SKF 81297 hydrobromide

Name: SKF 81297 hydrobromide
Brand: MedChemExpress
SKU: HY-12236
Rating: 4.5 (1 reviews)

Cat. No.: HY-12236 Purity: 99.62%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

SKF 81297 hydrobromide is a potent and selective dopamine D1 receptor agonist.

For research use only. We do not sell to patients.

SKF 81297 hydrobromide Chemical Structure

CAS No. : 67287-39-2

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 79	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 119	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 260	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 390	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 585	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of SKF 81297 hydrobromide:

(R)-SKF-81297 hydrobromide Get quote
SKF 81297 Get quote

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•Related Screening Libraries:

•Related Small Molecules:

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View All Dopamine Receptor Isoform Specific Products:

View All Isoforms

Dopamine Receptor D₁ Receptor D₂ Receptor D₃ Receptor D₄ Receptor D₅ Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

SKF 81297 hydrobromide is a potent and selective dopamine D1 receptor agonist^[1].

IC₅₀ & Target

D₁ Receptor

In Vivo

SKF 81297 hydrobromide (0.05-0.3 mg/kg, i.m., once) stimulates motor behaviour of MPTP-lesioned monkeys^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Four male rhesus monkeys (Macaca mulatta, 7.0-11.3 kg)^[1]
Dosage:	0.05-0.3 mg/kg
Administration:	Injected intramuscularly (i.m.), once
Result:	Significantly increased rotational behaviour and right-sided hand use in unilateral MPTP-lesioned rhesus monkeys.

Molecular Weight

370.67

Formula

C₁₆H₁₇BrClNO₂

CAS No.

67287-39-2

Appearance

Solid

Color

Off-white to yellow

SMILES

OC1=CC2=C(C(Cl)=C1O)CCNCC2C3=CC=CC=C3.Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 120 mg/mL (323.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 20 mg/mL (53.96 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : ≥ 20 mg/mL (53.96 mM)

Ethanol : ≥ 2 mg/mL (5.40 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6978 mL	13.4891 mL	26.9782 mL
5 mM	0.5396 mL	2.6978 mL	5.3956 mL
10 mM	0.2698 mL	1.3489 mL	2.6978 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 3 mg/mL (8.09 mM); Clear solution

This protocol yields a clear solution of ≥ 3 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 3 mg/mL (8.09 mM); Clear solution

This protocol yields a clear solution of ≥ 3 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.62%

Select Batch:

Data Sheet (280 KB) SDS (252 KB)

COA (258 KB) HNMR (259 KB) RP-HPLC (262 KB) LCMS (102 KB) Elemental Analysis Report (117 KB)

Handling Instructions (2659 KB)

References

[1]. Vermeulen RJ, et al. The selective dopamine D1 receptor agonist, SKF 81297, stimulates motor behaviour of MPTP-lesioned monkeys. Eur J Pharmacol. 1993 Apr 22;235(1):143-7. [Content Brief]

[2]. Auger ML, et al. Amelioration of cognitive impairments induced by GABA hypofunction in the male rat prefrontal cortex by direct and indirect dopamine D1 agonists SKF-81297 and d-Govadine. Neuropharmacology. 2020 Jan 1;162:107844. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol / DMSO / DMF / DMSO	1 mM	2.6978 mL	13.4891 mL	26.9782 mL	67.4454 mL
Ethanol / DMSO / DMF / DMSO	5 mM	0.5396 mL	2.6978 mL	5.3956 mL	13.4891 mL
DMSO / DMF / DMSO	10 mM	0.2698 mL	1.3489 mL	2.6978 mL	6.7445 mL
	15 mM	0.1799 mL	0.8993 mL	1.7985 mL	4.4964 mL
	20 mM	0.1349 mL	0.6745 mL	1.3489 mL	3.3723 mL
	25 mM	0.1079 mL	0.5396 mL	1.0791 mL	2.6978 mL
	30 mM	0.0899 mL	0.4496 mL	0.8993 mL	2.2482 mL
	40 mM	0.0674 mL	0.3372 mL	0.6745 mL	1.6861 mL
	50 mM	0.0540 mL	0.2698 mL	0.5396 mL	1.3489 mL
DMSO	60 mM	0.0450 mL	0.2248 mL	0.4496 mL	1.1241 mL
	80 mM	0.0337 mL	0.1686 mL	0.3372 mL	0.8431 mL
	100 mM	0.0270 mL	0.1349 mL	0.2698 mL	0.6745 mL