂₄H₂₆O₁₄

CAS No.

241125-81-5

Appearance

Solid

Color

Light yellow to green yellow

SMILES

O[C@@H]1[C@H]([C@H](C(C(O)=CC(OC2=CC=C(O)C=C32)=C4C3=O)=C4O)O[C@H](CO)[C@H]1O)O[C@@](OC[C@]5(O)CO)([H])[C@@H]5O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (185.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8572 mL	9.2859 mL	18.5718 mL
5 mM	0.3714 mL	1.8572 mL	3.7144 mL
10 mM	0.1857 mL	0.9286 mL	1.8572 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.64 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.64 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.12%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (253 KB) HNMR (181 KB) CNMR (187 KB) RP-HPLC (206 KB) MS (108 KB)

Handling Instructions (2659 KB)

References

[1]. Wang X，et al. Ultra-fast liquid chromatography with tandem mass spectrometry determination of eight bioactive components of Kai-Xin-San in rat plasma and its application to a comparative pharmacokinetic study in normal and Alzheimer's disease rats.J Sep [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8572 mL	9.2859 mL	18.5718 mL	46.4296 mL
	5 mM	0.3714 mL	1.8572 mL	3.7144 mL	9.2859 mL
	10 mM	0.1857 mL	0.9286 mL	1.8572 mL	4.6430 mL
	15 mM	0.1238 mL	0.6191 mL	1.2381 mL	3.0953 mL
	20 mM	0.0929 mL	0.4643 mL	0.9286 mL	2.3215 mL
	25 mM	0.0743 mL	0.3714 mL	0.7429 mL	1.8572 mL
	30 mM	0.0619 mL	0.3095 mL	0.6191 mL	1.5477 mL
	40 mM	0.0464 mL	0.2321 mL	0.4643 mL	1.1607 mL
	50 mM	0.0371 mL	0.1857 mL	0.3714 mL	0.9286 mL
	60 mM	0.0310 mL	0.1548 mL	0.3095 mL	0.7738 mL
	80 mM	0.0232 mL	0.1161 mL	0.2321 mL	0.5804 mL
	100 mM	0.0186 mL	0.0929 mL	0.1857 mL	0.4643 mL