Sirtuin-1 inhibitor 1

Cat. No.: HY-156781 Purity: 98.09%: FAQs
Data Sheet SDS COA Handling Instructions

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Sirtuin-1 inhibitor 1 (Compound 8) is an inhibitor of Sirtuin-1 that plays important roles in obesity-induced diabetes and aging-related diseases.

For research use only. We do not sell to patients.

Sirtuin-1 inhibitor 1 Chemical Structure

CAS No. : 945114-10-3

Size	Price	Stock	Quantity
5 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 720	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7

Biological Activity
Purity & Documentation
References
Customer Review

Description

Sirtuin-1 inhibitor 1 (Compound 8) is an inhibitor of Sirtuin-1 that plays important roles in obesity-induced diabetes and aging-related diseases^[1].

IC₅₀ & Target

SIRT1

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	23.94 μM Compound: 14l	Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay	[PMID: 32663641]
HT-29	IC₅₀	12.743 μM Compound: 14l	Antiproliferative activity against human HT-29 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay	[PMID: 32663641]

Molecular Weight

331.37

Formula

C₂₀H₁₇N₃O₂

CAS No.

945114-10-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=C(NC(C2=CC=CC=C2)=O)C=C1)NC3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 20.83 mg/mL (62.86 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0178 mL	15.0889 mL	30.1777 mL
5 mM	0.6036 mL	3.0178 mL	6.0355 mL
10 mM	0.3018 mL	1.5089 mL	3.0178 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.09%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (245 KB) HNMR (263 KB) LCMS (97 KB)

Handling Instructions (2659 KB)

References

[1]. Anastasiia Gryniukova, et al. AI-Powered Virtual Screening of Large Compound Libraries Leads to the Discovery of Novel Inhibitors of Sirtuin-1. J Med Chem. 2023 Aug 10;66(15):10241-10251. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0178 mL	15.0889 mL	30.1777 mL	75.4444 mL
	5 mM	0.6036 mL	3.0178 mL	6.0355 mL	15.0889 mL
	10 mM	0.3018 mL	1.5089 mL	3.0178 mL	7.5444 mL
	15 mM	0.2012 mL	1.0059 mL	2.0118 mL	5.0296 mL
	20 mM	0.1509 mL	0.7544 mL	1.5089 mL	3.7722 mL
	25 mM	0.1207 mL	0.6036 mL	1.2071 mL	3.0178 mL
	30 mM	0.1006 mL	0.5030 mL	1.0059 mL	2.5148 mL
	40 mM	0.0754 mL	0.3772 mL	0.7544 mL	1.8861 mL
	50 mM	0.0604 mL	0.3018 mL	0.6036 mL	1.5089 mL
	60 mM	0.0503 mL	0.2515 mL	0.5030 mL	1.2574 mL