2. Apoptosis
  3. MDM-2/p53
  4. SLMP53-1

SLMP53-1 is a wild-type and mutant p53 reactivator with promising antitumor activity. SLMP53-1 mediates the reprograming of glucose metabolism in cancer cells. SLMP53-1 depletes angiogenesis, decreasing endothelial cell tube formation and vascular endothelial growth factor (VEGF) expression levels.

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SLMP53-1 Chemical Structure

SLMP53-1 Chemical Structure

CAS No. : 1643469-17-3

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 418 In-stock
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Based on 1 publication(s) in Google Scholar

SLMP53-1 Related Antibodies

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Description

SLMP53-1 is a wild-type and mutant p53 reactivator with promising antitumor activity. SLMP53-1 mediates the reprograming of glucose metabolism in cancer cells. SLMP53-1 depletes angiogenesis, decreasing endothelial cell tube formation and vascular endothelial growth factor (VEGF) expression levels[1][2].

Molecular Weight

318.37

Formula

C20H18N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N2[C@@](OC[C@@H]2CC3=CNC4=C3C=CC=C4)(C)C5=C1C=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (785.25 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1410 mL 15.7050 mL 31.4100 mL
5 mM 0.6282 mL 3.1410 mL 6.2820 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1410 mL 15.7050 mL 31.4100 mL 78.5250 mL
5 mM 0.6282 mL 3.1410 mL 6.2820 mL 15.7050 mL
10 mM 0.3141 mL 1.5705 mL 3.1410 mL 7.8525 mL
15 mM 0.2094 mL 1.0470 mL 2.0940 mL 5.2350 mL
20 mM 0.1570 mL 0.7852 mL 1.5705 mL 3.9262 mL
25 mM 0.1256 mL 0.6282 mL 1.2564 mL 3.1410 mL
30 mM 0.1047 mL 0.5235 mL 1.0470 mL 2.6175 mL
40 mM 0.0785 mL 0.3926 mL 0.7852 mL 1.9631 mL
50 mM 0.0628 mL 0.3141 mL 0.6282 mL 1.5705 mL
60 mM 0.0523 mL 0.2617 mL 0.5235 mL 1.3087 mL
80 mM 0.0393 mL 0.1963 mL 0.3926 mL 0.9816 mL
100 mM 0.0314 mL 0.1570 mL 0.3141 mL 0.7852 mL
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SLMP53-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SLMP53-11643469-17-3MDM-2/p53anti-angiogenicanti-migratoryantitumorglucose metabolismInhibitorinhibitorinhibit

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